Best TWAS P=1.43e-09 · Best GWAS P=1.45e-08 conditioned to 0.42
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-78O7.2 | 0.08 | 0.06 | lasso | 5 | 0.07 | 3.2e-06 | 5.3 | -6.0 | 1.4e-09 | -0.87 | 0.02 | 0.97 | TRUE |
2 | GTEx | Esophagus Mucosa | RP11-78O7.2 | 0.06 | 0.07 | lasso | 2 | 0.06 | 4.7e-05 | -5.0 | -5.2 | 2.1e-07 | -0.69 | 0.03 | 0.94 | FALSE |
3 | GTEx | Esophagus Muscularis | RP11-78O7.2 | 0.08 | 0.09 | lasso | 1 | 0.08 | 1.9e-05 | 5.3 | -5.3 | 1.0e-07 | -0.90 | 0.03 | 0.97 | FALSE |
4 | GTEx | Nerve Tibial | RP11-78O7.2 | 0.09 | 0.07 | lasso | 2 | 0.06 | 2.6e-05 | 5.3 | -5.3 | 9.5e-08 | -0.90 | 0.02 | 0.97 | FALSE |
5 | METSIM | Adipose | RP11-78O7.2 | 0.07 | 0.07 | lasso | 15 | 0.06 | 7.8e-10 | 5.3 | -5.5 | 4.6e-08 | -0.93 | 0.02 | 0.98 | FALSE |
6 | YFS | Blood | AKAP10 | 0.37 | 0.50 | lasso | 6 | 0.50 | 1.2e-194 | 5.4 | 5.2 | 2.0e-07 | 0.88 | 0.03 | 0.97 | FALSE |