[Hub]/) : Traits : Systolic Blood Pressure :

chr9:125,006,622-129,422,783

Best TWAS P=1.58e-13 · Best GWAS P=5.2e-13 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PPP6C 0.06 0.10 lasso 3 0.07 3.2e-06 6.2 -5.7 1.2e-08 0.25 0.89 0.10 TRUE
2 GTEx Adipose Subcutaneous PSMB7 0.08 0.04 lasso 6 0.04 3.4e-04 -6.3 6.1 9.0e-10 -0.06 0.07 0.92 FALSE
3 GTEx Artery Tibial PSMB7 0.07 0.04 enet 7 0.03 4.1e-03 -6.3 7.2 8.3e-13 -0.06 0.02 0.96 TRUE
4 GTEx Artery Tibial GAPVD1 0.11 0.16 enet 19 0.16 6.4e-13 -5.7 -6.3 2.5e-10 0.50 0.98 0.02 FALSE
5 GTEx Artery Tibial PBX3 0.11 0.07 lasso 2 0.06 8.1e-06 4.5 5.5 5.2e-08 -0.63 0.60 0.08 FALSE
6 GTEx Artery Tibial PRPS1P2 0.06 0.06 enet 6 0.05 9.2e-05 5.6 5.6 2.2e-08 -0.21 0.91 0.05 FALSE
7 GTEx Breast Mammary Tissue (Male) PPP6C 0.12 0.03 enet 12 0.03 6.5e-02 5.6 -5.4 7.9e-08 0.17 0.07 0.08 TRUE
8 GTEx Breast Mammary Tissue (Female) PPP6C 0.14 0.04 lasso 4 0.04 3.1e-02 5.5 -5.5 2.9e-08 0.25 0.36 0.06 FALSE
9 GTEx Cells EBV-transformed lymphocytes GOLGA1 0.13 0.00 enet 8 0.06 3.8e-03 5.9 5.3 1.4e-07 -0.25 0.40 0.08 TRUE
10 GTEx Cells Transformed fibroblasts MAPKAP1 0.04 0.03 lasso 3 0.02 6.5e-03 -7.1 -7.0 1.8e-12 0.92 0.04 0.92 FALSE
11 GTEx Cells Transformed fibroblasts PBX3 0.05 0.02 enet 7 0.00 1.4e-01 -5.8 6.0 1.6e-09 -0.86 0.14 0.65 FALSE
12 GTEx Cells Transformed fibroblasts PRPS1P2 0.09 0.11 enet 8 0.13 9.6e-10 5.9 5.7 1.5e-08 -0.18 0.94 0.06 FALSE
13 GTEx Colon Sigmoid PSMB7 0.15 0.10 lasso 3 0.09 3.3e-04 -6.6 6.5 6.3e-11 -0.04 0.02 0.96 FALSE
14 GTEx Colon Transverse PRPS1P2 0.11 0.10 lasso 1 0.08 1.8e-04 5.9 5.9 3.3e-09 -0.25 0.50 0.25 FALSE
15 GTEx Esophagus Mucosa PPP6C 0.07 0.07 enet 21 0.08 7.1e-06 5.8 -5.4 6.1e-08 0.19 0.96 0.04 TRUE
16 GTEx Esophagus Mucosa PRPS1P2 0.07 0.08 lasso 3 0.07 1.5e-05 5.6 5.6 2.7e-08 -0.23 0.76 0.12 FALSE
17 GTEx Esophagus Muscularis RABGAP1 0.10 0.01 lasso 5 0.03 3.7e-03 -4.8 5.5 3.7e-08 0.02 0.12 0.73 FALSE
18 GTEx Esophagus Muscularis PBX3 0.12 0.08 lasso 7 0.09 4.2e-06 4.5 5.7 9.7e-09 -0.65 0.70 0.29 FALSE
19 GTEx Heart Atrial Appendage PBX3 0.10 0.08 lasso 6 0.04 9.0e-03 4.7 5.2 2.5e-07 -0.57 0.27 0.16 TRUE
20 GTEx Muscle Skeletal GAPVD1 0.13 0.10 lasso 3 0.09 4.7e-09 -5.7 5.7 1.2e-08 -0.52 0.98 0.02 TRUE
21 GTEx Nerve Tibial GAPVD1 0.17 0.08 lasso 10 0.10 9.3e-08 5.8 -6.5 1.0e-10 0.35 0.96 0.04 FALSE
22 GTEx Pancreas PBX3 0.13 0.02 enet 26 0.00 3.2e-01 -5.9 6.4 1.3e-10 -0.66 0.05 0.81 TRUE
23 GTEx Pancreas OLFML2A 0.15 0.03 lasso 5 0.09 1.2e-04 7.1 7.0 2.0e-12 -0.06 0.01 0.92 TRUE
24 GTEx Pancreas PRPS1P2 0.16 0.13 lasso 6 0.12 8.7e-06 5.6 5.7 9.7e-09 -0.22 0.91 0.05 FALSE
25 GTEx Testis PBX3 0.19 0.22 lasso 3 0.20 4.7e-09 4.7 5.2 1.5e-07 -0.55 0.78 0.21 FALSE
26 GTEx Thyroid NEK6 0.20 0.21 lasso 4 0.20 1.3e-15 -6.6 6.0 2.7e-09 -0.05 0.00 1.00 FALSE
27 GTEx Thyroid PSMB7 0.06 0.04 lasso 2 0.06 4.1e-05 -6.3 6.6 5.4e-11 -0.07 0.02 0.97 FALSE
28 GTEx Thyroid GAPVD1 0.05 0.05 enet 13 0.01 6.6e-02 -5.8 -6.1 1.2e-09 0.50 0.86 0.03 FALSE
29 GTEx Thyroid PBX3 0.07 0.00 lasso 6 0.01 4.7e-02 4.8 6.1 1.3e-09 -0.34 0.24 0.46 FALSE
30 METSIM Adipose RABGAP1 0.04 0.03 lasso 9 0.05 1.2e-08 -5.0 5.2 1.9e-07 0.00 0.07 0.93 FALSE
31 NTR Blood MAPKAP1 0.03 0.01 blup 441 0.02 2.3e-07 -6.1 -7.4 1.6e-13 0.80 0.30 0.69 TRUE
32 NTR Blood RABGAP1 0.03 0.01 blup 460 0.02 4.3e-06 3.4 -5.5 2.8e-08 -0.02 0.19 0.81 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma LOC100129034 0.12 0.00 lasso 4 0.04 1.7e-03 -6.1 -5.7 1.2e-08 -0.04 0.01 0.50 FALSE
34 The Cancer Genome Atlas Esophageal Carcinoma PPP6C 0.17 0.04 blup 46 0.08 1.7e-03 7.0 -6.5 6.1e-11 0.18 0.02 0.63 TRUE
35 The Cancer Genome Atlas Glioblastoma Multiforme RABGAP1 0.17 0.17 lasso 7 0.21 5.6e-07 -4.8 -5.5 3.5e-08 -0.01 0.03 0.96 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RABGAP1 0.02 0.01 blup 56 0.01 7.4e-03 -5.6 -5.4 8.2e-08 0.01 0.02 0.84 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPP6C 0.07 0.08 lasso 3 0.09 5.4e-10 5.5 -5.2 2.3e-07 0.21 0.91 0.09 FALSE
38 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RABGAP1 0.04 0.04 lasso 4 0.04 2.9e-03 -5.1 -5.2 1.7e-07 0.00 0.03 0.60 FALSE
39 The Cancer Genome Atlas Brain Lower Grade Glioma PPP6C 0.02 0.02 lasso 2 0.01 1.5e-02 5.9 -5.9 4.4e-09 0.24 0.06 0.05 FALSE
40 The Cancer Genome Atlas Lung Adenocarcinoma PPP6C 0.02 0.02 lasso 4 0.02 7.6e-04 5.6 -5.7 1.3e-08 0.22 0.60 0.11 FALSE
41 The Cancer Genome Atlas Pancreatic Adenocarcinoma NEK6 0.14 0.02 blup 87 0.05 2.8e-03 2.8 -5.2 2.0e-07 0.05 0.02 0.69 FALSE
42 The Cancer Genome Atlas Prostate Adenocarcinoma GAPVD1 0.02 0.04 enet 4 0.01 9.8e-03 -5.5 5.9 3.4e-09 -0.51 0.17 0.18 TRUE
43 The Cancer Genome Atlas Prostate Adenocarcinoma PBX3 0.03 0.03 blup 65 0.04 5.4e-05 4.6 5.3 9.7e-08 -0.56 0.48 0.48 FALSE
44 The Cancer Genome Atlas Prostate Adenocarcinoma PPP6C 0.06 0.08 lasso 7 0.07 1.8e-07 5.9 -5.9 4.1e-09 0.21 0.85 0.15 TRUE
45 The Cancer Genome Atlas Prostate Adenocarcinoma PSMB7 0.03 0.04 lasso 4 0.04 1.2e-04 -6.0 6.3 3.3e-10 -0.03 0.05 0.90 FALSE
46 The Cancer Genome Atlas Stomach Adenocarcinoma PPP6C 0.05 0.04 blup 46 0.03 3.8e-03 5.6 -5.8 5.6e-09 0.23 0.49 0.16 FALSE
47 The Cancer Genome Atlas Testicular Germ Cell Tumors RABGAP1 0.12 0.05 blup 58 0.06 4.2e-03 -5.2 -5.8 8.0e-09 0.00 0.03 0.95 TRUE
48 The Cancer Genome Atlas Thyroid Carcinoma PPP6C 0.08 0.13 enet 9 0.13 5.5e-13 5.9 -5.4 6.4e-08 0.23 0.83 0.17 FALSE
49 The Cancer Genome Atlas Thyroid Carcinoma PSMB7 0.06 0.06 lasso 4 0.04 3.7e-05 -5.6 5.6 2.6e-08 -0.04 0.28 0.71 FALSE