Best TWAS P=1.57e-08 · Best GWAS P=2.51e-07 conditioned to 0.668
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | MEGF9 | 0.24 | -0.01 | enet | 20 | 0.01 | 2.0e-01 | 3.6 | 5.7 | 1.6e-08 | 0.42 | 0.06 | 0.12 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | PSMD5-AS1 | 0.65 | 0.51 | enet | 35 | 0.55 | 9.6e-29 | 5.0 | 5.5 | 2.8e-08 | 0.95 | 0.00 | 0.99 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | PSMD5-AS1 | 0.56 | 0.48 | lasso | 14 | 0.50 | 1.8e-31 | 5.2 | 5.1 | 2.9e-07 | 0.98 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PSMD5-AS1 | 0.73 | 0.68 | lasso | 10 | 0.70 | 3.1e-81 | 5.2 | 5.2 | 2.1e-07 | 0.99 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Small Intestine Terminal Ileum | PSMD5-AS1 | 0.49 | 0.48 | enet | 14 | 0.41 | 2.5e-10 | 5.0 | 5.2 | 2.4e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC253039 | 0.18 | 0.26 | lasso | 6 | 0.27 | 1.4e-54 | 5.2 | 5.3 | 1.1e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOC253039 | 0.54 | 0.53 | lasso | 4 | 0.52 | 2.0e-34 | 5.1 | 5.2 | 2.4e-07 | 1.00 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC253039 | 0.20 | 0.25 | blup | 37 | 0.25 | 1.8e-28 | 5.0 | 5.3 | 8.6e-08 | 0.96 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC253039 | 0.48 | 0.53 | enet | 10 | 0.53 | 1.4e-65 | 5.1 | 5.2 | 2.6e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | LOC253039 | 0.24 | 0.26 | lasso | 2 | 0.23 | 5.7e-07 | 5.1 | 5.1 | 3.0e-07 | 0.99 | 0.00 | 0.99 | FALSE |