Best TWAS P=5.19e-10 · Best GWAS P=5e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | ZNF618 | 0.48 | 0.24 | enet | 10 | 0.17 | 4.4e-05 | 6.6 | 6.2 | 5.2e-10 | 0.96 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Muscularis | POLE3 | 0.16 | 0.16 | lasso | 4 | 0.16 | 7.2e-10 | -5.4 | 5.4 | 7.1e-08 | 0.02 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Spleen | POLE3 | 0.37 | 0.22 | lasso | 5 | 0.22 | 2.7e-06 | -5.4 | 5.2 | 1.5e-07 | 0.03 | 0.02 | 0.94 | FALSE |
| 4 | GTEx | Whole Blood | RGS3 | 0.26 | 0.14 | lasso | 5 | 0.12 | 1.6e-11 | -5.4 | 5.5 | 5.1e-08 | 0.02 | 0.53 | 0.47 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POLE3 | 0.10 | 0.04 | lasso | 5 | 0.03 | 7.9e-05 | -5.5 | 5.8 | 6.5e-09 | 0.03 | 0.00 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POLE3 | 0.09 | 0.07 | lasso | 2 | 0.05 | 1.8e-06 | -5.4 | 5.4 | 6.9e-08 | 0.02 | 0.00 | 1.00 | FALSE |