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chr11:106,485,489-108,027,561

Best TWAS P=9.73e-24 · Best GWAS P=3.45e-30 conditioned to 1.24e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CWF19L2	0.14	0.05	lasso	3	0.10	7.5e-09	-4.9	5.8	6.2e-09	0.46	0.94	0.06	FALSE
2	GTEx	Adipose Subcutaneous	RP11-819C21.1	0.19	0.21	lasso	5	0.20	7.4e-16	-7.0	-8.1	7.7e-16	-0.57	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	CWF19L2	0.19	0.00	enet	15	0.00	1.9e-01	-5.1	6.2	4.5e-10	0.59	0.04	0.76	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-819C21.1	0.19	0.17	enet	26	0.16	9.0e-09	-6.9	-7.2	4.9e-13	-0.51	0.96	0.03	FALSE
5	GTEx	Artery Aorta	RP11-819C21.1	0.13	0.07	lasso	6	0.10	3.4e-06	-4.9	-6.8	1.1e-11	-0.51	0.76	0.20	FALSE
6	GTEx	Artery Tibial	CWF19L2	0.24	0.18	lasso	6	0.22	3.7e-17	-5.4	5.3	9.9e-08	0.39	1.00	0.00	FALSE
7	GTEx	Artery Tibial	RP11-819C21.1	0.19	0.09	lasso	8	0.09	2.3e-07	-7.0	-8.0	1.3e-15	-0.53	0.84	0.15	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RP11-819C21.1	0.37	0.16	enet	23	0.24	8.8e-07	-3.3	-7.4	1.2e-13	-0.47	0.37	0.17	FALSE
9	GTEx	Brain Cerebellum	RP11-819C21.1	0.18	0.08	enet	2	0.02	8.8e-02	10.0	-9.8	1.3e-22	-0.76	0.06	0.44	FALSE
10	GTEx	Brain Hippocampus	RP11-819C21.1	0.22	0.06	lasso	6	0.05	2.2e-02	-6.9	-6.2	6.0e-10	-0.45	0.16	0.10	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	RP11-819C21.1	0.39	0.17	enet	26	0.23	1.0e-06	-6.9	-8.5	1.6e-17	-0.61	0.14	0.79	FALSE
12	GTEx	Breast Mammary Tissue	RP11-819C21.1	0.14	0.09	enet	12	0.09	2.6e-05	10.0	-9.1	1.2e-19	-0.67	0.17	0.78	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RP11-819C21.1	0.15	-0.01	lasso	1	-0.01	7.0e-01	10.0	-10.0	9.7e-24	-0.80	0.04	0.19	TRUE
14	GTEx	Breast Mammary Tissue (Female)	CWF19L2	0.19	0.14	lasso	13	0.08	2.4e-03	-5.1	5.9	4.5e-09	0.43	0.33	0.24	FALSE
15	GTEx	Breast Mammary Tissue (Female)	RP11-819C21.1	0.12	0.06	lasso	13	0.02	7.4e-02	4.4	-5.9	2.9e-09	-0.54	0.07	0.57	FALSE
16	GTEx	Cells Transformed fibroblasts	CWF19L2	0.13	0.05	enet	19	0.06	2.6e-05	10.0	8.1	5.1e-16	0.65	0.88	0.07	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-819C21.1	0.11	0.06	lasso	8	0.05	2.1e-04	7.7	-8.3	1.3e-16	-0.60	0.82	0.10	FALSE
18	GTEx	Colon Sigmoid	RP11-819C21.1	0.17	0.05	enet	20	0.08	6.4e-04	-2.8	-7.3	3.8e-13	-0.50	0.42	0.42	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	CWF19L2	0.16	0.06	lasso	3	0.04	1.1e-02	-5.4	6.6	4.6e-11	0.47	0.17	0.48	FALSE
20	GTEx	Esophagus Mucosa	CWF19L2	0.20	0.14	lasso	5	0.12	3.4e-08	-5.1	7.0	3.3e-12	0.55	0.90	0.10	FALSE
21	GTEx	Esophagus Mucosa	RP11-819C21.1	0.20	0.18	enet	21	0.20	3.6e-13	-7.0	-7.4	1.3e-13	-0.49	0.99	0.01	FALSE
22	GTEx	Esophagus Muscularis	CWF19L2	0.35	0.16	lasso	8	0.28	5.8e-17	-5.4	5.5	2.8e-08	0.44	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	CWF19L2	0.10	0.07	lasso	4	0.05	1.4e-03	7.6	9.1	1.1e-19	0.69	0.56	0.14	FALSE
24	GTEx	Heart Left Ventricle	RP11-819C21.1	0.13	0.04	lasso	3	0.04	4.6e-03	-7.0	-7.2	6.5e-13	-0.49	0.03	0.86	FALSE
25	GTEx	Lung	CWF19L2	0.19	0.12	lasso	7	0.13	7.8e-10	-5.4	7.0	2.6e-12	0.52	0.93	0.07	FALSE
26	GTEx	Lung	RP11-819C21.1	0.09	0.07	lasso	6	0.07	2.6e-06	-8.8	-8.8	1.3e-18	-0.65	0.04	0.94	FALSE
27	GTEx	Muscle Skeletal	CWF19L2	0.08	0.05	lasso	3	0.05	1.1e-05	10.0	9.9	3.1e-23	0.80	0.04	0.96	FALSE
28	GTEx	Nerve Tibial	CWF19L2	0.11	0.10	lasso	6	0.11	5.5e-08	-5.4	5.5	4.9e-08	0.37	0.99	0.00	FALSE
29	GTEx	Nerve Tibial	RP11-819C21.1	0.40	0.24	enet	46	0.39	2.1e-29	-6.9	-8.7	2.3e-18	-0.66	1.00	0.00	FALSE
30	GTEx	Ovary	RP11-819C21.1	0.31	0.11	enet	28	0.22	3.9e-06	6.6	-7.8	4.1e-15	-0.69	0.06	0.84	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	CWF19L2	0.18	0.12	enet	22	0.10	2.5e-06	-5.1	7.2	4.4e-13	0.58	0.89	0.11	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	RP11-819C21.1	0.27	0.10	lasso	5	0.19	9.4e-11	-7.0	-9.9	3.3e-23	-0.81	0.01	0.99	FALSE
33	GTEx	Skin Sun Exposed Lower leg	CWF19L2	0.10	0.01	enet	13	0.05	4.7e-05	5.9	6.2	5.7e-10	0.49	0.76	0.08	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RP11-819C21.1	0.28	0.23	enet	33	0.24	4.8e-20	-7.0	-7.7	1.6e-14	-0.60	1.00	0.00	FALSE
35	GTEx	Stomach	RP11-819C21.1	0.10	0.01	lasso	4	0.03	9.9e-03	-5.1	-7.2	7.2e-13	-0.56	0.24	0.29	FALSE
36	GTEx	Testis	CWF19L2	0.20	0.09	lasso	6	0.09	1.0e-04	10.0	9.4	5.7e-21	0.72	0.52	0.18	FALSE
37	GTEx	Thyroid	RP11-819C21.1	0.14	0.11	enet	21	0.13	3.0e-10	-7.0	-8.1	5.3e-16	-0.62	0.46	0.54	FALSE
38	GTEx	Whole Blood	RP11-819C21.1	0.06	0.03	lasso	2	0.01	4.8e-02	6.6	-6.7	1.6e-11	-0.53	0.16	0.27	FALSE
39	METSIM	Adipose	CWF19L2	0.08	0.03	blup	517	0.05	6.5e-08	10.0	7.8	4.9e-15	0.62	0.96	0.04	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	RP11-819C21.1	0.16	0.11	enet	15	0.12	2.9e-15	-7.0	-6.4	1.2e-10	-0.44	1.00	0.00	FALSE
41	YFS	Blood	CWF19L2	0.26	0.16	enet	101	0.22	2.2e-68	10.0	6.5	1.0e-10	0.61	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CWF19L2	0.09	0.00	blup	106	0.04	5.3e-04	-5.1	6.5	6.0e-11	0.61	0.06	0.29	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALKBH8	0.06	0.02	blup	97	0.04	4.2e-08	-3.1	5.3	1.4e-07	0.39	0.97	0.00	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	CWF19L2	0.16	0.04	blup	106	0.09	1.4e-18	5.9	6.9	5.0e-12	0.51	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	CWF19L2	0.11	0.01	blup	105	0.02	3.0e-02	-4.9	8.5	2.3e-17	0.62	0.06	0.08	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CWF19L2	0.05	0.00	blup	106	0.01	3.4e-02	4.5	8.3	7.1e-17	0.71	0.03	0.06	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CWF19L2	0.08	0.00	blup	106	0.03	3.0e-04	-4.4	6.9	5.4e-12	0.66	0.40	0.06	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CWF19L2	0.15	0.03	blup	106	0.03	9.7e-03	5.9	5.4	7.4e-08	0.57	0.03	0.03	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	CWF19L2	0.05	0.00	blup	106	0.02	2.2e-03	3.4	6.7	2.8e-11	0.59	0.11	0.04	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	CWF19L2	0.10	0.03	lasso	4	0.07	1.2e-07	6.4	6.8	1.5e-11	0.55	0.23	0.67	FALSE
51	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CWF19L2	0.13	0.01	enet	9	0.04	1.4e-02	-6.9	8.4	6.2e-17	0.65	0.02	0.43	FALSE