Best TWAS P=1.46e-08 · Best GWAS P=2.8e-09 conditioned to 0.0681
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | UBE2E3 | 0.09 | 0.00 | lasso | 3 | 0.01 | 1.6e-01 | -5.5 | -5.3 | 8.7e-08 | 0.04 | 0.02 | 0.79 | FALSE |
| 2 | GTEx | Nerve Tibial | UBE2E3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 6.4e-03 | -5.5 | -5.5 | 4.1e-08 | 0.03 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Testis | ZNF385B | 0.21 | 0.07 | lasso | 9 | 0.05 | 3.4e-03 | -5.8 | 5.7 | 1.5e-08 | -0.85 | 0.02 | 0.96 | TRUE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF385B | 0.14 | 0.08 | lasso | 5 | 0.09 | 9.8e-06 | -5.3 | 5.7 | 1.6e-08 | -0.70 | 0.04 | 0.94 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UBE2E3 | 0.02 | 0.00 | blup | 61 | 0.01 | 1.1e-02 | 3.9 | -5.5 | 4.3e-08 | 0.04 | 0.02 | 0.64 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2E3 | 0.04 | 0.02 | blup | 61 | 0.02 | 1.4e-03 | -5.5 | -5.2 | 2.2e-07 | 0.06 | 0.01 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBE2E3 | 0.05 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -5.5 | -5.3 | 1.1e-07 | 0.02 | 0.01 | 0.99 | FALSE |