[Hub]/) : Traits : Systolic Blood Pressure :

chr17:17,051,974-18,923,818

Best TWAS P=9.18e-12 · Best GWAS P=3.95e-10 conditioned to 0.000346

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LLGL1 0.09 0.02 enet 14 0.04 4.8e-06 4.6 5.2 2.0e-07 0.17 0.42 0.33 FALSE
2 CommonMind Brain Pre-frontal Cortex TOP3A 0.15 0.04 lasso 7 0.08 4.3e-10 3.6 -5.6 2.4e-08 -0.11 0.97 0.03 FALSE
3 GTEx Adipose Subcutaneous TOM1L2 0.04 0.04 lasso 3 0.04 5.3e-04 5.1 -5.2 2.0e-07 -0.71 0.22 0.74 FALSE
4 GTEx Adipose Subcutaneous TOP3A 0.12 0.03 lasso 3 0.03 1.1e-03 5.9 -5.4 7.6e-08 0.11 0.04 0.90 FALSE
5 GTEx Adipose Visceral Omentum TOM1L2 0.15 0.13 lasso 4 0.11 3.6e-06 4.9 -5.1 2.8e-07 -0.74 0.32 0.67 FALSE
6 GTEx Adipose Visceral Omentum TOP3A 0.08 0.00 enet 15 0.00 6.5e-01 3.7 -6.8 1.3e-11 -0.24 0.06 0.20 FALSE
7 GTEx Adrenal Gland SHMT1 0.57 0.25 enet 25 0.33 9.9e-13 5.9 5.3 1.4e-07 -0.11 0.02 0.98 FALSE
8 GTEx Artery Aorta TOP3A 0.13 0.11 enet 8 0.15 1.8e-08 3.8 -5.2 2.0e-07 0.11 0.15 0.85 FALSE
9 GTEx Artery Tibial TOM1L2 0.06 0.02 enet 15 0.04 3.8e-04 5.9 -6.2 6.9e-10 -0.63 0.08 0.90 FALSE
10 GTEx Brain Putamen basal ganglia LRRC48 0.14 0.01 lasso 18 0.02 1.3e-01 5.5 5.5 3.3e-08 0.61 0.07 0.52 FALSE
11 GTEx Cells Transformed fibroblasts TOP3A 0.32 0.12 enet 31 0.12 2.3e-09 3.6 -5.2 1.8e-07 -0.06 0.93 0.07 FALSE
12 GTEx Colon Transverse DRG2 0.10 0.07 lasso 7 0.08 1.4e-04 4.8 -5.2 1.9e-07 -0.62 0.12 0.87 FALSE
13 GTEx Esophagus Mucosa TOP3A 0.08 0.04 enet 10 0.05 4.1e-04 -3.7 -5.5 2.8e-08 0.06 0.14 0.66 FALSE
14 GTEx Esophagus Muscularis TOM1L2 0.06 0.07 enet 12 0.05 4.3e-04 5.4 -5.6 2.6e-08 -0.64 0.15 0.84 FALSE
15 GTEx Heart Left Ventricle SHMT1 0.27 0.20 enet 22 0.27 8.4e-15 5.9 6.3 2.5e-10 0.04 0.01 0.99 FALSE
16 GTEx Muscle Skeletal TOM1L2 0.08 0.11 lasso 6 0.10 5.3e-10 5.1 -5.3 1.3e-07 -0.80 0.48 0.52 FALSE
17 GTEx Muscle Skeletal TOP3A 0.17 0.08 enet 11 0.10 5.4e-10 5.9 -5.7 1.1e-08 0.06 0.02 0.98 FALSE
18 GTEx Muscle Skeletal AC122129.1 0.13 0.14 lasso 4 0.13 7.3e-13 5.0 -5.2 2.4e-07 -0.73 0.32 0.68 FALSE
19 GTEx Nerve Tibial TOP3A 0.35 0.21 lasso 12 0.18 1.1e-12 -4.9 -6.0 2.4e-09 0.01 0.62 0.38 FALSE
20 GTEx Ovary TOM1L2 0.28 0.01 lasso 7 0.04 3.1e-02 5.4 -6.8 9.2e-12 -0.49 0.10 0.52 TRUE
21 GTEx Skin Sun Exposed Lower leg TOP3A 0.09 0.05 lasso 4 0.05 6.7e-05 5.9 -5.5 4.6e-08 0.10 0.06 0.78 FALSE
22 GTEx Small Intestine Terminal Ileum TOP3A 0.25 0.09 lasso 5 0.06 1.8e-02 -4.1 -5.6 2.7e-08 0.06 0.09 0.22 FALSE
23 GTEx Thyroid LRRC48 0.04 0.01 enet 16 0.01 2.7e-02 5.1 5.1 2.9e-07 0.47 0.12 0.71 FALSE
24 GTEx Thyroid TOP3A 0.14 0.08 lasso 3 0.09 1.5e-07 5.9 -5.9 4.3e-09 0.08 0.05 0.95 FALSE
25 GTEx Whole Blood SHMT1 0.28 0.11 lasso 7 0.21 9.8e-19 5.9 5.8 6.5e-09 0.00 0.01 0.99 FALSE
26 NTR Blood SHMT1 0.03 0.01 bslmm 264 0.01 4.7e-05 -4.9 6.3 3.4e-10 0.00 0.48 0.43 FALSE
27 ROSMAP Brain Pre-frontal Cortex GID4 0.07 0.04 lasso 5 0.03 4.1e-05 5.1 5.6 1.9e-08 0.51 0.17 0.83 FALSE
28 YFS Blood SHMT1 0.46 0.28 bslmm 255 0.41 7.3e-145 -3.6 5.4 6.3e-08 -0.01 0.85 0.15 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma TOM1L2 0.01 0.01 blup 83 0.01 1.8e-03 6.3 -5.6 2.1e-08 -0.75 0.03 0.92 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LLGL1 0.08 0.02 blup 53 0.05 6.0e-06 4.6 6.5 1.1e-10 0.18 0.03 0.84 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma SHMT1 0.06 0.02 blup 32 0.04 9.4e-06 -5.1 6.1 9.7e-10 0.01 0.03 0.92 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma TOP3A 0.12 0.08 lasso 3 0.09 5.0e-10 5.9 -5.1 3.1e-07 0.06 0.00 1.00 FALSE
33 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SHMT1 0.20 0.18 lasso 5 0.16 3.2e-08 -5.1 5.4 5.4e-08 -0.03 0.09 0.91 FALSE
34 The Cancer Genome Atlas Pancreatic Adenocarcinoma ATPAF2 0.13 0.00 blup 44 0.04 8.4e-03 5.5 6.0 2.6e-09 0.50 0.02 0.77 FALSE
35 The Cancer Genome Atlas Pancreatic Adenocarcinoma SHMT1 0.12 0.08 enet 5 0.07 8.8e-04 -5.1 5.3 1.2e-07 -0.09 0.01 0.75 FALSE
36 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LRRC48 0.07 0.05 enet 12 0.04 7.0e-03 5.3 5.6 1.7e-08 0.67 0.03 0.71 FALSE
37 The Cancer Genome Atlas Stomach Adenocarcinoma SHMT1 0.17 0.10 lasso 2 0.08 1.0e-06 -4.9 5.2 2.7e-07 -0.04 0.12 0.87 FALSE
38 The Cancer Genome Atlas Thyroid Carcinoma C17orf39 0.05 0.05 blup 49 0.05 5.8e-06 5.4 5.4 6.3e-08 0.66 0.02 0.97 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma SMCR7 0.10 0.01 blup 33 0.05 8.9e-06 3.6 -5.2 2.3e-07 -0.05 0.01 0.98 FALSE
40 The Cancer Genome Atlas Thyroid Carcinoma TOP3A 0.10 0.07 lasso 4 0.07 2.2e-07 5.9 -6.1 9.3e-10 0.03 0.00 1.00 TRUE