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chr17:17,051,974-18,923,818

Best TWAS P=9.18e-12 · Best GWAS P=3.95e-10 conditioned to 0.000346

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LLGL1	0.09	0.02	enet	14	0.04	4.8e-06	4.6	5.2	2.0e-07	0.17	0.42	0.33	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TOP3A	0.15	0.04	lasso	7	0.08	4.3e-10	3.6	-5.6	2.4e-08	-0.11	0.97	0.03	FALSE
3	GTEx	Adipose Subcutaneous	TOM1L2	0.04	0.04	lasso	3	0.04	5.3e-04	5.1	-5.2	2.0e-07	-0.71	0.22	0.74	FALSE
4	GTEx	Adipose Subcutaneous	TOP3A	0.12	0.03	lasso	3	0.03	1.1e-03	5.9	-5.4	7.6e-08	0.11	0.04	0.90	FALSE
5	GTEx	Adipose Visceral Omentum	TOM1L2	0.15	0.13	lasso	4	0.11	3.6e-06	4.9	-5.1	2.8e-07	-0.74	0.32	0.67	FALSE
6	GTEx	Adipose Visceral Omentum	TOP3A	0.08	0.00	enet	15	0.00	6.5e-01	3.7	-6.8	1.3e-11	-0.24	0.06	0.20	FALSE
7	GTEx	Adrenal Gland	SHMT1	0.57	0.25	enet	25	0.33	9.9e-13	5.9	5.3	1.4e-07	-0.11	0.02	0.98	FALSE
8	GTEx	Artery Aorta	TOP3A	0.13	0.11	enet	8	0.15	1.8e-08	3.8	-5.2	2.0e-07	0.11	0.15	0.85	FALSE
9	GTEx	Artery Tibial	TOM1L2	0.06	0.02	enet	15	0.04	3.8e-04	5.9	-6.2	6.9e-10	-0.63	0.08	0.90	FALSE
10	GTEx	Brain Putamen basal ganglia	LRRC48	0.14	0.01	lasso	18	0.02	1.3e-01	5.5	5.5	3.3e-08	0.61	0.07	0.52	FALSE
11	GTEx	Cells Transformed fibroblasts	TOP3A	0.32	0.12	enet	31	0.12	2.3e-09	3.6	-5.2	1.8e-07	-0.06	0.93	0.07	FALSE
12	GTEx	Colon Transverse	DRG2	0.10	0.07	lasso	7	0.08	1.4e-04	4.8	-5.2	1.9e-07	-0.62	0.12	0.87	FALSE
13	GTEx	Esophagus Mucosa	TOP3A	0.08	0.04	enet	10	0.05	4.1e-04	-3.7	-5.5	2.8e-08	0.06	0.14	0.66	FALSE
14	GTEx	Esophagus Muscularis	TOM1L2	0.06	0.07	enet	12	0.05	4.3e-04	5.4	-5.6	2.6e-08	-0.64	0.15	0.84	FALSE
15	GTEx	Heart Left Ventricle	SHMT1	0.27	0.20	enet	22	0.27	8.4e-15	5.9	6.3	2.5e-10	0.04	0.01	0.99	FALSE
16	GTEx	Muscle Skeletal	TOM1L2	0.08	0.11	lasso	6	0.10	5.3e-10	5.1	-5.3	1.3e-07	-0.80	0.48	0.52	FALSE
17	GTEx	Muscle Skeletal	TOP3A	0.17	0.08	enet	11	0.10	5.4e-10	5.9	-5.7	1.1e-08	0.06	0.02	0.98	FALSE
18	GTEx	Muscle Skeletal	AC122129.1	0.13	0.14	lasso	4	0.13	7.3e-13	5.0	-5.2	2.4e-07	-0.73	0.32	0.68	FALSE
19	GTEx	Nerve Tibial	TOP3A	0.35	0.21	lasso	12	0.18	1.1e-12	-4.9	-6.0	2.4e-09	0.01	0.62	0.38	FALSE
20	GTEx	Ovary	TOM1L2	0.28	0.01	lasso	7	0.04	3.1e-02	5.4	-6.8	9.2e-12	-0.49	0.10	0.52	TRUE
21	GTEx	Skin Sun Exposed Lower leg	TOP3A	0.09	0.05	lasso	4	0.05	6.7e-05	5.9	-5.5	4.6e-08	0.10	0.06	0.78	FALSE
22	GTEx	Small Intestine Terminal Ileum	TOP3A	0.25	0.09	lasso	5	0.06	1.8e-02	-4.1	-5.6	2.7e-08	0.06	0.09	0.22	FALSE
23	GTEx	Thyroid	LRRC48	0.04	0.01	enet	16	0.01	2.7e-02	5.1	5.1	2.9e-07	0.47	0.12	0.71	FALSE
24	GTEx	Thyroid	TOP3A	0.14	0.08	lasso	3	0.09	1.5e-07	5.9	-5.9	4.3e-09	0.08	0.05	0.95	FALSE
25	GTEx	Whole Blood	SHMT1	0.28	0.11	lasso	7	0.21	9.8e-19	5.9	5.8	6.5e-09	0.00	0.01	0.99	FALSE
26	NTR	Blood	SHMT1	0.03	0.01	bslmm	264	0.01	4.7e-05	-4.9	6.3	3.4e-10	0.00	0.48	0.43	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	GID4	0.07	0.04	lasso	5	0.03	4.1e-05	5.1	5.6	1.9e-08	0.51	0.17	0.83	FALSE
28	YFS	Blood	SHMT1	0.46	0.28	bslmm	255	0.41	7.3e-145	-3.6	5.4	6.3e-08	-0.01	0.85	0.15	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOM1L2	0.01	0.01	blup	83	0.01	1.8e-03	6.3	-5.6	2.1e-08	-0.75	0.03	0.92	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LLGL1	0.08	0.02	blup	53	0.05	6.0e-06	4.6	6.5	1.1e-10	0.18	0.03	0.84	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	SHMT1	0.06	0.02	blup	32	0.04	9.4e-06	-5.1	6.1	9.7e-10	0.01	0.03	0.92	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	TOP3A	0.12	0.08	lasso	3	0.09	5.0e-10	5.9	-5.1	3.1e-07	0.06	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SHMT1	0.20	0.18	lasso	5	0.16	3.2e-08	-5.1	5.4	5.4e-08	-0.03	0.09	0.91	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ATPAF2	0.13	0.00	blup	44	0.04	8.4e-03	5.5	6.0	2.6e-09	0.50	0.02	0.77	FALSE
35	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SHMT1	0.12	0.08	enet	5	0.07	8.8e-04	-5.1	5.3	1.2e-07	-0.09	0.01	0.75	FALSE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC48	0.07	0.05	enet	12	0.04	7.0e-03	5.3	5.6	1.7e-08	0.67	0.03	0.71	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	SHMT1	0.17	0.10	lasso	2	0.08	1.0e-06	-4.9	5.2	2.7e-07	-0.04	0.12	0.87	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf39	0.05	0.05	blup	49	0.05	5.8e-06	5.4	5.4	6.3e-08	0.66	0.02	0.97	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	SMCR7	0.10	0.01	blup	33	0.05	8.9e-06	3.6	-5.2	2.3e-07	-0.05	0.01	0.98	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	TOP3A	0.10	0.07	lasso	4	0.07	2.2e-07	5.9	-6.1	9.3e-10	0.03	0.00	1.00	TRUE