Hub : Genes

HIBADH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1400 0.0300 1.6e-11 0.067 0.098 0.132 0.106 0.097 1.5e-08 6.2e-12 9.4e-16 6.9e-13 8.3e-12
2 GTEx Artery Aorta 0.2230 0.0550 2.2e-06 0.068 NA 0.150 NA 0.092 1.3e-04 NA 1.3e-08 NA 9.2e-06
3 GTEx Artery Tibial 0.1681 0.0422 1.1e-07 0.093 NA 0.107 NA 0.107 8.8e-08 NA 9.2e-09 NA 9.3e-09
4 GTEx Brain Cerebellar Hemisphere 0.3130 0.0990 1.1e-03 0.128 NA 0.106 NA 0.098 3.7e-04 NA 1.2e-03 NA 1.7e-03
5 GTEx Brain Cerebellum 0.1870 0.0710 5.5e-03 0.168 NA 0.110 NA 0.143 1.1e-05 NA 4.0e-04 NA 5.2e-05
6 GTEx Cells EBV-transformed lymphocytes 0.2900 0.0890 4.4e-04 0.097 NA 0.043 NA 0.094 4.6e-04 NA 1.6e-02 NA 5.6e-04
7 GTEx Cells Transformed fibroblasts 0.2160 0.0460 6.9e-10 0.095 NA 0.142 NA 0.153 1.4e-07 NA 9.3e-11 NA 1.4e-11
8 GTEx Colon Transverse 0.2110 0.0560 3.8e-05 0.063 NA 0.007 NA 0.037 5.9e-04 NA 1.4e-01 NA 7.2e-03
9 GTEx Esophagus Mucosa 0.1270 0.0380 3.7e-05 0.090 NA 0.083 NA 0.104 1.4e-06 NA 3.2e-06 NA 1.8e-07
10 GTEx Esophagus Muscularis 0.1480 0.0540 1.7e-03 0.009 NA 0.017 NA 0.023 8.2e-02 NA 3.2e-02 NA 1.4e-02
11 GTEx Lung 0.2224 0.0501 1.1e-09 0.106 NA 0.160 NA 0.149 1.7e-08 NA 2.8e-12 NA 1.8e-11
12 GTEx Muscle Skeletal 0.2114 0.0431 7.2e-14 0.185 NA 0.216 NA 0.212 6.8e-18 NA 6.9e-21 NA 1.7e-20
13 GTEx Nerve Tibial 0.1345 0.0447 5.8e-04 0.106 NA 0.040 NA 0.075 6.1e-08 NA 7.4e-04 NA 5.2e-06
14 ROSMAP Brain Pre-frontal Cortex 0.1132 0.0285 9.4e-10 0.081 0.088 0.087 0.100 0.091 1.3e-10 2.1e-11 2.9e-11 8.8e-13 9.8e-12
15 YFS Blood 0.1028 0.0207 0.0e+00 0.038 0.087 0.090 0.091 0.087 2.2e-12 6.5e-27 7.6e-28 4.5e-28 3.9e-27
16 TCGA Breast Invasive Carcinoma 0.0091 0.0056 9.7e-03 0.006 0.009 0.004 NA 0.003 2.2e-02 5.0e-03 3.5e-02 NA 5.4e-02
17 TCGA Head and Neck Squamous Cell Carcinoma 0.0305 0.0171 2.5e-03 0.000 0.011 0.000 NA 0.001 3.2e-01 1.8e-02 2.8e-01 NA 2.3e-01
18 TCGA Kidney Renal Clear Cell Carcinoma 0.0859 0.0430 2.4e-05 0.012 0.045 0.049 NA 0.036 1.3e-02 7.4e-06 3.2e-06 NA 6.4e-05
19 TCGA Pheochromocytoma and Paraganglioma 0.1920 0.0790 5.3e-04 0.110 0.097 0.073 NA 0.110 4.1e-05 1.1e-04 7.7e-04 NA 4.0e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 0.8 1.3 4.3 -1.1 -1.4 -1.8 -0.5 -1.2 -1.1 -1.1 -0.6 -0.8 -0.6 -1.0 -1.4 0.8 -2.1 -0.5 -0.8 -1.4 -1.2 0.1
Bipolar Disorder or Schizophrenia 0.8 1.9 6.7 -1.5 -1.6 -1.7 0.1 -1.5 -1.1 -1.5 -0.6 -0.6 -0.6 -1.1 -2.1 0.8 -2.6 -0.7 -1.2 -1.7 -1.9 -0.0
Depressed Affect (Nagel 2018) 0.3 0.7 2.8 1.7 -0.2 -0.2 -0.3 -0.8 -0.8 0.7 -0.1 -1.0 -0.3 0.7 0.5 -1.7 0.0 0.9 0.4 0.7 0.7 1.2
Depression (Nagel 2018) 0.9 1.4 4.0 2.0 1.4 1.3 0.6 1.2 0.4 1.2 0.9 0.5 1.4 1.6 0.9 -1.9 1.0 1.0 0.3 1.3 1.4 0.3
Intelligence (Savage-Jansen 2018) 0.8 2.4 8.2 1.4 -0.2 -0.1 0.6 0.5 1.2 2.1 0.8 0.5 0.4 1.1 2.9 -0.9 2.6 0.5 2.8 2.0 2.2 1.3
Neuroticism (Nagel 2018) 0.5 1.2 5.2 2.2 -0.4 -0.0 -0.7 -1.1 -0.8 0.9 0.1 -0.9 0.4 0.3 0.6 -1.5 0.2 1.1 1.0 0.7 1.7 2.3
Schizophrenia (2018) 0.4 0.8 2.8 -1.1 -0.9 -0.8 0.4 -0.9 -0.4 -1.0 -0.3 -0.1 -0.3 -0.6 -1.6 0.4 -1.7 -0.5 -0.9 -1.0 -1.5 -0.1
Schizophrenia vs Biploar Disorder 1.4 1.9 3.9 -1.1 -0.5 -1.0 -0.5 -1.2 -1.6 -1.9 -1.8 -1.6 -1.7 -1.3 -1.4 1.1 -1.6 -0.3 -2.0 -1.7 -1.7 -0.9
Worry (Nagel 2018) 0.6 1.2 8.3 1.6 -0.2 0.4 -0.6 -1.4 -0.6 0.3 0.5 -0.4 1.4 -0.3 -0.5 -0.7 -0.2 1.6 0.7 0.2 1.6 2.9
Alzheimer’s Disease (in mother) 0.5 0.6 2.7 1.3 -0.1 -1.0 0.5 0.0 0.6 0.7 -0.3 0.2 -0.4 0.3 1.4 0.4 1.1 -0.5 1.6 1.2 -0.1 0.4
Alzheimer’s Disease (in father) 0.6 0.7 3.1 0.1 1.8 1.5 0.4 0.8 -0.2 0.1 0.4 0.1 0.8 0.5 -0.4 -0.9 -0.0 1.7 -0.8 -0.0 0.8 -0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 1.5 0.8 1.2 0.1 1.2 1.0 0.5 0.9 0.3 0.5 0.1 0.9 1.1 -0.3 0.9 0.2 0.8 1.0 0.3 -0.3
Crohns Disease (2017) 0.8 1.7 7.9 -0.1 1.8 1.9 1.1 2.8 0.4 0.9 -0.0 0.3 -0.0 1.2 1.5 -1.3 0.7 0.2 -0.8 0.6 1.1 -2.7
Irritable Bowel Disease (IBD) 0.4 0.9 2.9 0.6 1.4 1.4 0.7 1.6 -0.2 0.7 -0.1 -0.2 0.7 0.8 1.0 -1.7 0.4 1.1 -0.7 0.4 1.0 -1.1
Ulcerative Colitis (UC) 0.4 0.7 2.5 1.4 0.6 0.4 0.1 0.3 -0.3 1.0 0.2 -0.5 1.0 0.6 1.0 -1.6 0.7 1.3 0.5 0.7 1.1 0.8
Major Depression (MDD) 1.6 2.0 7.7 2.1 0.0 0.3 -0.8 -0.2 -0.6 1.6 0.3 -0.9 0.4 0.7 2.1 -1.8 1.4 1.8 1.6 1.3 2.8 1.9
Reaction Time 3.6 6.9 13.4 -1.7 -3.7 -2.6 -2.9 -3.5 -2.5 -3.2 -3.0 -2.4 -1.7 -3.6 -2.2 3.5 -2.9 -0.2 -1.1 -2.7 -2.1 1.1
Verbal and Numeric Reasoning (VNR) 0.5 1.3 4.7 1.0 -1.0 -0.8 -0.0 -0.0 0.6 1.5 0.3 0.1 -0.2 0.8 2.1 -0.4 2.2 0.2 2.1 1.3 1.3 1.2
Breast Cancer 0.9 2.2 8.3 -1.5 0.3 0.8 -0.1 -0.5 -0.9 -2.2 -0.8 -0.8 -0.4 -1.3 -2.9 1.0 -2.3 0.2 -2.7 -1.9 -1.8 -1.0
Ovarian Cancer 1.4 1.9 4.0 -1.8 -1.0 0.3 -1.2 -1.2 -1.4 -1.8 -1.5 -1.3 -0.2 -1.9 -1.8 0.5 -2.0 -0.6 -1.8 -2.0 -0.2 0.2
Prostate Cancer 10.2 14.3 53.6 1.2 -6.5 -7.3 -5.0 -5.1 -1.8 -0.5 -3.1 -3.2 -4.1 -3.3 2.7 3.9 0.5 -3.6 4.3 -0.6 -0.0 4.2
Age at First Birth 0.2 0.3 1.4 0.1 0.6 -0.3 0.1 0.5 0.3 0.7 0.1 -0.2 -0.6 0.5 1.2 -0.0 1.1 0.0 0.6 0.4 0.2 -0.5
Bipolar Disorder (2011) 0.1 0.1 0.6 -0.1 -0.5 -0.6 0.3 -0.3 0.1 -0.1 0.0 -0.0 -0.6 -0.0 -0.3 0.3 -0.4 -0.3 0.2 -0.1 -0.8 -0.3
Body Mass Index (BMI) (2010) 0.6 0.9 3.9 1.0 0.9 0.9 0.7 0.3 0.5 1.3 0.8 0.2 0.7 1.2 0.7 -2.0 0.9 1.0 0.6 1.1 1.1 0.6
Coronary Artery Disease (CAD) 1.4 1.6 8.7 -0.3 -2.3 -3.0 -0.9 -0.9 -0.8 -0.0 -1.1 -1.4 -2.5 -0.2 0.6 0.2 -0.6 -1.6 0.3 -0.5 -0.9 -0.9
Crohns Disease (2012) 0.8 1.3 5.9 -0.7 1.6 2.0 1.0 2.2 -0.1 0.2 -0.0 0.2 0.4 0.8 0.3 -1.2 0.1 -0.1 -1.5 -0.0 0.4 -2.4
Mean Putamen Volume 1.4 1.6 6.8 -1.7 0.0 0.6 0.4 -0.6 -0.7 -1.7 -0.0 0.1 0.5 -0.9 -2.6 0.9 -2.1 0.3 -1.9 -1.5 -1.9 -0.6
Fasting Glucose 0.3 0.3 1.4 0.6 0.8 1.2 0.6 0.4 -0.1 -0.2 -0.1 -0.0 0.5 0.2 -0.4 -0.5 -0.3 1.0 -0.7 -0.0 -0.4 -0.5
HbA1C 0.4 0.5 1.1 0.9 0.8 0.8 0.9 0.6 0.6 0.9 1.0 0.7 0.4 1.0 0.1 -1.1 0.5 0.6 0.4 0.8 0.1 -0.1
HDL Cholesterol 0.2 0.3 1.1 0.1 -0.8 -0.0 -0.8 -0.8 -0.4 -0.6 -0.3 -0.4 0.4 -0.5 -0.7 0.5 -0.1 0.7 0.0 -0.1 -0.4 1.0
LDL Cholesterol 0.3 0.5 2.1 -0.4 1.4 1.0 1.0 0.6 0.4 0.2 0.7 0.7 1.0 0.4 -0.5 -1.1 -0.7 0.8 -0.6 0.0 0.3 -0.1
Lupus 0.6 0.8 3.4 -1.9 -0.8 -0.1 0.8 -0.1 -0.1 -1.0 0.1 0.3 0.4 -0.4 -1.5 0.9 -1.5 -1.1 -0.8 -1.2 -1.1 -0.4
Neuroticism (2016) 1.1 1.6 6.5 2.5 0.3 -0.0 -0.6 -0.2 -0.5 1.6 0.2 -1.1 -0.1 0.8 2.1 -1.7 1.4 0.7 1.4 1.1 2.2 1.4
Primary Biliary Cirrhosis 0.5 0.7 1.8 1.1 0.0 0.5 0.8 0.5 1.1 1.1 1.1 0.9 0.6 1.1 0.2 -1.3 0.6 0.4 0.9 1.1 0.9 0.5
Rheumatoid Arthritis 0.8 1.1 3.6 0.7 -0.2 1.0 -0.5 -1.4 -1.3 -0.8 -0.6 -1.1 0.6 -0.5 -1.8 -0.8 -1.5 1.9 -1.2 -0.7 -0.1 1.2
Schizophrenia (2014) 0.9 2.0 6.0 -2.0 -0.8 -1.2 0.4 -1.0 -0.8 -1.8 -0.7 -0.3 -0.7 -1.1 -2.3 1.2 -2.5 -1.2 -1.6 -1.7 -2.1 -0.9
Triglycerides 0.5 0.9 2.5 0.2 1.2 0.8 1.2 1.6 0.8 1.1 0.6 0.8 0.4 1.3 1.1 -1.0 0.8 -0.3 0.4 1.0 0.3 -1.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.2 0.6 0.6 0.8 0.7 1.2 0.3 1.0 0.8 0.1 0.1 1.0 0.4 -1.5 0.4 -1.0 0.1 0.4 0.9 -1.4
Ulcerative Colitis 0.1 0.1 0.6 0.4 0.6 -0.2 0.2 -0.1 -0.3 0.2 -0.3 -0.5 0.0 -0.1 0.5 -0.4 0.2 0.8 0.0 0.1 0.0 0.3
Blood Eosinophil Count 0.5 4.1 11.2 0.1 -2.3 -0.6 -2.8 -3.3 -3.2 -1.5 -2.2 -3.2 -0.2 -2.7 -0.9 -0.1 -1.8 0.9 -1.2 -2.1 0.7 2.7
Blood Platelet Count 0.1 1.2 4.4 1.2 1.6 0.3 2.1 0.7 1.3 1.1 1.4 1.3 1.2 1.2 0.6 -0.7 1.0 0.8 1.1 1.1 0.4 0.4
Blood Red Count 0.1 1.3 4.1 2.0 -0.9 -0.9 -1.2 -0.3 0.5 1.5 0.7 0.3 1.1 0.2 1.6 -0.7 1.0 -0.1 2.0 0.8 1.6 1.3
Blood White Count 0.6 4.2 12.3 3.1 1.9 0.9 2.1 2.2 1.6 2.6 1.4 0.9 0.2 2.6 3.5 -1.4 2.8 0.3 2.4 2.6 1.6 -0.8
Heel T-Score 5.4 43.3 130.0 -4.4 3.9 3.5 11.4 10.2 10.2 4.4 6.9 11.0 1.0 7.2 1.2 -0.4 3.9 -8.2 3.0 5.6 -1.9 -8.3
BMI 0.3 1.8 5.5 0.7 1.5 0.7 1.4 1.5 0.5 2.0 1.0 0.3 0.1 1.8 2.2 -2.4 1.3 0.8 0.7 1.3 2.0 -0.4
Height 0.4 7.8 28.3 5.3 1.2 4.4 -1.9 1.3 -0.9 2.8 0.2 -1.9 1.9 1.5 3.7 -4.1 3.4 0.4 1.0 2.1 5.2 1.2
Waist Hip Ratio (WHR) 0.5 2.1 11.1 3.3 -0.5 0.8 -1.6 -1.8 -1.4 0.2 -0.6 -1.6 0.7 -0.4 1.0 0.1 1.0 2.3 1.2 0.4 1.1 2.8
Systolic Blood Pressure 1.7 8.5 30.2 2.9 1.3 -1.7 0.2 2.9 3.2 3.7 1.1 1.6 -1.7 2.7 5.5 0.0 5.5 -2.5 4.4 3.4 1.3 -1.8
Smoking Status 0.1 0.2 0.8 -0.1 0.2 -0.3 0.0 0.3 -0.5 0.3 -0.4 -0.6 -0.9 0.3 0.9 -0.5 -0.2 -0.0 -0.1 0.0 0.2 -0.7
Allergy or Eczema 2.1 5.5 12.2 2.9 3.0 3.5 1.2 1.7 2.0 2.3 2.5 1.8 3.3 1.8 1.3 -2.4 1.9 2.7 1.4 2.1 3.2 1.4
Cardiovascular Disease 2.0 6.5 31.5 2.7 -0.1 -2.2 -0.9 1.5 1.6 3.4 0.5 0.4 -1.6 1.8 5.6 -0.4 4.5 -2.1 4.4 2.8 2.6 0.0
Hypothyroidism (self reported) 0.4 0.8 2.8 -1.7 0.3 0.8 1.2 0.9 0.3 -0.5 0.9 0.8 1.1 0.3 -1.1 -0.3 -0.9 -0.8 -1.4 -0.6 -0.3 -1.1
Respiratory disease 1.7 3.9 13.5 2.4 2.5 3.7 1.9 1.7 1.1 1.4 2.0 1.4 2.5 1.9 -0.3 -2.9 0.3 2.8 -0.2 1.6 1.9 0.9
Type 2 Diabetes (T2D) (2018) 0.5 1.0 4.7 2.2 -0.4 -0.2 -0.5 -0.2 -0.5 0.9 -0.6 -1.2 -0.6 0.1 1.9 -0.5 1.0 0.5 1.3 0.7 1.6 1.0
Lung FEV1/FVC ratio 0.4 1.9 4.5 -1.3 -1.8 -2.1 -0.4 -1.5 -1.2 -1.4 -1.1 -1.0 -1.8 -1.3 -0.7 1.6 -1.4 -0.8 -0.6 -1.7 -1.8 -0.7
Lung FVC 0.7 3.4 11.0 -2.8 0.9 -1.0 2.4 2.4 3.0 0.1 1.5 3.3 -0.4 1.6 -1.2 1.4 -0.3 -1.4 -0.1 0.7 -2.3 -2.7
Neuroticism 0.5 1.2 3.5 1.9 -0.6 -0.5 -1.1 -1.2 -1.1 0.9 -0.5 -1.5 -0.4 0.0 1.1 -1.3 0.5 0.5 1.1 0.6 1.5 1.8
Chronotype (morning person) 2.9 6.7 14.9 -3.9 -1.5 -1.4 -0.1 -1.2 -1.5 -3.4 -1.8 -0.9 -2.1 -2.4 -3.7 2.9 -3.6 -2.0 -3.4 -3.2 -3.7 -2.3
Hair Pigment 0.1 3.5 10.5 -0.3 -0.5 1.5 -2.4 -1.8 -3.2 -2.1 -1.4 -2.8 0.7 -2.1 -1.6 0.2 -2.1 0.9 -2.9 -2.8 0.6 0.8
Tanning 0.7 8.9 15.6 -2.2 -4.0 -3.9 -2.6 -2.8 -2.6 -3.1 -3.6 -2.8 -3.9 -3.1 -1.4 3.0 -3.0 -2.8 -1.9 -3.3 -3.5 -1.7
Hand grip strength (left) 2.0 5.2 15.2 -1.2 3.0 3.9 3.4 3.5 2.5 0.8 2.6 3.0 2.8 2.3 -0.9 -1.6 0.5 0.8 -1.3 1.2 0.3 -2.3
Number of treatments/medications taken 1.4 2.5 7.8 2.8 1.3 1.0 0.5 1.2 0.6 2.1 0.9 0.3 1.0 1.7 1.9 -2.4 2.1 1.3 1.3 1.7 2.3 0.6
Average weekly spirits intake 0.3 0.4 1.0 0.9 0.1 0.0 -0.8 -0.8 -1.0 -0.1 -0.7 -1.0 -0.3 -0.7 0.6 -0.2 -0.1 0.3 0.1 -0.4 0.8 0.8
Sensitivity / hurt feelings 0.3 0.5 2.0 -0.5 0.1 0.2 -0.3 0.1 -1.1 -0.9 -0.8 -0.9 -0.7 -0.4 -0.8 0.2 -0.7 -0.0 -1.4 -0.7 -0.5 -1.0
Frequency of depressed mood in last 2 weeks 0.8 1.2 5.0 2.2 0.3 0.6 0.3 0.0 0.5 1.0 0.4 0.2 1.2 0.7 1.1 -1.0 1.3 1.1 1.4 1.5 1.1 1.6
Hearing difficulty/problems: Yes 1.1 1.6 5.1 1.8 0.8 0.5 -0.3 0.6 0.6 1.9 0.8 0.2 0.5 1.1 1.8 -1.8 1.5 0.6 1.5 1.4 2.3 1.4
Relative age of first facial hair 0.4 0.8 3.5 0.3 0.3 1.1 -0.2 -0.5 0.2 -1.1 0.5 0.7 1.3 -0.5 -1.8 1.2 -0.4 1.9 -0.7 -0.4 -0.9 0.8
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.2 -0.2 -0.5 -0.0 -1.5 -1.6 -1.8 -1.2 -0.9 -1.5 0.2 -1.1 -1.3 -0.1 -1.5 0.9 -1.4 -1.3 -0.3 0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.3 2.3 0.3 0.7 0.4 -0.5 0.2 -0.3 0.5 0.2 -0.4 0.7 0.3 0.5 -1.5 -0.1 0.7 -0.6 -0.1 1.0 0.2
Ever had hysterectomy (womb removed) 0.5 0.6 2.6 1.0 0.9 0.3 -0.1 0.6 0.6 1.1 0.7 0.4 0.7 1.0 0.8 -1.6 0.7 -0.1 0.4 0.9 0.9 0.4
Systolic blood pressure, automated reading 1.2 3.6 12.4 0.9 1.0 -1.2 0.7 2.5 2.1 2.1 0.6 1.2 -1.3 2.0 3.5 0.2 3.1 -2.4 2.0 1.7 0.3 -2.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.4 -0.3 -0.0 0.7 0.8 0.6 0.3 -0.3 0.1 0.6 -0.0 0.3 -0.2 0.4 0.1 -0.8 -0.4 0.1 -0.8 -1.2
Angina 0.4 0.5 1.6 0.6 -1.3 -0.7 -1.1 -1.0 -0.3 0.5 0.1 -0.5 -0.6 -0.1 0.2 -0.4 0.3 -0.4 0.9 -0.0 0.6 1.1
Medication for hormone replacement therapy 0.9 1.0 6.1 1.7 0.2 0.2 -0.7 -0.2 -1.1 1.1 -0.4 -1.4 0.0 0.7 1.5 -2.5 0.5 0.5 0.0 0.4 1.4 0.5
Vitamin and mineral supplements 0.7 1.0 4.2 -2.0 -0.5 -0.5 -0.0 0.0 -0.7 -1.2 -0.8 -0.5 -1.1 -0.6 -0.3 1.4 -0.6 -1.1 -1.2 -1.2 -1.3 -1.3
Supplements: Zinc 0.3 0.3 1.3 0.8 -0.2 0.4 -0.5 -0.3 0.3 0.2 0.7 0.4 1.2 -0.1 -0.0 0.1 0.5 1.1 0.6 0.2 0.6 1.1
Medication: Co-codamol 1.0 1.2 2.6 1.0 1.6 1.3 0.5 1.0 0.8 1.1 1.1 0.8 1.4 1.0 0.8 -1.2 1.3 1.2 0.6 1.1 1.3 0.5
Medication: Metformin 0.7 1.0 4.7 2.2 0.1 0.7 -0.7 -0.2 -1.1 0.6 -1.0 -1.7 -0.2 0.1 1.5 -1.1 0.8 0.8 0.4 0.4 1.5 0.7
Diabetes (father) 1.0 1.3 4.8 2.2 -0.4 -1.1 -1.4 -0.6 -0.7 1.2 -0.6 -1.2 -0.6 -0.0 2.2 -0.8 0.9 0.0 1.6 0.6 1.6 0.8
Diabetes (mother) 0.8 1.1 4.6 1.1 2.1 1.5 0.8 0.9 0.1 1.0 0.8 0.2 0.9 1.0 0.3 -2.0 0.3 0.9 -0.2 0.4 1.5 0.0
Severe depression (siblings) 2.0 2.3 8.8 2.6 0.6 1.4 -0.7 -1.0 -0.5 0.8 0.9 -0.4 2.0 0.2 -0.2 -1.9 0.2 3.0 0.5 0.6 2.3 2.9
Pack years adult smoking proportion 0.7 1.0 2.9 -0.5 -0.5 -0.0 -0.8 -0.9 -1.5 -1.3 -1.4 -1.4 -1.0 -1.0 -1.0 -0.1 -1.3 -0.0 -1.7 -1.1 -0.6 -0.2
Impedance of leg (right) 0.6 3.1 12.0 2.3 -1.3 -1.1 -3.4 -1.7 -2.7 -0.6 -2.9 -3.5 -2.0 -1.3 1.5 0.7 0.2 0.2 0.2 -0.6 0.2 0.6
Leg fat-free mass (left) 0.8 4.4 9.9 1.9 1.8 2.6 1.6 2.1 1.6 2.7 2.2 1.4 2.0 2.3 2.3 -2.8 2.3 0.5 1.6 2.3 3.1 0.5
Trunk fat percentage 0.5 2.0 10.4 2.1 0.3 0.3 -0.6 0.2 -1.0 1.6 -0.7 -1.6 -0.6 0.5 3.2 -1.5 1.6 0.3 1.4 0.9 2.6 0.6
Hand grip strength (right) 1.2 3.1 12.8 -1.8 1.8 3.6 2.5 2.4 1.5 -0.3 1.8 2.3 2.5 1.0 -1.7 -0.6 -0.4 0.0 -1.8 0.2 -0.2 -1.9
Townsend deprivation index at recruitment 1.1 1.5 3.1 0.8 1.7 1.8 1.5 1.5 1.0 0.9 1.3 1.1 1.6 1.4 0.0 -1.7 0.6 1.2 -0.2 1.2 1.1 0.0
Current tobacco smoking 0.3 0.5 2.0 -0.1 -0.2 0.1 -0.2 -0.8 -0.9 -1.0 -0.5 -0.7 -0.1 -0.4 -1.1 0.3 -1.2 1.4 -1.0 -0.6 -0.7 0.4
Average weekly fortified wine intake 0.3 0.4 1.6 0.1 -0.6 -0.4 -0.6 -0.5 0.6 -0.2 0.3 0.6 0.4 -0.7 0.2 1.1 0.4 -0.2 1.1 0.1 0.4 1.3
Maternal smoking around birth 0.4 0.6 3.7 0.5 1.9 1.1 0.5 1.4 0.1 0.5 0.4 0.3 0.4 0.7 0.7 -1.1 0.5 0.1 -0.4 0.3 0.7 -1.1
Fed-up feelings 0.5 0.9 3.2 1.2 1.2 1.1 1.0 1.1 0.1 1.0 0.4 -0.0 -0.0 1.5 0.8 -1.8 1.1 0.8 0.0 1.3 0.6 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.7 1.0 1.6 1.7 1.6 1.6 1.3 0.7 1.4 1.5 1.9 1.4 -0.3 -1.1 0.7 0.7 -0.1 1.1 0.4 -0.4
Relative age voice broke 0.6 0.9 4.7 -1.0 -0.0 -0.1 0.9 0.7 0.6 -0.9 0.2 1.0 -0.4 0.2 -1.1 1.5 -0.6 -0.3 -0.9 -0.3 -2.2 -1.5
Taking other prescription medications 1.0 1.6 5.7 2.4 0.4 0.7 -0.9 -1.0 -1.1 0.8 -0.1 -1.2 0.8 0.2 0.1 -1.8 0.3 2.2 0.6 0.5 1.8 2.3
Age when periods started (menarche) 1.4 3.4 9.2 -3.0 -1.1 -0.7 -0.8 -0.3 -1.4 -2.4 -1.6 -1.0 -1.4 -1.4 -2.4 1.8 -2.1 -1.0 -2.9 -2.2 -2.4 -2.0
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 5.7 1.6 1.0 0.9 0.8 0.9 1.1 1.7 1.4 1.1 1.4 1.7 0.8 -2.4 1.0 0.3 0.6 1.4 0.9 0.4
Heel bone mineral density (BMD) T-score, automated (left) 3.9 8.8 32.4 -1.3 2.6 2.5 5.7 4.6 4.2 2.3 3.5 4.7 1.2 3.9 0.1 -1.9 1.4 -1.9 0.7 2.7 -0.1 -2.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 2.6 1.1 0.5 0.9 0.5 0.1 0.0 0.5 1.0 0.2 0.5 1.0 -0.4 -1.6 -0.3 1.3 -0.5 0.2 0.6 0.7
Qualifications: CSEs or equivalent 0.7 1.0 4.0 -0.6 1.6 1.6 1.0 1.5 0.3 -0.5 0.5 0.7 0.4 0.7 -0.8 -0.2 -0.8 -0.6 -1.5 0.0 -0.5 -2.0
Serious illness, injury or assault to yourself 1.4 1.6 6.6 2.6 -0.2 -0.8 -1.0 -0.7 0.1 1.3 0.2 -0.4 0.2 0.5 1.6 -0.6 1.4 1.9 2.1 1.2 1.4 2.0
High blood pressure 1.5 4.2 18.5 2.1 0.6 -1.6 -0.3 1.6 1.9 2.7 0.7 0.8 -1.0 1.6 4.3 -0.2 3.7 -1.3 3.2 2.2 2.0 -0.3
Hayfever, allergic rhinitis or eczema 3.8 8.2 14.6 3.5 3.5 3.3 1.6 2.7 2.6 3.4 2.9 2.4 3.1 2.7 2.4 -3.0 3.0 2.3 2.4 3.2 3.8 1.0
Multivitamins +/- minerals 1.3 1.7 5.1 1.9 1.2 0.8 0.7 0.8 1.2 1.9 1.1 0.8 1.1 1.3 0.8 -2.2 0.9 1.2 1.4 1.5 1.7 0.6
Stomach or abdominal pain in last month 0.5 0.6 2.5 0.5 1.2 0.2 0.3 1.0 -0.2 1.0 0.1 -0.5 -0.5 0.9 1.6 -1.4 1.0 0.2 -0.0 0.6 0.5 -1.1
Supplements: Glucosamine 2.0 2.6 5.0 2.2 1.8 1.4 0.7 1.0 1.1 2.1 1.8 1.1 1.6 1.5 1.1 -2.2 1.5 1.4 1.5 1.8 2.2 1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.7 0.1 -0.6 -0.6 -0.9 -0.5 -1.0 -0.1 -1.1 -1.3 -0.6 -0.2 0.4 -0.4 -0.3 0.3 -0.3 -0.3 0.1 0.2
Medication: Atenolol 0.5 0.7 2.2 0.6 -0.7 -1.5 -0.8 0.3 0.5 0.6 -0.2 0.1 -1.0 0.4 1.4 0.8 1.5 -0.5 1.2 0.7 -0.4 -0.7
Medication: Levothyroxine sodium 0.6 1.0 4.7 -0.3 0.6 1.8 1.0 0.5 0.2 -0.1 1.4 0.8 2.2 0.4 -1.3 -1.2 -1.0 1.0 -1.3 -0.2 0.4 0.0
Sitting height 1.6 11.2 21.0 3.1 2.0 2.0 2.2 3.9 4.0 4.6 3.5 3.2 1.9 4.1 3.9 -3.0 4.5 -2.5 3.8 4.3 3.3 -0.5
Chronic bronchitis/emphysema (father) 0.3 0.4 1.7 0.1 0.6 0.0 0.7 -0.3 0.6 0.3 1.3 0.9 0.9 0.2 -0.9 -0.8 -0.5 0.6 0.2 0.1 0.1 0.7
High blood pressure (mother) 0.3 0.4 1.0 0.3 0.5 -0.1 0.2 0.8 1.0 0.8 0.8 1.0 0.1 0.7 0.6 -0.3 1.0 -0.7 0.9 0.6 -0.1 -0.7
Body mass index (BMI) 0.5 2.1 6.8 1.0 1.9 1.4 1.2 1.4 0.4 1.9 1.0 0.4 0.9 1.5 1.9 -2.6 1.1 1.4 0.6 1.2 2.5 0.2
Impedance of leg (left) 0.6 2.9 11.3 2.2 -1.0 -0.8 -3.2 -1.4 -2.6 -0.5 -2.7 -3.4 -1.8 -1.2 1.8 0.7 0.5 -0.0 0.3 -0.5 0.6 0.5
Leg predicted mass (left) 0.8 4.5 9.8 1.9 1.8 2.6 1.7 2.2 1.7 2.8 2.2 1.4 2.0 2.3 2.3 -2.8 2.3 0.4 1.6 2.4 3.1 0.5
Trunk fat mass 0.7 2.9 12.2 2.6 0.8 1.1 -0.4 0.7 -0.7 2.2 -0.2 -1.3 -0.1 1.1 3.5 -2.4 1.9 0.6 1.5 1.4 3.3 0.7
Waist circumference 0.5 1.7 6.9 1.9 0.9 1.1 -0.1 0.7 -0.4 1.6 0.1 -0.8 0.1 1.0 2.6 -1.9 1.5 0.7 1.0 1.1 2.4 0.5
Number of incorrect matches in round 1.9 3.1 10.3 -1.6 -0.4 0.3 -0.9 -2.0 -1.9 -2.4 -0.9 -1.1 0.7 -2.0 -3.2 0.8 -2.9 0.8 -2.6 -2.5 -1.6 0.4
Past tobacco smoking 0.6 1.2 3.7 0.2 -0.9 -0.1 -1.1 -1.9 -0.8 -1.1 -0.1 -0.4 1.3 -1.3 -1.7 0.6 -1.1 1.4 -0.5 -0.9 -0.2 1.9
Alcohol usually taken with meals 0.2 0.3 0.9 0.9 -0.4 -0.4 -0.8 -0.2 -0.5 0.2 -0.7 -0.8 -0.9 -0.2 0.8 0.0 0.7 0.4 0.3 0.2 0.5 0.4
Nervous feelings 0.2 0.4 2.8 1.3 -0.3 0.2 0.1 -0.8 -0.2 0.3 0.3 -0.1 0.8 0.1 -0.1 -0.4 0.1 0.6 0.7 0.6 0.5 1.7
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 3.6 1.3 1.0 1.4 1.7 1.2 1.7 1.0 1.5 1.8 1.9 1.3 0.1 -0.5 1.3 0.7 1.2 1.7 0.6 0.4
Hearing difficulty/problems with background noise 0.3 0.4 2.0 0.8 1.4 1.0 0.1 0.8 0.2 0.6 0.3 0.1 0.4 0.8 0.4 -1.1 0.7 -0.0 -0.2 0.6 0.2 -0.6
Hair/balding pattern: Pattern 2 1.4 1.8 6.3 -0.6 1.9 2.0 2.5 2.5 1.5 0.7 1.1 1.6 0.9 1.4 0.5 -0.3 0.3 -0.2 -0.1 1.0 0.7 -1.3
Had menopause 0.3 0.4 2.1 1.0 0.1 0.2 -0.1 -0.3 0.2 0.6 0.5 0.1 0.4 0.0 0.7 -0.2 0.6 0.5 1.0 0.3 1.0 1.5
Had other major operations 0.1 0.2 1.0 0.7 0.1 -0.1 0.1 -0.5 0.3 0.2 0.4 0.3 0.7 -0.0 -0.5 -0.5 0.0 -0.1 0.4 0.3 0.1 1.0
Forced vital capacity (FVC) 0.6 2.2 4.4 0.9 0.6 0.3 1.0 2.1 1.8 2.0 1.2 1.3 -0.5 2.0 2.0 -1.0 1.8 -2.1 1.6 1.9 0.8 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 4.7 10.7 34.7 -0.4 2.9 2.7 5.9 4.8 4.7 2.9 4.1 5.2 1.7 4.5 0.1 -2.6 1.8 -1.4 1.0 3.3 0.1 -2.6
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.7 0.1 0.3 0.2 -0.1 -0.1 -0.1 0.1 0.1 0.0 0.1 -0.1 -0.3 -0.8 -0.2 -0.2 -0.2 -0.0 0.2 0.1
Qualifications: None of the above 0.7 1.5 7.7 -1.2 1.6 0.9 1.4 1.4 0.1 -0.4 0.2 0.3 -0.6 0.9 -1.1 -0.9 -0.9 -0.4 -2.4 -0.4 -1.6 -2.8
Financial difficulties in last 2 years 1.3 1.8 4.8 0.8 1.5 1.7 1.9 2.0 1.2 1.2 1.3 1.4 0.7 2.2 0.5 -1.5 1.2 1.2 0.2 1.6 0.4 -0.8
Mouth/teeth dental problems 0.6 0.9 6.1 -0.1 -1.2 -1.6 0.7 -0.1 0.7 0.2 -0.3 0.5 -1.4 0.1 0.2 0.4 -0.0 -2.5 0.8 0.1 -1.3 -0.9
Heart attack 0.8 1.0 2.6 1.4 -1.4 -1.6 -1.4 -1.1 -0.7 0.3 -0.6 -1.1 -1.4 -0.3 1.1 0.2 0.7 -0.3 1.2 0.2 0.6 1.4
Allergy 3.1 7.1 12.5 -3.1 -3.2 -3.5 -1.7 -2.5 -2.5 -2.9 -3.1 -2.5 -3.2 -2.6 -1.4 3.2 -2.0 -2.4 -1.6 -2.9 -3.4 -1.1
Pain all over the body in last month 0.8 0.8 3.5 0.3 1.6 1.9 -0.0 0.5 -0.1 0.2 0.4 -0.0 1.1 0.5 -0.0 -1.4 -0.3 1.7 -1.0 0.1 1.0 0.4
Diabetes (self-reported) 1.1 1.7 6.4 2.5 0.8 0.4 0.3 0.9 -0.2 1.5 -0.4 -0.9 -0.4 1.1 2.5 -1.2 1.9 0.9 1.4 1.4 1.9 0.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.7 -0.0 1.5 1.6 1.1 1.0 0.5 0.5 0.8 0.9 1.2 0.6 -0.4 -1.1 0.1 0.6 -0.5 0.3 0.6 -0.4
Medication: Ramipril 1.9 2.4 7.7 2.5 0.9 0.4 -0.6 1.2 0.7 1.9 0.7 0.1 0.2 1.4 2.8 -1.2 2.6 0.5 1.9 1.6 2.8 0.9
Medication: Simvastatin 0.6 0.9 2.8 1.7 -1.2 -1.1 -1.4 -0.7 -0.7 0.4 -1.1 -1.4 -1.0 -0.3 1.4 -0.0 0.6 0.7 0.8 0.3 0.8 0.8
Fluid intelligence score 0.7 1.5 5.2 0.3 -2.3 -2.0 -0.5 -0.9 0.4 0.5 -0.6 -0.2 -1.2 -0.2 1.9 1.7 1.7 -0.4 2.3 0.7 -0.0 1.0
Illnesses of siblings 2.5 3.5 12.8 -2.0 -2.4 -2.0 -0.4 -1.7 -0.6 -2.4 -1.8 -0.6 -1.6 -2.2 -1.9 3.6 -1.3 -1.3 -0.6 -1.6 -2.9 -0.8
Neuroticism score 0.2 0.5 2.5 1.6 -0.1 0.2 -0.3 -0.5 -0.7 0.6 -0.1 -0.8 0.1 0.3 0.3 -1.4 0.2 0.6 0.3 0.5 0.9 1.1
Weight 1.0 5.1 17.1 3.0 1.9 2.4 0.6 1.8 0.5 3.1 1.2 -0.1 1.3 2.1 3.5 -3.5 2.6 1.0 1.7 2.2 4.1 0.8
Impedance of arm (right) 1.3 6.0 14.1 0.4 -3.5 -3.1 -3.8 -2.8 -2.7 -1.6 -3.4 -3.4 -3.1 -2.8 1.2 3.2 -0.3 -2.0 0.9 -1.4 -0.8 0.8
Arm fat percentage (right) 0.4 1.6 8.6 1.5 0.1 -0.3 -0.7 -0.1 -1.0 1.4 -0.8 -1.6 -1.0 0.2 2.9 -1.2 1.2 0.6 1.3 0.6 2.4 0.6
Trunk fat-free mass 0.9 5.2 12.9 2.6 2.5 3.4 0.8 2.3 1.1 2.8 2.0 0.8 2.2 2.3 2.4 -3.4 2.4 1.3 1.1 2.3 3.6 0.5
Hip circumference 0.5 2.1 9.2 1.1 1.0 0.9 0.1 1.6 0.1 2.1 0.3 -0.4 -0.1 1.3 3.0 -2.1 1.7 -0.7 1.0 1.4 2.8 -0.3
Time employed in main current job 2.4 2.8 10.2 -3.2 -0.6 -0.2 1.0 0.3 -0.6 -1.9 -0.7 0.2 -0.7 -0.7 -2.3 1.2 -2.3 -1.8 -2.4 -1.8 -2.5 -2.1
Alcohol intake versus 10 years previously 5.9 8.8 21.7 3.9 2.6 0.8 2.3 2.8 2.3 4.4 2.1 1.2 0.5 3.8 4.7 -3.7 3.8 0.6 3.4 3.7 3.4 -0.2
Father’s age at death 2.3 3.1 7.6 -1.6 -2.8 -1.9 -2.0 -2.5 -1.5 -1.9 -1.8 -1.4 -0.9 -2.4 -1.5 1.9 -1.6 -1.1 -0.7 -2.0 -1.3 1.0
Worrier / anxious feelings 0.5 0.9 2.5 1.5 -0.6 -1.3 0.1 -0.2 -0.0 1.2 0.0 -0.6 -1.6 0.9 1.3 -1.0 0.8 -0.7 1.3 0.9 0.7 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.7 1.9 0.6 0.7 0.7 1.2 0.7 1.2 1.0 0.7 1.0 1.5 0.9 -1.5 1.0 0.7 0.6 1.5 0.9 -0.0
Falls in the last year 2.9 4.0 9.1 -0.1 -2.9 -2.2 -2.8 -3.0 -2.5 -1.8 -2.3 -2.6 -1.4 -2.7 -0.5 2.0 -1.2 -0.2 0.0 -1.8 -0.4 2.3
Hair/balding pattern: Pattern 3 0.6 1.0 3.1 0.3 -1.5 -1.7 -1.5 -1.4 -0.9 -0.3 -0.9 -1.1 -0.9 -1.0 0.8 1.2 0.3 0.1 0.8 -0.4 -0.2 0.9
Number of live births 2.0 2.9 4.9 -1.8 -1.7 -1.8 -1.9 -1.1 -1.7 -1.7 -2.0 -1.8 -2.2 -1.5 -0.1 1.4 -1.5 -2.1 -1.6 -1.9 -1.7 -1.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 4.5 0.2 0.0 -0.5 0.6 1.3 1.2 1.1 0.7 1.0 -0.9 1.3 1.2 -0.1 1.0 -2.1 1.2 1.1 -0.1 -1.3
Pulse rate 0.7 1.1 2.8 1.3 1.2 1.3 1.0 0.5 1.1 0.8 1.7 1.3 1.6 1.1 -0.5 -1.5 -0.0 1.1 0.2 0.9 0.6 0.5
Happiness 0.4 0.5 1.7 0.1 -0.8 -1.3 -0.7 -0.6 -0.2 -0.3 -0.7 -0.4 -1.0 -0.3 0.4 1.1 0.4 -0.4 0.7 0.1 -1.1 -0.3
Noisy workplace 0.4 0.5 3.2 -0.4 -0.3 -0.1 0.6 -0.1 0.7 -0.8 0.3 0.7 -0.1 0.1 -1.5 0.6 -0.6 -0.3 -0.7 -0.1 -1.8 -0.5
Qualifications: A levels/AS levels or equivalent 0.6 1.3 7.1 1.3 -1.1 -1.2 -0.3 -0.4 0.7 1.5 0.4 0.3 -0.4 0.3 1.8 -0.0 1.7 -0.5 2.7 1.1 1.3 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.3 -0.3 -1.3 -0.7 -0.3 -1.5 -0.9 -1.0 -0.5 -0.7 -0.5 -0.7 -1.5 0.8 -1.3 0.6 -0.5 -0.9 -0.8 0.8
Mouth/teeth dental problems: Dentures 0.2 0.3 1.5 -0.8 -0.1 0.2 -0.3 -0.0 -0.6 -0.7 -0.1 -0.4 0.0 -0.3 -0.8 0.2 -0.8 0.5 -1.2 -0.8 -0.2 -0.2
Asthma 1.9 3.7 10.1 3.2 1.9 2.9 0.7 1.0 1.0 1.9 1.6 0.8 2.4 1.4 1.1 -2.6 1.1 2.5 1.0 1.8 2.7 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 2.9 -0.5 -0.9 -0.5 -0.7 -1.4 -1.1 -1.4 -0.8 -0.9 -0.3 -1.4 -1.4 0.6 -1.7 0.3 -1.3 -1.5 -0.9 0.3
Medication: Cholesterol lowering 0.6 0.9 4.7 2.2 -0.8 -0.9 -1.1 -0.9 -0.6 0.6 -0.6 -1.2 -0.7 0.2 1.1 -0.5 0.8 0.8 1.0 0.6 0.5 0.9
Depression (self-reported) 1.5 1.8 4.7 1.1 1.0 0.8 1.3 0.9 1.9 1.2 1.7 2.1 2.2 0.7 0.1 -0.6 1.1 0.4 1.7 1.7 1.3 1.2
Medication: Lansoprazole 0.5 0.6 2.0 0.0 0.3 0.3 -1.4 -0.1 -1.3 -0.5 -0.9 -1.4 -0.2 -0.8 0.3 0.2 -0.2 0.3 -0.6 -0.8 1.3 0.6
Prospective memory result 0.6 0.8 2.1 -0.4 1.4 0.7 1.1 1.0 1.2 0.6 1.4 1.4 1.3 0.6 -0.6 -0.7 0.1 -0.7 -0.0 0.2 0.6 -0.4
Lung cancer (father) 0.5 0.6 2.3 0.5 -0.2 1.0 -0.1 -0.8 -0.8 -0.8 -0.1 -0.7 0.6 -0.6 -0.9 0.1 -0.6 1.5 -0.8 -0.6 0.2 1.4
Illnesses of mother 1.5 1.9 3.8 -1.5 -1.5 -0.2 -0.8 -1.5 -1.7 -1.9 -1.5 -1.6 -0.2 -1.6 -1.7 1.1 -1.9 0.7 -1.7 -1.5 -0.9 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.9 0.5 -0.0 -0.3 0.8 1.4 1.5 1.2 0.8 1.2 -0.7 1.2 1.6 0.2 1.3 -2.2 1.6 1.3 0.4 -1.1
Pulse wave Arterial Stiffness index 1.4 1.6 6.2 1.9 0.0 0.2 -1.1 -0.3 -0.2 1.5 0.5 -0.5 0.9 0.6 1.7 -1.5 1.1 0.9 1.6 0.8 2.5 2.2
Impedance of arm (left) 1.2 5.7 13.4 0.4 -3.7 -3.2 -3.4 -2.9 -2.2 -1.6 -3.2 -3.0 -3.0 -2.6 0.9 3.4 -0.2 -2.3 1.1 -1.3 -1.3 0.7
Arm fat mass (right) 0.7 2.9 11.0 2.2 1.4 1.3 0.3 1.2 -0.1 2.3 0.4 -0.6 0.3 1.4 3.3 -2.5 2.0 1.1 1.5 1.6 3.3 0.5
Trunk predicted mass 0.9 5.1 12.7 2.6 2.5 3.4 0.8 2.3 1.2 2.8 2.0 0.8 2.2 2.3 2.4 -3.3 2.4 1.2 1.1 2.3 3.6 0.5
Standing height 0.5 5.3 18.7 4.3 0.4 2.4 -1.2 1.1 0.2 2.8 0.7 -0.8 1.1 1.5 3.9 -2.2 3.4 -0.9 2.5 2.4 3.8 1.1
Length of working week for main job 0.3 0.4 1.4 -1.1 -0.2 0.1 0.7 0.5 0.8 -0.2 0.8 1.2 0.7 0.1 -0.8 0.7 -0.2 -0.9 0.2 0.2 -0.1 0.1
Exposure to tobacco smoke at home 1.3 1.4 4.3 -1.6 -0.4 0.1 -0.5 -0.5 -0.7 -1.7 -1.1 -0.6 -0.4 -1.1 -1.9 0.6 -2.1 -0.6 -2.0 -1.4 -1.5 -1.0
Breastfed as a baby 0.5 0.6 2.3 -1.2 -0.2 -0.2 -0.2 -0.4 -0.4 -1.1 -0.5 -0.2 -0.0 -0.6 -1.5 0.3 -1.2 0.3 -1.3 -1.1 -1.0 -0.7
Tense / ‘highly strung’ 1.0 1.6 3.7 -0.2 -1.1 -0.6 -1.1 -1.9 -1.8 -1.5 -1.3 -1.6 -0.5 -1.7 -1.5 0.9 -1.8 0.6 -1.0 -1.5 -0.7 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.3 1.8 0.5 0.4 0.5 0.5 1.0 1.3 1.0 0.6 1.0 1.2 1.0 -0.9 1.4 1.2 1.4 1.5 0.9 0.9
Hair/balding pattern: Pattern 4 0.4 1.0 3.3 -1.5 -0.4 -0.2 -1.4 -0.2 -1.4 -1.1 -1.3 -1.3 -0.6 -0.6 -1.0 0.1 -1.0 -0.2 -1.8 -1.2 -0.3 -0.9
Birth weight of first child 1.8 3.2 8.9 3.0 0.8 0.9 1.0 0.8 1.8 2.3 1.7 1.1 1.9 1.6 2.0 -1.9 1.4 1.5 2.5 2.3 2.1 1.6
Peak expiratory flow (PEF) 0.1 0.2 1.0 0.3 -0.3 -0.5 -0.5 -0.1 0.1 0.3 -0.2 -0.1 -0.7 0.0 0.8 0.5 0.5 -0.5 1.0 0.4 0.1 0.1
Pulse wave reflection index 0.6 0.7 3.0 0.3 -1.0 -0.5 -1.7 -1.1 -0.9 0.1 -0.6 -1.0 0.3 -0.7 0.4 -0.0 0.2 0.8 0.6 -0.3 1.2 1.7
Ever highly irritable/argumentative for 2 days 1.8 2.2 8.1 1.3 2.2 2.9 1.2 1.3 0.7 0.7 1.5 1.3 2.4 1.0 -0.5 -1.5 0.3 2.4 -0.1 0.9 1.6 0.7
Loud music exposure frequency 1.2 1.3 5.1 -1.4 0.6 0.1 0.2 0.3 -1.1 -1.1 -1.2 -0.8 -1.4 -0.4 -1.1 -0.2 -1.2 -0.5 -2.3 -1.0 -1.3 -2.0
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.2 0.9 0.4 0.7 0.9 0.3 1.1 0.9 1.3 1.3 1.5 0.8 0.2 -0.6 1.2 0.5 1.3 1.0 0.7 1.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.2 1.2 2.0 1.6 -0.0 0.6 0.2 0.9 0.6 0.2 1.4 0.6 1.1 -1.0 1.5 1.9 0.6 1.0 1.9 1.1
Blood clot in the leg (DVT) 0.6 0.8 2.8 -0.6 0.7 0.7 1.4 1.3 1.4 0.3 1.2 1.7 0.7 1.0 -0.7 -0.3 -0.1 -0.4 -0.5 0.3 -0.7 -1.0
Medication: Paracetamol 0.5 0.8 6.5 -0.2 1.1 0.3 0.3 1.4 0.4 0.2 -0.2 0.2 -0.8 1.0 -0.0 -0.9 0.1 -0.6 -1.1 0.2 -0.9 -2.6
Headache pain in last month 0.3 0.5 3.5 -0.7 0.2 0.5 0.5 1.4 0.4 0.2 0.2 0.6 -0.0 0.6 0.4 -0.5 0.1 -1.1 -0.6 0.2 -0.2 -1.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.3 -1.8 0.8 1.7 1.1 0.5 0.4 -0.7 0.7 1.0 1.4 -0.4 -1.3 0.2 -1.0 -0.5 -0.9 -0.5 -0.1 -0.3
Glaucoma (self-reported) 0.9 1.0 3.7 -1.2 -1.0 -0.3 -0.3 -1.4 -0.8 -1.2 -0.5 -0.5 0.2 -1.1 -1.9 0.5 -1.8 -0.7 -0.7 -1.1 -0.8 0.9
Gout (self-reported) 0.4 0.6 2.7 1.3 -0.5 -0.5 -0.4 -0.0 -0.4 0.7 -0.5 -1.0 -1.1 0.7 1.6 -0.5 0.6 -0.2 1.0 0.6 0.7 0.2
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.5 -1.7 -0.4 0.7 0.6 -0.2 -0.6 -1.0 0.6 0.0 0.8 -0.3 -1.8 -0.4 -1.9 -0.6 -1.8 -1.2 -0.4 -0.2
Medication: Amlodipine 0.3 0.4 1.3 0.3 -0.8 -0.5 0.5 -0.0 1.1 0.3 0.9 1.1 -0.1 0.4 -0.3 0.5 0.3 -0.9 0.7 0.4 -0.5 0.2
Medication: Ventolin 100micrograms inhaler 2.8 3.5 7.0 1.9 2.2 2.5 1.8 2.2 1.9 2.2 1.9 1.7 1.5 2.4 1.2 -2.6 1.5 0.1 0.9 2.3 2.0 -0.1
Birth weight 0.5 1.2 5.2 1.1 -0.8 -1.9 -0.7 -0.3 0.7 1.3 -0.2 -0.2 -0.8 0.3 2.2 -0.1 0.8 0.0 2.3 1.1 0.9 0.7
Chronic bronchitis/emphysema (mother) 1.1 1.3 5.3 2.0 0.5 0.6 -0.3 -0.1 0.4 0.8 0.4 0.1 0.8 0.6 1.0 -0.5 1.4 2.3 1.3 1.2 1.3 2.0
High blood pressure (siblings) 0.8 1.2 4.8 1.1 0.8 0.5 0.1 1.3 0.2 1.6 0.4 -0.1 -0.4 1.4 2.2 -2.1 0.9 -0.1 0.5 1.0 1.6 -0.4
Forced vital capacity (FVC), Best measure 1.0 3.8 7.0 1.4 0.7 0.7 1.5 2.6 2.6 2.4 1.8 2.0 -0.1 2.5 2.5 -0.7 2.4 -2.5 2.3 2.5 1.3 -1.3
Body fat percentage 0.5 2.0 10.5 2.1 0.6 0.4 -0.5 0.3 -1.0 1.7 -0.7 -1.6 -0.6 0.7 3.2 -1.8 1.5 0.7 1.2 0.9 2.7 0.5
Leg fat percentage (right) 0.7 2.4 8.5 2.2 1.0 0.5 -0.9 0.1 -1.5 1.6 -0.8 -2.0 -0.2 0.6 2.8 -2.6 0.9 1.7 0.5 0.6 2.9 0.8
Arm fat-free mass (right) 1.4 7.3 16.2 2.6 3.1 4.0 2.0 2.9 1.8 3.2 2.8 1.6 2.9 3.1 2.2 -4.0 2.5 1.4 1.1 2.7 3.7 0.3
Exposure to tobacco smoke outside home 0.4 0.5 1.5 0.6 -0.7 -0.4 -0.7 -1.2 -0.7 -0.7 -1.0 -1.0 -0.4 -0.8 -0.4 0.5 -0.6 1.2 -0.2 -0.3 -0.5 0.7
Comparative body size at age 10 0.8 2.1 9.1 0.5 -2.6 -3.0 -0.6 -1.6 0.5 0.6 -0.2 -0.0 -1.1 -0.7 1.6 1.6 0.8 -1.1 2.8 0.3 -0.0 1.8
Number of full brothers 1.4 1.8 4.3 -0.7 2.0 2.1 1.6 2.0 1.0 0.7 1.6 1.4 1.4 1.7 -0.4 -1.8 -0.2 -0.1 -1.0 0.6 0.5 -1.4
Worry too long after embarrassment 0.4 0.7 2.9 1.7 0.1 -0.3 -0.6 -0.3 0.1 1.0 -0.1 -0.2 -0.0 0.2 1.3 -0.4 1.5 0.6 1.4 1.0 0.9 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 3.1 0.6 -1.3 -0.7 -1.0 -1.5 -0.5 -0.5 -0.4 -0.6 -0.0 -1.0 -0.3 0.7 -0.3 0.8 0.6 -0.0 -0.2 1.8
Wheeze or whistling in the chest in last year 1.0 1.9 7.9 0.9 2.1 2.6 1.4 1.4 0.2 0.9 1.3 0.6 1.6 1.2 -0.5 -2.8 -0.2 0.7 -1.0 0.6 1.6 -0.2
Number of children fathered 0.5 0.5 1.8 0.2 -1.1 -1.4 -1.2 -0.7 -0.6 -0.0 -0.7 -0.7 -1.1 -0.4 0.6 0.4 0.2 -0.7 0.7 0.0 -0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.8 0.4 0.6 0.3 1.2 0.9 1.6 0.8 1.7 1.7 1.1 1.1 -0.3 -0.3 0.6 0.2 1.1 1.0 0.6 0.4
Age at first live birth 0.5 0.8 2.0 0.6 1.1 0.3 1.3 1.4 1.1 0.9 0.8 1.1 -0.3 1.4 0.8 -0.2 1.2 0.6 0.6 1.1 0.1 -0.8
Pulse wave peak to peak time 1.0 1.2 4.9 -1.6 -0.2 -0.1 0.9 0.2 0.1 -1.4 -0.5 0.3 -0.9 -0.6 -1.3 1.5 -0.8 -1.0 -1.3 -0.7 -2.2 -2.0
Health satisfaction 0.2 0.3 0.6 0.3 0.7 0.7 0.6 0.7 0.4 0.5 0.6 0.6 0.2 0.7 -0.0 -0.8 0.2 0.3 -0.0 0.4 0.5 -0.2
Shortness of breath walking on level ground 0.6 0.7 2.0 -0.8 -0.6 0.1 -0.5 -0.8 -0.9 -1.1 -0.6 -0.8 0.5 -1.3 -1.2 0.5 -1.4 -0.2 -1.0 -1.2 0.4 1.1
Qualifications: College or University degree 1.1 3.6 12.9 0.1 -3.6 -3.0 -1.9 -2.4 -0.3 -0.2 -1.4 -1.0 -2.2 -1.9 1.0 2.7 0.8 -2.0 2.7 -0.1 0.1 2.1
Eye problems/disorders: None of the above 0.6 0.7 3.1 -0.2 1.3 0.7 1.0 1.8 1.1 0.4 0.7 1.1 -0.0 1.1 0.5 -0.1 0.9 -0.2 -0.2 0.6 -0.1 -1.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 4.9 0.1 0.8 0.6 0.2 -0.6 -0.7 -0.5 -0.2 -0.5 0.9 -0.1 -1.0 -0.5 -0.8 2.2 -0.9 -0.1 -0.3 0.6
Emphysema/chronic bronchitis 0.7 0.8 3.5 1.0 1.3 1.9 -0.1 0.6 -0.1 0.4 0.6 0.1 1.1 0.3 0.0 -1.1 0.1 1.5 -0.1 0.6 1.4 0.9
Medication for pain relief, constipation, heartburn 0.2 0.3 1.8 -0.2 -0.3 -0.1 -0.2 -0.7 0.1 0.1 0.3 0.1 0.7 -0.5 0.3 0.5 0.4 -0.0 1.0 0.1 0.6 1.3
Neck or shoulder pain in last month 0.4 0.5 1.6 0.8 -0.2 0.5 -1.1 -0.9 -0.9 0.1 -0.4 -1.0 0.6 -0.5 0.1 -1.3 -0.2 0.5 -0.2 -0.2 0.9 1.1
Medication: Blood pressure 0.4 0.6 3.3 0.6 -0.3 -1.8 -0.7 0.3 0.1 0.3 -0.5 -0.4 -1.8 0.7 0.7 0.2 0.8 -0.3 0.1 0.2 -1.1 -1.1
Angina (self-reported) 0.3 0.4 1.9 0.3 -1.4 -0.8 -1.0 -0.8 -0.2 0.4 0.0 -0.5 -1.0 -0.1 0.2 -0.2 0.2 -0.9 0.8 -0.1 0.4 0.7
Migraine (self-reported) 0.4 0.6 2.1 -1.0 -1.4 -0.7 -0.7 -0.9 -0.2 -0.6 -0.4 -0.2 -0.2 -0.8 -0.6 0.9 -0.5 -1.4 0.2 -0.6 -0.4 0.5
Medication: Ibuprofen 0.7 0.9 2.3 -0.0 0.2 0.5 -0.4 -1.0 -1.0 -1.0 -0.2 -0.7 0.8 -1.0 -1.3 -0.4 -1.4 1.5 -1.4 -1.3 -0.0 0.8
Medication: Allopurinol 0.6 0.8 2.5 1.6 -0.9 -1.0 -0.2 -0.1 0.2 1.0 0.4 -0.1 -1.0 0.9 1.3 -0.3 0.9 -0.6 1.6 1.0 0.4 0.6
Medication: Omeprazole 0.6 0.7 2.1 -1.2 -0.9 -1.1 -0.8 0.0 -0.5 -0.5 -1.1 -0.6 -1.4 -0.5 0.3 1.0 -0.4 -1.2 -0.2 -0.6 -0.7 -1.0
Medication: Seretide 50 evohaler 0.7 0.8 3.8 0.5 1.1 1.2 1.3 0.2 0.5 0.4 1.0 0.7 0.7 1.0 -1.3 -1.9 -0.4 0.8 -0.8 0.5 -0.5 0.2
Mean time to correctly identify matches 4.9 9.3 17.2 -2.6 -3.6 -2.5 -3.3 -3.8 -2.9 -4.0 -3.1 -2.5 -1.5 -4.2 -3.2 3.9 -3.7 -0.0 -2.2 -3.6 -2.6 1.0
Heart disease (mother) 1.1 1.3 3.5 -0.0 1.5 1.4 1.5 1.9 1.0 1.2 1.6 1.3 0.5 1.4 0.5 -1.6 0.3 0.2 -0.3 0.6 0.6 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.3 -0.2 0.9 0.3 0.1 0.0 0.1 -0.3 0.6 0.6 0.8 0.1 -1.2 -0.3 -0.3 0.1 -0.7 -0.5 -0.3 0.1
Whole body fat mass 0.8 3.2 13.3 2.7 1.1 1.1 -0.2 1.0 -0.5 2.4 -0.0 -1.1 -0.1 1.4 3.6 -2.6 2.1 0.8 1.5 1.6 3.4 0.5
Leg fat mass (right) 1.0 3.8 13.6 2.8 1.7 1.5 -0.0 1.1 -0.5 2.6 0.2 -1.1 0.5 1.6 3.3 -3.4 1.7 1.6 1.1 1.6 3.7 0.7
Arm predicted mass (right) 1.6 8.0 18.1 2.8 3.3 4.1 2.1 3.0 2.0 3.4 2.9 1.8 3.0 3.2 2.3 -4.2 2.7 1.5 1.2 2.9 3.8 0.3
Pulse rate, automated reading 1.6 5.3 10.4 2.9 2.3 2.3 1.8 1.1 2.1 2.6 3.1 2.1 3.2 2.3 0.8 -3.2 1.2 2.3 1.7 2.4 2.5 1.8
Alcohol intake frequency. 2.3 5.4 10.6 2.6 1.4 1.0 2.3 1.9 3.0 3.0 2.8 2.6 1.5 3.1 2.1 -1.9 2.7 0.9 3.0 3.2 1.6 0.7
Comparative height size at age 10 1.2 6.8 26.0 5.1 0.6 2.4 -1.3 0.3 0.4 2.9 1.2 -0.7 1.9 1.4 3.7 -2.5 3.3 1.4 3.0 2.6 4.5 3.0
Number of full sisters 0.6 0.7 3.8 1.1 1.0 1.0 0.4 0.3 0.4 0.6 0.7 0.4 1.2 0.9 -0.6 -1.9 -0.2 0.9 -0.1 0.8 0.8 0.6
Suffer from ‘nerves’ 0.3 0.4 2.5 -0.3 0.3 0.8 0.6 0.1 0.0 -0.7 0.3 0.4 0.7 -0.0 -1.6 0.0 -0.7 0.5 -1.1 -0.4 -0.7 -0.3
Overall health rating 0.4 0.9 3.7 1.6 -0.6 -0.7 -0.6 -0.0 -1.1 0.8 -0.8 -1.4 -1.1 0.5 1.9 -0.8 0.9 -0.3 0.7 0.8 0.9 0.5
Chest pain or discomfort 0.3 0.5 3.0 1.2 0.7 0.4 -0.6 -0.2 -1.1 0.3 -0.1 -0.8 -0.3 0.2 0.1 -1.7 -0.3 0.9 -0.7 0.1 0.7 0.1
Had major operations 0.2 0.3 1.0 0.2 -0.4 -0.5 -0.4 -0.9 -0.9 0.2 -0.3 -0.9 -0.4 -0.2 -0.1 -1.0 -0.2 0.7 -0.2 -0.3 0.0 0.5
Age at last live birth 0.5 0.8 1.8 0.8 0.8 0.5 1.0 1.3 0.6 0.8 0.3 0.5 -0.4 1.3 1.2 -0.5 1.2 0.8 0.2 1.0 0.0 -1.3
Family relationship satisfaction 0.3 0.4 1.2 0.4 0.9 0.8 0.5 1.1 0.4 0.5 0.1 0.2 0.1 0.9 0.6 -0.6 0.9 0.3 -0.1 0.8 0.0 -0.9
Leg pain on walking 1.8 2.3 9.3 -1.8 -0.2 0.1 -0.1 -0.7 -1.5 -1.8 -0.7 -0.9 -0.5 -1.0 -2.6 -0.2 -3.0 0.2 -2.8 -2.1 -1.3 -0.8
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 6.6 1.5 2.6 2.4 0.9 2.0 0.3 1.5 1.1 0.4 1.4 1.6 1.5 -2.2 1.3 1.4 0.0 1.1 2.3 -0.4
Commuting to job workplace: Car/motor vehicle 1.1 1.3 3.5 1.1 1.5 1.9 1.0 1.1 0.6 0.9 1.4 1.0 1.6 1.1 0.3 -1.4 0.7 1.2 0.3 0.9 1.2 0.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.2 -0.7 -1.1 -1.4 -1.2 -1.2 -1.1 -0.7 -1.5 -1.4 -1.4 -1.4 0.2 0.6 -0.7 -1.2 -0.3 -1.0 -0.5 -0.1
Medication: Aspirin 0.4 0.6 1.7 0.9 -0.6 -0.4 -1.2 -1.1 -0.8 -0.3 -0.6 -0.9 0.2 -0.7 -0.1 0.1 -0.5 1.2 -0.1 -0.5 0.7 1.3
Supplements: Vitamin C 0.3 0.4 2.0 1.4 -0.3 0.4 -1.2 -0.6 -0.5 -0.1 -0.3 -0.6 0.2 -0.4 0.5 0.6 0.5 0.6 0.5 0.3 0.4 0.8
Knee pain experienced in last month 0.6 1.0 3.5 -0.6 0.2 0.8 -0.3 -0.6 -1.6 -1.1 -0.7 -1.2 0.0 -0.8 -1.3 -0.1 -1.9 0.5 -1.9 -1.3 -0.3 0.1
Hypertension (Self-reported) 1.5 4.1 19.0 1.9 0.6 -1.6 -0.4 1.8 1.9 2.6 0.6 0.9 -1.1 1.6 4.4 -0.1 3.6 -1.4 3.2 2.2 2.0 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 6.1 -1.1 0.4 -0.8 0.2 1.7 0.0 0.4 -0.6 -0.2 -1.7 0.6 1.6 0.1 0.7 -2.2 -0.1 -0.1 0.2 -2.5
Illnesses of father: Heart disease 1.0 1.4 5.6 1.1 -1.4 -2.0 -0.7 -0.5 -0.1 0.5 -1.0 -0.8 -2.4 0.0 2.0 1.0 1.1 -1.3 1.7 0.7 0.1 0.1
Illnesses of siblings: Diabetes 3.1 3.8 10.8 3.0 2.4 1.5 0.3 1.1 0.6 2.4 1.5 0.3 1.6 1.8 2.4 -2.6 2.0 1.7 1.7 2.1 3.3 1.5
Smoking status: Previous 0.9 1.4 4.6 0.0 0.6 -0.2 1.1 1.8 1.0 1.6 0.3 0.5 -1.2 1.3 2.1 -0.7 1.4 -1.8 1.1 1.2 0.7 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.2 10.3 2.7 0.3 0.5 0.7 1.1 1.4 2.4 0.8 0.5 -0.0 1.6 3.2 -1.0 2.9 -0.8 3.0 2.5 2.0 0.5
Whole body fat-free mass 1.0 5.7 12.8 2.5 2.4 3.4 1.4 2.5 1.6 3.0 2.3 1.3 2.4 2.5 2.5 -3.3 2.6 1.0 1.4 2.5 3.6 0.5
Leg fat-free mass (right) 0.8 4.2 9.3 1.7 1.7 2.7 1.8 2.1 1.7 2.6 2.3 1.5 2.1 2.2 2.1 -2.6 2.2 0.3 1.6 2.2 3.0 0.5
Arm fat percentage (left) 0.3 1.4 7.3 1.6 0.1 -0.2 -0.4 -0.0 -0.7 1.4 -0.5 -1.2 -0.7 0.5 2.7 -1.3 1.2 0.6 1.4 0.8 2.2 0.7
Average weekly red wine intake 1.0 1.5 6.0 1.1 -0.9 -0.6 -1.9 -1.8 -1.0 -0.3 -1.2 -1.5 -0.2 -1.5 0.2 0.5 0.3 1.8 0.7 -0.4 1.0 2.5
Handedness (chirality/laterality): Left-handed 3.3 4.0 6.4 1.6 2.3 2.5 1.8 2.4 1.5 2.2 1.7 1.4 1.8 2.5 1.7 -2.3 2.5 1.6 1.2 2.4 2.4 0.2
Mood swings 0.2 0.4 1.5 0.8 -0.2 -0.1 -0.5 -0.8 -0.9 0.1 -0.6 -1.1 -0.1 0.1 0.3 -0.9 -0.1 1.2 -0.0 0.3 0.0 0.9
Loneliness, isolation 0.4 0.5 3.2 -0.7 0.3 0.6 0.5 -0.0 -0.0 -0.3 0.4 0.4 0.9 -0.1 -1.8 -1.1 -1.1 0.0 -1.2 -0.3 -0.3 -0.1
Long-standing illness, disability or infirmity 2.0 3.1 10.9 2.5 1.9 2.1 0.6 1.0 0.4 2.0 1.4 0.4 1.8 2.0 0.9 -3.3 1.4 1.9 0.8 1.9 2.4 1.3
Ever had bowel cancer screening 0.4 0.5 1.9 0.4 -0.3 -0.9 -1.4 -1.1 -0.9 0.1 -0.4 -1.0 0.0 -0.7 0.3 -0.6 -0.2 0.5 0.1 -0.5 0.6 1.1
Diabetes diagnosed by doctor 0.8 1.2 4.4 2.1 0.7 0.4 0.7 0.9 0.4 1.3 -0.0 -0.1 0.0 1.1 2.0 -0.7 1.9 0.4 1.5 1.4 1.2 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.0 -0.3 0.0 -0.6 -0.5 -0.4 -0.5 -0.6 -0.5 -0.5 -0.7 -0.3 -0.4 0.3 -0.6 -0.6 -0.7 -0.8 -1.0 -0.9
Friendships satisfaction 0.3 0.3 0.9 0.5 0.7 0.8 0.5 0.8 0.6 0.3 0.3 0.4 0.2 1.0 0.2 -0.2 0.9 0.8 0.1 0.9 -0.3 -0.5
Qualifications: nursing, teaching 0.3 0.5 3.8 0.1 -0.8 -0.1 -0.6 -1.2 0.1 0.2 0.4 0.1 1.0 -0.4 -0.1 -0.0 0.2 0.5 0.9 0.0 0.7 2.0
Commuting to job workplace: Walk 1.1 1.2 3.3 0.9 0.6 -0.4 0.7 1.3 1.3 1.6 0.9 0.7 -0.3 1.5 1.8 -0.7 1.4 -0.3 1.5 1.4 0.6 -0.8
Eye problems/disorders: Cataract 1.1 1.2 3.7 1.6 0.0 0.4 0.2 -0.1 0.9 1.5 1.2 0.8 1.0 0.6 0.9 -0.7 1.2 0.7 1.9 1.2 1.6 1.8
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.2 1.1 0.1 0.4 -1.4 -1.0 -0.3 0.7 0.6 -0.4 1.2 0.0 0.3 -1.0 0.6 1.9 0.9 0.4 1.4 2.0
Medication for cholesterol 1.7 2.6 13.3 -2.2 0.3 1.1 1.1 -0.6 -0.3 -2.1 0.2 0.6 0.6 -0.9 -3.6 1.2 -2.6 0.9 -2.3 -1.3 -2.4 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.7 4.3 12.5 -3.0 -1.4 -0.6 -0.2 -1.5 -1.5 -2.8 -1.5 -0.9 -1.0 -1.7 -3.2 1.6 -3.0 -0.6 -2.9 -2.5 -3.5 -1.3
Back pain experienced in last month 0.5 0.7 1.9 1.2 0.7 0.5 -1.3 0.2 0.0 0.7 0.4 0.0 1.2 0.0 1.4 -0.2 0.9 0.6 1.0 0.7 1.3 0.6
Mineral and other dietary supplements 1.9 2.6 7.9 -2.7 -1.2 -0.7 -0.0 -0.2 -0.5 -2.2 -1.1 -0.2 -1.1 -1.0 -1.5 2.6 -1.1 -1.6 -1.8 -1.5 -2.8 -2.0
Breast cancer (self-reported) 1.2 1.5 4.5 -0.2 -1.2 -0.6 -1.3 -2.1 -0.7 -1.4 -0.8 -0.5 -0.0 -1.6 -2.0 1.4 -1.2 0.7 -0.4 -0.9 -1.1 1.8
Asthma (self-reported) 1.3 2.6 8.0 2.8 1.5 2.6 0.8 0.8 0.9 1.5 1.5 0.9 2.1 1.2 0.6 -2.2 0.8 2.1 0.7 1.6 2.1 1.6
Osteoporosis (self-reported) 1.5 1.9 9.1 3.0 0.3 -0.2 -0.6 -0.6 0.1 1.7 0.4 -0.5 0.2 1.1 1.4 -1.7 1.6 1.2 2.1 1.6 1.6 2.0
Osteoarthritis (self-reported) 0.2 0.3 2.5 0.4 0.1 0.7 -0.0 0.1 -0.2 0.3 0.3 0.1 0.9 0.2 -0.4 -1.6 -0.6 0.4 -0.7 -0.2 0.6 0.4
Medication: Aspirin 0.4 0.5 1.9 0.8 -0.5 0.1 -1.0 -1.0 -0.9 -0.3 -0.5 -0.9 0.4 -0.7 -0.2 -0.1 -0.4 1.4 -0.3 -0.6 0.7 1.1
Medication: Gliclazide 0.4 0.5 1.3 1.0 0.6 0.7 -0.2 0.8 -0.4 0.4 -0.7 -0.8 -0.3 0.6 1.1 -1.1 0.7 0.2 -0.2 0.2 0.9 -0.9
Illnesses of father: None of the above (group 1) 1.4 1.7 5.7 -2.4 -0.4 0.7 0.4 0.1 -0.5 -1.7 -0.5 0.3 0.3 -1.0 -2.2 1.0 -1.4 -1.4 -2.1 -1.5 -1.8 -1.3
Smoking status: Current 0.4 0.7 2.0 -0.6 -0.0 0.3 0.0 -0.5 -0.8 -1.2 -0.5 -0.5 -0.1 -0.3 -1.4 0.2 -1.4 1.3 -1.4 -0.7 -1.0 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 4.3 -1.6 -0.8 -1.1 1.7 0.7 1.5 -0.3 0.6 1.7 -1.0 0.4 -0.8 1.4 -0.5 -1.6 0.2 0.1 -2.1 -1.4
Whole body water mass 0.9 5.4 12.6 2.4 2.4 3.4 1.3 2.3 1.4 2.9 2.2 1.2 2.4 2.4 2.4 -3.3 2.5 1.1 1.3 2.4 3.5 0.5
Leg predicted mass (right) 0.8 4.1 9.5 1.7 1.7 2.7 1.7 2.0 1.6 2.5 2.2 1.4 2.1 2.1 2.1 -2.6 2.1 0.3 1.5 2.1 3.1 0.6
Arm fat mass (left) 0.6 2.5 9.4 2.2 1.2 1.2 0.2 0.9 -0.1 2.1 0.4 -0.6 0.4 1.2 3.0 -2.2 1.8 1.0 1.4 1.4 3.1 0.7
Number of self-reported non-cancer illnesses 0.9 1.5 3.8 2.0 0.8 0.8 0.4 0.9 1.0 1.7 1.5 0.9 1.3 1.5 0.9 -1.8 1.3 0.0 1.1 1.3 1.8 0.8
Average weekly champagne plus white wine intake 0.7 0.9 2.8 -0.9 -1.0 -0.7 -0.8 -1.4 -0.6 -1.3 -0.8 -0.7 -0.2 -1.3 -0.8 1.7 -0.8 0.6 -0.4 -1.0 -0.9 1.0
Miserableness 0.6 1.1 4.1 2.0 0.0 0.8 -0.2 -0.8 -0.4 0.8 0.8 -0.3 1.4 0.7 -0.2 -2.0 0.2 1.7 0.4 0.7 1.0 1.9
Guilty feelings 1.0 1.5 4.5 2.0 0.7 0.6 -0.0 0.1 0.5 1.6 1.0 0.2 1.1 0.7 1.2 -2.0 0.9 0.7 1.4 1.3 2.1 1.6
Wears glasses or contact lenses 1.0 1.1 3.6 0.8 -1.1 -1.2 -1.9 -1.4 -1.4 -0.4 -1.1 -1.7 -0.6 -1.1 0.7 0.4 0.2 0.5 0.2 -0.6 0.7 1.6
Ever taken oral contraceptive pill 0.4 0.5 2.3 0.7 -0.3 -0.3 -1.2 -1.1 -0.7 -0.2 -0.5 -0.8 0.4 -0.5 0.3 -0.0 0.4 0.6 0.4 -0.2 0.6 1.5
Hearing aid user 0.4 0.4 1.8 0.8 0.4 0.6 -0.7 -0.2 0.2 0.3 0.2 0.2 0.8 -0.0 0.4 -0.2 0.3 1.0 0.6 0.7 1.1 1.3
Mother’s age at death 1.2 1.5 3.2 -1.8 -0.4 -0.5 -0.3 -0.1 -1.1 -1.6 -1.3 -0.8 -1.0 -0.9 -1.1 1.3 -1.4 -0.7 -1.8 -1.5 -1.7 -1.6
Financial situation satisfaction 0.3 0.3 1.5 0.0 -0.5 -0.9 -0.5 -0.2 -0.2 -0.3 -0.9 -0.6 -1.2 -0.1 0.5 0.5 0.6 0.0 0.0 0.1 -1.1 -0.6
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.6 1.4 1.4 1.2 1.3 1.2 0.9 1.6 1.0 0.7 -0.1 1.4 1.9 -1.3 1.9 0.2 1.2 1.6 1.3 0.0
Commuting to job workplace: Public transport 1.0 1.2 5.0 0.6 -1.1 -2.2 0.3 0.1 1.4 0.8 0.4 0.7 -1.2 0.9 0.9 0.9 1.0 -1.4 1.9 1.2 -0.8 -0.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.6 -1.1 -1.1 -0.4 -0.4 -1.1 -0.8 -0.9 -0.5 -0.5 0.1 -1.0 -1.1 0.7 -1.3 -1.1 -0.3 -0.8 -0.5 0.7
Medication: Blood pressure 1.5 2.8 13.0 1.3 -0.6 -1.9 -1.4 0.5 1.1 1.7 0.0 0.3 -1.2 0.3 3.6 0.8 3.0 -2.2 2.9 1.3 1.5 -0.1
Pain type(s) experienced in last month: Hip pain 1.3 1.7 2.9 -1.3 -1.3 -1.5 -1.6 -0.7 -1.6 -1.1 -1.3 -1.4 -1.3 -1.2 -0.6 0.4 -1.5 -1.7 -1.5 -1.6 -1.2 -1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.5 1.2 1.3 0.7 0.6 0.5 0.5 1.2 0.6 0.2 0.5 0.4 1.0 -1.3 0.6 0.8 0.9 0.7 1.9 0.7
High cholesterol (Self-reported) 1.1 2.0 5.7 -0.1 -2.4 -2.4 -1.7 -1.8 -1.6 -0.9 -1.8 -1.9 -1.9 -1.3 0.1 1.0 -1.1 -0.9 -0.2 -1.1 -0.8 0.3
Medication: Bendroflumethiazide 0.4 0.6 2.9 -0.4 -0.6 -1.7 -0.5 0.4 0.8 -0.2 -0.3 0.3 -1.5 -0.2 0.5 1.7 0.5 -0.7 0.5 -0.1 -0.6 -0.7
Medication: Paracetamol 0.4 0.6 3.3 0.0 1.1 0.6 0.3 1.1 0.1 0.1 -0.1 -0.0 -0.3 0.9 -0.4 -1.2 -0.3 -0.0 -1.4 -0.0 -0.5 -1.8
Medication: Lisinopril 0.5 0.7 2.3 -0.4 -1.3 -1.5 -0.8 -0.2 0.1 -0.3 -0.7 -0.2 -1.4 -0.6 0.6 1.2 0.3 -1.5 0.3 -0.3 -0.7 -0.6
Medication: Atorvastatin 0.2 0.2 0.7 0.8 0.1 0.1 0.3 0.0 0.3 0.6 0.6 0.6 0.5 0.2 0.1 -0.4 0.6 -0.5 0.7 0.4 0.5 0.4
Illnesses of father: High blood pressure 1.0 1.2 4.2 1.2 0.4 -0.4 -0.2 0.8 1.2 1.3 0.5 0.7 0.1 0.9 2.0 -0.0 1.8 1.0 1.9 1.3 1.3 0.3
Alcohol drinker status: Never 0.8 0.9 2.5 -1.5 -1.2 -0.6 0.1 -1.0 -0.1 -1.2 -0.1 0.4 -0.0 -1.0 -1.6 1.5 -1.4 -0.3 -0.6 -0.8 -1.3 0.2
Ever smoked 0.5 0.9 2.6 0.3 1.1 0.4 1.3 1.6 0.7 1.0 0.2 0.5 -0.8 1.2 1.4 -0.5 1.1 -0.5 0.6 1.1 0.2 -1.4
Basal metabolic rate 1.0 5.8 15.1 2.7 2.4 3.2 1.2 2.4 1.3 3.1 2.1 1.0 2.2 2.5 2.9 -3.4 2.7 1.0 1.6 2.5 3.9 0.6
Leg fat percentage (left) 0.7 2.5 10.2 2.2 1.3 0.9 -0.5 0.4 -1.2 1.8 -0.4 -1.7 0.1 0.8 2.9 -2.8 1.1 1.7 0.6 0.7 3.2 0.9
Arm fat-free mass (left) 1.5 7.5 16.3 2.8 3.2 4.0 1.8 2.9 1.7 3.3 2.6 1.4 2.8 2.9 2.7 -3.9 2.8 1.5 1.2 2.7 4.0 0.3
Number of operations (self-reported) 0.5 0.7 4.9 0.5 0.7 0.5 -0.0 -0.5 -0.6 0.3 0.3 -0.2 1.0 0.4 -1.1 -2.2 -0.4 1.4 -1.1 -0.2 -0.1 0.4
Average weekly beer plus cider intake 0.3 0.4 1.2 -0.9 0.1 -0.3 1.1 0.7 0.5 0.0 0.5 0.7 -0.1 0.8 -0.7 -0.5 -0.7 -0.4 -0.5 0.2 -0.8 -0.9
Irritability 1.3 2.2 8.5 1.6 -0.6 -0.0 -1.8 -1.9 -2.1 0.2 -0.9 -2.2 0.6 -1.2 0.2 -1.7 -0.7 1.9 0.3 -0.4 2.1 2.9
Risk taking 1.6 2.4 8.4 -1.8 -1.5 -1.2 -0.3 -1.8 -1.4 -1.9 -1.0 -1.1 -0.9 -1.6 -2.5 0.9 -2.9 -0.0 -1.7 -2.0 -1.1 0.5
Ever had prostate specific antigen (PSA) test 1.0 1.1 3.5 1.6 -0.6 -1.4 -1.9 -1.6 -1.2 0.4 -0.9 -1.4 -0.7 -0.6 1.0 -0.3 0.8 0.9 0.9 0.3 0.1 1.2
Fractured/broken bones in last 5 years 2.4 3.1 6.4 -1.2 -2.4 -2.0 -1.8 -2.5 -2.1 -2.0 -1.6 -1.9 -1.1 -2.2 -1.6 1.9 -1.8 -0.3 -1.0 -1.9 -1.5 1.3
Age started oral contraceptive pill 0.3 0.4 1.3 -0.5 -0.9 -1.0 -0.5 -0.5 0.7 0.1 0.7 0.8 0.2 -0.4 -0.3 1.0 0.2 -1.1 1.0 -0.0 -0.2 0.6
Diastolic blood pressure, automated reading 0.5 1.5 9.5 0.7 0.2 -1.6 -0.9 0.8 0.4 1.4 -0.5 -0.5 -1.5 0.6 3.1 -0.2 1.9 -1.2 1.5 0.7 0.9 -1.2
Ever depressed for a whole week 0.9 1.2 7.1 1.1 0.8 1.0 -0.4 -0.7 -0.6 0.3 0.5 -0.4 1.1 0.1 -0.9 -2.0 -0.5 2.7 -0.6 -0.0 1.1 1.6
Unable to work because of sickness or disability 0.5 0.7 2.8 -0.1 1.0 1.7 0.6 0.4 -0.1 -0.3 0.4 0.2 1.1 0.4 -1.2 -0.9 -1.0 1.3 -1.3 -0.1 -0.1 -0.1
Commuting to job workplace: Cycle 2.3 2.7 8.5 -2.9 -1.6 -1.5 -0.4 -0.7 -0.6 -2.1 -1.0 -0.2 -1.4 -1.3 -2.5 1.9 -2.1 -1.0 -1.8 -1.8 -2.4 -1.1
Myopia 0.6 0.9 3.3 1.7 -0.5 -0.8 -0.9 -0.4 0.1 1.2 -0.2 -0.3 0.1 0.2 1.5 -0.6 1.2 0.5 1.8 1.0 1.1 1.3
Vascular/heart problems diagnosed by doctor 1.5 4.0 17.9 -1.9 0.1 2.0 0.7 -1.3 -1.7 -2.6 -0.6 -0.6 1.2 -1.4 -4.2 -0.0 -3.5 1.8 -3.4 -2.0 -2.0 0.1
Cholesterol lowering medication 0.7 1.1 3.1 0.6 -1.6 -1.8 -1.4 -1.0 -0.7 0.0 -1.2 -1.1 -1.0 -1.0 1.5 1.0 0.2 -0.8 1.2 -0.4 0.7 0.8
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 4.8 -1.2 -1.4 -1.6 -1.1 -0.3 -0.8 -0.6 -1.3 -1.0 -2.2 -0.5 0.3 0.9 -0.7 -1.9 -0.1 -0.7 -0.7 -0.9
Pain experienced in last month 0.4 0.7 2.4 0.4 -0.5 -0.8 0.8 0.6 1.2 0.7 0.6 1.1 -0.6 0.6 0.8 0.8 1.2 -1.1 1.6 0.9 0.0 -0.2
Supplements: Calcium 1.6 1.7 7.0 2.6 -0.7 -0.7 -1.7 -1.2 -0.2 1.1 -0.1 -0.8 0.0 0.1 1.3 -0.8 1.0 1.3 1.9 0.8 1.7 2.5
Basal cell carcinoma (self-reported) 0.5 0.6 1.6 -0.2 0.6 0.1 0.9 1.0 0.7 1.2 0.9 0.7 0.3 1.3 0.9 -1.2 0.9 -0.2 0.5 0.8 0.7 -0.6
Heart attack/myocardial infarction (self-reported) 0.7 1.0 2.3 1.5 -1.4 -1.5 -1.2 -0.9 -0.5 0.5 -0.5 -1.0 -1.4 -0.1 1.2 0.2 0.9 -0.4 1.3 0.4 0.6 1.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.5 -0.6 0.6 0.5 1.0 1.0 1.0 0.1 0.8 1.2 0.5 0.7 -0.7 -0.3 -0.2 -0.4 -0.7 0.1 -0.5 -0.8
Heart disease (siblings) 0.9 1.1 2.7 0.8 1.1 0.9 0.4 1.3 0.8 1.4 1.4 0.9 0.8 1.4 1.1 -1.6 0.7 -0.6 0.6 1.0 1.3 -0.2
Alcohol drinker status: Previous 0.4 0.4 1.1 -0.2 0.8 1.0 0.8 0.7 0.9 0.1 0.6 0.8 1.0 0.6 -0.8 -0.4 0.1 0.8 -0.2 0.5 0.2 0.1
Pack years of smoking 0.8 1.2 4.1 -1.1 -0.5 -0.1 -0.5 -0.6 -1.4 -1.4 -1.5 -1.4 -1.3 -0.9 -1.2 -0.0 -1.5 -0.5 -2.0 -1.3 -0.9 -0.7
Impedance of whole body 0.9 4.4 11.8 1.1 -2.8 -2.4 -3.4 -2.3 -2.5 -1.3 -3.1 -3.2 -2.7 -2.2 1.2 2.4 -0.0 -1.6 0.7 -1.1 -0.7 0.5
Leg fat mass (left) 1.0 4.0 14.2 2.7 1.9 1.8 0.3 1.4 -0.2 2.7 0.5 -0.8 0.7 1.7 3.4 -3.5 1.9 1.5 1.2 1.7 3.8 0.6
Arm predicted mass (left) 1.2 6.3 14.6 2.4 3.0 3.8 1.7 2.8 1.4 3.1 2.3 1.2 2.4 2.7 2.6 -3.8 2.5 1.2 1.0 2.4 3.8 0.1