Best TWAS P=1.42e-09 · Best GWAS P=6.65e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | SAV1 | 0.19 | 0.06 | lasso | 7 | 0.02 | 1.3e-01 | 5.9 | 5.2 | 1.6e-07 | 0.90 | 0.03 | 0.77 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | MAP4K5 | 0.16 | 0.08 | lasso | 4 | 0.08 | 1.6e-06 | 5.1 | 5.5 | 3.1e-08 | 0.75 | 0.25 | 0.75 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SAV1 | 0.13 | 0.15 | enet | 14 | 0.15 | 5.1e-10 | 5.6 | 5.7 | 1.0e-08 | 0.94 | 0.10 | 0.90 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SAV1 | 0.07 | 0.05 | enet | 6 | 0.07 | 1.1e-06 | 6.0 | 6.1 | 1.4e-09 | 0.98 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SAV1 | 0.02 | 0.01 | lasso | 2 | 0.02 | 1.5e-04 | -5.2 | 5.7 | 9.4e-09 | 0.82 | 0.06 | 0.85 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | SAV1 | 0.06 | 0.06 | lasso | 1 | 0.04 | 1.7e-03 | 5.3 | 5.3 | 1.4e-07 | 0.92 | 0.04 | 0.68 | FALSE |