Hub : Genes

HIBADH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1400	0.0300	1.6e-11	0.067	0.098	0.132	0.106	0.097	1.5e-08	6.2e-12	9.4e-16	6.9e-13	8.3e-12
2	GTEx	Artery Aorta	0.2230	0.0550	2.2e-06	0.068	NA	0.150	NA	0.092	1.3e-04	NA	1.3e-08	NA	9.2e-06
3	GTEx	Artery Tibial	0.1681	0.0422	1.1e-07	0.093	NA	0.107	NA	0.107	8.8e-08	NA	9.2e-09	NA	9.3e-09
4	GTEx	Brain Cerebellar Hemisphere	0.3130	0.0990	1.1e-03	0.128	NA	0.106	NA	0.098	3.7e-04	NA	1.2e-03	NA	1.7e-03
5	GTEx	Brain Cerebellum	0.1870	0.0710	5.5e-03	0.168	NA	0.110	NA	0.143	1.1e-05	NA	4.0e-04	NA	5.2e-05
6	GTEx	Cells EBV-transformed lymphocytes	0.2900	0.0890	4.4e-04	0.097	NA	0.043	NA	0.094	4.6e-04	NA	1.6e-02	NA	5.6e-04
7	GTEx	Cells Transformed fibroblasts	0.2160	0.0460	6.9e-10	0.095	NA	0.142	NA	0.153	1.4e-07	NA	9.3e-11	NA	1.4e-11
8	GTEx	Colon Transverse	0.2110	0.0560	3.8e-05	0.063	NA	0.007	NA	0.037	5.9e-04	NA	1.4e-01	NA	7.2e-03
9	GTEx	Esophagus Mucosa	0.1270	0.0380	3.7e-05	0.090	NA	0.083	NA	0.104	1.4e-06	NA	3.2e-06	NA	1.8e-07
10	GTEx	Esophagus Muscularis	0.1480	0.0540	1.7e-03	0.009	NA	0.017	NA	0.023	8.2e-02	NA	3.2e-02	NA	1.4e-02
11	GTEx	Lung	0.2224	0.0501	1.1e-09	0.106	NA	0.160	NA	0.149	1.7e-08	NA	2.8e-12	NA	1.8e-11
12	GTEx	Muscle Skeletal	0.2114	0.0431	7.2e-14	0.185	NA	0.216	NA	0.212	6.8e-18	NA	6.9e-21	NA	1.7e-20
13	GTEx	Nerve Tibial	0.1345	0.0447	5.8e-04	0.106	NA	0.040	NA	0.075	6.1e-08	NA	7.4e-04	NA	5.2e-06
14	ROSMAP	Brain Pre-frontal Cortex	0.1132	0.0285	9.4e-10	0.081	0.088	0.087	0.100	0.091	1.3e-10	2.1e-11	2.9e-11	8.8e-13	9.8e-12
15	YFS	Blood	0.1028	0.0207	0.0e+00	0.038	0.087	0.090	0.091	0.087	2.2e-12	6.5e-27	7.6e-28	4.5e-28	3.9e-27
16	TCGA	Breast Invasive Carcinoma	0.0091	0.0056	9.7e-03	0.006	0.009	0.004	NA	0.003	2.2e-02	5.0e-03	3.5e-02	NA	5.4e-02
17	TCGA	Head and Neck Squamous Cell Carcinoma	0.0305	0.0171	2.5e-03	0.000	0.011	0.000	NA	0.001	3.2e-01	1.8e-02	2.8e-01	NA	2.3e-01
18	TCGA	Kidney Renal Clear Cell Carcinoma	0.0859	0.0430	2.4e-05	0.012	0.045	0.049	NA	0.036	1.3e-02	7.4e-06	3.2e-06	NA	6.4e-05
19	TCGA	Pheochromocytoma and Paraganglioma	0.1920	0.0790	5.3e-04	0.110	0.097	0.073	NA	0.110	4.1e-05	1.1e-04	7.7e-04	NA	4.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Bipolar Disorder (2018)	0.8	1.3	4.3	-1.1	-1.4	-1.8	-0.5	-1.2	-1.1	-1.1	-0.6	-0.8	-0.6	-1.0	-1.4	0.8	-2.1	-0.5	-0.8	-1.4	-1.2	0.1
Bipolar Disorder or Schizophrenia	0.8	1.9	6.7	-1.5	-1.6	-1.7	0.1	-1.5	-1.1	-1.5	-0.6	-0.6	-0.6	-1.1	-2.1	0.8	-2.6	-0.7	-1.2	-1.7	-1.9	-0.0
Depressed Affect (Nagel 2018)	0.3	0.7	2.8	1.7	-0.2	-0.2	-0.3	-0.8	-0.8	0.7	-0.1	-1.0	-0.3	0.7	0.5	-1.7	0.0	0.9	0.4	0.7	0.7	1.2
Depression (Nagel 2018)	0.9	1.4	4.0	2.0	1.4	1.3	0.6	1.2	0.4	1.2	0.9	0.5	1.4	1.6	0.9	-1.9	1.0	1.0	0.3	1.3	1.4	0.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	8.2	1.4	-0.2	-0.1	0.6	0.5	1.2	2.1	0.8	0.5	0.4	1.1	2.9	-0.9	2.6	0.5	2.8	2.0	2.2	1.3
Neuroticism (Nagel 2018)	0.5	1.2	5.2	2.2	-0.4	-0.0	-0.7	-1.1	-0.8	0.9	0.1	-0.9	0.4	0.3	0.6	-1.5	0.2	1.1	1.0	0.7	1.7	2.3
Schizophrenia (2018)	0.4	0.8	2.8	-1.1	-0.9	-0.8	0.4	-0.9	-0.4	-1.0	-0.3	-0.1	-0.3	-0.6	-1.6	0.4	-1.7	-0.5	-0.9	-1.0	-1.5	-0.1
Schizophrenia vs Biploar Disorder	1.4	1.9	3.9	-1.1	-0.5	-1.0	-0.5	-1.2	-1.6	-1.9	-1.8	-1.6	-1.7	-1.3	-1.4	1.1	-1.6	-0.3	-2.0	-1.7	-1.7	-0.9
Worry (Nagel 2018)	0.6	1.2	8.3	1.6	-0.2	0.4	-0.6	-1.4	-0.6	0.3	0.5	-0.4	1.4	-0.3	-0.5	-0.7	-0.2	1.6	0.7	0.2	1.6	2.9
Alzheimer’s Disease (in mother)	0.5	0.6	2.7	1.3	-0.1	-1.0	0.5	0.0	0.6	0.7	-0.3	0.2	-0.4	0.3	1.4	0.4	1.1	-0.5	1.6	1.2	-0.1	0.4
Alzheimer’s Disease (in father)	0.6	0.7	3.1	0.1	1.8	1.5	0.4	0.8	-0.2	0.1	0.4	0.1	0.8	0.5	-0.4	-0.9	-0.0	1.7	-0.8	-0.0	0.8	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.8	1.2	0.1	1.2	1.0	0.5	0.9	0.3	0.5	0.1	0.9	1.1	-0.3	0.9	0.2	0.8	1.0	0.3	-0.3
Crohns Disease (2017)	0.8	1.7	7.9	-0.1	1.8	1.9	1.1	2.8	0.4	0.9	-0.0	0.3	-0.0	1.2	1.5	-1.3	0.7	0.2	-0.8	0.6	1.1	-2.7
Irritable Bowel Disease (IBD)	0.4	0.9	2.9	0.6	1.4	1.4	0.7	1.6	-0.2	0.7	-0.1	-0.2	0.7	0.8	1.0	-1.7	0.4	1.1	-0.7	0.4	1.0	-1.1
Ulcerative Colitis (UC)	0.4	0.7	2.5	1.4	0.6	0.4	0.1	0.3	-0.3	1.0	0.2	-0.5	1.0	0.6	1.0	-1.6	0.7	1.3	0.5	0.7	1.1	0.8
Major Depression (MDD)	1.6	2.0	7.7	2.1	0.0	0.3	-0.8	-0.2	-0.6	1.6	0.3	-0.9	0.4	0.7	2.1	-1.8	1.4	1.8	1.6	1.3	2.8	1.9
Reaction Time	3.6	6.9	13.4	-1.7	-3.7	-2.6	-2.9	-3.5	-2.5	-3.2	-3.0	-2.4	-1.7	-3.6	-2.2	3.5	-2.9	-0.2	-1.1	-2.7	-2.1	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.7	1.0	-1.0	-0.8	-0.0	-0.0	0.6	1.5	0.3	0.1	-0.2	0.8	2.1	-0.4	2.2	0.2	2.1	1.3	1.3	1.2
Breast Cancer	0.9	2.2	8.3	-1.5	0.3	0.8	-0.1	-0.5	-0.9	-2.2	-0.8	-0.8	-0.4	-1.3	-2.9	1.0	-2.3	0.2	-2.7	-1.9	-1.8	-1.0
Ovarian Cancer	1.4	1.9	4.0	-1.8	-1.0	0.3	-1.2	-1.2	-1.4	-1.8	-1.5	-1.3	-0.2	-1.9	-1.8	0.5	-2.0	-0.6	-1.8	-2.0	-0.2	0.2
Prostate Cancer	10.2	14.3	53.6	1.2	-6.5	-7.3	-5.0	-5.1	-1.8	-0.5	-3.1	-3.2	-4.1	-3.3	2.7	3.9	0.5	-3.6	4.3	-0.6	-0.0	4.2
Age at First Birth	0.2	0.3	1.4	0.1	0.6	-0.3	0.1	0.5	0.3	0.7	0.1	-0.2	-0.6	0.5	1.2	-0.0	1.1	0.0	0.6	0.4	0.2	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.6	-0.1	-0.5	-0.6	0.3	-0.3	0.1	-0.1	0.0	-0.0	-0.6	-0.0	-0.3	0.3	-0.4	-0.3	0.2	-0.1	-0.8	-0.3
Body Mass Index (BMI) (2010)	0.6	0.9	3.9	1.0	0.9	0.9	0.7	0.3	0.5	1.3	0.8	0.2	0.7	1.2	0.7	-2.0	0.9	1.0	0.6	1.1	1.1	0.6
Coronary Artery Disease (CAD)	1.4	1.6	8.7	-0.3	-2.3	-3.0	-0.9	-0.9	-0.8	-0.0	-1.1	-1.4	-2.5	-0.2	0.6	0.2	-0.6	-1.6	0.3	-0.5	-0.9	-0.9
Crohns Disease (2012)	0.8	1.3	5.9	-0.7	1.6	2.0	1.0	2.2	-0.1	0.2	-0.0	0.2	0.4	0.8	0.3	-1.2	0.1	-0.1	-1.5	-0.0	0.4	-2.4
Mean Putamen Volume	1.4	1.6	6.8	-1.7	0.0	0.6	0.4	-0.6	-0.7	-1.7	-0.0	0.1	0.5	-0.9	-2.6	0.9	-2.1	0.3	-1.9	-1.5	-1.9	-0.6
Fasting Glucose	0.3	0.3	1.4	0.6	0.8	1.2	0.6	0.4	-0.1	-0.2	-0.1	-0.0	0.5	0.2	-0.4	-0.5	-0.3	1.0	-0.7	-0.0	-0.4	-0.5
HbA1C	0.4	0.5	1.1	0.9	0.8	0.8	0.9	0.6	0.6	0.9	1.0	0.7	0.4	1.0	0.1	-1.1	0.5	0.6	0.4	0.8	0.1	-0.1
HDL Cholesterol	0.2	0.3	1.1	0.1	-0.8	-0.0	-0.8	-0.8	-0.4	-0.6	-0.3	-0.4	0.4	-0.5	-0.7	0.5	-0.1	0.7	0.0	-0.1	-0.4	1.0
LDL Cholesterol	0.3	0.5	2.1	-0.4	1.4	1.0	1.0	0.6	0.4	0.2	0.7	0.7	1.0	0.4	-0.5	-1.1	-0.7	0.8	-0.6	0.0	0.3	-0.1
Lupus	0.6	0.8	3.4	-1.9	-0.8	-0.1	0.8	-0.1	-0.1	-1.0	0.1	0.3	0.4	-0.4	-1.5	0.9	-1.5	-1.1	-0.8	-1.2	-1.1	-0.4
Neuroticism (2016)	1.1	1.6	6.5	2.5	0.3	-0.0	-0.6	-0.2	-0.5	1.6	0.2	-1.1	-0.1	0.8	2.1	-1.7	1.4	0.7	1.4	1.1	2.2	1.4
Primary Biliary Cirrhosis	0.5	0.7	1.8	1.1	0.0	0.5	0.8	0.5	1.1	1.1	1.1	0.9	0.6	1.1	0.2	-1.3	0.6	0.4	0.9	1.1	0.9	0.5
Rheumatoid Arthritis	0.8	1.1	3.6	0.7	-0.2	1.0	-0.5	-1.4	-1.3	-0.8	-0.6	-1.1	0.6	-0.5	-1.8	-0.8	-1.5	1.9	-1.2	-0.7	-0.1	1.2
Schizophrenia (2014)	0.9	2.0	6.0	-2.0	-0.8	-1.2	0.4	-1.0	-0.8	-1.8	-0.7	-0.3	-0.7	-1.1	-2.3	1.2	-2.5	-1.2	-1.6	-1.7	-2.1	-0.9
Triglycerides	0.5	0.9	2.5	0.2	1.2	0.8	1.2	1.6	0.8	1.1	0.6	0.8	0.4	1.3	1.1	-1.0	0.8	-0.3	0.4	1.0	0.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.2	0.6	0.6	0.8	0.7	1.2	0.3	1.0	0.8	0.1	0.1	1.0	0.4	-1.5	0.4	-1.0	0.1	0.4	0.9	-1.4
Ulcerative Colitis	0.1	0.1	0.6	0.4	0.6	-0.2	0.2	-0.1	-0.3	0.2	-0.3	-0.5	0.0	-0.1	0.5	-0.4	0.2	0.8	0.0	0.1	0.0	0.3
Blood Eosinophil Count	0.5	4.1	11.2	0.1	-2.3	-0.6	-2.8	-3.3	-3.2	-1.5	-2.2	-3.2	-0.2	-2.7	-0.9	-0.1	-1.8	0.9	-1.2	-2.1	0.7	2.7
Blood Platelet Count	0.1	1.2	4.4	1.2	1.6	0.3	2.1	0.7	1.3	1.1	1.4	1.3	1.2	1.2	0.6	-0.7	1.0	0.8	1.1	1.1	0.4	0.4
Blood Red Count	0.1	1.3	4.1	2.0	-0.9	-0.9	-1.2	-0.3	0.5	1.5	0.7	0.3	1.1	0.2	1.6	-0.7	1.0	-0.1	2.0	0.8	1.6	1.3
Blood White Count	0.6	4.2	12.3	3.1	1.9	0.9	2.1	2.2	1.6	2.6	1.4	0.9	0.2	2.6	3.5	-1.4	2.8	0.3	2.4	2.6	1.6	-0.8
Heel T-Score	5.4	43.3	130.0	-4.4	3.9	3.5	11.4	10.2	10.2	4.4	6.9	11.0	1.0	7.2	1.2	-0.4	3.9	-8.2	3.0	5.6	-1.9	-8.3
BMI	0.3	1.8	5.5	0.7	1.5	0.7	1.4	1.5	0.5	2.0	1.0	0.3	0.1	1.8	2.2	-2.4	1.3	0.8	0.7	1.3	2.0	-0.4
Height	0.4	7.8	28.3	5.3	1.2	4.4	-1.9	1.3	-0.9	2.8	0.2	-1.9	1.9	1.5	3.7	-4.1	3.4	0.4	1.0	2.1	5.2	1.2
Waist Hip Ratio (WHR)	0.5	2.1	11.1	3.3	-0.5	0.8	-1.6	-1.8	-1.4	0.2	-0.6	-1.6	0.7	-0.4	1.0	0.1	1.0	2.3	1.2	0.4	1.1	2.8
Systolic Blood Pressure	1.7	8.5	30.2	2.9	1.3	-1.7	0.2	2.9	3.2	3.7	1.1	1.6	-1.7	2.7	5.5	0.0	5.5	-2.5	4.4	3.4	1.3	-1.8
Smoking Status	0.1	0.2	0.8	-0.1	0.2	-0.3	0.0	0.3	-0.5	0.3	-0.4	-0.6	-0.9	0.3	0.9	-0.5	-0.2	-0.0	-0.1	0.0	0.2	-0.7
Allergy or Eczema	2.1	5.5	12.2	2.9	3.0	3.5	1.2	1.7	2.0	2.3	2.5	1.8	3.3	1.8	1.3	-2.4	1.9	2.7	1.4	2.1	3.2	1.4
Cardiovascular Disease	2.0	6.5	31.5	2.7	-0.1	-2.2	-0.9	1.5	1.6	3.4	0.5	0.4	-1.6	1.8	5.6	-0.4	4.5	-2.1	4.4	2.8	2.6	0.0
Hypothyroidism (self reported)	0.4	0.8	2.8	-1.7	0.3	0.8	1.2	0.9	0.3	-0.5	0.9	0.8	1.1	0.3	-1.1	-0.3	-0.9	-0.8	-1.4	-0.6	-0.3	-1.1
Respiratory disease	1.7	3.9	13.5	2.4	2.5	3.7	1.9	1.7	1.1	1.4	2.0	1.4	2.5	1.9	-0.3	-2.9	0.3	2.8	-0.2	1.6	1.9	0.9
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.7	2.2	-0.4	-0.2	-0.5	-0.2	-0.5	0.9	-0.6	-1.2	-0.6	0.1	1.9	-0.5	1.0	0.5	1.3	0.7	1.6	1.0
Lung FEV1/FVC ratio	0.4	1.9	4.5	-1.3	-1.8	-2.1	-0.4	-1.5	-1.2	-1.4	-1.1	-1.0	-1.8	-1.3	-0.7	1.6	-1.4	-0.8	-0.6	-1.7	-1.8	-0.7
Lung FVC	0.7	3.4	11.0	-2.8	0.9	-1.0	2.4	2.4	3.0	0.1	1.5	3.3	-0.4	1.6	-1.2	1.4	-0.3	-1.4	-0.1	0.7	-2.3	-2.7
Neuroticism	0.5	1.2	3.5	1.9	-0.6	-0.5	-1.1	-1.2	-1.1	0.9	-0.5	-1.5	-0.4	0.0	1.1	-1.3	0.5	0.5	1.1	0.6	1.5	1.8
Chronotype (morning person)	2.9	6.7	14.9	-3.9	-1.5	-1.4	-0.1	-1.2	-1.5	-3.4	-1.8	-0.9	-2.1	-2.4	-3.7	2.9	-3.6	-2.0	-3.4	-3.2	-3.7	-2.3
Hair Pigment	0.1	3.5	10.5	-0.3	-0.5	1.5	-2.4	-1.8	-3.2	-2.1	-1.4	-2.8	0.7	-2.1	-1.6	0.2	-2.1	0.9	-2.9	-2.8	0.6	0.8
Tanning	0.7	8.9	15.6	-2.2	-4.0	-3.9	-2.6	-2.8	-2.6	-3.1	-3.6	-2.8	-3.9	-3.1	-1.4	3.0	-3.0	-2.8	-1.9	-3.3	-3.5	-1.7
Hand grip strength (left)	2.0	5.2	15.2	-1.2	3.0	3.9	3.4	3.5	2.5	0.8	2.6	3.0	2.8	2.3	-0.9	-1.6	0.5	0.8	-1.3	1.2	0.3	-2.3
Number of treatments/medications taken	1.4	2.5	7.8	2.8	1.3	1.0	0.5	1.2	0.6	2.1	0.9	0.3	1.0	1.7	1.9	-2.4	2.1	1.3	1.3	1.7	2.3	0.6
Average weekly spirits intake	0.3	0.4	1.0	0.9	0.1	0.0	-0.8	-0.8	-1.0	-0.1	-0.7	-1.0	-0.3	-0.7	0.6	-0.2	-0.1	0.3	0.1	-0.4	0.8	0.8
Sensitivity / hurt feelings	0.3	0.5	2.0	-0.5	0.1	0.2	-0.3	0.1	-1.1	-0.9	-0.8	-0.9	-0.7	-0.4	-0.8	0.2	-0.7	-0.0	-1.4	-0.7	-0.5	-1.0
Frequency of depressed mood in last 2 weeks	0.8	1.2	5.0	2.2	0.3	0.6	0.3	0.0	0.5	1.0	0.4	0.2	1.2	0.7	1.1	-1.0	1.3	1.1	1.4	1.5	1.1	1.6
Hearing difficulty/problems: Yes	1.1	1.6	5.1	1.8	0.8	0.5	-0.3	0.6	0.6	1.9	0.8	0.2	0.5	1.1	1.8	-1.8	1.5	0.6	1.5	1.4	2.3	1.4
Relative age of first facial hair	0.4	0.8	3.5	0.3	0.3	1.1	-0.2	-0.5	0.2	-1.1	0.5	0.7	1.3	-0.5	-1.8	1.2	-0.4	1.9	-0.7	-0.4	-0.9	0.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.2	-0.2	-0.5	-0.0	-1.5	-1.6	-1.8	-1.2	-0.9	-1.5	0.2	-1.1	-1.3	-0.1	-1.5	0.9	-1.4	-1.3	-0.3	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	2.3	0.3	0.7	0.4	-0.5	0.2	-0.3	0.5	0.2	-0.4	0.7	0.3	0.5	-1.5	-0.1	0.7	-0.6	-0.1	1.0	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.6	1.0	0.9	0.3	-0.1	0.6	0.6	1.1	0.7	0.4	0.7	1.0	0.8	-1.6	0.7	-0.1	0.4	0.9	0.9	0.4
Systolic blood pressure, automated reading	1.2	3.6	12.4	0.9	1.0	-1.2	0.7	2.5	2.1	2.1	0.6	1.2	-1.3	2.0	3.5	0.2	3.1	-2.4	2.0	1.7	0.3	-2.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-0.3	-0.0	0.7	0.8	0.6	0.3	-0.3	0.1	0.6	-0.0	0.3	-0.2	0.4	0.1	-0.8	-0.4	0.1	-0.8	-1.2
Angina	0.4	0.5	1.6	0.6	-1.3	-0.7	-1.1	-1.0	-0.3	0.5	0.1	-0.5	-0.6	-0.1	0.2	-0.4	0.3	-0.4	0.9	-0.0	0.6	1.1
Medication for hormone replacement therapy	0.9	1.0	6.1	1.7	0.2	0.2	-0.7	-0.2	-1.1	1.1	-0.4	-1.4	0.0	0.7	1.5	-2.5	0.5	0.5	0.0	0.4	1.4	0.5
Vitamin and mineral supplements	0.7	1.0	4.2	-2.0	-0.5	-0.5	-0.0	0.0	-0.7	-1.2	-0.8	-0.5	-1.1	-0.6	-0.3	1.4	-0.6	-1.1	-1.2	-1.2	-1.3	-1.3
Supplements: Zinc	0.3	0.3	1.3	0.8	-0.2	0.4	-0.5	-0.3	0.3	0.2	0.7	0.4	1.2	-0.1	-0.0	0.1	0.5	1.1	0.6	0.2	0.6	1.1
Medication: Co-codamol	1.0	1.2	2.6	1.0	1.6	1.3	0.5	1.0	0.8	1.1	1.1	0.8	1.4	1.0	0.8	-1.2	1.3	1.2	0.6	1.1	1.3	0.5
Medication: Metformin	0.7	1.0	4.7	2.2	0.1	0.7	-0.7	-0.2	-1.1	0.6	-1.0	-1.7	-0.2	0.1	1.5	-1.1	0.8	0.8	0.4	0.4	1.5	0.7
Diabetes (father)	1.0	1.3	4.8	2.2	-0.4	-1.1	-1.4	-0.6	-0.7	1.2	-0.6	-1.2	-0.6	-0.0	2.2	-0.8	0.9	0.0	1.6	0.6	1.6	0.8
Diabetes (mother)	0.8	1.1	4.6	1.1	2.1	1.5	0.8	0.9	0.1	1.0	0.8	0.2	0.9	1.0	0.3	-2.0	0.3	0.9	-0.2	0.4	1.5	0.0
Severe depression (siblings)	2.0	2.3	8.8	2.6	0.6	1.4	-0.7	-1.0	-0.5	0.8	0.9	-0.4	2.0	0.2	-0.2	-1.9	0.2	3.0	0.5	0.6	2.3	2.9
Pack years adult smoking proportion	0.7	1.0	2.9	-0.5	-0.5	-0.0	-0.8	-0.9	-1.5	-1.3	-1.4	-1.4	-1.0	-1.0	-1.0	-0.1	-1.3	-0.0	-1.7	-1.1	-0.6	-0.2
Impedance of leg (right)	0.6	3.1	12.0	2.3	-1.3	-1.1	-3.4	-1.7	-2.7	-0.6	-2.9	-3.5	-2.0	-1.3	1.5	0.7	0.2	0.2	0.2	-0.6	0.2	0.6
Leg fat-free mass (left)	0.8	4.4	9.9	1.9	1.8	2.6	1.6	2.1	1.6	2.7	2.2	1.4	2.0	2.3	2.3	-2.8	2.3	0.5	1.6	2.3	3.1	0.5
Trunk fat percentage	0.5	2.0	10.4	2.1	0.3	0.3	-0.6	0.2	-1.0	1.6	-0.7	-1.6	-0.6	0.5	3.2	-1.5	1.6	0.3	1.4	0.9	2.6	0.6
Hand grip strength (right)	1.2	3.1	12.8	-1.8	1.8	3.6	2.5	2.4	1.5	-0.3	1.8	2.3	2.5	1.0	-1.7	-0.6	-0.4	0.0	-1.8	0.2	-0.2	-1.9
Townsend deprivation index at recruitment	1.1	1.5	3.1	0.8	1.7	1.8	1.5	1.5	1.0	0.9	1.3	1.1	1.6	1.4	0.0	-1.7	0.6	1.2	-0.2	1.2	1.1	0.0
Current tobacco smoking	0.3	0.5	2.0	-0.1	-0.2	0.1	-0.2	-0.8	-0.9	-1.0	-0.5	-0.7	-0.1	-0.4	-1.1	0.3	-1.2	1.4	-1.0	-0.6	-0.7	0.4
Average weekly fortified wine intake	0.3	0.4	1.6	0.1	-0.6	-0.4	-0.6	-0.5	0.6	-0.2	0.3	0.6	0.4	-0.7	0.2	1.1	0.4	-0.2	1.1	0.1	0.4	1.3
Maternal smoking around birth	0.4	0.6	3.7	0.5	1.9	1.1	0.5	1.4	0.1	0.5	0.4	0.3	0.4	0.7	0.7	-1.1	0.5	0.1	-0.4	0.3	0.7	-1.1
Fed-up feelings	0.5	0.9	3.2	1.2	1.2	1.1	1.0	1.1	0.1	1.0	0.4	-0.0	-0.0	1.5	0.8	-1.8	1.1	0.8	0.0	1.3	0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.7	1.0	1.6	1.7	1.6	1.6	1.3	0.7	1.4	1.5	1.9	1.4	-0.3	-1.1	0.7	0.7	-0.1	1.1	0.4	-0.4
Relative age voice broke	0.6	0.9	4.7	-1.0	-0.0	-0.1	0.9	0.7	0.6	-0.9	0.2	1.0	-0.4	0.2	-1.1	1.5	-0.6	-0.3	-0.9	-0.3	-2.2	-1.5
Taking other prescription medications	1.0	1.6	5.7	2.4	0.4	0.7	-0.9	-1.0	-1.1	0.8	-0.1	-1.2	0.8	0.2	0.1	-1.8	0.3	2.2	0.6	0.5	1.8	2.3
Age when periods started (menarche)	1.4	3.4	9.2	-3.0	-1.1	-0.7	-0.8	-0.3	-1.4	-2.4	-1.6	-1.0	-1.4	-1.4	-2.4	1.8	-2.1	-1.0	-2.9	-2.2	-2.4	-2.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	5.7	1.6	1.0	0.9	0.8	0.9	1.1	1.7	1.4	1.1	1.4	1.7	0.8	-2.4	1.0	0.3	0.6	1.4	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	3.9	8.8	32.4	-1.3	2.6	2.5	5.7	4.6	4.2	2.3	3.5	4.7	1.2	3.9	0.1	-1.9	1.4	-1.9	0.7	2.7	-0.1	-2.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.6	1.1	0.5	0.9	0.5	0.1	0.0	0.5	1.0	0.2	0.5	1.0	-0.4	-1.6	-0.3	1.3	-0.5	0.2	0.6	0.7
Qualifications: CSEs or equivalent	0.7	1.0	4.0	-0.6	1.6	1.6	1.0	1.5	0.3	-0.5	0.5	0.7	0.4	0.7	-0.8	-0.2	-0.8	-0.6	-1.5	0.0	-0.5	-2.0
Serious illness, injury or assault to yourself	1.4	1.6	6.6	2.6	-0.2	-0.8	-1.0	-0.7	0.1	1.3	0.2	-0.4	0.2	0.5	1.6	-0.6	1.4	1.9	2.1	1.2	1.4	2.0
High blood pressure	1.5	4.2	18.5	2.1	0.6	-1.6	-0.3	1.6	1.9	2.7	0.7	0.8	-1.0	1.6	4.3	-0.2	3.7	-1.3	3.2	2.2	2.0	-0.3
Hayfever, allergic rhinitis or eczema	3.8	8.2	14.6	3.5	3.5	3.3	1.6	2.7	2.6	3.4	2.9	2.4	3.1	2.7	2.4	-3.0	3.0	2.3	2.4	3.2	3.8	1.0
Multivitamins +/- minerals	1.3	1.7	5.1	1.9	1.2	0.8	0.7	0.8	1.2	1.9	1.1	0.8	1.1	1.3	0.8	-2.2	0.9	1.2	1.4	1.5	1.7	0.6
Stomach or abdominal pain in last month	0.5	0.6	2.5	0.5	1.2	0.2	0.3	1.0	-0.2	1.0	0.1	-0.5	-0.5	0.9	1.6	-1.4	1.0	0.2	-0.0	0.6	0.5	-1.1
Supplements: Glucosamine	2.0	2.6	5.0	2.2	1.8	1.4	0.7	1.0	1.1	2.1	1.8	1.1	1.6	1.5	1.1	-2.2	1.5	1.4	1.5	1.8	2.2	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.7	0.1	-0.6	-0.6	-0.9	-0.5	-1.0	-0.1	-1.1	-1.3	-0.6	-0.2	0.4	-0.4	-0.3	0.3	-0.3	-0.3	0.1	0.2
Medication: Atenolol	0.5	0.7	2.2	0.6	-0.7	-1.5	-0.8	0.3	0.5	0.6	-0.2	0.1	-1.0	0.4	1.4	0.8	1.5	-0.5	1.2	0.7	-0.4	-0.7
Medication: Levothyroxine sodium	0.6	1.0	4.7	-0.3	0.6	1.8	1.0	0.5	0.2	-0.1	1.4	0.8	2.2	0.4	-1.3	-1.2	-1.0	1.0	-1.3	-0.2	0.4	0.0
Sitting height	1.6	11.2	21.0	3.1	2.0	2.0	2.2	3.9	4.0	4.6	3.5	3.2	1.9	4.1	3.9	-3.0	4.5	-2.5	3.8	4.3	3.3	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.7	0.1	0.6	0.0	0.7	-0.3	0.6	0.3	1.3	0.9	0.9	0.2	-0.9	-0.8	-0.5	0.6	0.2	0.1	0.1	0.7
High blood pressure (mother)	0.3	0.4	1.0	0.3	0.5	-0.1	0.2	0.8	1.0	0.8	0.8	1.0	0.1	0.7	0.6	-0.3	1.0	-0.7	0.9	0.6	-0.1	-0.7
Body mass index (BMI)	0.5	2.1	6.8	1.0	1.9	1.4	1.2	1.4	0.4	1.9	1.0	0.4	0.9	1.5	1.9	-2.6	1.1	1.4	0.6	1.2	2.5	0.2
Impedance of leg (left)	0.6	2.9	11.3	2.2	-1.0	-0.8	-3.2	-1.4	-2.6	-0.5	-2.7	-3.4	-1.8	-1.2	1.8	0.7	0.5	-0.0	0.3	-0.5	0.6	0.5
Leg predicted mass (left)	0.8	4.5	9.8	1.9	1.8	2.6	1.7	2.2	1.7	2.8	2.2	1.4	2.0	2.3	2.3	-2.8	2.3	0.4	1.6	2.4	3.1	0.5
Trunk fat mass	0.7	2.9	12.2	2.6	0.8	1.1	-0.4	0.7	-0.7	2.2	-0.2	-1.3	-0.1	1.1	3.5	-2.4	1.9	0.6	1.5	1.4	3.3	0.7
Waist circumference	0.5	1.7	6.9	1.9	0.9	1.1	-0.1	0.7	-0.4	1.6	0.1	-0.8	0.1	1.0	2.6	-1.9	1.5	0.7	1.0	1.1	2.4	0.5
Number of incorrect matches in round	1.9	3.1	10.3	-1.6	-0.4	0.3	-0.9	-2.0	-1.9	-2.4	-0.9	-1.1	0.7	-2.0	-3.2	0.8	-2.9	0.8	-2.6	-2.5	-1.6	0.4
Past tobacco smoking	0.6	1.2	3.7	0.2	-0.9	-0.1	-1.1	-1.9	-0.8	-1.1	-0.1	-0.4	1.3	-1.3	-1.7	0.6	-1.1	1.4	-0.5	-0.9	-0.2	1.9
Alcohol usually taken with meals	0.2	0.3	0.9	0.9	-0.4	-0.4	-0.8	-0.2	-0.5	0.2	-0.7	-0.8	-0.9	-0.2	0.8	0.0	0.7	0.4	0.3	0.2	0.5	0.4
Nervous feelings	0.2	0.4	2.8	1.3	-0.3	0.2	0.1	-0.8	-0.2	0.3	0.3	-0.1	0.8	0.1	-0.1	-0.4	0.1	0.6	0.7	0.6	0.5	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	3.6	1.3	1.0	1.4	1.7	1.2	1.7	1.0	1.5	1.8	1.9	1.3	0.1	-0.5	1.3	0.7	1.2	1.7	0.6	0.4
Hearing difficulty/problems with background noise	0.3	0.4	2.0	0.8	1.4	1.0	0.1	0.8	0.2	0.6	0.3	0.1	0.4	0.8	0.4	-1.1	0.7	-0.0	-0.2	0.6	0.2	-0.6
Hair/balding pattern: Pattern 2	1.4	1.8	6.3	-0.6	1.9	2.0	2.5	2.5	1.5	0.7	1.1	1.6	0.9	1.4	0.5	-0.3	0.3	-0.2	-0.1	1.0	0.7	-1.3
Had menopause	0.3	0.4	2.1	1.0	0.1	0.2	-0.1	-0.3	0.2	0.6	0.5	0.1	0.4	0.0	0.7	-0.2	0.6	0.5	1.0	0.3	1.0	1.5
Had other major operations	0.1	0.2	1.0	0.7	0.1	-0.1	0.1	-0.5	0.3	0.2	0.4	0.3	0.7	-0.0	-0.5	-0.5	0.0	-0.1	0.4	0.3	0.1	1.0
Forced vital capacity (FVC)	0.6	2.2	4.4	0.9	0.6	0.3	1.0	2.1	1.8	2.0	1.2	1.3	-0.5	2.0	2.0	-1.0	1.8	-2.1	1.6	1.9	0.8	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.7	34.7	-0.4	2.9	2.7	5.9	4.8	4.7	2.9	4.1	5.2	1.7	4.5	0.1	-2.6	1.8	-1.4	1.0	3.3	0.1	-2.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.7	0.1	0.3	0.2	-0.1	-0.1	-0.1	0.1	0.1	0.0	0.1	-0.1	-0.3	-0.8	-0.2	-0.2	-0.2	-0.0	0.2	0.1
Qualifications: None of the above	0.7	1.5	7.7	-1.2	1.6	0.9	1.4	1.4	0.1	-0.4	0.2	0.3	-0.6	0.9	-1.1	-0.9	-0.9	-0.4	-2.4	-0.4	-1.6	-2.8
Financial difficulties in last 2 years	1.3	1.8	4.8	0.8	1.5	1.7	1.9	2.0	1.2	1.2	1.3	1.4	0.7	2.2	0.5	-1.5	1.2	1.2	0.2	1.6	0.4	-0.8
Mouth/teeth dental problems	0.6	0.9	6.1	-0.1	-1.2	-1.6	0.7	-0.1	0.7	0.2	-0.3	0.5	-1.4	0.1	0.2	0.4	-0.0	-2.5	0.8	0.1	-1.3	-0.9
Heart attack	0.8	1.0	2.6	1.4	-1.4	-1.6	-1.4	-1.1	-0.7	0.3	-0.6	-1.1	-1.4	-0.3	1.1	0.2	0.7	-0.3	1.2	0.2	0.6	1.4
Allergy	3.1	7.1	12.5	-3.1	-3.2	-3.5	-1.7	-2.5	-2.5	-2.9	-3.1	-2.5	-3.2	-2.6	-1.4	3.2	-2.0	-2.4	-1.6	-2.9	-3.4	-1.1
Pain all over the body in last month	0.8	0.8	3.5	0.3	1.6	1.9	-0.0	0.5	-0.1	0.2	0.4	-0.0	1.1	0.5	-0.0	-1.4	-0.3	1.7	-1.0	0.1	1.0	0.4
Diabetes (self-reported)	1.1	1.7	6.4	2.5	0.8	0.4	0.3	0.9	-0.2	1.5	-0.4	-0.9	-0.4	1.1	2.5	-1.2	1.9	0.9	1.4	1.4	1.9	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.7	-0.0	1.5	1.6	1.1	1.0	0.5	0.5	0.8	0.9	1.2	0.6	-0.4	-1.1	0.1	0.6	-0.5	0.3	0.6	-0.4
Medication: Ramipril	1.9	2.4	7.7	2.5	0.9	0.4	-0.6	1.2	0.7	1.9	0.7	0.1	0.2	1.4	2.8	-1.2	2.6	0.5	1.9	1.6	2.8	0.9
Medication: Simvastatin	0.6	0.9	2.8	1.7	-1.2	-1.1	-1.4	-0.7	-0.7	0.4	-1.1	-1.4	-1.0	-0.3	1.4	-0.0	0.6	0.7	0.8	0.3	0.8	0.8
Fluid intelligence score	0.7	1.5	5.2	0.3	-2.3	-2.0	-0.5	-0.9	0.4	0.5	-0.6	-0.2	-1.2	-0.2	1.9	1.7	1.7	-0.4	2.3	0.7	-0.0	1.0
Illnesses of siblings	2.5	3.5	12.8	-2.0	-2.4	-2.0	-0.4	-1.7	-0.6	-2.4	-1.8	-0.6	-1.6	-2.2	-1.9	3.6	-1.3	-1.3	-0.6	-1.6	-2.9	-0.8
Neuroticism score	0.2	0.5	2.5	1.6	-0.1	0.2	-0.3	-0.5	-0.7	0.6	-0.1	-0.8	0.1	0.3	0.3	-1.4	0.2	0.6	0.3	0.5	0.9	1.1
Weight	1.0	5.1	17.1	3.0	1.9	2.4	0.6	1.8	0.5	3.1	1.2	-0.1	1.3	2.1	3.5	-3.5	2.6	1.0	1.7	2.2	4.1	0.8
Impedance of arm (right)	1.3	6.0	14.1	0.4	-3.5	-3.1	-3.8	-2.8	-2.7	-1.6	-3.4	-3.4	-3.1	-2.8	1.2	3.2	-0.3	-2.0	0.9	-1.4	-0.8	0.8
Arm fat percentage (right)	0.4	1.6	8.6	1.5	0.1	-0.3	-0.7	-0.1	-1.0	1.4	-0.8	-1.6	-1.0	0.2	2.9	-1.2	1.2	0.6	1.3	0.6	2.4	0.6
Trunk fat-free mass	0.9	5.2	12.9	2.6	2.5	3.4	0.8	2.3	1.1	2.8	2.0	0.8	2.2	2.3	2.4	-3.4	2.4	1.3	1.1	2.3	3.6	0.5
Hip circumference	0.5	2.1	9.2	1.1	1.0	0.9	0.1	1.6	0.1	2.1	0.3	-0.4	-0.1	1.3	3.0	-2.1	1.7	-0.7	1.0	1.4	2.8	-0.3
Time employed in main current job	2.4	2.8	10.2	-3.2	-0.6	-0.2	1.0	0.3	-0.6	-1.9	-0.7	0.2	-0.7	-0.7	-2.3	1.2	-2.3	-1.8	-2.4	-1.8	-2.5	-2.1
Alcohol intake versus 10 years previously	5.9	8.8	21.7	3.9	2.6	0.8	2.3	2.8	2.3	4.4	2.1	1.2	0.5	3.8	4.7	-3.7	3.8	0.6	3.4	3.7	3.4	-0.2
Father’s age at death	2.3	3.1	7.6	-1.6	-2.8	-1.9	-2.0	-2.5	-1.5	-1.9	-1.8	-1.4	-0.9	-2.4	-1.5	1.9	-1.6	-1.1	-0.7	-2.0	-1.3	1.0
Worrier / anxious feelings	0.5	0.9	2.5	1.5	-0.6	-1.3	0.1	-0.2	-0.0	1.2	0.0	-0.6	-1.6	0.9	1.3	-1.0	0.8	-0.7	1.3	0.9	0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.7	1.9	0.6	0.7	0.7	1.2	0.7	1.2	1.0	0.7	1.0	1.5	0.9	-1.5	1.0	0.7	0.6	1.5	0.9	-0.0
Falls in the last year	2.9	4.0	9.1	-0.1	-2.9	-2.2	-2.8	-3.0	-2.5	-1.8	-2.3	-2.6	-1.4	-2.7	-0.5	2.0	-1.2	-0.2	0.0	-1.8	-0.4	2.3
Hair/balding pattern: Pattern 3	0.6	1.0	3.1	0.3	-1.5	-1.7	-1.5	-1.4	-0.9	-0.3	-0.9	-1.1	-0.9	-1.0	0.8	1.2	0.3	0.1	0.8	-0.4	-0.2	0.9
Number of live births	2.0	2.9	4.9	-1.8	-1.7	-1.8	-1.9	-1.1	-1.7	-1.7	-2.0	-1.8	-2.2	-1.5	-0.1	1.4	-1.5	-2.1	-1.6	-1.9	-1.7	-1.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.5	0.2	0.0	-0.5	0.6	1.3	1.2	1.1	0.7	1.0	-0.9	1.3	1.2	-0.1	1.0	-2.1	1.2	1.1	-0.1	-1.3
Pulse rate	0.7	1.1	2.8	1.3	1.2	1.3	1.0	0.5	1.1	0.8	1.7	1.3	1.6	1.1	-0.5	-1.5	-0.0	1.1	0.2	0.9	0.6	0.5
Happiness	0.4	0.5	1.7	0.1	-0.8	-1.3	-0.7	-0.6	-0.2	-0.3	-0.7	-0.4	-1.0	-0.3	0.4	1.1	0.4	-0.4	0.7	0.1	-1.1	-0.3
Noisy workplace	0.4	0.5	3.2	-0.4	-0.3	-0.1	0.6	-0.1	0.7	-0.8	0.3	0.7	-0.1	0.1	-1.5	0.6	-0.6	-0.3	-0.7	-0.1	-1.8	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.3	7.1	1.3	-1.1	-1.2	-0.3	-0.4	0.7	1.5	0.4	0.3	-0.4	0.3	1.8	-0.0	1.7	-0.5	2.7	1.1	1.3	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	-0.3	-1.3	-0.7	-0.3	-1.5	-0.9	-1.0	-0.5	-0.7	-0.5	-0.7	-1.5	0.8	-1.3	0.6	-0.5	-0.9	-0.8	0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	1.5	-0.8	-0.1	0.2	-0.3	-0.0	-0.6	-0.7	-0.1	-0.4	0.0	-0.3	-0.8	0.2	-0.8	0.5	-1.2	-0.8	-0.2	-0.2
Asthma	1.9	3.7	10.1	3.2	1.9	2.9	0.7	1.0	1.0	1.9	1.6	0.8	2.4	1.4	1.1	-2.6	1.1	2.5	1.0	1.8	2.7	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.9	-0.5	-0.9	-0.5	-0.7	-1.4	-1.1	-1.4	-0.8	-0.9	-0.3	-1.4	-1.4	0.6	-1.7	0.3	-1.3	-1.5	-0.9	0.3
Medication: Cholesterol lowering	0.6	0.9	4.7	2.2	-0.8	-0.9	-1.1	-0.9	-0.6	0.6	-0.6	-1.2	-0.7	0.2	1.1	-0.5	0.8	0.8	1.0	0.6	0.5	0.9
Depression (self-reported)	1.5	1.8	4.7	1.1	1.0	0.8	1.3	0.9	1.9	1.2	1.7	2.1	2.2	0.7	0.1	-0.6	1.1	0.4	1.7	1.7	1.3	1.2
Medication: Lansoprazole	0.5	0.6	2.0	0.0	0.3	0.3	-1.4	-0.1	-1.3	-0.5	-0.9	-1.4	-0.2	-0.8	0.3	0.2	-0.2	0.3	-0.6	-0.8	1.3	0.6
Prospective memory result	0.6	0.8	2.1	-0.4	1.4	0.7	1.1	1.0	1.2	0.6	1.4	1.4	1.3	0.6	-0.6	-0.7	0.1	-0.7	-0.0	0.2	0.6	-0.4
Lung cancer (father)	0.5	0.6	2.3	0.5	-0.2	1.0	-0.1	-0.8	-0.8	-0.8	-0.1	-0.7	0.6	-0.6	-0.9	0.1	-0.6	1.5	-0.8	-0.6	0.2	1.4
Illnesses of mother	1.5	1.9	3.8	-1.5	-1.5	-0.2	-0.8	-1.5	-1.7	-1.9	-1.5	-1.6	-0.2	-1.6	-1.7	1.1	-1.9	0.7	-1.7	-1.5	-0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.9	0.5	-0.0	-0.3	0.8	1.4	1.5	1.2	0.8	1.2	-0.7	1.2	1.6	0.2	1.3	-2.2	1.6	1.3	0.4	-1.1
Pulse wave Arterial Stiffness index	1.4	1.6	6.2	1.9	0.0	0.2	-1.1	-0.3	-0.2	1.5	0.5	-0.5	0.9	0.6	1.7	-1.5	1.1	0.9	1.6	0.8	2.5	2.2
Impedance of arm (left)	1.2	5.7	13.4	0.4	-3.7	-3.2	-3.4	-2.9	-2.2	-1.6	-3.2	-3.0	-3.0	-2.6	0.9	3.4	-0.2	-2.3	1.1	-1.3	-1.3	0.7
Arm fat mass (right)	0.7	2.9	11.0	2.2	1.4	1.3	0.3	1.2	-0.1	2.3	0.4	-0.6	0.3	1.4	3.3	-2.5	2.0	1.1	1.5	1.6	3.3	0.5
Trunk predicted mass	0.9	5.1	12.7	2.6	2.5	3.4	0.8	2.3	1.2	2.8	2.0	0.8	2.2	2.3	2.4	-3.3	2.4	1.2	1.1	2.3	3.6	0.5
Standing height	0.5	5.3	18.7	4.3	0.4	2.4	-1.2	1.1	0.2	2.8	0.7	-0.8	1.1	1.5	3.9	-2.2	3.4	-0.9	2.5	2.4	3.8	1.1
Length of working week for main job	0.3	0.4	1.4	-1.1	-0.2	0.1	0.7	0.5	0.8	-0.2	0.8	1.2	0.7	0.1	-0.8	0.7	-0.2	-0.9	0.2	0.2	-0.1	0.1
Exposure to tobacco smoke at home	1.3	1.4	4.3	-1.6	-0.4	0.1	-0.5	-0.5	-0.7	-1.7	-1.1	-0.6	-0.4	-1.1	-1.9	0.6	-2.1	-0.6	-2.0	-1.4	-1.5	-1.0
Breastfed as a baby	0.5	0.6	2.3	-1.2	-0.2	-0.2	-0.2	-0.4	-0.4	-1.1	-0.5	-0.2	-0.0	-0.6	-1.5	0.3	-1.2	0.3	-1.3	-1.1	-1.0	-0.7
Tense / ‘highly strung’	1.0	1.6	3.7	-0.2	-1.1	-0.6	-1.1	-1.9	-1.8	-1.5	-1.3	-1.6	-0.5	-1.7	-1.5	0.9	-1.8	0.6	-1.0	-1.5	-0.7	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.3	1.8	0.5	0.4	0.5	0.5	1.0	1.3	1.0	0.6	1.0	1.2	1.0	-0.9	1.4	1.2	1.4	1.5	0.9	0.9
Hair/balding pattern: Pattern 4	0.4	1.0	3.3	-1.5	-0.4	-0.2	-1.4	-0.2	-1.4	-1.1	-1.3	-1.3	-0.6	-0.6	-1.0	0.1	-1.0	-0.2	-1.8	-1.2	-0.3	-0.9
Birth weight of first child	1.8	3.2	8.9	3.0	0.8	0.9	1.0	0.8	1.8	2.3	1.7	1.1	1.9	1.6	2.0	-1.9	1.4	1.5	2.5	2.3	2.1	1.6
Peak expiratory flow (PEF)	0.1	0.2	1.0	0.3	-0.3	-0.5	-0.5	-0.1	0.1	0.3	-0.2	-0.1	-0.7	0.0	0.8	0.5	0.5	-0.5	1.0	0.4	0.1	0.1
Pulse wave reflection index	0.6	0.7	3.0	0.3	-1.0	-0.5	-1.7	-1.1	-0.9	0.1	-0.6	-1.0	0.3	-0.7	0.4	-0.0	0.2	0.8	0.6	-0.3	1.2	1.7
Ever highly irritable/argumentative for 2 days	1.8	2.2	8.1	1.3	2.2	2.9	1.2	1.3	0.7	0.7	1.5	1.3	2.4	1.0	-0.5	-1.5	0.3	2.4	-0.1	0.9	1.6	0.7
Loud music exposure frequency	1.2	1.3	5.1	-1.4	0.6	0.1	0.2	0.3	-1.1	-1.1	-1.2	-0.8	-1.4	-0.4	-1.1	-0.2	-1.2	-0.5	-2.3	-1.0	-1.3	-2.0
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.2	0.9	0.4	0.7	0.9	0.3	1.1	0.9	1.3	1.3	1.5	0.8	0.2	-0.6	1.2	0.5	1.3	1.0	0.7	1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.2	1.2	2.0	1.6	-0.0	0.6	0.2	0.9	0.6	0.2	1.4	0.6	1.1	-1.0	1.5	1.9	0.6	1.0	1.9	1.1
Blood clot in the leg (DVT)	0.6	0.8	2.8	-0.6	0.7	0.7	1.4	1.3	1.4	0.3	1.2	1.7	0.7	1.0	-0.7	-0.3	-0.1	-0.4	-0.5	0.3	-0.7	-1.0
Medication: Paracetamol	0.5	0.8	6.5	-0.2	1.1	0.3	0.3	1.4	0.4	0.2	-0.2	0.2	-0.8	1.0	-0.0	-0.9	0.1	-0.6	-1.1	0.2	-0.9	-2.6
Headache pain in last month	0.3	0.5	3.5	-0.7	0.2	0.5	0.5	1.4	0.4	0.2	0.2	0.6	-0.0	0.6	0.4	-0.5	0.1	-1.1	-0.6	0.2	-0.2	-1.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.3	-1.8	0.8	1.7	1.1	0.5	0.4	-0.7	0.7	1.0	1.4	-0.4	-1.3	0.2	-1.0	-0.5	-0.9	-0.5	-0.1	-0.3
Glaucoma (self-reported)	0.9	1.0	3.7	-1.2	-1.0	-0.3	-0.3	-1.4	-0.8	-1.2	-0.5	-0.5	0.2	-1.1	-1.9	0.5	-1.8	-0.7	-0.7	-1.1	-0.8	0.9
Gout (self-reported)	0.4	0.6	2.7	1.3	-0.5	-0.5	-0.4	-0.0	-0.4	0.7	-0.5	-1.0	-1.1	0.7	1.6	-0.5	0.6	-0.2	1.0	0.6	0.7	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.5	-1.7	-0.4	0.7	0.6	-0.2	-0.6	-1.0	0.6	0.0	0.8	-0.3	-1.8	-0.4	-1.9	-0.6	-1.8	-1.2	-0.4	-0.2
Medication: Amlodipine	0.3	0.4	1.3	0.3	-0.8	-0.5	0.5	-0.0	1.1	0.3	0.9	1.1	-0.1	0.4	-0.3	0.5	0.3	-0.9	0.7	0.4	-0.5	0.2
Medication: Ventolin 100micrograms inhaler	2.8	3.5	7.0	1.9	2.2	2.5	1.8	2.2	1.9	2.2	1.9	1.7	1.5	2.4	1.2	-2.6	1.5	0.1	0.9	2.3	2.0	-0.1
Birth weight	0.5	1.2	5.2	1.1	-0.8	-1.9	-0.7	-0.3	0.7	1.3	-0.2	-0.2	-0.8	0.3	2.2	-0.1	0.8	0.0	2.3	1.1	0.9	0.7
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.3	2.0	0.5	0.6	-0.3	-0.1	0.4	0.8	0.4	0.1	0.8	0.6	1.0	-0.5	1.4	2.3	1.3	1.2	1.3	2.0
High blood pressure (siblings)	0.8	1.2	4.8	1.1	0.8	0.5	0.1	1.3	0.2	1.6	0.4	-0.1	-0.4	1.4	2.2	-2.1	0.9	-0.1	0.5	1.0	1.6	-0.4
Forced vital capacity (FVC), Best measure	1.0	3.8	7.0	1.4	0.7	0.7	1.5	2.6	2.6	2.4	1.8	2.0	-0.1	2.5	2.5	-0.7	2.4	-2.5	2.3	2.5	1.3	-1.3
Body fat percentage	0.5	2.0	10.5	2.1	0.6	0.4	-0.5	0.3	-1.0	1.7	-0.7	-1.6	-0.6	0.7	3.2	-1.8	1.5	0.7	1.2	0.9	2.7	0.5
Leg fat percentage (right)	0.7	2.4	8.5	2.2	1.0	0.5	-0.9	0.1	-1.5	1.6	-0.8	-2.0	-0.2	0.6	2.8	-2.6	0.9	1.7	0.5	0.6	2.9	0.8
Arm fat-free mass (right)	1.4	7.3	16.2	2.6	3.1	4.0	2.0	2.9	1.8	3.2	2.8	1.6	2.9	3.1	2.2	-4.0	2.5	1.4	1.1	2.7	3.7	0.3
Exposure to tobacco smoke outside home	0.4	0.5	1.5	0.6	-0.7	-0.4	-0.7	-1.2	-0.7	-0.7	-1.0	-1.0	-0.4	-0.8	-0.4	0.5	-0.6	1.2	-0.2	-0.3	-0.5	0.7
Comparative body size at age 10	0.8	2.1	9.1	0.5	-2.6	-3.0	-0.6	-1.6	0.5	0.6	-0.2	-0.0	-1.1	-0.7	1.6	1.6	0.8	-1.1	2.8	0.3	-0.0	1.8
Number of full brothers	1.4	1.8	4.3	-0.7	2.0	2.1	1.6	2.0	1.0	0.7	1.6	1.4	1.4	1.7	-0.4	-1.8	-0.2	-0.1	-1.0	0.6	0.5	-1.4
Worry too long after embarrassment	0.4	0.7	2.9	1.7	0.1	-0.3	-0.6	-0.3	0.1	1.0	-0.1	-0.2	-0.0	0.2	1.3	-0.4	1.5	0.6	1.4	1.0	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.1	0.6	-1.3	-0.7	-1.0	-1.5	-0.5	-0.5	-0.4	-0.6	-0.0	-1.0	-0.3	0.7	-0.3	0.8	0.6	-0.0	-0.2	1.8
Wheeze or whistling in the chest in last year	1.0	1.9	7.9	0.9	2.1	2.6	1.4	1.4	0.2	0.9	1.3	0.6	1.6	1.2	-0.5	-2.8	-0.2	0.7	-1.0	0.6	1.6	-0.2
Number of children fathered	0.5	0.5	1.8	0.2	-1.1	-1.4	-1.2	-0.7	-0.6	-0.0	-0.7	-0.7	-1.1	-0.4	0.6	0.4	0.2	-0.7	0.7	0.0	-0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.8	0.4	0.6	0.3	1.2	0.9	1.6	0.8	1.7	1.7	1.1	1.1	-0.3	-0.3	0.6	0.2	1.1	1.0	0.6	0.4
Age at first live birth	0.5	0.8	2.0	0.6	1.1	0.3	1.3	1.4	1.1	0.9	0.8	1.1	-0.3	1.4	0.8	-0.2	1.2	0.6	0.6	1.1	0.1	-0.8
Pulse wave peak to peak time	1.0	1.2	4.9	-1.6	-0.2	-0.1	0.9	0.2	0.1	-1.4	-0.5	0.3	-0.9	-0.6	-1.3	1.5	-0.8	-1.0	-1.3	-0.7	-2.2	-2.0
Health satisfaction	0.2	0.3	0.6	0.3	0.7	0.7	0.6	0.7	0.4	0.5	0.6	0.6	0.2	0.7	-0.0	-0.8	0.2	0.3	-0.0	0.4	0.5	-0.2
Shortness of breath walking on level ground	0.6	0.7	2.0	-0.8	-0.6	0.1	-0.5	-0.8	-0.9	-1.1	-0.6	-0.8	0.5	-1.3	-1.2	0.5	-1.4	-0.2	-1.0	-1.2	0.4	1.1
Qualifications: College or University degree	1.1	3.6	12.9	0.1	-3.6	-3.0	-1.9	-2.4	-0.3	-0.2	-1.4	-1.0	-2.2	-1.9	1.0	2.7	0.8	-2.0	2.7	-0.1	0.1	2.1
Eye problems/disorders: None of the above	0.6	0.7	3.1	-0.2	1.3	0.7	1.0	1.8	1.1	0.4	0.7	1.1	-0.0	1.1	0.5	-0.1	0.9	-0.2	-0.2	0.6	-0.1	-1.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	4.9	0.1	0.8	0.6	0.2	-0.6	-0.7	-0.5	-0.2	-0.5	0.9	-0.1	-1.0	-0.5	-0.8	2.2	-0.9	-0.1	-0.3	0.6
Emphysema/chronic bronchitis	0.7	0.8	3.5	1.0	1.3	1.9	-0.1	0.6	-0.1	0.4	0.6	0.1	1.1	0.3	0.0	-1.1	0.1	1.5	-0.1	0.6	1.4	0.9
Medication for pain relief, constipation, heartburn	0.2	0.3	1.8	-0.2	-0.3	-0.1	-0.2	-0.7	0.1	0.1	0.3	0.1	0.7	-0.5	0.3	0.5	0.4	-0.0	1.0	0.1	0.6	1.3
Neck or shoulder pain in last month	0.4	0.5	1.6	0.8	-0.2	0.5	-1.1	-0.9	-0.9	0.1	-0.4	-1.0	0.6	-0.5	0.1	-1.3	-0.2	0.5	-0.2	-0.2	0.9	1.1
Medication: Blood pressure	0.4	0.6	3.3	0.6	-0.3	-1.8	-0.7	0.3	0.1	0.3	-0.5	-0.4	-1.8	0.7	0.7	0.2	0.8	-0.3	0.1	0.2	-1.1	-1.1
Angina (self-reported)	0.3	0.4	1.9	0.3	-1.4	-0.8	-1.0	-0.8	-0.2	0.4	0.0	-0.5	-1.0	-0.1	0.2	-0.2	0.2	-0.9	0.8	-0.1	0.4	0.7
Migraine (self-reported)	0.4	0.6	2.1	-1.0	-1.4	-0.7	-0.7	-0.9	-0.2	-0.6	-0.4	-0.2	-0.2	-0.8	-0.6	0.9	-0.5	-1.4	0.2	-0.6	-0.4	0.5
Medication: Ibuprofen	0.7	0.9	2.3	-0.0	0.2	0.5	-0.4	-1.0	-1.0	-1.0	-0.2	-0.7	0.8	-1.0	-1.3	-0.4	-1.4	1.5	-1.4	-1.3	-0.0	0.8
Medication: Allopurinol	0.6	0.8	2.5	1.6	-0.9	-1.0	-0.2	-0.1	0.2	1.0	0.4	-0.1	-1.0	0.9	1.3	-0.3	0.9	-0.6	1.6	1.0	0.4	0.6
Medication: Omeprazole	0.6	0.7	2.1	-1.2	-0.9	-1.1	-0.8	0.0	-0.5	-0.5	-1.1	-0.6	-1.4	-0.5	0.3	1.0	-0.4	-1.2	-0.2	-0.6	-0.7	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	3.8	0.5	1.1	1.2	1.3	0.2	0.5	0.4	1.0	0.7	0.7	1.0	-1.3	-1.9	-0.4	0.8	-0.8	0.5	-0.5	0.2
Mean time to correctly identify matches	4.9	9.3	17.2	-2.6	-3.6	-2.5	-3.3	-3.8	-2.9	-4.0	-3.1	-2.5	-1.5	-4.2	-3.2	3.9	-3.7	-0.0	-2.2	-3.6	-2.6	1.0
Heart disease (mother)	1.1	1.3	3.5	-0.0	1.5	1.4	1.5	1.9	1.0	1.2	1.6	1.3	0.5	1.4	0.5	-1.6	0.3	0.2	-0.3	0.6	0.6	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.3	-0.2	0.9	0.3	0.1	0.0	0.1	-0.3	0.6	0.6	0.8	0.1	-1.2	-0.3	-0.3	0.1	-0.7	-0.5	-0.3	0.1
Whole body fat mass	0.8	3.2	13.3	2.7	1.1	1.1	-0.2	1.0	-0.5	2.4	-0.0	-1.1	-0.1	1.4	3.6	-2.6	2.1	0.8	1.5	1.6	3.4	0.5
Leg fat mass (right)	1.0	3.8	13.6	2.8	1.7	1.5	-0.0	1.1	-0.5	2.6	0.2	-1.1	0.5	1.6	3.3	-3.4	1.7	1.6	1.1	1.6	3.7	0.7
Arm predicted mass (right)	1.6	8.0	18.1	2.8	3.3	4.1	2.1	3.0	2.0	3.4	2.9	1.8	3.0	3.2	2.3	-4.2	2.7	1.5	1.2	2.9	3.8	0.3
Pulse rate, automated reading	1.6	5.3	10.4	2.9	2.3	2.3	1.8	1.1	2.1	2.6	3.1	2.1	3.2	2.3	0.8	-3.2	1.2	2.3	1.7	2.4	2.5	1.8
Alcohol intake frequency.	2.3	5.4	10.6	2.6	1.4	1.0	2.3	1.9	3.0	3.0	2.8	2.6	1.5	3.1	2.1	-1.9	2.7	0.9	3.0	3.2	1.6	0.7
Comparative height size at age 10	1.2	6.8	26.0	5.1	0.6	2.4	-1.3	0.3	0.4	2.9	1.2	-0.7	1.9	1.4	3.7	-2.5	3.3	1.4	3.0	2.6	4.5	3.0
Number of full sisters	0.6	0.7	3.8	1.1	1.0	1.0	0.4	0.3	0.4	0.6	0.7	0.4	1.2	0.9	-0.6	-1.9	-0.2	0.9	-0.1	0.8	0.8	0.6
Suffer from ‘nerves’	0.3	0.4	2.5	-0.3	0.3	0.8	0.6	0.1	0.0	-0.7	0.3	0.4	0.7	-0.0	-1.6	0.0	-0.7	0.5	-1.1	-0.4	-0.7	-0.3
Overall health rating	0.4	0.9	3.7	1.6	-0.6	-0.7	-0.6	-0.0	-1.1	0.8	-0.8	-1.4	-1.1	0.5	1.9	-0.8	0.9	-0.3	0.7	0.8	0.9	0.5
Chest pain or discomfort	0.3	0.5	3.0	1.2	0.7	0.4	-0.6	-0.2	-1.1	0.3	-0.1	-0.8	-0.3	0.2	0.1	-1.7	-0.3	0.9	-0.7	0.1	0.7	0.1
Had major operations	0.2	0.3	1.0	0.2	-0.4	-0.5	-0.4	-0.9	-0.9	0.2	-0.3	-0.9	-0.4	-0.2	-0.1	-1.0	-0.2	0.7	-0.2	-0.3	0.0	0.5
Age at last live birth	0.5	0.8	1.8	0.8	0.8	0.5	1.0	1.3	0.6	0.8	0.3	0.5	-0.4	1.3	1.2	-0.5	1.2	0.8	0.2	1.0	0.0	-1.3
Family relationship satisfaction	0.3	0.4	1.2	0.4	0.9	0.8	0.5	1.1	0.4	0.5	0.1	0.2	0.1	0.9	0.6	-0.6	0.9	0.3	-0.1	0.8	0.0	-0.9
Leg pain on walking	1.8	2.3	9.3	-1.8	-0.2	0.1	-0.1	-0.7	-1.5	-1.8	-0.7	-0.9	-0.5	-1.0	-2.6	-0.2	-3.0	0.2	-2.8	-2.1	-1.3	-0.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	6.6	1.5	2.6	2.4	0.9	2.0	0.3	1.5	1.1	0.4	1.4	1.6	1.5	-2.2	1.3	1.4	0.0	1.1	2.3	-0.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.5	1.1	1.5	1.9	1.0	1.1	0.6	0.9	1.4	1.0	1.6	1.1	0.3	-1.4	0.7	1.2	0.3	0.9	1.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	-0.7	-1.1	-1.4	-1.2	-1.2	-1.1	-0.7	-1.5	-1.4	-1.4	-1.4	0.2	0.6	-0.7	-1.2	-0.3	-1.0	-0.5	-0.1
Medication: Aspirin	0.4	0.6	1.7	0.9	-0.6	-0.4	-1.2	-1.1	-0.8	-0.3	-0.6	-0.9	0.2	-0.7	-0.1	0.1	-0.5	1.2	-0.1	-0.5	0.7	1.3
Supplements: Vitamin C	0.3	0.4	2.0	1.4	-0.3	0.4	-1.2	-0.6	-0.5	-0.1	-0.3	-0.6	0.2	-0.4	0.5	0.6	0.5	0.6	0.5	0.3	0.4	0.8
Knee pain experienced in last month	0.6	1.0	3.5	-0.6	0.2	0.8	-0.3	-0.6	-1.6	-1.1	-0.7	-1.2	0.0	-0.8	-1.3	-0.1	-1.9	0.5	-1.9	-1.3	-0.3	0.1
Hypertension (Self-reported)	1.5	4.1	19.0	1.9	0.6	-1.6	-0.4	1.8	1.9	2.6	0.6	0.9	-1.1	1.6	4.4	-0.1	3.6	-1.4	3.2	2.2	2.0	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	6.1	-1.1	0.4	-0.8	0.2	1.7	0.0	0.4	-0.6	-0.2	-1.7	0.6	1.6	0.1	0.7	-2.2	-0.1	-0.1	0.2	-2.5
Illnesses of father: Heart disease	1.0	1.4	5.6	1.1	-1.4	-2.0	-0.7	-0.5	-0.1	0.5	-1.0	-0.8	-2.4	0.0	2.0	1.0	1.1	-1.3	1.7	0.7	0.1	0.1
Illnesses of siblings: Diabetes	3.1	3.8	10.8	3.0	2.4	1.5	0.3	1.1	0.6	2.4	1.5	0.3	1.6	1.8	2.4	-2.6	2.0	1.7	1.7	2.1	3.3	1.5
Smoking status: Previous	0.9	1.4	4.6	0.0	0.6	-0.2	1.1	1.8	1.0	1.6	0.3	0.5	-1.2	1.3	2.1	-0.7	1.4	-1.8	1.1	1.2	0.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	10.3	2.7	0.3	0.5	0.7	1.1	1.4	2.4	0.8	0.5	-0.0	1.6	3.2	-1.0	2.9	-0.8	3.0	2.5	2.0	0.5
Whole body fat-free mass	1.0	5.7	12.8	2.5	2.4	3.4	1.4	2.5	1.6	3.0	2.3	1.3	2.4	2.5	2.5	-3.3	2.6	1.0	1.4	2.5	3.6	0.5
Leg fat-free mass (right)	0.8	4.2	9.3	1.7	1.7	2.7	1.8	2.1	1.7	2.6	2.3	1.5	2.1	2.2	2.1	-2.6	2.2	0.3	1.6	2.2	3.0	0.5
Arm fat percentage (left)	0.3	1.4	7.3	1.6	0.1	-0.2	-0.4	-0.0	-0.7	1.4	-0.5	-1.2	-0.7	0.5	2.7	-1.3	1.2	0.6	1.4	0.8	2.2	0.7
Average weekly red wine intake	1.0	1.5	6.0	1.1	-0.9	-0.6	-1.9	-1.8	-1.0	-0.3	-1.2	-1.5	-0.2	-1.5	0.2	0.5	0.3	1.8	0.7	-0.4	1.0	2.5
Handedness (chirality/laterality): Left-handed	3.3	4.0	6.4	1.6	2.3	2.5	1.8	2.4	1.5	2.2	1.7	1.4	1.8	2.5	1.7	-2.3	2.5	1.6	1.2	2.4	2.4	0.2
Mood swings	0.2	0.4	1.5	0.8	-0.2	-0.1	-0.5	-0.8	-0.9	0.1	-0.6	-1.1	-0.1	0.1	0.3	-0.9	-0.1	1.2	-0.0	0.3	0.0	0.9
Loneliness, isolation	0.4	0.5	3.2	-0.7	0.3	0.6	0.5	-0.0	-0.0	-0.3	0.4	0.4	0.9	-0.1	-1.8	-1.1	-1.1	0.0	-1.2	-0.3	-0.3	-0.1
Long-standing illness, disability or infirmity	2.0	3.1	10.9	2.5	1.9	2.1	0.6	1.0	0.4	2.0	1.4	0.4	1.8	2.0	0.9	-3.3	1.4	1.9	0.8	1.9	2.4	1.3
Ever had bowel cancer screening	0.4	0.5	1.9	0.4	-0.3	-0.9	-1.4	-1.1	-0.9	0.1	-0.4	-1.0	0.0	-0.7	0.3	-0.6	-0.2	0.5	0.1	-0.5	0.6	1.1
Diabetes diagnosed by doctor	0.8	1.2	4.4	2.1	0.7	0.4	0.7	0.9	0.4	1.3	-0.0	-0.1	0.0	1.1	2.0	-0.7	1.9	0.4	1.5	1.4	1.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	-0.3	0.0	-0.6	-0.5	-0.4	-0.5	-0.6	-0.5	-0.5	-0.7	-0.3	-0.4	0.3	-0.6	-0.6	-0.7	-0.8	-1.0	-0.9
Friendships satisfaction	0.3	0.3	0.9	0.5	0.7	0.8	0.5	0.8	0.6	0.3	0.3	0.4	0.2	1.0	0.2	-0.2	0.9	0.8	0.1	0.9	-0.3	-0.5
Qualifications: nursing, teaching	0.3	0.5	3.8	0.1	-0.8	-0.1	-0.6	-1.2	0.1	0.2	0.4	0.1	1.0	-0.4	-0.1	-0.0	0.2	0.5	0.9	0.0	0.7	2.0
Commuting to job workplace: Walk	1.1	1.2	3.3	0.9	0.6	-0.4	0.7	1.3	1.3	1.6	0.9	0.7	-0.3	1.5	1.8	-0.7	1.4	-0.3	1.5	1.4	0.6	-0.8
Eye problems/disorders: Cataract	1.1	1.2	3.7	1.6	0.0	0.4	0.2	-0.1	0.9	1.5	1.2	0.8	1.0	0.6	0.9	-0.7	1.2	0.7	1.9	1.2	1.6	1.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.2	1.1	0.1	0.4	-1.4	-1.0	-0.3	0.7	0.6	-0.4	1.2	0.0	0.3	-1.0	0.6	1.9	0.9	0.4	1.4	2.0
Medication for cholesterol	1.7	2.6	13.3	-2.2	0.3	1.1	1.1	-0.6	-0.3	-2.1	0.2	0.6	0.6	-0.9	-3.6	1.2	-2.6	0.9	-2.3	-1.3	-2.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	12.5	-3.0	-1.4	-0.6	-0.2	-1.5	-1.5	-2.8	-1.5	-0.9	-1.0	-1.7	-3.2	1.6	-3.0	-0.6	-2.9	-2.5	-3.5	-1.3
Back pain experienced in last month	0.5	0.7	1.9	1.2	0.7	0.5	-1.3	0.2	0.0	0.7	0.4	0.0	1.2	0.0	1.4	-0.2	0.9	0.6	1.0	0.7	1.3	0.6
Mineral and other dietary supplements	1.9	2.6	7.9	-2.7	-1.2	-0.7	-0.0	-0.2	-0.5	-2.2	-1.1	-0.2	-1.1	-1.0	-1.5	2.6	-1.1	-1.6	-1.8	-1.5	-2.8	-2.0
Breast cancer (self-reported)	1.2	1.5	4.5	-0.2	-1.2	-0.6	-1.3	-2.1	-0.7	-1.4	-0.8	-0.5	-0.0	-1.6	-2.0	1.4	-1.2	0.7	-0.4	-0.9	-1.1	1.8
Asthma (self-reported)	1.3	2.6	8.0	2.8	1.5	2.6	0.8	0.8	0.9	1.5	1.5	0.9	2.1	1.2	0.6	-2.2	0.8	2.1	0.7	1.6	2.1	1.6
Osteoporosis (self-reported)	1.5	1.9	9.1	3.0	0.3	-0.2	-0.6	-0.6	0.1	1.7	0.4	-0.5	0.2	1.1	1.4	-1.7	1.6	1.2	2.1	1.6	1.6	2.0
Osteoarthritis (self-reported)	0.2	0.3	2.5	0.4	0.1	0.7	-0.0	0.1	-0.2	0.3	0.3	0.1	0.9	0.2	-0.4	-1.6	-0.6	0.4	-0.7	-0.2	0.6	0.4
Medication: Aspirin	0.4	0.5	1.9	0.8	-0.5	0.1	-1.0	-1.0	-0.9	-0.3	-0.5	-0.9	0.4	-0.7	-0.2	-0.1	-0.4	1.4	-0.3	-0.6	0.7	1.1
Medication: Gliclazide	0.4	0.5	1.3	1.0	0.6	0.7	-0.2	0.8	-0.4	0.4	-0.7	-0.8	-0.3	0.6	1.1	-1.1	0.7	0.2	-0.2	0.2	0.9	-0.9
Illnesses of father: None of the above (group 1)	1.4	1.7	5.7	-2.4	-0.4	0.7	0.4	0.1	-0.5	-1.7	-0.5	0.3	0.3	-1.0	-2.2	1.0	-1.4	-1.4	-2.1	-1.5	-1.8	-1.3
Smoking status: Current	0.4	0.7	2.0	-0.6	-0.0	0.3	0.0	-0.5	-0.8	-1.2	-0.5	-0.5	-0.1	-0.3	-1.4	0.2	-1.4	1.3	-1.4	-0.7	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	4.3	-1.6	-0.8	-1.1	1.7	0.7	1.5	-0.3	0.6	1.7	-1.0	0.4	-0.8	1.4	-0.5	-1.6	0.2	0.1	-2.1	-1.4
Whole body water mass	0.9	5.4	12.6	2.4	2.4	3.4	1.3	2.3	1.4	2.9	2.2	1.2	2.4	2.4	2.4	-3.3	2.5	1.1	1.3	2.4	3.5	0.5
Leg predicted mass (right)	0.8	4.1	9.5	1.7	1.7	2.7	1.7	2.0	1.6	2.5	2.2	1.4	2.1	2.1	2.1	-2.6	2.1	0.3	1.5	2.1	3.1	0.6
Arm fat mass (left)	0.6	2.5	9.4	2.2	1.2	1.2	0.2	0.9	-0.1	2.1	0.4	-0.6	0.4	1.2	3.0	-2.2	1.8	1.0	1.4	1.4	3.1	0.7
Number of self-reported non-cancer illnesses	0.9	1.5	3.8	2.0	0.8	0.8	0.4	0.9	1.0	1.7	1.5	0.9	1.3	1.5	0.9	-1.8	1.3	0.0	1.1	1.3	1.8	0.8
Average weekly champagne plus white wine intake	0.7	0.9	2.8	-0.9	-1.0	-0.7	-0.8	-1.4	-0.6	-1.3	-0.8	-0.7	-0.2	-1.3	-0.8	1.7	-0.8	0.6	-0.4	-1.0	-0.9	1.0
Miserableness	0.6	1.1	4.1	2.0	0.0	0.8	-0.2	-0.8	-0.4	0.8	0.8	-0.3	1.4	0.7	-0.2	-2.0	0.2	1.7	0.4	0.7	1.0	1.9
Guilty feelings	1.0	1.5	4.5	2.0	0.7	0.6	-0.0	0.1	0.5	1.6	1.0	0.2	1.1	0.7	1.2	-2.0	0.9	0.7	1.4	1.3	2.1	1.6
Wears glasses or contact lenses	1.0	1.1	3.6	0.8	-1.1	-1.2	-1.9	-1.4	-1.4	-0.4	-1.1	-1.7	-0.6	-1.1	0.7	0.4	0.2	0.5	0.2	-0.6	0.7	1.6
Ever taken oral contraceptive pill	0.4	0.5	2.3	0.7	-0.3	-0.3	-1.2	-1.1	-0.7	-0.2	-0.5	-0.8	0.4	-0.5	0.3	-0.0	0.4	0.6	0.4	-0.2	0.6	1.5
Hearing aid user	0.4	0.4	1.8	0.8	0.4	0.6	-0.7	-0.2	0.2	0.3	0.2	0.2	0.8	-0.0	0.4	-0.2	0.3	1.0	0.6	0.7	1.1	1.3
Mother’s age at death	1.2	1.5	3.2	-1.8	-0.4	-0.5	-0.3	-0.1	-1.1	-1.6	-1.3	-0.8	-1.0	-0.9	-1.1	1.3	-1.4	-0.7	-1.8	-1.5	-1.7	-1.6
Financial situation satisfaction	0.3	0.3	1.5	0.0	-0.5	-0.9	-0.5	-0.2	-0.2	-0.3	-0.9	-0.6	-1.2	-0.1	0.5	0.5	0.6	0.0	0.0	0.1	-1.1	-0.6
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.6	1.4	1.4	1.2	1.3	1.2	0.9	1.6	1.0	0.7	-0.1	1.4	1.9	-1.3	1.9	0.2	1.2	1.6	1.3	0.0
Commuting to job workplace: Public transport	1.0	1.2	5.0	0.6	-1.1	-2.2	0.3	0.1	1.4	0.8	0.4	0.7	-1.2	0.9	0.9	0.9	1.0	-1.4	1.9	1.2	-0.8	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	-1.1	-1.1	-0.4	-0.4	-1.1	-0.8	-0.9	-0.5	-0.5	0.1	-1.0	-1.1	0.7	-1.3	-1.1	-0.3	-0.8	-0.5	0.7
Medication: Blood pressure	1.5	2.8	13.0	1.3	-0.6	-1.9	-1.4	0.5	1.1	1.7	0.0	0.3	-1.2	0.3	3.6	0.8	3.0	-2.2	2.9	1.3	1.5	-0.1
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.9	-1.3	-1.3	-1.5	-1.6	-0.7	-1.6	-1.1	-1.3	-1.4	-1.3	-1.2	-0.6	0.4	-1.5	-1.7	-1.5	-1.6	-1.2	-1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.5	1.2	1.3	0.7	0.6	0.5	0.5	1.2	0.6	0.2	0.5	0.4	1.0	-1.3	0.6	0.8	0.9	0.7	1.9	0.7
High cholesterol (Self-reported)	1.1	2.0	5.7	-0.1	-2.4	-2.4	-1.7	-1.8	-1.6	-0.9	-1.8	-1.9	-1.9	-1.3	0.1	1.0	-1.1	-0.9	-0.2	-1.1	-0.8	0.3
Medication: Bendroflumethiazide	0.4	0.6	2.9	-0.4	-0.6	-1.7	-0.5	0.4	0.8	-0.2	-0.3	0.3	-1.5	-0.2	0.5	1.7	0.5	-0.7	0.5	-0.1	-0.6	-0.7
Medication: Paracetamol	0.4	0.6	3.3	0.0	1.1	0.6	0.3	1.1	0.1	0.1	-0.1	-0.0	-0.3	0.9	-0.4	-1.2	-0.3	-0.0	-1.4	-0.0	-0.5	-1.8
Medication: Lisinopril	0.5	0.7	2.3	-0.4	-1.3	-1.5	-0.8	-0.2	0.1	-0.3	-0.7	-0.2	-1.4	-0.6	0.6	1.2	0.3	-1.5	0.3	-0.3	-0.7	-0.6
Medication: Atorvastatin	0.2	0.2	0.7	0.8	0.1	0.1	0.3	0.0	0.3	0.6	0.6	0.6	0.5	0.2	0.1	-0.4	0.6	-0.5	0.7	0.4	0.5	0.4
Illnesses of father: High blood pressure	1.0	1.2	4.2	1.2	0.4	-0.4	-0.2	0.8	1.2	1.3	0.5	0.7	0.1	0.9	2.0	-0.0	1.8	1.0	1.9	1.3	1.3	0.3
Alcohol drinker status: Never	0.8	0.9	2.5	-1.5	-1.2	-0.6	0.1	-1.0	-0.1	-1.2	-0.1	0.4	-0.0	-1.0	-1.6	1.5	-1.4	-0.3	-0.6	-0.8	-1.3	0.2
Ever smoked	0.5	0.9	2.6	0.3	1.1	0.4	1.3	1.6	0.7	1.0	0.2	0.5	-0.8	1.2	1.4	-0.5	1.1	-0.5	0.6	1.1	0.2	-1.4
Basal metabolic rate	1.0	5.8	15.1	2.7	2.4	3.2	1.2	2.4	1.3	3.1	2.1	1.0	2.2	2.5	2.9	-3.4	2.7	1.0	1.6	2.5	3.9	0.6
Leg fat percentage (left)	0.7	2.5	10.2	2.2	1.3	0.9	-0.5	0.4	-1.2	1.8	-0.4	-1.7	0.1	0.8	2.9	-2.8	1.1	1.7	0.6	0.7	3.2	0.9
Arm fat-free mass (left)	1.5	7.5	16.3	2.8	3.2	4.0	1.8	2.9	1.7	3.3	2.6	1.4	2.8	2.9	2.7	-3.9	2.8	1.5	1.2	2.7	4.0	0.3
Number of operations (self-reported)	0.5	0.7	4.9	0.5	0.7	0.5	-0.0	-0.5	-0.6	0.3	0.3	-0.2	1.0	0.4	-1.1	-2.2	-0.4	1.4	-1.1	-0.2	-0.1	0.4
Average weekly beer plus cider intake	0.3	0.4	1.2	-0.9	0.1	-0.3	1.1	0.7	0.5	0.0	0.5	0.7	-0.1	0.8	-0.7	-0.5	-0.7	-0.4	-0.5	0.2	-0.8	-0.9
Irritability	1.3	2.2	8.5	1.6	-0.6	-0.0	-1.8	-1.9	-2.1	0.2	-0.9	-2.2	0.6	-1.2	0.2	-1.7	-0.7	1.9	0.3	-0.4	2.1	2.9
Risk taking	1.6	2.4	8.4	-1.8	-1.5	-1.2	-0.3	-1.8	-1.4	-1.9	-1.0	-1.1	-0.9	-1.6	-2.5	0.9	-2.9	-0.0	-1.7	-2.0	-1.1	0.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.5	1.6	-0.6	-1.4	-1.9	-1.6	-1.2	0.4	-0.9	-1.4	-0.7	-0.6	1.0	-0.3	0.8	0.9	0.9	0.3	0.1	1.2
Fractured/broken bones in last 5 years	2.4	3.1	6.4	-1.2	-2.4	-2.0	-1.8	-2.5	-2.1	-2.0	-1.6	-1.9	-1.1	-2.2	-1.6	1.9	-1.8	-0.3	-1.0	-1.9	-1.5	1.3
Age started oral contraceptive pill	0.3	0.4	1.3	-0.5	-0.9	-1.0	-0.5	-0.5	0.7	0.1	0.7	0.8	0.2	-0.4	-0.3	1.0	0.2	-1.1	1.0	-0.0	-0.2	0.6
Diastolic blood pressure, automated reading	0.5	1.5	9.5	0.7	0.2	-1.6	-0.9	0.8	0.4	1.4	-0.5	-0.5	-1.5	0.6	3.1	-0.2	1.9	-1.2	1.5	0.7	0.9	-1.2
Ever depressed for a whole week	0.9	1.2	7.1	1.1	0.8	1.0	-0.4	-0.7	-0.6	0.3	0.5	-0.4	1.1	0.1	-0.9	-2.0	-0.5	2.7	-0.6	-0.0	1.1	1.6
Unable to work because of sickness or disability	0.5	0.7	2.8	-0.1	1.0	1.7	0.6	0.4	-0.1	-0.3	0.4	0.2	1.1	0.4	-1.2	-0.9	-1.0	1.3	-1.3	-0.1	-0.1	-0.1
Commuting to job workplace: Cycle	2.3	2.7	8.5	-2.9	-1.6	-1.5	-0.4	-0.7	-0.6	-2.1	-1.0	-0.2	-1.4	-1.3	-2.5	1.9	-2.1	-1.0	-1.8	-1.8	-2.4	-1.1
Myopia	0.6	0.9	3.3	1.7	-0.5	-0.8	-0.9	-0.4	0.1	1.2	-0.2	-0.3	0.1	0.2	1.5	-0.6	1.2	0.5	1.8	1.0	1.1	1.3
Vascular/heart problems diagnosed by doctor	1.5	4.0	17.9	-1.9	0.1	2.0	0.7	-1.3	-1.7	-2.6	-0.6	-0.6	1.2	-1.4	-4.2	-0.0	-3.5	1.8	-3.4	-2.0	-2.0	0.1
Cholesterol lowering medication	0.7	1.1	3.1	0.6	-1.6	-1.8	-1.4	-1.0	-0.7	0.0	-1.2	-1.1	-1.0	-1.0	1.5	1.0	0.2	-0.8	1.2	-0.4	0.7	0.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.8	-1.2	-1.4	-1.6	-1.1	-0.3	-0.8	-0.6	-1.3	-1.0	-2.2	-0.5	0.3	0.9	-0.7	-1.9	-0.1	-0.7	-0.7	-0.9
Pain experienced in last month	0.4	0.7	2.4	0.4	-0.5	-0.8	0.8	0.6	1.2	0.7	0.6	1.1	-0.6	0.6	0.8	0.8	1.2	-1.1	1.6	0.9	0.0	-0.2
Supplements: Calcium	1.6	1.7	7.0	2.6	-0.7	-0.7	-1.7	-1.2	-0.2	1.1	-0.1	-0.8	0.0	0.1	1.3	-0.8	1.0	1.3	1.9	0.8	1.7	2.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-0.2	0.6	0.1	0.9	1.0	0.7	1.2	0.9	0.7	0.3	1.3	0.9	-1.2	0.9	-0.2	0.5	0.8	0.7	-0.6
Heart attack/myocardial infarction (self-reported)	0.7	1.0	2.3	1.5	-1.4	-1.5	-1.2	-0.9	-0.5	0.5	-0.5	-1.0	-1.4	-0.1	1.2	0.2	0.9	-0.4	1.3	0.4	0.6	1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-0.6	0.6	0.5	1.0	1.0	1.0	0.1	0.8	1.2	0.5	0.7	-0.7	-0.3	-0.2	-0.4	-0.7	0.1	-0.5	-0.8
Heart disease (siblings)	0.9	1.1	2.7	0.8	1.1	0.9	0.4	1.3	0.8	1.4	1.4	0.9	0.8	1.4	1.1	-1.6	0.7	-0.6	0.6	1.0	1.3	-0.2
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.2	0.8	1.0	0.8	0.7	0.9	0.1	0.6	0.8	1.0	0.6	-0.8	-0.4	0.1	0.8	-0.2	0.5	0.2	0.1
Pack years of smoking	0.8	1.2	4.1	-1.1	-0.5	-0.1	-0.5	-0.6	-1.4	-1.4	-1.5	-1.4	-1.3	-0.9	-1.2	-0.0	-1.5	-0.5	-2.0	-1.3	-0.9	-0.7
Impedance of whole body	0.9	4.4	11.8	1.1	-2.8	-2.4	-3.4	-2.3	-2.5	-1.3	-3.1	-3.2	-2.7	-2.2	1.2	2.4	-0.0	-1.6	0.7	-1.1	-0.7	0.5
Leg fat mass (left)	1.0	4.0	14.2	2.7	1.9	1.8	0.3	1.4	-0.2	2.7	0.5	-0.8	0.7	1.7	3.4	-3.5	1.9	1.5	1.2	1.7	3.8	0.6
Arm predicted mass (left)	1.2	6.3	14.6	2.4	3.0	3.8	1.7	2.8	1.4	3.1	2.3	1.2	2.4	2.7	2.6	-3.8	2.5	1.2	1.0	2.4	3.8	0.1