Best TWAS P=1.53e-12 · Best GWAS P=1.26e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C11orf1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.4e-07 | 7.1 | -7.1 | 1.5e-12 | -1.00 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | LAYN | 0.24 | 0.12 | lasso | 7 | 0.13 | 6.2e-04 | 4.5 | -5.2 | 2.2e-07 | -0.61 | 0.17 | 0.18 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SIK2 | 0.13 | 0.03 | lasso | 4 | 0.02 | 2.2e-02 | 5.4 | 5.7 | 1.5e-08 | 0.67 | 0.10 | 0.67 | FALSE |
| 4 | GTEx | Muscle Skeletal | C11orf1 | 0.04 | 0.05 | lasso | 4 | 0.02 | 3.5e-03 | 6.5 | -6.5 | 6.1e-11 | -0.96 | 0.03 | 0.95 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | CRYAB | 0.12 | 0.10 | lasso | 5 | 0.07 | 7.7e-05 | 6.5 | 6.6 | 5.4e-11 | 0.96 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | C11orf1 | 0.07 | 0.03 | lasso | 4 | 0.03 | 5.8e-03 | -3.0 | -5.5 | 5.1e-08 | -0.80 | 0.03 | 0.91 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CRYAB | 0.07 | 0.04 | lasso | 10 | 0.02 | 1.3e-02 | 7.0 | 7.0 | 2.3e-12 | 0.98 | 0.02 | 0.96 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | C11orf1 | 0.06 | 0.05 | lasso | 2 | 0.02 | 9.6e-03 | 7.0 | -7.0 | 2.1e-12 | -0.98 | 0.02 | 0.97 | FALSE |
| 9 | GTEx | Testis | PPP2R1B | 0.34 | 0.21 | lasso | 10 | 0.36 | 1.5e-16 | 6.2 | -6.0 | 1.7e-09 | -0.84 | 0.03 | 0.97 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | C11orf1 | 0.04 | 0.02 | lasso | 2 | 0.03 | 2.1e-04 | 6.5 | -6.6 | 4.1e-11 | -0.96 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CRYAB | 0.03 | 0.02 | lasso | 1 | 0.01 | 2.2e-03 | 6.5 | 6.5 | 5.9e-11 | 0.96 | 0.00 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIK2 | 0.04 | 0.01 | blup | 35 | 0.01 | 6.7e-03 | 5.9 | 5.2 | 2.2e-07 | 0.71 | 0.01 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | C11orf1 | 0.11 | 0.07 | enet | 2 | 0.08 | 3.4e-05 | 6.5 | -6.4 | 1.6e-10 | -0.94 | 0.00 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | FDXACB1 | 0.08 | 0.07 | lasso | 3 | 0.05 | 5.6e-04 | 6.5 | -6.5 | 5.7e-11 | -0.95 | 0.00 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C11orf1 | 0.07 | 0.06 | enet | 3 | 0.08 | 7.0e-09 | 6.5 | -6.4 | 1.2e-10 | -0.90 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FDXACB1 | 0.13 | 0.05 | lasso | 1 | 0.05 | 2.4e-06 | 6.5 | -6.5 | 5.9e-11 | -0.96 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C11orf1 | 0.09 | 0.01 | blup | 5 | 0.03 | 2.0e-02 | -3.5 | -5.5 | 5.2e-08 | -0.75 | 0.00 | 0.26 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | HSPB2 | 0.03 | 0.01 | blup | 5 | 0.03 | 2.3e-04 | 6.5 | 5.6 | 2.1e-08 | 0.81 | 0.00 | 0.93 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FDXACB1 | 0.03 | 0.02 | lasso | 1 | 0.02 | 5.9e-03 | 6.5 | -6.5 | 5.9e-11 | -0.96 | 0.00 | 0.89 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf1 | 0.04 | 0.03 | blup | 5 | 0.02 | 1.8e-03 | 6.5 | -5.7 | 1.6e-08 | -0.85 | 0.00 | 0.88 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIK2 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.6e-06 | 6.0 | 6.0 | 2.6e-09 | 0.75 | 0.01 | 0.99 | FALSE |