Best TWAS P=2.43e-36 · Best GWAS P=3.74e-36 conditioned to 0.234
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NEK10 | 0.04 | 0.03 | blup | 450 | 0.03 | 9.5e-05 | 6.0 | -8.8 | 1.2e-18 | 0.57 | 0.61 | 0.14 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC4A7 | 0.09 | 0.00 | enet | 27 | 0.04 | 2.9e-05 | 7.2 | -6.4 | 1.7e-10 | 0.40 | 0.09 | 0.58 | FALSE |
| 3 | GTEx | Artery Aorta | SLC4A7 | 0.10 | 0.08 | enet | 15 | 0.08 | 5.4e-05 | -12.5 | -12.6 | 2.4e-36 | 0.92 | 0.00 | 0.99 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | SLC4A7 | 0.15 | 0.02 | enet | 21 | 0.04 | 4.0e-04 | -12.5 | -11.5 | 1.6e-30 | 0.80 | 0.00 | 0.99 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK10 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.3e-05 | -8.8 | 9.1 | 6.9e-20 | -0.69 | 0.12 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC4A7 | 0.02 | 0.02 | blup | 69 | 0.01 | 3.7e-04 | -10.0 | 6.4 | 1.3e-10 | -0.66 | 0.17 | 0.58 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC4A7 | 0.08 | 0.02 | lasso | 4 | 0.04 | 1.4e-03 | 6.3 | -9.5 | 1.9e-21 | 0.28 | 0.02 | 0.28 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK10 | 0.04 | 0.04 | lasso | 2 | 0.03 | 3.0e-04 | -7.1 | 7.2 | 5.0e-13 | -0.54 | 0.73 | 0.02 | FALSE |