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chr11:99,859,184-101,559,718

Best TWAS P=4.17e-83 · Best GWAS P=3.04e-81 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ARHGAP42 0.08 0.03 enet 14 0.05 2.8e-06 -12.4 -11.4 4.9e-30 0.50 0.98 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex TMEM133 0.05 0.01 bslmm 541 0.02 4.7e-03 -12.4 -7.8 6.2e-15 0.31 0.14 0.09 FALSE
3 GTEx Artery Aorta ARHGAP42 0.22 0.15 enet 18 0.19 1.7e-10 -18.6 -17.7 6.9e-70 0.86 0.00 1.00 FALSE
4 GTEx Artery Aorta TMEM133 0.30 0.15 enet 34 0.19 7.1e-11 -19.1 -15.6 8.6e-55 0.72 0.00 1.00 FALSE
5 GTEx Artery Tibial ARHGAP42 0.24 0.24 lasso 4 0.24 2.4e-18 -19.1 -19.3 4.2e-83 0.98 0.00 1.00 TRUE
6 GTEx Artery Tibial TMEM133 0.26 0.25 enet 28 0.27 1.3e-21 -19.1 -19.3 1.1e-82 0.94 0.00 1.00 FALSE
7 GTEx Cells Transformed fibroblasts ARHGAP42 0.15 0.10 enet 20 0.08 2.6e-06 7.2 -9.6 8.0e-22 0.46 0.71 0.23 FALSE
8 ROSMAP Brain Pre-frontal Cortex ARHGAP42 0.04 0.00 lasso 2 0.00 1.9e-01 -11.5 -11.1 1.7e-28 0.51 0.11 0.19 FALSE
9 The Cancer Genome Atlas Breast Invasive Carcinoma ARHGAP42 0.04 0.01 blup 266 0.02 1.1e-04 11.6 -13.6 2.2e-42 0.57 0.04 0.88 FALSE