TWAS hub - SLC4A7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0890	0.0330	0.00057	-0.001	0.013	0.036	0.020	0.025	4.2e-01	0.00980	2.9e-05	1.7e-03	4.6e-04
2	GTEx	Artery Aorta	0.1010	0.0440	0.00300	0.084	NA	0.076	NA	0.058	2.2e-05	NA	5.4e-05	NA	3.9e-04
3	GTEx	Cells Transformed fibroblasts	0.1470	0.0480	0.00021	0.020	NA	0.042	NA	0.021	1.1e-02	NA	4.0e-04	NA	1.0e-02
4	GTEx	Muscle Skeletal	0.0728	0.0338	0.00280	0.049	NA	0.008	NA	0.041	1.4e-05	NA	5.0e-02	NA	5.9e-05
5	YFS	Blood	0.0270	0.0115	0.00260	0.009	0.009	0.013	0.015	0.013	3.6e-04	0.00041	2.3e-05	9.6e-06	2.6e-05
6	TCGA	Breast Invasive Carcinoma	0.0206	0.0105	0.00170	0.016	0.015	0.013	NA	0.012	2.0e-04	0.00037	9.9e-04	NA	1.3e-03
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0840	0.0520	0.00520	0.015	0.026	0.027	NA	0.038	3.1e-02	0.00680	5.8e-03	NA	1.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Breast Cancer	40.8	98.2	256.0	6.6	10.3	9.2	-13.4	2.6	-16.0	3.1
Breast cancer (self-reported)	14.3	17.0	31.8	-1.8	-5.1	-5.6	2.8	1.0	5.5	-4.4
Systolic Blood Pressure	13.7	68.6	158.8	-6.4	-12.6	-11.5	-0.2	4.0	6.4	-9.5
Medication: Blood pressure	13.3	23.5	58.1	-4.6	-7.6	-6.7	-0.7	3.4	3.5	-3.9
High blood pressure	11.3	31.4	68.7	-5.7	-8.3	-7.6	-2.9	4.2	2.6	-5.2
Vascular/heart problems diagnosed by doctor	10.9	29.8	66.7	5.4	8.2	7.4	2.6	-4.2	-2.9	5.1
Hypertension (Self-reported)	10.7	29.8	67.4	-6.0	-8.2	-7.1	-2.2	3.6	3.0	-5.3
Medication: Amlodipine	8.1	11.4	27.2	-3.8	-3.7	-5.2	-2.0	2.1	1.4	-3.7
Medication: Bendroflumethiazide	7.6	11.6	27.3	-2.2	-5.2	-5.2	-1.4	1.1	2.4	-3.7
Cardiovascular Disease	7.4	24.3	50.3	-3.9	-7.1	-7.0	-1.1	1.9	3.1	-6.4
Medication for cholesterol, blood pressure or diabetes	6.7	11.1	26.5	3.6	5.1	4.4	0.7	-2.7	-2.1	2.6
Medication: Blood pressure	6.7	12.7	30.2	-3.5	-5.5	-5.0	-1.3	2.4	2.3	-3.0
Mother’s age at death	6.3	7.9	12.0	3.4	2.7	3.0	-3.5	-0.3	-2.8	2.7
High blood pressure (mother)	6.2	8.7	26.1	-1.6	-5.1	-3.9	-1.0	0.2	2.2	-3.4
Illnesses of father: High blood pressure	5.1	6.3	13.7	-1.1	-3.4	-3.7	0.3	0.1	3.3	-2.6
Systolic blood pressure, automated reading	5.0	14.6	33.1	-2.7	-5.7	-4.4	-1.5	2.1	1.6	-5.8
Mouth/teeth dental problems: Mouth ulcers	5.0	8.0	12.7	0.7	-3.6	-2.6	3.3	-2.9	3.5	-2.0
High blood pressure (siblings)	4.9	7.1	20.8	-1.8	-3.6	-4.6	0.8	-0.4	2.9	-1.9
Medication: Lisinopril	4.9	6.3	14.1	-1.1	-3.8	-3.1	-0.9	1.9	1.5	-3.6
Illnesses of mother	4.7	5.8	11.5	2.7	3.4	3.1	2.1	-2.0	-0.9	1.7
Medication: Atenolol	3.8	4.8	11.0	-1.4	-3.3	-2.6	-0.8	2.9	0.7	-2.1
Heart disease (mother)	3.7	4.5	11.8	-3.0	-2.6	-3.4	0.2	0.7	1.3	-1.2
Ever used hormone-replacement therapy (HRT)	3.5	4.4	12.1	0.4	0.5	1.5	-3.5	2.3	-3.2	0.7
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	10.5	1.4	3.2	2.1	-1.3	-2.1	-1.9	0.7
Medication for cholesterol	3.2	4.8	11.5	2.9	3.4	2.7	1.8	-1.3	-0.2	1.4
LDL Cholesterol	2.9	4.5	11.9	1.6	3.0	2.2	-1.6	0.7	-3.4	0.9
Illnesses of siblings	2.8	3.9	15.3	0.6	2.0	3.9	0.1	-0.8	-1.9	1.9
Pulse rate, automated reading	2.6	8.4	13.1	3.2	3.4	3.6	-2.8	0.9	-3.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.4	16.4	-1.4	-2.7	-2.5	1.9	0.2	4.0	-1.4
Number of treatments/medications taken	2.3	4.2	13.0	-2.5	-3.6	-2.1	-0.9	2.0	0.6	-0.9
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	6.2	-2.5	-2.1	-1.1	0.1	2.4	0.4	-0.7
Medication: Ramipril	2.3	2.9	6.8	-1.7	-2.6	-2.5	-0.1	0.2	1.4	-1.6
Ovarian Cancer	2.2	2.9	9.3	-1.2	-1.8	-0.5	-3.1	1.2	-0.9	-1.8
Body fat percentage	2.1	8.3	21.0	2.3	3.6	3.1	-2.4	0.4	-4.6	1.7
Pulse rate	2.0	3.3	6.1	1.8	2.5	1.5	-1.3	0.7	-2.1	2.4
Back pain experienced in last month	2.0	2.9	5.3	0.3	2.3	2.2	-0.9	2.2	0.1	2.2
Number of operations (self-reported)	2.0	3.0	10.5	-2.5	-3.2	-1.5	0.7	0.6	1.1	0.3
Comparative body size at age 10	1.9	5.3	14.1	0.7	2.7	1.1	-3.8	1.5	-3.2	0.9
Medication: Aspirin	1.9	2.5	5.5	-0.1	-2.0	-2.4	-0.7	2.2	0.8	-1.5
Number of self-reported non-cancer illnesses	1.9	3.4	8.6	-2.8	-2.9	-2.0	-1.3	1.1	0.4	-0.1
Leg fat percentage (left)	1.9	6.8	19.4	1.9	3.0	3.0	-2.1	0.3	-4.4	1.5
Trunk fat percentage	1.8	7.4	18.1	2.2	3.5	2.8	-2.2	0.6	-4.3	1.8
Number of incorrect matches in round	1.8	2.9	5.5	-1.3	-2.4	-0.9	2.1	-2.1	1.8	0.8
Leg fat percentage (right)	1.8	6.6	17.1	1.9	3.0	3.1	-2.1	-0.0	-4.1	1.2
Hearing difficulty/problems with background noise	1.7	2.7	10.0	0.9	-3.2	-2.1	0.0	0.7	1.6	-0.8
Impedance of arm (right)	1.7	7.8	20.8	2.0	4.6	4.4	0.2	-0.4	-2.2	2.3
Mean time to correctly identify matches	1.7	3.3	11.3	-1.4	-2.6	-3.4	1.2	0.5	1.0	0.7
Medication: Aspirin	1.7	2.2	5.0	-0.2	-1.7	-2.2	-0.7	1.9	0.5	-1.8
Mean Putamen Volume	1.6	1.8	3.5	0.8	1.3	1.1	-1.9	0.1	-1.7	-1.6
Hearing difficulty/problems: Yes	1.6	2.5	9.4	-0.5	-3.1	-2.0	-0.7	-0.8	1.2	-1.0
Ever had hysterectomy (womb removed)	1.6	1.8	5.1	-2.3	-0.8	-0.9	-0.7	2.2	-0.6	0.7
Serious illness, injury or assault to yourself	1.6	2.0	5.2	-0.2	-1.8	-2.3	-0.0	1.1	1.7	-1.1
Arm fat percentage (right)	1.6	6.4	14.4	2.7	3.3	2.7	-2.1	-0.4	-3.8	0.7
Trunk fat-free mass	1.6	9.0	25.3	-1.7	-5.0	-4.2	-1.0	0.3	2.3	-3.3
Number of full sisters	1.6	2.0	5.1	2.3	1.4	0.6	0.1	0.5	-1.9	1.5
Crohns Disease (2012)	1.5	2.5	8.0	2.8	0.4	-0.9	0.8	-1.3	-0.2	-2.5
Fasting Glucose	1.5	1.9	4.5	-0.5	1.3	1.0	-0.7	1.4	-1.8	2.1
Ulcerative Colitis	1.5	2.2	6.5	0.0	-1.9	-1.0	1.4	-0.0	1.4	-2.6
Blood Platelet Count	1.5	16.8	24.5	5.0	5.0	4.1	4.7	-2.5	-2.0	4.3
Supplements: Zinc	1.5	1.7	8.4	1.3	1.0	-0.1	0.0	-0.3	-0.6	2.9
Had menopause	1.5	1.9	6.6	0.3	1.4	2.6	-1.4	-0.7	-1.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	10.5	-1.8	-2.2	-1.2	1.7	0.4	3.2	-1.0
Impedance of arm (left)	1.5	6.9	18.9	1.8	4.3	4.2	0.6	-0.2	-1.6	2.3
Trunk predicted mass	1.5	8.6	24.0	-1.7	-4.9	-4.1	-1.0	0.2	2.2	-3.3
Arm fat percentage (left)	1.5	6.0	13.2	2.5	3.3	2.6	-2.0	-0.1	-3.6	0.8
Eye problems/disorders: Cataract	1.5	1.8	5.2	-0.4	-2.3	-1.6	0.1	-1.7	0.5	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.8	0.5	0.3	0.6	-2.2	2.1	-1.4	0.6
Irritability	1.5	2.5	7.5	1.2	-1.5	-1.9	1.6	-0.3	2.7	0.1
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	6.6	0.9	1.2	2.6	-0.5	1.0	-1.3	1.3
Heel T-Score	1.4	11.5	23.0	-2.0	-3.7	-3.4	4.4	-2.1	4.8	-2.0
Frequency of depressed mood in last 2 weeks	1.4	2.0	7.2	-1.5	-0.7	-0.0	2.7	0.5	1.9	0.5
Angina	1.4	1.8	3.2	-1.8	-1.6	-1.3	0.7	1.0	1.2	-1.4
Maternal smoking around birth	1.4	2.1	6.9	2.6	1.8	0.4	1.2	-0.2	0.3	1.5
Sitting height	1.4	9.9	24.9	-1.5	-5.0	-3.8	-2.3	3.1	2.0	-2.9
Hair/balding pattern: Pattern 2	1.4	1.8	3.5	1.9	1.7	1.7	-1.5	-0.3	-1.1	0.1
Hair/balding pattern: Pattern 4	1.4	3.4	9.7	-1.4	-1.2	-1.4	3.1	-1.7	2.3	0.7
Financial situation satisfaction	1.4	1.7	7.4	2.7	1.1	1.2	-0.6	-1.1	-0.3	0.0
Risk taking	1.4	2.1	5.7	-1.9	-1.5	-1.0	0.5	-0.5	2.4	-1.2
Age started oral contraceptive pill	1.4	1.7	4.7	-0.3	1.2	1.6	-1.7	-0.3	-2.2	0.6
Impedance of whole body	1.4	7.2	17.3	1.6	4.2	4.1	0.2	0.7	-2.3	2.8
Alzheimer’s Disease (in father)	1.3	1.5	3.5	-1.7	-1.8	-0.2	-0.5	1.9	0.7	-0.0
Bipolar Disorder (2011)	1.3	1.2	2.4	-0.9	-1.3	-1.6	0.6	0.6	1.3	-1.0
Diabetes (father)	1.3	1.6	3.9	1.0	1.7	2.0	-0.8	-0.1	-1.4	0.8
Angina (self-reported)	1.3	1.6	3.2	-1.8	-1.5	-1.2	0.6	1.1	1.1	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.7	1.9	-0.4	-1.4	-0.1	0.1	0.4	-1.9
Wears glasses or contact lenses	1.3	1.5	3.9	-1.0	-0.3	0.8	-2.0	1.9	-0.7	-0.7
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.4	-0.1	-1.8	-1.8	-0.1	2.1	1.1	-0.4
Crohns Disease (2017)	1.2	2.6	6.7	1.2	-0.2	-1.6	1.0	-2.3	1.2	-2.6
HbA1C	1.2	1.3	3.1	1.5	1.7	0.8	0.9	-0.9	-0.6	1.2
Heart attack	1.2	1.5	4.3	0.3	-1.6	-1.6	-0.1	2.1	0.9	-0.4
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	8.5	0.6	-0.8	-0.0	2.5	-1.8	2.9	-2.9
Birth weight of first child	1.2	2.3	6.2	1.0	2.5	1.6	0.1	-2.0	-0.8	1.2
Peak expiratory flow (PEF)	1.2	2.7	7.9	-0.5	-0.5	-0.1	1.5	-2.8	2.0	-2.0
Loud music exposure frequency	1.2	1.3	2.8	1.5	1.3	1.4	0.8	-0.1	0.0	1.7
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.3	1.4	1.2	1.0	0.0	-1.1	1.6	-2.3
Arm predicted mass (right)	1.2	5.9	15.3	-1.2	-3.9	-3.8	-1.4	0.9	1.3	-2.4
Whole body fat-free mass	1.2	7.0	18.5	-1.3	-4.3	-4.0	-1.1	0.3	1.9	-2.8
Friendships satisfaction	1.2	1.5	2.8	1.3	-0.9	0.0	1.6	-1.7	1.2	1.0
Commuting to job workplace: Walk	1.2	1.3	3.4	1.4	-0.7	-1.8	0.2	-0.2	1.3	1.1
Depression (Nagel 2018)	1.1	1.6	4.9	-0.4	-1.0	0.7	2.1	-0.5	2.2	-0.1
Irritable Bowel Disease (IBD)	1.1	2.7	9.2	0.1	-0.6	-1.5	1.2	-2.0	1.3	-3.0
Reaction Time	1.1	2.1	8.8	-1.2	-1.8	-3.0	0.8	0.1	0.6	0.7
Age at First Birth	1.1	1.6	3.7	1.9	1.4	0.5	-0.1	-1.2	-1.2	-1.4
Coronary Artery Disease (CAD)	1.1	1.3	2.5	-1.6	-1.5	0.2	-1.2	1.5	-0.7	0.2
Blood White Count	1.1	8.3	18.7	4.3	2.9	3.9	1.6	-1.9	-2.7	1.4
Waist Hip Ratio (WHR)	1.1	4.8	16.2	1.2	0.6	1.5	4.0	-3.0	1.9	1.0
Hand grip strength (right)	1.1	2.9	7.0	-1.3	-2.7	-1.8	-0.1	0.4	2.0	-2.1
Had other major operations	1.1	1.3	3.5	-1.2	-1.9	-0.7	0.2	-0.5	1.1	-1.5
Forced vital capacity (FVC)	1.1	4.3	12.7	-0.1	-1.2	0.3	2.7	-0.4	3.6	-2.8
Father’s age at death	1.1	1.5	3.0	1.4	1.4	1.7	-0.4	-1.0	-0.9	-1.4
Falls in the last year	1.1	1.4	5.2	0.4	1.4	0.9	-2.3	0.1	-1.2	0.7
Arm fat-free mass (right)	1.1	5.7	14.9	-1.1	-3.9	-3.8	-1.2	0.6	1.4	-2.3
Eye problems/disorders: None of the above	1.1	1.3	5.5	0.5	0.7	0.6	2.3	0.2	1.0	-1.2
Medication: Omeprazole	1.1	1.3	5.0	1.2	0.9	2.2	0.2	0.1	-0.8	1.1
Smoking status: Previous	1.1	1.7	4.1	-2.0	-1.1	-1.3	-1.8	0.5	-0.5	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	4.7	-0.5	-0.9	-1.1	0.8	-0.3	2.2	-1.4
Whole body water mass	1.1	6.5	16.9	-1.3	-4.1	-3.9	-1.3	0.3	1.6	-2.7
Arm fat-free mass (left)	1.1	5.7	14.7	-1.3	-3.8	-3.7	-1.7	0.8	0.9	-2.4
Commuting to job workplace: Cycle	1.1	1.3	3.8	-0.3	0.1	-0.5	1.6	-1.4	1.9	0.6
Arm predicted mass (left)	1.1	5.6	14.6	-1.3	-3.8	-3.5	-1.5	0.5	1.0	-2.7
Lung FEV1/FVC ratio	1.0	4.8	18.9	1.7	-0.3	0.3	0.7	-4.3	1.0	-3.2
Average weekly spirits intake	1.0	1.3	3.6	0.7	1.9	1.9	0.7	-0.5	-0.8	-0.3
Severe depression (siblings)	1.0	1.2	2.9	1.0	1.5	1.7	-0.2	-0.6	-1.0	0.7
Medication: Levothyroxine sodium	1.0	1.7	6.3	-2.5	-1.0	0.7	-0.6	1.3	-1.1	-0.8
Impedance of leg (left)	1.0	4.9	10.9	0.9	3.1	3.3	-0.1	0.9	-2.5	2.4
Medication: Simvastatin	1.0	1.5	5.1	-2.3	-1.4	-1.7	-0.0	-0.0	-0.2	-0.6
Worrier / anxious feelings	1.0	1.9	8.5	0.5	-1.0	-0.6	2.9	-0.2	1.6	0.5
Number of live births	1.0	1.4	5.7	0.1	0.4	0.4	-2.4	1.3	-1.3	-0.3
Happiness	1.0	1.3	2.0	1.3	0.3	1.1	1.4	-1.1	0.9	1.4
Tense / ‘highly strung’	1.0	1.6	6.3	0.6	-0.3	-0.4	2.5	-0.6	2.0	0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.5	1.2	1.7	2.1	0.4	-0.0	0.2	0.3
Diastolic blood pressure, automated reading	1.0	3.1	9.2	-0.8	-1.3	-1.0	-3.0	-0.2	-0.4	-3.0
Pain experienced in last month	1.0	1.7	3.3	0.1	-1.0	-1.8	1.5	-1.5	0.6	-1.6
Supplements: Calcium	1.0	1.1	2.4	1.2	0.2	1.0	1.6	-1.5	-0.4	0.9
Worry (Nagel 2018)	0.9	1.9	8.3	-0.1	-1.0	-0.4	2.9	-0.7	1.8	0.2
HDL Cholesterol	0.9	1.4	3.5	1.9	1.1	0.7	-0.5	1.6	-1.4	-0.0
Neuroticism (2016)	0.9	1.3	4.5	-1.0	-2.1	-1.2	0.4	0.2	1.3	0.5
Height	0.9	17.5	40.6	-4.6	-6.4	-4.7	-1.6	3.2	3.4	-3.9
Lung FVC	0.9	4.5	19.7	-0.1	0.6	1.0	4.4	-1.5	2.5	-1.4
Chronotype (morning person)	0.9	2.1	4.9	-0.6	-1.4	-2.2	-1.1	2.1	1.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.6	0.6	-1.4	-0.7	-1.4	1.6	-0.1	-1.0
Medication for hormone replacement therapy	0.9	1.0	2.6	1.4	0.4	0.7	-1.1	-0.3	-1.6	-0.5
Impedance of leg (right)	0.9	4.6	11.9	0.9	3.2	3.5	-0.1	0.3	-2.2	2.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.5	1.2	-0.8	-0.9	2.1	-1.1	2.1	-0.6
Supplements: Glucosamine	0.9	1.2	3.6	0.7	1.1	1.2	0.3	-1.9	-1.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.4	0.6	1.4	1.8	1.2	-0.4	-0.3	0.8
Medication: Cholesterol lowering	0.9	1.4	2.6	-1.0	-1.2	-0.9	-1.6	1.2	-0.7	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	9.5	1.5	0.3	1.2	1.7	-1.4	1.5	-3.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	6.5	2.5	0.1	0.2	-0.3	0.8	-1.0	0.5
Gout (self-reported)	0.9	1.3	2.8	-1.7	-0.7	-1.3	-0.3	-1.4	-0.0	-1.4
Neck or shoulder pain in last month	0.9	1.3	4.2	0.7	1.4	2.1	-1.1	-0.4	0.7	-0.5
Medication: Seretide 50 evohaler	0.9	1.0	2.6	0.4	1.1	1.1	0.5	0.3	-1.2	1.6
Family relationship satisfaction	0.9	1.1	6.7	2.6	-0.4	0.3	0.8	-0.4	0.1	0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-0.4	-1.5	-1.5	1.1	-0.5	0.3	1.1
Osteoarthritis (self-reported)	0.9	1.1	2.3	-1.5	-0.7	-0.1	-1.4	1.4	-0.5	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.1	0.4	-0.5	0.5	2.2	-0.8	1.5	0.1
Medication: Atorvastatin	0.9	1.2	4.7	1.2	0.1	-0.1	-2.2	0.9	-0.8	-0.6
Ever depressed for a whole week	0.9	1.1	4.3	0.1	1.3	2.1	-0.2	0.1	-0.8	1.1
Cholesterol lowering medication	0.9	1.3	3.2	-1.8	-1.3	-1.6	-0.4	-1.1	0.4	0.1
Heart disease (siblings)	0.9	1.2	2.9	0.0	-0.4	-1.6	-0.0	0.3	1.5	-1.7
Intelligence (Savage-Jansen 2018)	0.8	2.4	7.1	0.0	-0.5	-1.0	1.7	-2.7	2.3	0.4
Alzheimer’s Disease (in mother)	0.8	1.0	2.6	-1.4	1.0	0.2	-1.6	0.4	-1.0	-0.4
Sensitivity / hurt feelings	0.8	1.4	3.0	1.7	1.2	1.7	0.9	-0.9	-0.8	0.4
Medication: Co-codamol	0.8	0.9	3.9	0.4	-1.2	-0.7	-0.7	2.0	-0.1	0.3
Taking other prescription medications	0.8	1.3	3.6	-1.1	-0.5	0.2	-1.0	1.6	-0.6	1.9
Qualifications: CSEs or equivalent	0.8	1.0	3.7	0.1	1.0	-0.0	-1.4	1.9	-0.7	-0.4
Trunk fat mass	0.8	3.6	10.9	1.5	1.8	1.4	-2.4	0.9	-3.3	0.6
Past tobacco smoking	0.8	1.4	4.9	2.2	1.2	1.4	0.7	-0.2	-0.7	0.7
Neuroticism score	0.8	1.7	5.5	0.5	-1.4	-0.6	2.3	-0.3	1.7	-0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	1.5	1.5	0.3	0.4	0.1	-0.9	1.1
Birth weight	0.8	1.8	3.6	-0.4	-0.9	-1.6	1.3	-1.9	1.9	0.3
Number of children fathered	0.8	1.0	1.5	-0.7	-0.5	0.5	1.2	-1.2	1.1	-1.2
Whole body fat mass	0.8	3.2	9.6	1.7	1.6	1.2	-2.3	0.4	-3.1	0.3
Leg fat-free mass (right)	0.8	4.2	11.4	-0.4	-3.2	-3.4	-0.8	0.3	1.2	-2.3
Qualifications: nursing, teaching	0.8	1.3	4.3	-0.2	0.7	1.1	-2.1	0.0	-1.2	-1.4
Leg predicted mass (right)	0.8	4.2	11.5	-0.4	-3.2	-3.4	-0.8	0.2	1.3	-2.3
Basal metabolic rate	0.8	4.6	11.7	-0.7	-3.4	-3.3	-1.4	0.4	0.9	-2.5
Leg fat mass (left)	0.8	3.0	10.4	1.7	1.4	1.3	-2.1	0.3	-3.2	0.2
Bipolar Disorder or Schizophrenia	0.7	1.7	5.3	1.0	0.1	-0.8	2.3	-0.6	2.2	-0.6
Alzheimer’s Disease (including proxy)	0.7	1.1	3.4	-1.9	-0.5	-0.4	-0.9	1.6	0.2	-0.7
Ulcerative Colitis (UC)	0.7	1.4	3.8	-1.1	-1.1	-0.9	1.0	-0.8	0.9	-2.0
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.9	0.4	-0.6	-1.2	0.9	-2.2	1.8	-0.7
Body Mass Index (BMI) (2010)	0.7	0.9	2.5	0.2	1.1	0.2	-1.6	-0.5	-1.6	-0.0
Allergy or Eczema	0.7	1.8	6.5	1.2	0.2	-0.0	2.5	-1.3	1.6	-0.5
Neuroticism	0.7	1.6	7.1	-0.2	-0.4	1.0	2.7	-0.4	1.3	1.0
Hand grip strength (left)	0.7	2.0	6.3	0.1	-1.7	-1.1	0.5	-0.3	1.7	-2.5
Leg fat-free mass (left)	0.7	3.4	8.9	-0.3	-2.8	-3.0	-1.0	0.0	1.0	-2.2
Stomach or abdominal pain in last month	0.7	0.8	3.0	1.4	-0.4	-0.3	-0.3	1.7	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.0	1.4	0.8	0.7	1.4	-0.9	1.4	0.0
Qualifications: None of the above	0.7	1.5	3.6	-1.9	-0.6	-0.3	-0.1	1.5	-1.7	1.1
Noisy workplace	0.7	0.8	1.9	-0.7	-1.4	-0.4	1.1	-0.2	1.3	0.7
Arm fat mass (right)	0.7	2.9	7.6	1.9	1.5	1.3	-2.2	-0.0	-2.8	-0.3
Blood clot in the leg (DVT)	0.7	0.9	3.5	0.5	0.1	-0.4	-1.9	-0.5	-1.4	0.5
Forced vital capacity (FVC), Best measure	0.7	2.6	8.0	1.0	0.3	1.6	1.8	-0.4	1.8	-2.8
Emphysema/chronic bronchitis	0.7	0.8	3.0	1.5	0.1	-0.3	0.4	-1.7	0.5	0.2
Leg fat mass (right)	0.7	2.9	9.5	1.7	1.5	1.4	-2.0	0.0	-3.1	-0.1
Suffer from ‘nerves’	0.7	1.1	4.5	-0.2	-2.1	-1.2	0.6	0.2	0.4	-1.2
Average weekly red wine intake	0.7	1.1	2.1	1.4	-0.1	-0.7	1.4	-1.1	0.8	-1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	2.0	1.0	1.4	1.1	0.2	1.0	-1.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.9	2.0	0.9	0.8	1.6	-1.1	0.5	-0.5
Ever taken oral contraceptive pill	0.7	0.8	2.3	0.9	1.5	0.8	-0.2	0.9	-1.0	-0.0
Commuting to job workplace: Public transport	0.7	0.8	3.2	1.2	0.8	1.8	-0.2	0.3	0.3	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.9	3.2	-0.5	-0.3	-1.2	0.1	0.8	-0.6	1.8
Lupus	0.6	0.9	3.5	0.2	-0.7	-0.6	1.9	-0.0	1.1	1.0
BMI	0.6	3.5	11.0	1.8	1.5	0.9	-2.6	-0.7	-3.3	-0.6
Relative age of first facial hair	0.6	1.3	3.6	1.1	-0.5	-1.5	0.0	1.3	-0.0	-1.9
Townsend deprivation index at recruitment	0.6	0.8	2.7	0.0	-0.8	-1.6	0.6	-0.6	1.3	0.5
Average weekly fortified wine intake	0.6	0.7	1.9	0.1	0.0	0.6	1.2	-0.8	1.4	0.5
Leg predicted mass (left)	0.6	3.4	8.8	-0.3	-2.8	-3.0	-1.0	-0.1	1.1	-2.2
Diabetes (self-reported)	0.6	0.9	1.9	-1.0	0.6	1.2	-1.1	-0.5	-1.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.9	0.3	-0.7	-1.7	0.4	-0.9	0.6	-0.8
Hip circumference	0.6	2.4	7.1	1.1	-0.8	-1.3	-2.7	1.2	-1.6	-1.6
Asthma	0.6	1.2	3.5	-0.3	1.9	1.0	-0.6	0.8	-0.7	1.5
Depression (self-reported)	0.6	0.7	1.6	0.9	-0.8	-0.6	-0.5	0.9	0.4	-1.3
Standing height	0.6	6.3	19.4	-1.9	-4.4	-2.9	-0.9	1.4	2.1	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.6	0.3	-1.2	-0.8	1.3	-0.5	1.3	-1.1
Number of full brothers	0.6	0.7	2.1	-0.2	0.1	-1.1	-0.5	-1.4	1.0	0.7
Health satisfaction	0.6	0.7	3.7	1.9	0.3	0.3	-0.8	0.1	-0.7	0.2
Loneliness, isolation	0.6	0.9	2.9	0.4	-0.7	0.0	1.7	0.8	1.1	1.0
Smoking status: Current	0.6	0.9	3.9	-0.9	0.5	0.7	2.0	-0.2	0.7	0.4
Arm fat mass (left)	0.6	2.6	6.9	1.8	1.4	1.0	-2.3	0.1	-2.6	-0.5
Miserableness	0.6	1.1	2.9	-0.1	-0.5	-0.9	1.7	-0.8	1.6	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.2	1.8	0.1	-0.5	-0.2	-0.8	-0.1	-0.7
Ever smoked	0.6	1.0	4.1	-2.0	-0.7	-0.9	-0.5	0.5	1.1	-0.4
Unable to work because of sickness or disability	0.6	0.8	2.6	1.6	-0.4	-0.8	-0.6	-0.9	0.4	-1.0
Bipolar Disorder (2018)	0.5	0.7	1.7	0.7	-0.1	-1.0	1.3	-0.4	1.2	-0.6
Neuroticism (Nagel 2018)	0.5	1.3	4.9	0.9	-0.7	0.2	2.2	-0.4	1.6	0.1
Schizophrenia (2018)	0.5	1.1	3.6	0.7	0.3	-0.2	1.9	-0.4	1.8	0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	-0.8	-1.3	-0.7	-0.0	0.1	0.2	1.3
Primary Biliary Cirrhosis	0.5	0.7	1.7	-1.3	0.2	0.7	-1.2	-0.3	-0.7	0.9
Rheumatoid Arthritis	0.5	0.7	2.2	-1.1	-0.1	0.9	1.5	-0.1	0.3	0.9
Fed-up feelings	0.5	0.9	2.2	1.1	-0.7	0.4	1.2	-0.1	1.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.7	-0.1	-1.3	0.7	0.6	-0.6	1.1	-0.8
Age when periods started (menarche)	0.5	1.2	2.7	-1.6	-0.6	-1.2	0.8	0.4	1.3	1.2
Multivitamins +/- minerals	0.5	0.7	1.6	0.8	0.5	0.9	-0.6	-1.3	-0.3	1.0
Body mass index (BMI)	0.5	2.2	6.2	1.8	1.3	0.7	-1.9	-0.1	-2.5	-0.2
Allergy	0.5	1.1	2.6	-1.5	-0.6	-0.1	-1.6	1.4	-0.7	-0.4
Pain all over the body in last month	0.5	0.5	1.4	0.9	-0.4	0.4	1.2	-1.0	0.3	-0.3
Fluid intelligence score	0.5	1.0	4.4	0.5	-0.3	-0.0	0.4	-2.1	1.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	0.6	-1.3	-0.4	0.5	0.7	1.4	1.0
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	-1.3	-1.0	0.4	0.7	0.2	1.3	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	0.4	0.1	0.9	-1.2	-0.3	-1.0	0.7
Length of working week for main job	0.5	0.5	2.5	-0.1	-0.3	-0.0	0.8	-0.2	1.6	-0.7
Medication: Paracetamol	0.5	0.8	2.4	0.2	-1.2	0.5	1.6	-0.4	0.6	1.0
Headache pain in last month	0.5	0.9	3.6	-0.8	-0.6	-0.7	-1.9	0.1	0.0	1.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	4.6	-2.1	-0.4	1.4	0.4	0.5	0.2	-0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	0.5	0.6	1.1	0.9	-0.4	1.0	-0.3
Exposure to tobacco smoke outside home	0.5	0.6	2.3	0.3	-0.1	-1.5	-1.0	-0.8	-0.3	0.4
Worry too long after embarrassment	0.5	0.9	5.5	-0.0	-0.6	-0.1	-0.4	-0.2	-0.4	-2.4
Pulse wave peak to peak time	0.5	0.6	2.2	-0.3	-0.3	0.2	-0.9	-1.5	0.2	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	2.3	0.3	1.5	0.1	0.0	-1.3	-0.1	-1.1
Migraine (self-reported)	0.5	0.6	3.6	-0.1	0.2	-0.1	-0.4	0.1	-0.7	1.9
Medication: Ibuprofen	0.5	0.6	1.8	-0.1	-0.2	1.3	1.1	-0.6	0.4	0.8
Medication: Allopurinol	0.5	0.7	1.9	-1.4	0.4	-0.5	-0.5	-0.6	-1.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	1.0	0.5	-0.2	-1.1	-1.0	-0.3	0.9
Alcohol intake frequency.	0.5	1.0	3.3	0.2	-1.7	-1.8	-0.7	0.5	0.0	-0.5
Comparative height size at age 10	0.5	2.7	7.0	-1.3	-2.6	-1.1	-1.5	1.5	0.6	-2.0
Leg pain on walking	0.5	0.6	2.0	1.4	0.1	1.4	0.0	0.2	-0.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	0.7	1.0	0.9	-0.5	1.0	-0.5	0.8
Diabetes diagnosed by doctor	0.5	0.9	3.2	-1.4	0.0	0.2	-1.8	-0.3	-0.7	-0.5
Asthma (self-reported)	0.5	0.9	2.5	-0.4	1.6	0.5	-0.5	0.7	-0.6	1.6
Medication: Gliclazide	0.5	0.6	2.8	0.2	-0.5	0.1	-0.9	1.7	-0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	-0.2	-0.9	0.9	-1.1	1.0	0.4	-0.4
Alcohol drinker status: Never	0.5	0.6	1.6	-0.0	-1.1	-1.3	0.4	-0.5	-0.6	-0.5
Basal cell carcinoma (self-reported)	0.5	0.5	2.0	0.7	-0.1	-1.0	0.3	-0.0	0.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.9	0.4	0.0	-0.5	-1.4	-0.2	-1.2	0.6
Pack years of smoking	0.5	0.7	2.3	-0.3	0.3	0.1	-1.3	0.3	-0.8	-1.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.7	0.4	-0.5	0.4	1.7	-0.4	1.5	0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	0.3	0.4	-0.3	-1.2	-0.7	-1.1	-0.3
Respiratory disease	0.4	0.8	1.7	-0.3	1.1	0.3	-0.6	1.0	-1.3	1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.0	-0.8	0.0	0.2	-1.0	-0.3	0.0	-1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.4	-0.5	-0.6	-0.8	-1.2	0.3	-0.1	0.4
Medication: Metformin	0.4	0.5	1.3	-0.8	-1.1	-0.3	-0.8	0.3	0.1	-1.0
Current tobacco smoking	0.4	0.7	2.0	-0.8	0.7	1.2	1.4	0.2	0.2	0.0
Alcohol usually taken with meals	0.4	0.7	2.9	-0.8	-1.7	-0.3	0.5	0.6	0.9	-0.1
Mouth/teeth dental problems	0.4	0.7	2.0	-0.1	1.4	0.5	-0.6	-0.3	-0.9	-1.0
Alcohol intake versus 10 years previously	0.4	0.7	1.9	-0.3	-1.0	-1.2	0.4	-0.5	-0.0	1.4
Mouth/teeth dental problems: Dentures	0.4	0.7	2.2	-1.5	-0.5	0.3	-0.1	1.2	0.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.7	-0.4	0.9	1.1	-0.6	0.3	0.4
Medication: Lansoprazole	0.4	0.4	1.3	1.2	0.3	-0.3	-0.5	0.5	-0.9	-0.3
Prospective memory result	0.4	0.5	1.6	-0.8	-1.3	-0.8	-0.4	-0.4	-0.1	-0.4
Pulse wave Arterial Stiffness index	0.4	0.5	2.8	0.0	-0.1	-0.4	0.7	1.7	-0.0	0.4
Pulse wave reflection index	0.4	0.5	1.2	-0.0	-0.8	-0.7	1.1	-0.1	0.3	-1.0
Wheeze or whistling in the chest in last year	0.4	0.8	2.6	0.4	0.2	0.8	-0.1	1.6	0.5	1.3
Shortness of breath walking on level ground	0.4	0.4	1.6	0.4	0.7	1.3	-0.7	0.1	-0.5	0.2
Age at last live birth	0.4	0.6	1.7	0.5	0.6	-0.5	-1.0	-0.0	-0.9	-1.3
Supplements: Vitamin C	0.4	0.4	1.6	1.2	0.6	0.5	-0.4	-0.7	-0.2	-0.3
Knee pain experienced in last month	0.4	0.6	1.7	-0.2	0.3	1.3	-1.2	0.2	-0.9	0.2
Mineral and other dietary supplements	0.4	0.5	1.3	-0.5	0.1	-0.7	-1.2	0.3	-0.3	-1.1
Average weekly beer plus cider intake	0.4	0.6	2.0	0.6	0.3	-1.4	-0.3	-0.3	-0.5	-1.2
Major Depression (MDD)	0.3	0.4	1.0	-0.8	0.2	0.4	0.8	-1.0	0.5	0.5
Schizophrenia (2014)	0.3	0.7	1.5	1.1	-0.6	-0.9	1.2	-0.2	1.0	0.2
Triglycerides	0.3	0.5	1.8	-1.3	0.8	0.0	-0.4	-0.8	0.4	0.2
Blood Eosinophil Count	0.3	2.4	6.2	2.1	1.4	2.5	0.5	0.4	-1.1	1.6
Vitamin and mineral supplements	0.3	0.4	1.6	-0.7	-0.1	-1.3	0.1	0.9	0.2	0.3
Diabetes (mother)	0.3	0.4	0.9	-0.9	0.8	0.7	0.9	-0.5	-0.1	-0.1
Pack years adult smoking proportion	0.3	0.4	1.5	-0.2	0.5	0.4	-0.8	0.3	-0.6	-1.2
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.0	0.5	1.0	0.8	-0.7	-0.1	-0.0
Waist circumference	0.3	1.2	3.4	1.9	0.3	0.2	-1.2	-0.4	-1.6	-0.8
Nervous feelings	0.3	0.5	2.0	1.2	-0.1	0.2	1.4	-0.4	-0.2	0.3
Financial difficulties in last 2 years	0.3	0.5	1.4	-0.3	-0.9	-0.2	-0.5	-1.2	0.2	-0.8
Weight	0.3	1.5	4.8	0.7	-0.9	-0.8	-2.2	0.6	-1.3	-1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	1.3	0.6	0.7	-1.3	0.7	-0.3	-0.7
Exposure to tobacco smoke at home	0.3	0.3	0.8	0.9	0.5	-0.2	-0.6	-0.1	0.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.8	-0.0	0.9	0.3	-0.2	-0.2	-1.1
Age at first live birth	0.3	0.6	2.0	0.9	0.2	-0.3	-0.4	-0.0	-1.4	-1.0
Overall health rating	0.3	0.7	2.1	0.3	-1.4	-0.2	-0.9	0.8	0.2	-1.1
Chest pain or discomfort	0.3	0.4	1.3	0.8	-0.6	-0.3	0.7	-0.2	1.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	-1.2	-0.4	0.3	0.3	0.8	0.6	0.4
Long-standing illness, disability or infirmity	0.3	0.5	0.9	-1.0	-0.5	0.6	-0.9	0.7	-0.4	0.4
Ever had bowel cancer screening	0.3	0.3	0.9	-0.4	0.3	0.9	-0.3	-0.3	-0.8	0.5
Average weekly champagne plus white wine intake	0.3	0.5	0.9	0.7	0.5	1.0	0.9	-0.6	0.5	-0.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	0.7	0.3	-0.2	-1.1	0.6	-0.8	0.2
Medication: Paracetamol	0.3	0.5	1.3	0.2	-0.7	0.5	1.2	-0.5	0.5	1.1
Fractured/broken bones in last 5 years	0.3	0.4	1.1	-0.5	0.2	0.9	-1.0	-0.1	-1.0	0.2
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.2	-0.9	-0.4	-0.0	-0.2	-0.3	1.0
Blood Red Count	0.2	2.2	3.8	1.6	1.9	1.3	-2.0	-0.7	-1.6	0.9
Smoking Status	0.2	0.5	2.2	-1.5	-0.1	0.4	0.6	0.5	0.6	-0.7
Hypothyroidism (self reported)	0.2	0.5	1.6	-1.2	0.0	1.1	0.5	0.2	0.7	-0.3
Hair Pigment	0.2	4.3	19.6	-0.9	-1.8	-2.3	-0.8	4.4	-0.6	0.1
Relative age voice broke	0.2	0.3	0.6	-0.1	0.2	-0.8	0.4	-0.7	-0.7	-0.6
Time employed in main current job	0.2	0.3	0.9	-0.0	-0.8	-0.2	-0.5	0.4	0.2	-0.9
Lung cancer (father)	0.2	0.2	0.7	-0.2	0.4	0.2	-0.8	-0.0	-0.4	0.7
Breastfed as a baby	0.2	0.3	1.0	0.0	-0.4	-0.4	-0.6	-0.6	-0.2	1.0
Glaucoma (self-reported)	0.2	0.2	0.9	1.0	-0.1	-0.7	-0.3	-0.1	-0.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.1	-0.8	-0.2	0.4	0.7	0.6	0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.7	0.8	-0.1	-0.5	-0.2	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.6	-0.2	-0.6	-0.7	-0.3	0.8	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.6	-0.4	0.1	-0.2	0.4	-0.5	-0.8
Illnesses of father: Heart disease	0.2	0.3	1.2	-0.2	0.2	-0.4	-0.2	-1.1	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.0	0.9	-0.6	-0.0	-0.2	1.4	0.3	-0.6
Mood swings	0.2	0.4	0.8	0.5	0.8	0.2	0.5	-0.6	-0.4	0.9
Osteoporosis (self-reported)	0.2	0.3	0.8	-0.5	-0.6	0.4	0.5	-0.9	0.1	0.1
Hearing aid user	0.2	0.2	0.8	-0.1	-0.9	-0.7	0.5	0.2	0.2	-0.4
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.2	0.5	-0.4	-0.1	-1.1	-0.7	-0.4
Myopia	0.2	0.3	1.2	-0.2	1.1	0.6	0.2	-0.5	0.1	-0.4
Prostate Cancer	0.1	0.2	1.3	-0.1	0.0	0.1	0.1	1.1	-0.1	0.3
Tanning	0.1	1.0	2.6	-1.0	-0.9	-0.2	0.3	-1.2	1.0	1.6
Qualifications: College or University degree	0.1	0.4	1.3	-0.2	0.1	0.2	1.1	-0.4	1.0	0.0
Had major operations	0.1	0.1	0.5	-0.4	-0.7	-0.3	-0.3	0.1	0.2	0.0
Guilty feelings	0.1	0.2	1.0	1.0	0.2	0.6	0.1	0.2	0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.3	0.0	0.2	-0.2	-0.2	-0.0	-0.2

Hub : Genes

SLC4A7

Models

Trait associations