Best TWAS P=3.54e-16 · Best GWAS P=1.82e-16 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | FHL5 | 0.11 | 0.00 | lasso | 4 | -0.01 | 8.3e-01 | 7.85 | -6.0 | 1.6e-09 | -0.59 | 0.05 | 0.26 | FALSE |
2 | GTEx | Artery Tibial | UFL1 | 0.08 | 0.05 | lasso | 4 | 0.04 | 7.9e-04 | 8.12 | 8.1 | 6.5e-16 | 0.96 | 0.03 | 0.96 | FALSE |
3 | GTEx | Artery Tibial | FHL5 | 0.08 | 0.00 | enet | 48 | 0.02 | 7.2e-03 | 8.12 | -6.2 | 5.9e-10 | -0.51 | 0.03 | 0.85 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | GPR63 | 0.25 | -0.01 | enet | 37 | -0.01 | 7.9e-01 | 7.96 | 5.1 | 2.8e-07 | 0.62 | 0.04 | 0.32 | FALSE |
5 | GTEx | Nerve Tibial | UFL1 | 0.09 | 0.11 | lasso | 8 | 0.08 | 2.8e-06 | 8.15 | 8.2 | 3.5e-16 | 0.99 | 0.02 | 0.97 | TRUE |
6 | GTEx | Pancreas | UFL1 | 0.08 | 0.11 | enet | 7 | 0.09 | 1.1e-04 | 7.42 | 7.7 | 1.9e-14 | 0.95 | 0.04 | 0.91 | FALSE |
7 | GTEx | Testis | FHL5 | 0.11 | 0.11 | lasso | 5 | 0.10 | 3.5e-05 | 4.34 | -5.1 | 2.9e-07 | -0.61 | 0.09 | 0.73 | FALSE |
8 | GTEx | Thyroid | UFL1 | 0.06 | 0.00 | lasso | 2 | 0.00 | 6.6e-01 | 8.20 | 7.2 | 4.8e-13 | 0.92 | 0.03 | 0.84 | FALSE |
9 | NTR | Blood | KIAA0776 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.1e-07 | 6.02 | 6.0 | 1.8e-09 | 0.68 | 0.98 | 0.02 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | FHL5 | 0.04 | 0.03 | bslmm | 444 | 0.02 | 2.9e-03 | 7.42 | -7.7 | 1.0e-14 | -0.87 | 0.05 | 0.93 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | FUT9 | 0.04 | 0.00 | bslmm | 486 | 0.01 | 1.1e-02 | 0.15 | 5.8 | 7.1e-09 | 0.53 | 0.07 | 0.38 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | FHL5 | 0.03 | 0.02 | blup | 55 | 0.01 | 7.1e-03 | 8.12 | -7.8 | 8.3e-15 | -0.90 | 0.01 | 0.88 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FHL5 | 0.03 | 0.03 | enet | 3 | 0.02 | 1.9e-03 | 8.10 | -7.5 | 6.6e-14 | -0.85 | 0.01 | 0.74 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | FHL5 | 0.07 | 0.00 | blup | 55 | 0.01 | 4.8e-02 | 8.21 | -6.7 | 1.8e-11 | -0.74 | 0.01 | 0.59 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0776 | 0.05 | 0.07 | lasso | 2 | 0.06 | 1.8e-06 | 8.15 | 8.1 | 3.9e-16 | 0.99 | 0.01 | 0.99 | FALSE |