[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr1:37,480,144-39,186,794

Best TWAS P=1.17e-12 · Best GWAS P=4.36e-11 conditioned to 0.87

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	SF3A3	0.17	0.12	lasso	4	0.11	2.6e-09	-5.2	-5.3	1.4e-07	-0.73	0.82	0.18	FALSE
2	GTEx	Adipose Visceral Omentum	FHL3	0.10	0.02	enet	9	0.00	1.9e-01	-5.5	-5.7	1.5e-08	-0.78	0.09	0.65	FALSE
3	GTEx	Adipose Visceral Omentum	SF3A3	0.20	0.18	lasso	2	0.18	1.5e-09	-5.3	-5.3	1.3e-07	-0.73	0.81	0.19	FALSE
4	GTEx	Adrenal Gland	FHL3	0.24	0.15	enet	17	0.34	7.4e-13	-5.2	-6.2	5.5e-10	-0.79	0.01	0.99	FALSE
5	GTEx	Artery Aorta	FHL3	0.35	0.22	lasso	4	0.27	3.9e-15	-5.2	-6.2	5.1e-10	-0.89	0.01	0.99	FALSE
6	GTEx	Artery Aorta	SF3A3	0.12	0.19	lasso	2	0.18	6.6e-10	-5.2	-5.2	1.6e-07	-0.72	0.74	0.26	FALSE
7	GTEx	Artery Aorta	INPP5B	0.21	0.13	lasso	3	0.21	5.5e-12	3.7	-5.4	5.4e-08	-0.76	0.16	0.84	FALSE
8	GTEx	Artery Coronary	FHL3	0.31	0.22	lasso	5	0.18	1.3e-06	-5.2	-5.2	1.7e-07	-0.69	0.25	0.67	FALSE
9	GTEx	Artery Coronary	INPP5B	0.27	0.28	enet	5	0.18	1.4e-06	-5.4	-5.6	2.5e-08	-0.70	0.08	0.92	FALSE
10	GTEx	Artery Coronary	RP11-109P14.10	0.26	0.10	enet	10	0.00	3.7e-01	-5.2	-5.7	1.4e-08	-0.79	0.02	0.96	FALSE
11	GTEx	Artery Tibial	FHL3	0.13	0.11	lasso	2	0.13	1.1e-10	-5.3	-5.7	1.1e-08	-0.81	0.22	0.78	FALSE
12	GTEx	Artery Tibial	UTP11L	0.09	0.14	lasso	3	0.12	1.1e-09	-5.3	-5.6	1.7e-08	-0.79	0.12	0.88	FALSE
13	GTEx	Breast Mammary Tissue	SF3A3	0.14	0.18	lasso	2	0.16	8.5e-09	-5.2	-5.3	1.1e-07	-0.72	0.81	0.18	FALSE
14	GTEx	Breast Mammary Tissue (Female)	SF3A3	0.08	0.16	lasso	1	0.10	6.2e-04	-5.2	-5.2	1.7e-07	-0.72	0.11	0.14	FALSE
15	GTEx	Cells Transformed fibroblasts	FHL3	0.24	0.17	lasso	4	0.15	1.4e-11	-5.3	-5.7	1.6e-08	-0.78	0.41	0.59	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	SF3A3	0.23	0.11	lasso	6	0.08	7.7e-04	-5.3	-5.2	2.1e-07	-0.70	0.13	0.76	FALSE
17	GTEx	Esophagus Mucosa	SF3A3	0.08	0.06	lasso	4	0.05	1.5e-04	-5.3	-5.3	9.4e-08	-0.73	0.47	0.50	FALSE
18	GTEx	Esophagus Muscularis	FHL3	0.10	0.02	enet	2	0.00	4.3e-01	-5.3	-5.1	2.9e-07	-0.80	0.03	0.74	FALSE
19	GTEx	Esophagus Muscularis	RP11-109P14.10	0.17	0.11	lasso	6	0.13	3.6e-08	4.2	-5.3	1.4e-07	-0.76	0.31	0.69	FALSE
20	GTEx	Heart Atrial Appendage	SF3A3	0.15	0.12	lasso	4	0.08	1.4e-04	-5.2	-5.2	2.5e-07	-0.71	0.28	0.34	FALSE
21	GTEx	Lung	FHL3	0.14	0.07	enet	24	0.13	6.0e-10	-5.4	-6.5	8.3e-11	-0.83	0.02	0.98	FALSE
22	GTEx	Lung	SF3A3	0.21	0.20	lasso	2	0.21	1.1e-15	-5.3	-5.3	1.3e-07	-0.73	0.82	0.18	FALSE
23	GTEx	Nerve Tibial	FHL3	0.20	0.12	lasso	7	0.14	1.9e-10	-5.4	-5.8	6.4e-09	-0.86	0.02	0.98	FALSE
24	GTEx	Nerve Tibial	SF3A3	0.35	0.36	lasso	4	0.35	7.6e-26	-5.2	-5.3	1.1e-07	-0.72	0.84	0.16	FALSE
25	GTEx	Pancreas	FHL3	0.17	0.05	lasso	3	0.10	6.6e-05	6.5	-6.9	4.8e-12	-0.90	0.00	1.00	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	FHL3	0.11	0.11	lasso	4	0.07	1.0e-04	-5.5	-5.5	3.5e-08	-0.75	0.03	0.96	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	SF3A3	0.24	0.14	lasso	4	0.15	1.1e-08	-5.2	-5.4	5.6e-08	-0.72	0.66	0.34	FALSE
28	GTEx	Skin Sun Exposed Lower leg	FHL3	0.15	0.09	lasso	5	0.10	1.2e-08	6.5	-6.0	1.8e-09	-0.90	0.00	1.00	FALSE
29	GTEx	Thyroid	SF3A3	0.13	0.16	lasso	2	0.16	1.7e-12	-5.2	-5.3	1.3e-07	-0.73	0.78	0.22	FALSE
30	GTEx	Whole Blood	SF3A3	0.16	0.08	lasso	4	0.09	2.3e-08	-4.4	-6.0	2.3e-09	-0.63	0.49	0.49	FALSE
31	METSIM	Adipose	FHL3	0.15	0.12	lasso	5	0.14	6.3e-20	6.5	-7.1	1.2e-12	-0.92	0.00	1.00	TRUE
32	METSIM	Adipose	SF3A3	0.08	0.11	lasso	3	0.11	7.4e-16	-5.3	-5.3	1.3e-07	-0.73	0.80	0.20	FALSE
33	NTR	Blood	SF3A3	0.10	0.12	lasso	6	0.13	7.2e-39	6.6	6.2	5.7e-10	0.97	0.00	1.00	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	EPHA10	0.10	0.06	enet	34	0.07	1.2e-09	6.6	-5.1	3.0e-07	-0.76	0.00	1.00	FALSE
35	YFS	Blood	FHL3	0.69	0.49	enet	33	0.57	8.2e-237	-4.4	-6.0	1.5e-09	-0.70	1.00	0.00	FALSE
36	YFS	Blood	SF3A3	0.50	0.29	enet	44	0.44	3.2e-162	-5.3	-6.1	1.3e-09	-0.71	0.81	0.19	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FHL3	0.08	0.02	enet	7	0.03	1.1e-03	-5.2	-6.1	1.1e-09	-0.72	0.00	0.96	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	FHL3	0.06	0.01	enet	10	0.01	4.2e-04	6.5	-6.8	1.2e-11	-0.81	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	FHL3	0.10	0.05	lasso	2	0.06	2.9e-04	-5.3	-6.2	4.2e-10	-0.90	0.00	0.98	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FHL3	0.05	0.01	blup	45	0.03	3.4e-04	6.5	-5.8	5.9e-09	-0.79	0.00	0.98	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	INPP5B	0.05	0.03	blup	68	0.05	6.7e-06	-5.4	-5.6	2.0e-08	-0.82	0.05	0.94	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	FHL3	0.03	0.02	blup	45	0.02	2.4e-03	-5.4	-5.7	1.6e-08	-0.89	0.01	0.76	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FHL3	0.08	0.08	lasso	2	0.08	1.4e-09	6.5	-6.4	1.6e-10	-0.97	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FHL3	0.13	0.03	enet	6	0.05	4.9e-04	6.5	-6.3	3.1e-10	-0.75	0.00	0.95	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	FHL3	0.10	0.05	lasso	2	0.03	2.2e-03	6.5	-6.5	6.2e-11	-0.98	0.00	0.96	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	FHL3	0.12	0.03	enet	8	0.03	6.4e-04	-5.4	-5.4	5.7e-08	-0.83	0.01	0.99	FALSE