Best TWAS P=4.99e-27 · Best GWAS P=8.66e-24 conditioned to 0.912
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP13-514E23.2 | 0.09 | 0.03 | enet | 11 | 0.04 | 2.0e-04 | 8.6 | 7.8 | 7.1e-15 | 0.63 | 0.05 | 0.85 | FALSE |
2 | GTEx | Artery Aorta | ARHGAP24 | 0.24 | 0.13 | enet | 8 | 0.14 | 2.2e-08 | 8.6 | 10.5 | 7.5e-26 | 0.87 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | RP13-514E23.2 | 0.26 | 0.09 | lasso | 6 | 0.10 | 2.2e-06 | 10.1 | 10.4 | 2.0e-25 | 0.90 | 0.00 | 1.00 | FALSE |
4 | GTEx | Artery Tibial | ARHGAP24 | 0.26 | 0.19 | enet | 14 | 0.21 | 2.7e-16 | 10.1 | 10.6 | 2.6e-26 | 0.91 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Tibial | RP13-514E23.2 | 0.22 | 0.16 | enet | 10 | 0.18 | 1.2e-13 | 10.1 | 10.8 | 5.0e-27 | 0.93 | 0.00 | 1.00 | TRUE |
6 | GTEx | Nerve Tibial | RP13-514E23.2 | 0.17 | 0.00 | lasso | 6 | 0.00 | 1.9e-01 | 9.6 | 6.2 | 4.1e-10 | 0.60 | 0.05 | 0.34 | FALSE |