Best TWAS P=1.84e-29 · Best GWAS P=1.35e-40 conditioned to 0.000306
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | SKAP2 | 0.15 | 0.04 | lasso | 5 | 0.04 | 3.8e-03 | 2.77 | 5.9 | 3.6e-09 | -0.10 | 0.11 | 0.41 | TRUE |
| 2 | GTEx | Muscle Skeletal | HIBADH | 0.21 | 0.18 | enet | 10 | 0.22 | 6.9e-21 | 5.79 | 5.5 | 5.0e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | SKAP2 | 0.17 | 0.02 | enet | 22 | 0.05 | 8.0e-05 | -1.43 | -6.5 | 7.4e-11 | 0.35 | 0.09 | 0.56 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | HIBADH | 0.11 | 0.08 | bslmm | 522 | 0.10 | 8.8e-13 | 5.60 | 5.5 | 3.7e-08 | -0.14 | 1.00 | 0.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HOXA10 | 0.02 | 0.01 | blup | 53 | 0.01 | 9.0e-03 | -13.34 | 11.3 | 1.8e-29 | -0.85 | 0.00 | 0.85 | TRUE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | EVX1 | 0.16 | 0.02 | blup | 50 | 0.12 | 1.4e-04 | 0.22 | -9.4 | 5.5e-21 | 0.74 | 0.01 | 0.48 | FALSE |