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chr2:190,225,250-192,525,536

Best TWAS P=4.38e-13 · Best GWAS P=2.45e-13 conditioned to 0.168

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NAB1	0.06	0.06	lasso	2	0.04	4.3e-06	-5.4	5.8	6.1e-09	-0.67	0.72	0.26	FALSE
2	GTEx	Adipose Subcutaneous	HIBCH	0.09	0.09	enet	9	0.09	9.0e-08	-3.9	5.7	1.1e-08	-0.37	0.93	0.03	FALSE
3	GTEx	Adipose Visceral Omentum	GLS	0.13	0.08	lasso	4	0.07	1.5e-04	-6.7	-7.2	4.6e-13	0.70	0.26	0.59	TRUE
4	GTEx	Adipose Visceral Omentum	NAB1	0.15	0.00	lasso	3	0.00	2.5e-01	-6.6	-6.8	1.3e-11	0.92	0.03	0.59	FALSE
5	GTEx	Adipose Visceral Omentum	HIBCH	0.11	0.10	lasso	6	0.11	1.6e-06	-3.9	6.2	4.6e-10	-0.36	0.25	0.57	FALSE
6	GTEx	Artery Aorta	TMEM194B	0.10	0.09	lasso	6	0.08	3.1e-05	5.3	-5.4	7.4e-08	0.21	0.88	0.03	FALSE
7	GTEx	Artery Aorta	AC005540.3	0.18	0.12	enet	22	0.18	2.9e-10	5.8	5.4	7.9e-08	-0.41	0.77	0.16	FALSE
8	GTEx	Artery Tibial	AC005540.3	0.10	0.09	lasso	4	0.08	7.4e-07	-6.6	7.2	5.1e-13	-0.68	0.43	0.52	FALSE
9	GTEx	Brain Hypothalamus	MSTN	0.24	-0.01	enet	18	0.09	4.8e-03	-1.2	-5.3	9.3e-08	0.21	0.07	0.28	FALSE
10	GTEx	Breast Mammary Tissue (Female)	INPP1	0.16	0.02	lasso	4	0.03	5.2e-02	-6.8	7.2	4.9e-13	-0.74	0.03	0.49	FALSE
11	GTEx	Cells Transformed fibroblasts	TMEM194B	0.13	0.12	enet	13	0.11	6.9e-09	5.3	-5.9	3.1e-09	0.28	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	AC005540.3	0.13	0.12	lasso	2	0.11	1.9e-08	-6.6	6.6	3.9e-11	-0.49	0.46	0.53	FALSE
13	GTEx	Colon Transverse	TMEM194B	0.20	0.13	lasso	4	0.11	8.2e-06	5.3	-5.3	9.7e-08	0.22	0.84	0.01	FALSE
14	GTEx	Esophagus Mucosa	GLS	0.07	0.01	lasso	6	0.01	5.4e-02	-6.0	-6.9	4.3e-12	0.85	0.10	0.18	FALSE
15	GTEx	Esophagus Muscularis	TMEM194B	0.10	0.06	lasso	3	0.03	5.6e-03	5.2	-5.3	1.4e-07	0.23	0.39	0.07	FALSE
16	GTEx	Muscle Skeletal	GLS	0.09	0.06	enet	21	0.05	1.0e-05	-6.6	-6.6	3.4e-11	0.50	0.46	0.54	FALSE
17	GTEx	Pituitary	HIBCH	0.34	0.13	enet	30	0.14	2.9e-04	-3.9	5.4	7.1e-08	-0.25	0.42	0.06	TRUE
18	GTEx	Small Intestine Terminal Ileum	HIBCH	0.20	0.07	enet	25	0.07	1.1e-02	-3.9	6.2	4.5e-10	-0.32	0.28	0.13	FALSE
19	GTEx	Testis	GLS	0.26	0.24	lasso	7	0.20	3.6e-09	-6.6	-7.0	1.7e-12	0.56	0.43	0.57	FALSE
20	GTEx	Testis	NAB1	0.14	0.06	enet	20	0.10	5.1e-05	-5.3	-6.9	5.7e-12	0.69	0.13	0.83	FALSE
21	GTEx	Testis	TMEM194B	0.47	0.48	enet	27	0.44	1.2e-21	5.2	-5.9	4.0e-09	0.26	1.00	0.00	FALSE
22	GTEx	Thyroid	MFSD6	0.12	0.01	lasso	5	0.05	2.0e-04	-4.5	-5.7	1.4e-08	0.35	0.92	0.01	FALSE
23	GTEx	Thyroid	TMEM194B	0.21	0.19	lasso	5	0.19	1.2e-14	5.3	-5.2	2.3e-07	0.19	1.00	0.00	FALSE
24	GTEx	Thyroid	AC005540.3	0.09	0.07	enet	5	0.04	2.5e-04	-6.6	7.2	6.8e-13	-0.65	0.24	0.70	FALSE
25	METSIM	Adipose	GLS	0.06	0.01	lasso	6	0.04	1.2e-06	-6.6	-5.4	7.2e-08	0.53	0.68	0.25	FALSE
26	YFS	Blood	GLS	0.08	0.08	lasso	8	0.08	4.7e-26	-6.6	-7.2	4.4e-13	0.64	0.51	0.49	FALSE
27	YFS	Blood	TMEM194B	0.01	0.00	blup	363	0.01	5.3e-04	5.3	-6.3	3.1e-10	0.44	0.29	0.32	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	GLS	0.02	0.01	enet	6	0.02	9.6e-05	5.8	-6.8	1.4e-11	0.64	0.16	0.72	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM194B	0.06	0.05	enet	8	0.07	2.2e-14	-4.9	-5.5	3.8e-08	0.18	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MFSD6	0.04	0.03	enet	4	0.03	1.8e-04	5.2	5.3	1.2e-07	-0.23	0.00	0.99	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NAB1	0.06	0.04	lasso	4	0.03	9.8e-05	5.5	5.8	7.0e-09	-0.24	0.68	0.13	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NAB1	0.05	0.02	blup	50	0.04	2.9e-03	5.8	7.0	1.7e-12	-0.45	0.04	0.16	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	GLS	0.02	0.01	blup	68	0.01	9.7e-03	-5.5	-6.2	8.0e-10	0.65	0.04	0.33	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM194B	0.09	0.02	blup	41	0.04	6.0e-03	5.2	-6.2	4.2e-10	0.37	0.01	0.77	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	GLS	0.16	0.07	lasso	6	0.11	1.3e-11	-6.6	-7.2	6.7e-13	0.66	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM194B	0.04	0.01	blup	41	0.02	3.8e-03	-4.9	-6.4	1.3e-10	0.32	0.02	0.85	FALSE
37	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM194B	0.13	0.12	lasso	2	0.09	4.3e-04	5.3	-5.2	2.2e-07	0.21	0.00	0.98	FALSE