Best TWAS P=4.34e-13 · Best GWAS P=4.82e-14 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RALGAPA1 | 0.10 | 0.06 | bslmm | 497 | 0.08 | 1.9e-10 | -6.1 | -5.7 | 9.3e-09 | -0.20 | 0.95 | 0.05 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RALGAPA1 | 0.13 | 0.16 | lasso | 5 | 0.16 | 5.2e-13 | -6.1 | -5.8 | 7.7e-09 | -0.17 | 0.97 | 0.03 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RALGAPA1 | 0.26 | 0.26 | lasso | 4 | 0.28 | 5.5e-15 | -6.1 | -6.3 | 3.0e-10 | -0.15 | 0.96 | 0.04 | FALSE |
| 4 | GTEx | Adrenal Gland | RALGAPA1 | 0.28 | 0.20 | lasso | 6 | 0.18 | 5.0e-07 | -6.1 | -6.1 | 1.4e-09 | -0.17 | 0.92 | 0.07 | FALSE |
| 5 | GTEx | Artery Aorta | RALGAPA1 | 0.31 | 0.38 | enet | 16 | 0.36 | 5.8e-21 | -6.1 | -6.2 | 6.0e-10 | -0.17 | 0.97 | 0.03 | FALSE |
| 6 | GTEx | Artery Coronary | RALGAPA1 | 0.26 | 0.28 | lasso | 7 | 0.31 | 4.1e-11 | -6.2 | -5.9 | 3.5e-09 | -0.17 | 0.92 | 0.07 | FALSE |
| 7 | GTEx | Artery Tibial | RALGAPA1 | 0.20 | 0.20 | enet | 9 | 0.20 | 1.5e-15 | -6.1 | -6.1 | 1.2e-09 | -0.16 | 0.97 | 0.03 | FALSE |
| 8 | GTEx | Brain Cerebellum | RALGAPA1 | 0.21 | 0.17 | lasso | 4 | 0.06 | 6.0e-03 | -6.1 | -6.1 | 1.2e-09 | -0.16 | 0.57 | 0.10 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | RALGAPA1 | 0.30 | 0.28 | lasso | 7 | 0.28 | 1.7e-14 | -6.1 | -6.1 | 7.8e-10 | -0.17 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Male) | RALGAPA1 | 0.31 | 0.23 | lasso | 6 | 0.16 | 1.4e-04 | -6.1 | -6.4 | 1.4e-10 | -0.15 | 0.38 | 0.05 | TRUE |
| 11 | GTEx | Cells EBV-transformed lymphocytes | RALGAPA1 | 0.47 | 0.45 | lasso | 15 | 0.46 | 6.6e-17 | -6.1 | -6.3 | 2.6e-10 | -0.17 | 0.96 | 0.04 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | RALGAPA1 | 0.33 | 0.44 | lasso | 4 | 0.44 | 1.1e-35 | -6.1 | -6.1 | 1.1e-09 | -0.16 | 0.97 | 0.03 | FALSE |
| 13 | GTEx | Colon Sigmoid | RALGAPA1 | 0.21 | 0.20 | lasso | 5 | 0.21 | 5.8e-08 | -5.9 | -6.0 | 2.1e-09 | -0.15 | 0.95 | 0.04 | FALSE |
| 14 | GTEx | Colon Transverse | RALGAPA1 | 0.48 | 0.51 | lasso | 5 | 0.52 | 4.6e-28 | -6.1 | -6.1 | 1.0e-09 | -0.16 | 0.96 | 0.04 | FALSE |
| 15 | GTEx | Esophagus Gastroesophageal Junction | RALGAPA1 | 0.32 | 0.26 | lasso | 6 | 0.25 | 2.0e-09 | -6.1 | -6.1 | 1.2e-09 | -0.17 | 0.96 | 0.04 | FALSE |
| 16 | GTEx | Esophagus Mucosa | RALGAPA1 | 0.36 | 0.44 | enet | 27 | 0.46 | 1.1e-33 | -6.1 | -6.1 | 9.8e-10 | -0.16 | 0.96 | 0.04 | FALSE |
| 17 | GTEx | Esophagus Muscularis | RALGAPA1 | 0.18 | 0.18 | enet | 9 | 0.17 | 1.6e-10 | -5.9 | -6.2 | 5.3e-10 | -0.16 | 0.93 | 0.07 | FALSE |
| 18 | GTEx | Lung | RALGAPA1 | 0.24 | 0.30 | lasso | 6 | 0.31 | 6.6e-24 | -6.1 | -6.1 | 1.0e-09 | -0.16 | 0.96 | 0.04 | FALSE |
| 19 | GTEx | Nerve Tibial | RALGAPA1 | 0.28 | 0.40 | lasso | 3 | 0.40 | 4.7e-30 | -6.1 | -6.0 | 1.6e-09 | -0.15 | 0.97 | 0.03 | FALSE |
| 20 | GTEx | Ovary | RALGAPA1 | 0.50 | 0.32 | lasso | 4 | 0.39 | 1.1e-10 | -6.1 | -6.1 | 1.1e-09 | -0.16 | 0.96 | 0.04 | FALSE |
| 21 | GTEx | Pancreas | RALGAPA1 | 0.34 | 0.33 | lasso | 5 | 0.32 | 4.3e-14 | -6.1 | -6.1 | 1.2e-09 | -0.16 | 0.96 | 0.04 | FALSE |
| 22 | GTEx | Pituitary | RALGAPA1 | 0.55 | 0.41 | lasso | 6 | 0.49 | 2.7e-14 | -6.1 | -6.0 | 2.3e-09 | -0.16 | 0.96 | 0.03 | FALSE |
| 23 | GTEx | Prostate | RALGAPA1 | 0.38 | 0.22 | enet | 12 | 0.21 | 5.3e-06 | -6.2 | -5.9 | 4.3e-09 | -0.17 | 0.83 | 0.05 | FALSE |
| 24 | GTEx | Skin Not Sun Exposed Suprapubic | RALGAPA1 | 0.25 | 0.22 | lasso | 4 | 0.26 | 1.5e-14 | -6.1 | -6.0 | 1.9e-09 | -0.17 | 0.97 | 0.03 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | RALGAPA1 | 0.14 | 0.14 | enet | 9 | 0.14 | 1.9e-11 | -6.1 | -6.2 | 6.9e-10 | -0.16 | 0.96 | 0.04 | FALSE |
| 26 | GTEx | Small Intestine Terminal Ileum | RALGAPA1 | 0.40 | 0.26 | lasso | 8 | 0.32 | 7.3e-08 | -6.5 | -6.0 | 2.2e-09 | -0.16 | 0.87 | 0.07 | FALSE |
| 27 | GTEx | Stomach | RALGAPA1 | 0.21 | 0.18 | lasso | 3 | 0.14 | 2.6e-07 | -6.1 | -5.9 | 3.9e-09 | -0.15 | 0.96 | 0.04 | FALSE |
| 28 | GTEx | Testis | RALGAPA1 | 0.33 | 0.25 | enet | 20 | 0.26 | 7.2e-12 | -6.1 | -6.2 | 6.6e-10 | -0.18 | 0.94 | 0.06 | FALSE |
| 29 | GTEx | Thyroid | RALGAPA1 | 0.30 | 0.38 | lasso | 2 | 0.36 | 2.7e-28 | -6.1 | -6.1 | 1.3e-09 | -0.15 | 0.97 | 0.03 | FALSE |
| 30 | GTEx | Uterus | RALGAPA1 | 0.42 | 0.39 | lasso | 8 | 0.37 | 1.4e-08 | -6.1 | -6.1 | 1.2e-09 | -0.15 | 0.84 | 0.04 | FALSE |
| 31 | GTEx | Vagina | RALGAPA1 | 0.54 | 0.38 | enet | 16 | 0.37 | 1.6e-09 | -6.2 | -5.7 | 1.0e-08 | -0.14 | 0.94 | 0.04 | FALSE |
| 32 | GTEx | Whole Blood | RALGAPA1 | 0.05 | 0.05 | lasso | 3 | 0.04 | 1.1e-04 | -6.1 | -6.2 | 6.4e-10 | -0.20 | 0.69 | 0.07 | FALSE |
| 33 | METSIM | Adipose | RALGAPA1 | 0.09 | 0.08 | blup | 488 | 0.10 | 2.1e-14 | -6.1 | -5.5 | 3.8e-08 | -0.07 | 0.94 | 0.06 | TRUE |
| 34 | NTR | Blood | NFKBIA | 0.26 | 0.09 | lasso | 10 | 0.12 | 3.4e-36 | 7.5 | 7.2 | 4.3e-13 | 0.92 | 0.00 | 1.00 | TRUE |
| 35 | YFS | Blood | NFKBIA | 0.24 | 0.11 | enet | 33 | 0.17 | 3.5e-53 | 7.5 | 6.2 | 6.0e-10 | 0.72 | 0.00 | 1.00 | TRUE |
| 36 | YFS | Blood | RALGAPA1 | 0.11 | 0.14 | lasso | 14 | 0.14 | 1.7e-44 | -6.2 | -6.2 | 7.1e-10 | -0.15 | 0.95 | 0.05 | FALSE |
| 37 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RALGAPA1 | 0.06 | 0.04 | lasso | 2 | 0.06 | 2.7e-04 | -4.4 | -5.5 | 3.1e-08 | -0.15 | 0.03 | 0.84 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | RALGAPA1 | 0.07 | 0.00 | blup | 99 | 0.03 | 6.6e-04 | -4.1 | -5.7 | 1.2e-08 | -0.10 | 0.04 | 0.81 | FALSE |