Best TWAS P=7.98e-11 · Best GWAS P=2.8e-13 conditioned to 4e-04
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | HOXD-AS1 | 0.20 | 0.12 | lasso | 4 | 0.10 | 6.8e-08 | -5.2 | -5.2 | 1.5e-07 | -0.46 | 1.00 | 0.00 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | HOXD-AS1 | 0.11 | 0.06 | lasso | 6 | 0.09 | 1.4e-11 | 7.3 | -6.5 | 8.0e-11 | -0.79 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HOXD3 | 0.06 | 0.04 | enet | 9 | 0.06 | 5.4e-07 | -5.3 | -6.1 | 1.3e-09 | -0.70 | 0.24 | 0.74 | FALSE |