TWAS hub - NEK10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0160	0.00120	0.032	0.031	0.017	0.03	0.024	8.0e-05	9.5e-05	3.4e-03	0.00014	6.3e-04
2	TCGA	Breast Invasive Carcinoma	0.0185	0.0088	0.00013	0.023	0.022	0.021	NA	0.023	1.3e-05	1.7e-05	2.4e-05	NA	1.3e-05
3	TCGA	Prostate Adenocarcinoma	0.0383	0.0205	0.00081	0.038	0.020	0.024	NA	0.031	6.6e-05	3.2e-03	1.2e-03	NA	3.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Breast Cancer	83.5	201.0	269.0	8.8	-16.4	-16.0
Breast cancer (self-reported)	26.0	31.0	46.9	-3.4	6.8	5.9
Medication: Blood pressure	17.5	30.8	45.7	-6.8	5.6	4.0
Systolic Blood Pressure	14.2	71.1	83.4	-8.8	9.1	7.2
Hypertension (Self-reported)	12.0	33.3	48.5	-7.0	5.7	4.3
High blood pressure	11.6	32.3	51.3	-7.2	5.5	4.0
Vascular/heart problems diagnosed by doctor	11.4	31.1	47.2	6.9	-5.5	-4.0
Medication for cholesterol, blood pressure or diabetes	8.9	14.7	24.2	4.9	-3.7	-2.5
Mother’s age at death	7.7	9.6	13.9	1.0	-3.7	-3.7
Illnesses of father: High blood pressure	7.2	8.9	11.2	-2.6	3.3	3.0
Cardiovascular Disease	7.1	23.3	28.8	-5.1	5.4	3.9
Medication: Amlodipine	6.9	9.6	19.0	-4.4	2.5	1.9
High blood pressure (mother)	5.8	8.2	9.4	-2.7	3.1	2.8
Medication: Bendroflumethiazide	5.8	8.9	14.8	-3.8	2.9	1.9
Medication: Blood pressure	5.7	10.8	15.8	-4.0	3.1	2.6
Illnesses of mother	5.2	6.4	14.6	3.8	-1.7	-1.3
Medication: Lisinopril	5.2	6.8	8.4	-2.6	2.9	2.2
High blood pressure (siblings)	4.7	6.8	9.6	-2.3	3.1	2.3
Heel bone mineral density (BMD) T-score, automated (left)	4.3	9.8	11.2	-2.7	3.3	3.3
LDL Cholesterol	4.2	6.6	7.7	2.2	-2.7	-2.8
Systolic blood pressure, automated reading	4.1	11.9	15.9	-4.0	3.5	2.7
Medication: Atenolol	3.8	4.8	8.4	-2.9	2.0	1.4
Alzheimer’s Disease (in father)	3.7	4.0	10.8	-3.3	1.0	0.4
Medication: Ramipril	3.5	4.5	5.8	-1.9	2.4	2.0
Irritability	3.5	5.9	6.8	-2.2	2.6	2.4
Medication for hormone replacement therapy	3.2	3.6	4.9	1.6	-1.8	-2.2
Pulse rate, automated reading	3.2	10.3	17.9	1.3	-4.2	-3.4
Age at First Birth	3.1	4.5	8.2	2.9	-1.8	-1.5
Body fat percentage	3.1	12.4	15.0	3.2	-3.9	-3.4
Leg fat percentage (left)	3.1	11.1	13.2	2.9	-3.6	-3.4
Bilateral oophorectomy (both ovaries removed)	3.0	3.4	4.6	-2.1	1.9	1.4
Arm fat percentage (right)	3.0	11.7	12.4	3.4	-3.5	-3.3
Diverticular disease/diverticulitis (self-reported)	2.9	3.5	4.5	2.1	-2.1	-1.2
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	7.7	-0.4	2.8	2.4
Risk taking	2.8	4.1	5.1	-1.9	2.3	1.9
Supplements: Calcium	2.8	3.1	7.8	2.8	-0.9	-0.9
Serious illness, injury or assault to yourself	2.7	3.3	4.6	-1.7	2.1	1.5
Comparative body size at age 10	2.7	7.6	11.2	1.5	-3.3	-3.0
Arm fat percentage (left)	2.7	10.7	12.4	3.1	-3.5	-3.2
Leg fat percentage (right)	2.6	9.2	10.9	2.8	-3.3	-3.0
Blood White Count	2.5	18.4	29.7	5.5	-3.4	-3.7
Severe depression (siblings)	2.5	2.8	3.2	1.5	-1.8	-1.7
Trunk fat percentage	2.5	10.0	11.9	2.9	-3.5	-3.1
Medication: Lansoprazole	2.5	2.9	3.7	1.9	-1.4	-1.7
Heart disease (mother)	2.5	3.0	5.1	-2.3	1.6	1.1
Age when periods started (menarche)	2.4	5.7	7.5	-2.1	2.7	2.3
Prospective memory result	2.4	2.9	5.2	-2.3	1.3	1.4
Age at first live birth	2.4	4.2	6.3	2.5	-1.3	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	5.3	-2.2	2.3	2.3
Pulse rate	2.2	3.7	6.5	0.9	-2.6	-1.9
Intelligence (Savage-Jansen 2018)	2.0	6.0	7.7	-2.1	2.5	2.8
Neuroticism (2016)	2.0	2.9	3.7	-1.8	1.9	1.3
Sitting height	2.0	14.4	25.5	-5.0	3.3	2.6
Forced vital capacity (FVC)	2.0	7.8	12.8	-1.2	3.6	3.1
Impedance of arm (right)	2.0	9.2	17.8	4.2	-2.2	-2.2
Age at last live birth	2.0	2.8	4.6	1.5	-1.3	-2.1
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	3.1	1.6	-1.8	-1.2
Heart attack/myocardial infarction (self-reported)	2.0	2.6	3.0	-1.7	1.7	1.4
Depression (Nagel 2018)	1.8	2.8	4.0	-1.1	2.0	1.8
Supplements: Glucosamine	1.8	2.3	4.8	2.2	-1.0	-1.1
Hair/balding pattern: Pattern 4	1.8	4.3	6.8	-0.2	2.5	2.6
Birth weight of first child	1.8	3.3	5.1	2.3	-1.8	-1.3
Rheumatoid Arthritis	1.7	2.3	3.9	-0.5	1.7	2.0
Type 2 Diabetes (T2D) (2012)	1.7	2.0	3.8	0.5	-2.0	-1.4
Diabetes (father)	1.7	2.1	2.7	1.4	-1.6	-1.3
Hand grip strength (right)	1.7	4.5	5.5	-2.3	2.1	1.9
Fed-up feelings	1.7	3.1	4.8	-1.2	1.7	2.2
Noisy workplace	1.7	2.1	2.8	-1.7	1.1	1.5
Number of children fathered	1.7	1.9	3.3	0.4	1.8	1.5
Number of operations (self-reported)	1.7	2.5	5.5	-2.3	1.0	0.9
Blood Platelet Count	1.6	19.0	38.1	6.2	-3.1	-3.1
Height	1.6	31.7	46.9	-6.8	5.2	4.6
Illnesses of siblings	1.6	2.2	2.9	1.7	-1.7	-0.9
Average weekly red wine intake	1.6	2.3	3.3	0.8	1.8	1.7
Heart attack	1.5	1.9	2.1	-1.5	1.5	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.1	0.5	-1.8	-1.4
Impedance of arm (left)	1.5	7.0	13.7	3.7	-2.1	-1.7
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.5	-0.6	1.9	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.3	0.7	-1.2	-1.8
Number of self-reported non-cancer illnesses	1.5	2.7	4.4	-2.1	1.5	1.2
Ever taken oral contraceptive pill	1.5	1.6	2.8	1.7	-1.3	-0.8
Age started oral contraceptive pill	1.5	1.9	2.8	1.1	-1.7	-1.2
Pain experienced in last month	1.5	2.4	3.4	1.6	1.9	1.2
Heel T-Score	1.4	11.2	18.8	-1.2	4.3	3.7
Frequency of depressed mood in last 2 weeks	1.4	2.0	2.8	-1.7	1.5	1.0
Hayfever, allergic rhinitis or eczema	1.4	3.0	4.7	0.1	2.2	2.1
Hearing difficulty/problems with background noise	1.4	2.2	4.8	-2.2	1.2	0.5
Hair/balding pattern: Pattern 2	1.4	1.8	2.7	0.5	-1.6	-1.6
Trunk fat-free mass	1.4	8.1	13.7	-3.7	2.6	1.9
Number of live births	1.4	2.0	2.9	-0.9	-1.7	-1.5
Medication: Ibuprofen	1.4	1.6	3.1	1.8	-0.9	-1.0
Medication: Omeprazole	1.4	1.6	2.4	1.6	-1.3	-0.9
Medication: Seretide 50 evohaler	1.4	1.7	4.2	2.1	-0.6	-0.7
Number of full sisters	1.4	1.8	2.1	1.5	-1.3	-1.2
Medication: Aspirin	1.4	1.8	3.8	-1.9	1.3	0.2
Supplements: Vitamin C	1.4	1.6	1.8	1.2	-1.3	-1.3
Medication for cholesterol	1.4	2.2	5.4	2.3	-1.0	-0.4
Alzheimer’s Disease (including proxy)	1.3	1.8	5.4	-2.3	0.2	0.2
BMI	1.3	7.8	9.8	2.3	-3.1	-2.9
Trunk predicted mass	1.3	7.5	12.9	-3.6	2.5	1.8
Eye problems/disorders: None of the above	1.3	1.5	2.6	0.7	1.6	1.2
Emphysema/chronic bronchitis	1.3	1.4	3.8	2.0	-0.6	-0.0
Medication: Allopurinol	1.3	1.7	3.7	0.7	-1.0	-1.9
Ever depressed for a whole week	1.3	1.6	2.7	1.3	-1.6	-0.6
Cholesterol lowering medication	1.3	1.9	3.0	-1.7	1.0	1.3
Heart disease (siblings)	1.3	1.6	1.9	-1.1	1.2	1.4
Mean Putamen Volume	1.2	1.4	2.3	0.3	-1.5	-1.4
Pack years adult smoking proportion	1.2	1.8	1.9	1.3	-1.4	-1.4
Had menopause	1.2	1.5	2.6	1.1	-1.6	-0.8
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	7.3	0.2	2.7	2.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	-1.6	0.8	1.1
Leg fat mass (left)	1.2	4.5	5.7	1.7	-2.4	-2.2
Number of treatments/medications taken	1.1	2.0	4.0	-2.0	1.2	0.7
Trunk fat mass	1.1	4.8	6.1	1.6	-2.5	-2.4
Past tobacco smoking	1.1	2.0	2.2	1.5	-1.3	-1.4
Arm fat mass (right)	1.1	4.4	5.5	1.7	-2.4	-2.2
Headache pain in last month	1.1	1.9	5.4	-2.3	-0.5	-0.3
Mean time to correctly identify matches	1.1	2.1	3.6	-1.5	1.9	0.7
Whole body fat mass	1.1	4.5	6.1	1.6	-2.5	-2.2
Arm predicted mass (right)	1.1	5.9	12.2	-3.5	1.8	1.4
Whole body fat-free mass	1.1	6.3	11.0	-3.3	2.2	1.7
Back pain experienced in last month	1.1	1.6	3.5	-0.4	-1.9	-1.0
Impedance of whole body	1.1	5.6	9.2	3.0	-2.1	-1.8
Sensitivity / hurt feelings	1.0	1.7	3.8	1.9	-0.8	-0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.0	-1.0	-1.4	-0.9
Chronic bronchitis/emphysema (father)	1.0	1.2	2.0	1.4	-1.1	-0.5
Arm fat-free mass (right)	1.0	5.3	11.2	-3.3	1.7	1.3
Leg fat mass (right)	1.0	3.7	4.6	1.6	-2.1	-2.0
Whole body water mass	1.0	5.4	10.2	-3.2	2.0	1.5
Wears glasses or contact lenses	1.0	1.2	1.4	-1.1	-1.0	-1.2
Ever smoked	1.0	1.7	2.2	-1.5	1.0	1.3
Commuting to job workplace: Cycle	1.0	1.2	2.0	-0.4	1.4	1.3
Pack years of smoking	1.0	1.5	1.6	1.3	-1.2	-1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.2	-1.1	1.5	1.8
Fasting Glucose	0.9	1.1	1.8	0.1	-1.4	-1.2
Ulcerative Colitis	0.9	1.4	2.2	-0.3	1.5	1.4
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.2	0.8	-0.9	-1.1
Stomach or abdominal pain in last month	0.9	1.1	2.1	-1.4	0.7	0.9
Falls in the last year	0.9	1.2	2.2	0.4	-1.5	-1.1
Arm fat mass (left)	0.9	3.7	4.8	1.4	-2.2	-2.0
Medication: Atorvastatin	0.9	1.1	1.9	-0.7	-0.9	-1.4
Arm fat-free mass (left)	0.9	4.8	10.3	-3.2	1.7	1.2
Unable to work because of sickness or disability	0.9	1.1	1.2	1.1	-1.0	-1.1
Arm predicted mass (left)	0.9	4.5	9.0	-3.0	1.7	1.2
Body Mass Index (BMI) (2010)	0.8	1.1	1.2	0.9	-1.0	-1.1
Coronary Artery Disease (CAD)	0.8	1.0	3.0	-1.7	-0.2	-0.1
Crohns Disease (2012)	0.8	1.3	3.1	1.8	0.9	0.2
Body mass index (BMI)	0.8	3.5	4.8	1.3	-2.2	-2.0
Impedance of leg (left)	0.8	3.9	5.5	2.4	-1.8	-1.7
Number of incorrect matches in round	0.8	1.3	2.3	-0.8	1.5	1.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	1.6	-0.6	0.1
Mouth/teeth dental problems	0.8	1.3	1.9	0.7	-1.2	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	1.3	-0.7	-0.9
Depression (self-reported)	0.8	1.0	1.3	-1.1	1.1	0.7
Standing height	0.8	8.0	10.6	-3.2	3.0	2.2
Tense / ‘highly strung’	0.8	1.4	2.1	-1.0	1.4	1.0
Overall health rating	0.8	1.8	4.1	-2.0	0.4	1.1
Leg pain on walking	0.8	1.0	1.3	1.1	-0.8	-1.1
Knee pain experienced in last month	0.8	1.2	1.8	-0.9	-1.1	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	0.0	-1.0	-1.3
Illnesses of father: None of the above (group 1)	0.8	1.0	1.8	0.9	-0.6	-1.3
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-0.2	-1.0	-1.4
Bipolar Disorder or Schizophrenia	0.7	1.7	2.9	0.0	1.7	1.5
Bipolar Disorder (2011)	0.7	0.7	1.0	-0.7	0.8	1.0
HbA1C	0.7	0.8	1.6	0.6	-1.3	-0.6
Average weekly spirits intake	0.7	0.8	2.3	1.5	-0.4	0.3
Impedance of leg (right)	0.7	3.2	5.4	2.3	-1.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	-1.1	0.7	1.0
Had other major operations	0.7	0.8	1.2	-0.9	0.7	1.1
Diabetes (self-reported)	0.7	1.1	2.2	0.4	-1.5	-0.9
Medication: Simvastatin	0.7	1.0	2.1	-0.7	1.4	0.7
Neuroticism score	0.7	1.5	3.0	-0.6	1.7	1.0
Father’s age at death	0.7	0.9	1.7	1.3	-0.8	-0.5
Hair/balding pattern: Pattern 3	0.7	1.1	1.8	-1.4	0.7	1.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	1.5	-0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	1.3	0.8	0.5
Forced vital capacity (FVC), Best measure	0.7	2.5	4.4	0.3	2.1	1.7
Osteoarthritis (self-reported)	0.7	0.9	1.3	-1.1	-0.6	-1.1
Miserableness	0.7	1.2	2.1	-0.3	1.2	1.4
Average weekly beer plus cider intake	0.7	1.0	2.5	0.3	-0.6	-1.6
Schizophrenia (2018)	0.6	1.3	2.1	-0.3	1.5	1.3
Crohns Disease (2017)	0.6	1.2	2.3	0.6	1.5	1.0
Lupus	0.6	0.9	1.1	-0.9	1.1	0.9
Blood Eosinophil Count	0.6	4.6	6.4	1.7	-2.1	-2.5
Waist Hip Ratio (WHR)	0.6	2.7	6.9	2.6	0.1	1.1
Allergy or Eczema	0.6	1.6	1.9	1.1	1.4	1.4
Lung FVC	0.6	2.9	4.9	1.1	2.2	1.6
Chronotype (morning person)	0.6	1.4	4.0	-2.0	-0.1	0.5
Hearing difficulty/problems: Yes	0.6	1.0	2.0	-1.4	0.9	0.4
Angina	0.6	0.8	1.5	-0.4	1.2	0.9
Alcohol usually taken with meals	0.6	1.0	1.3	-1.0	1.2	0.7
Fluid intelligence score	0.6	1.3	2.0	-1.0	0.9	1.4
Length of working week for main job	0.6	0.7	1.0	-0.4	1.0	0.9
Peak expiratory flow (PEF)	0.6	1.4	1.7	0.8	1.3	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	-1.4	0.1	0.5
Smoking status: Previous	0.6	0.9	1.9	-1.4	0.5	0.6
Osteoporosis (self-reported)	0.6	0.7	1.3	1.1	-0.8	-0.6
Medication: Aspirin	0.6	0.8	1.8	-1.4	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.0	-1.4	0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	-0.1	1.1	1.1
Schizophrenia vs Biploar Disorder	0.5	0.6	1.6	-1.3	0.6	-0.0
Alzheimer’s Disease (in mother)	0.5	0.6	0.8	-0.7	-0.9	-0.6
Reaction Time	0.5	1.0	2.0	-0.8	1.4	0.5
HDL Cholesterol	0.5	0.8	1.2	1.1	-0.4	-1.0
Schizophrenia (2014)	0.5	1.0	1.9	-0.7	1.4	0.8
Relative age of first facial hair	0.5	1.1	1.8	-1.1	1.4	0.6
Diabetes (mother)	0.5	0.6	1.2	1.1	-0.6	-0.6
Leg fat-free mass (left)	0.5	2.5	4.2	-2.0	1.4	1.1
Maternal smoking around birth	0.5	0.8	1.5	1.2	0.1	0.9
Leg predicted mass (left)	0.5	2.4	4.0	-2.0	1.4	1.1
Waist circumference	0.5	1.9	2.3	1.3	-1.5	-1.3
Allergy	0.5	1.3	2.4	-1.6	-0.8	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.5	-1.2	0.9	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.8	1.2	1.7	1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.3	0.1	1.2	1.1
Pulse wave peak to peak time	0.5	0.6	1.2	-1.1	0.1	0.8
Migraine (self-reported)	0.5	0.7	1.1	-0.4	-1.1	-0.8
Leg fat-free mass (right)	0.5	2.9	4.6	-2.1	1.6	1.2
Commuting to job workplace: Walk	0.5	0.5	0.7	-0.3	0.8	0.8
Eye problems/disorders: Cataract	0.5	0.5	1.3	-1.1	0.1	0.6
Leg predicted mass (right)	0.5	2.9	4.6	-2.1	1.6	1.2
Financial situation satisfaction	0.5	0.6	0.9	0.4	-1.0	-0.9
Basal metabolic rate	0.5	3.0	6.0	-2.5	1.5	1.0
Bipolar Disorder (2018)	0.4	0.6	0.8	0.5	0.9	0.8
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	-0.2	1.2	1.1
Worry (Nagel 2018)	0.4	0.8	2.1	-0.4	1.5	0.5
Irritable Bowel Disease (IBD)	0.4	1.0	1.3	0.8	1.2	1.1
Ovarian Cancer	0.4	0.6	0.9	-0.9	-0.2	-1.0
Prostate Cancer	0.4	0.6	0.9	-0.8	0.9	0.5
Smoking Status	0.4	0.9	1.7	-0.3	1.3	1.0
Hand grip strength (left)	0.4	1.1	2.0	-0.5	1.4	1.0
Medication: Metformin	0.4	0.5	0.7	-0.8	0.7	0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.0	0.8	1.0
Worrier / anxious feelings	0.4	0.7	1.8	-0.2	1.3	0.6
Lung cancer (father)	0.4	0.4	0.6	0.6	-0.6	-0.8
Exposure to tobacco smoke at home	0.4	0.4	0.9	0.1	-0.6	-0.9
Pulse wave reflection index	0.4	0.5	1.1	1.0	0.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	1.1	-0.5	-0.4
Exposure to tobacco smoke outside home	0.4	0.6	0.8	-0.6	-0.7	-0.9
Wheeze or whistling in the chest in last year	0.4	0.6	1.8	-1.4	-0.1	-0.2
Angina (self-reported)	0.4	0.5	0.9	-0.2	1.0	0.6
Comparative height size at age 10	0.4	2.0	3.6	-1.9	1.2	1.0
Suffer from ‘nerves’	0.4	0.6	1.4	-0.5	1.2	-0.1
Friendships satisfaction	0.4	0.5	0.8	-0.3	0.7	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.9	-0.5	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-0.4	1.3	0.6
Lung FEV1/FVC ratio	0.3	1.8	4.2	2.0	0.5	0.9
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-1.0	0.1	-0.1
Vitamin and mineral supplements	0.3	0.4	0.9	-0.9	0.4	0.3
Medication: Co-codamol	0.3	0.3	0.7	-0.5	-0.2	-0.8
Nervous feelings	0.3	0.5	0.9	0.8	-0.2	-1.0
Qualifications: None of the above	0.3	0.7	1.3	-0.3	-0.8	-1.1
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.6	0.1	-1.1
Pulse wave Arterial Stiffness index	0.3	0.4	0.6	0.8	0.1	-0.7
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.3	-0.8	-0.6
Glaucoma (self-reported)	0.3	0.3	0.7	0.3	-0.5	-0.8
Number of full brothers	0.3	0.4	0.6	-0.5	0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.3	-0.6	-0.9
Diabetes diagnosed by doctor	0.3	0.6	1.1	-0.8	-1.0	-0.3
Smoking status: Current	0.3	0.5	0.7	0.6	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	1.1	0.8	0.1
High cholesterol (Self-reported)	0.3	0.5	1.1	0.6	-0.2	-1.0
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.2	-0.4	-0.9
Diastolic blood pressure, automated reading	0.3	1.0	2.6	-1.6	0.3	0.6
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.1	0.6	0.8
Major Depression (MDD)	0.2	0.2	0.6	0.8	0.1	0.2
Blood Red Count	0.2	1.5	4.2	0.3	-2.0	-0.4
Hypothyroidism (self reported)	0.2	0.4	0.8	0.5	0.9	0.5
Neuroticism	0.2	0.5	1.2	0.1	1.1	0.5
Relative age voice broke	0.2	0.4	0.9	1.0	-0.0	-0.5
Taking other prescription medications	0.2	0.3	0.8	-0.9	-0.3	-0.2
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.9	0.2	0.0
Hip circumference	0.2	0.9	1.6	-0.6	-0.9	-1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	-0.7	0.3	0.5
Breastfed as a baby	0.2	0.3	0.6	-0.0	-0.6	-0.7
Medication: Paracetamol	0.2	0.3	0.6	0.8	0.3	0.1
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.1	-0.7	-0.5
Qualifications: College or University degree	0.2	0.8	1.3	-0.0	1.0	1.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.1	0.3	0.8
Alcohol intake frequency.	0.2	0.5	1.0	-1.0	0.1	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.6	0.4	0.4
Mood swings	0.2	0.3	0.7	0.8	-0.2	-0.5
Long-standing illness, disability or infirmity	0.2	0.2	0.4	-0.6	-0.6	-0.2
Ever had bowel cancer screening	0.2	0.2	0.4	0.4	-0.7	-0.3
Qualifications: nursing, teaching	0.2	0.3	0.4	0.6	-0.5	-0.6
Medication: Gliclazide	0.2	0.2	0.5	-0.7	0.3	0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.4	0.3	0.8
Hearing aid user	0.2	0.3	0.7	0.1	0.8	0.2
Alcohol drinker status: Never	0.2	0.2	0.3	0.5	-0.2	-0.6
Myopia	0.2	0.3	1.0	1.0	0.2	0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.3	0.6	0.4	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.6	-0.3	-0.0
Triglycerides	0.1	0.2	0.6	-0.8	-0.1	0.1
Respiratory disease	0.1	0.2	0.2	0.5	-0.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.3	-0.5	-0.3
Hair Pigment	0.1	3.3	8.9	-3.0	1.0	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.5	0.0	-0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	-0.3	-0.1
Supplements: Zinc	0.1	0.1	0.3	0.3	-0.6	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.2	0.1	0.5
Current tobacco smoking	0.1	0.2	0.4	0.6	0.4	0.2
Average weekly fortified wine intake	0.1	0.2	0.3	0.3	0.1	0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.7	0.1	-0.2
Multivitamins +/- minerals	0.1	0.2	0.4	0.6	-0.4	0.0
Pain all over the body in last month	0.1	0.1	0.3	-0.1	0.5	0.2
Weight	0.1	0.4	0.7	-0.2	-0.7	-0.9
Time employed in main current job	0.1	0.1	0.2	0.5	0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	0.5	0.4
Loud music exposure frequency	0.1	0.1	0.3	0.2	-0.6	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	0.7	-0.1	-0.2
Gout (self-reported)	0.1	0.2	0.4	-0.0	0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.6	0.7	0.2
Birth weight	0.1	0.3	0.5	-0.5	0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.4	0.4	0.3
Health satisfaction	0.1	0.2	0.3	0.1	-0.6	-0.4
Had major operations	0.1	0.2	0.3	0.0	-0.4	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	-0.3	-0.3
Illnesses of father: Heart disease	0.1	0.2	0.5	0.7	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	-0.5	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.2	0.4	0.1
Mineral and other dietary supplements	0.1	0.1	0.1	-0.4	-0.3	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.1	-0.4	0.3
Medication: Paracetamol	0.1	0.2	0.4	0.6	0.4	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.5	0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	-0.4	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.5	-0.2	-0.3
Tanning	0.0	0.4	1.0	-1.0	-0.1	0.2
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.4	0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.2	0.0	0.1
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.2	-0.3	-0.1
Happiness	0.0	0.1	0.1	-0.2	0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.0	0.1	-0.6
Asthma	0.0	0.0	0.0	0.2	-0.2	-0.0
Worry too long after embarrassment	0.0	0.0	0.1	-0.0	0.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.0	-0.2	0.3
Neck or shoulder pain in last month	0.0	0.1	0.2	-0.4	-0.1	0.1
Chest pain or discomfort	0.0	0.0	0.0	0.1	0.1	-0.2
Family relationship satisfaction	0.0	0.0	0.0	0.2	0.2	-0.2
Loneliness, isolation	0.0	0.0	0.0	-0.2	0.1	-0.2
Asthma (self-reported)	0.0	0.0	0.1	0.2	0.1	0.2
Guilty feelings	0.0	0.1	0.1	-0.2	0.4	0.1

Hub : Genes

NEK10

Models

Trait associations