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chr1:40,791,792-44,618,031

Best TWAS P=1.82e-20 · Best GWAS P=2.41e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ELOVL1	0.04	0.01	enet	11	0.01	6.3e-03	8.4	-8.9	3.9e-19	-0.78	0.07	0.91	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MED8	0.04	0.00	blup	455	0.01	1.1e-02	-3.0	6.7	1.5e-11	0.69	0.04	0.72	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TIE1	0.04	0.05	lasso	3	0.05	2.1e-06	8.5	-8.5	2.3e-17	-0.82	0.26	0.74	FALSE
4	GTEx	Adipose Subcutaneous	TIE1	0.10	0.05	lasso	3	0.05	4.4e-05	8.5	-8.5	1.6e-17	-0.84	0.12	0.88	FALSE
5	GTEx	Adipose Subcutaneous	MED8	0.07	0.00	enet	8	0.01	4.5e-02	9.0	8.0	1.3e-15	0.85	0.03	0.95	FALSE
6	GTEx	Adipose Subcutaneous	HYI	0.38	0.09	lasso	9	0.07	1.6e-06	-5.7	-5.2	1.5e-07	-0.56	0.79	0.21	FALSE
7	GTEx	Adipose Visceral Omentum	TIE1	0.13	0.09	lasso	4	0.06	7.5e-04	8.7	-8.5	1.5e-17	-0.86	0.07	0.88	FALSE
8	GTEx	Adipose Visceral Omentum	HYI	0.35	0.23	enet	25	0.24	2.0e-12	-5.9	-5.3	9.8e-08	-0.59	0.89	0.11	FALSE
9	GTEx	Adrenal Gland	HYI	0.15	0.18	lasso	1	0.14	8.0e-06	8.7	-8.7	3.2e-18	-0.87	0.06	0.91	FALSE
10	GTEx	Artery Aorta	MED8	0.10	0.05	enet	13	0.08	4.6e-05	8.2	7.6	2.2e-14	0.86	0.05	0.94	FALSE
11	GTEx	Artery Tibial	SCMH1	0.09	0.01	lasso	3	0.00	1.4e-01	4.5	5.3	1.4e-07	0.04	0.35	0.10	FALSE
12	GTEx	Artery Tibial	HYI	0.15	0.09	lasso	4	0.12	6.3e-10	-6.0	-8.0	9.5e-16	-0.73	0.11	0.89	FALSE
13	GTEx	Breast Mammary Tissue	TIE1	0.08	0.06	lasso	5	0.08	7.1e-05	8.4	-8.9	4.9e-19	-0.92	0.04	0.95	FALSE
14	GTEx	Breast Mammary Tissue (Female)	TIE1	0.10	0.07	enet	10	0.07	3.5e-03	7.6	-6.6	5.6e-11	-0.81	0.03	0.82	FALSE
15	GTEx	Cells Transformed fibroblasts	HYI	0.14	0.01	enet	18	0.02	7.0e-03	8.9	-7.1	1.7e-12	-0.82	0.03	0.96	FALSE
16	GTEx	Cells Transformed fibroblasts	RP1-92O14.6	0.12	0.02	lasso	5	0.03	3.6e-03	8.6	-8.5	1.6e-17	-0.83	0.06	0.93	FALSE
17	GTEx	Colon Transverse	HYI	0.16	0.05	lasso	6	0.09	6.9e-05	-6.0	-7.7	1.9e-14	-0.66	0.04	0.88	FALSE
18	GTEx	Esophagus Mucosa	HYI	0.08	0.05	enet	18	0.06	4.9e-05	8.7	-7.3	2.1e-13	-0.77	0.04	0.94	FALSE
19	GTEx	Esophagus Mucosa	RP1-92O14.6	0.12	0.11	lasso	3	0.09	8.3e-07	8.9	-8.8	8.6e-19	-0.88	0.05	0.95	FALSE
20	GTEx	Heart Left Ventricle	TIE1	0.22	0.04	lasso	11	0.04	5.3e-03	8.5	-8.2	3.2e-16	-0.88	0.06	0.93	FALSE
21	GTEx	Heart Left Ventricle	MED8	0.08	0.01	lasso	3	0.01	1.2e-01	2.4	-6.2	6.4e-10	-0.79	0.05	0.74	FALSE
22	GTEx	Lung	HYI	0.18	0.04	enet	22	0.06	1.8e-05	9.0	-7.7	1.5e-14	-0.76	0.03	0.97	FALSE
23	GTEx	Muscle Skeletal	TIE1	0.08	0.06	lasso	6	0.05	5.5e-06	8.6	-9.0	2.8e-19	-0.89	0.05	0.95	FALSE
24	GTEx	Muscle Skeletal	MED8	0.23	0.37	lasso	1	0.37	7.7e-38	8.9	-8.9	8.3e-19	-0.88	0.03	0.97	FALSE
25	GTEx	Muscle Skeletal	RP1-92O14.6	0.18	0.24	lasso	3	0.24	6.8e-23	8.9	-9.0	2.2e-19	-0.90	0.04	0.96	FALSE
26	GTEx	Nerve Tibial	TIE1	0.20	0.09	lasso	6	0.13	2.6e-09	8.5	-8.0	9.1e-16	-0.81	0.12	0.88	FALSE
27	GTEx	Nerve Tibial	MED8	0.13	0.07	enet	11	0.16	3.6e-11	8.9	8.9	4.3e-19	0.85	0.03	0.97	FALSE
28	GTEx	Pancreas	HYI	0.22	0.16	enet	9	0.20	9.7e-09	-5.9	-6.8	1.1e-11	-0.67	0.47	0.52	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	RP1-92O14.6	0.25	0.09	lasso	12	0.11	1.9e-06	8.9	-8.2	2.6e-16	-0.88	0.03	0.97	FALSE
30	GTEx	Skin Sun Exposed Lower leg	RP1-92O14.6	0.13	0.07	lasso	5	0.07	1.6e-06	8.7	-9.1	6.0e-20	-0.94	0.04	0.96	FALSE
31	GTEx	Stomach	HYI	0.16	0.06	lasso	6	0.07	4.1e-04	-6.0	-7.4	1.7e-13	-0.67	0.13	0.71	FALSE
32	GTEx	Testis	MED8	0.21	0.14	lasso	3	0.20	1.8e-09	-5.7	-8.1	4.6e-16	-0.84	0.09	0.91	FALSE
33	GTEx	Testis	SLFNL1	0.30	0.17	lasso	14	0.28	5.3e-13	-5.2	-5.8	5.3e-09	-0.03	0.07	0.93	FALSE
34	GTEx	Testis	SZT2	0.14	0.12	lasso	3	0.09	5.7e-05	8.7	9.1	1.5e-19	0.94	0.03	0.97	FALSE
35	GTEx	Thyroid	TIE1	0.10	0.05	lasso	3	0.05	1.3e-04	8.7	-8.9	4.2e-19	-0.88	0.04	0.95	FALSE
36	GTEx	Thyroid	MED8	0.08	0.07	lasso	3	0.06	2.0e-05	8.9	8.8	1.2e-18	0.88	0.08	0.92	FALSE
37	GTEx	Thyroid	HYI	0.16	0.13	lasso	6	0.12	1.2e-09	-5.9	-7.2	6.9e-13	-0.74	0.57	0.43	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	TIE1	0.08	0.10	lasso	3	0.10	1.3e-12	8.3	-8.3	7.6e-17	-0.83	0.29	0.71	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	HYI	0.35	0.35	lasso	7	0.36	8.6e-48	-5.9	-6.4	1.5e-10	-0.60	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	TMEM125	0.02	0.01	lasso	4	0.01	7.4e-03	8.3	-6.4	1.4e-10	-0.75	0.13	0.66	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1orf84	0.02	0.02	blup	44	0.01	2.0e-02	9.0	-8.9	5.5e-19	-0.98	0.02	0.74	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HYI	0.09	0.02	blup	33	0.02	8.6e-03	-6.0	-7.8	9.0e-15	-0.83	0.01	0.47	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MED8	0.03	0.00	blup	38	0.01	2.1e-02	8.8	-8.5	2.6e-17	-0.95	0.01	0.54	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf84	0.02	0.03	blup	46	0.03	3.4e-07	8.9	-9.1	8.1e-20	-0.94	0.03	0.97	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	HYI	0.09	0.05	lasso	2	0.05	5.1e-10	-5.9	-6.1	1.0e-09	-0.57	0.99	0.01	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLFNL1	0.03	0.01	enet	6	0.02	5.6e-05	4.4	-6.2	7.2e-10	-0.02	0.08	0.77	TRUE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	TIE1	0.01	0.02	lasso	1	0.01	1.8e-03	8.3	-8.3	1.5e-16	-0.82	0.02	0.94	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	HYI	0.10	0.05	enet	5	0.09	1.1e-05	-6.0	-8.0	1.1e-15	-0.77	0.03	0.93	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1orf84	0.05	0.04	lasso	1	0.03	7.6e-05	-5.7	-5.7	9.4e-09	-0.60	0.17	0.56	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HYI	0.02	0.01	blup	34	0.02	6.1e-03	8.9	-9.0	3.0e-19	-0.99	0.02	0.77	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED8	0.02	0.03	enet	5	0.02	9.0e-04	8.7	-8.8	1.7e-18	-0.96	0.02	0.94	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA0467	0.03	0.00	blup	54	0.02	2.7e-03	7.5	8.2	3.7e-16	0.91	0.02	0.54	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ELOVL1	0.06	0.04	blup	36	0.03	4.7e-03	8.9	-8.8	1.8e-18	-0.91	0.01	0.92	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FOXJ3	0.14	0.02	enet	23	0.05	6.3e-04	-6.8	-6.9	4.7e-12	0.04	0.00	0.95	TRUE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	C1orf84	0.01	0.02	blup	45	0.02	3.0e-03	8.9	-9.1	8.5e-20	-0.98	0.02	0.82	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCMH1	0.04	0.01	enet	7	0.02	2.5e-03	3.7	5.8	5.0e-09	0.03	0.01	0.80	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	TIE1	0.02	0.02	blup	46	0.02	9.0e-04	8.4	-8.2	2.1e-16	-0.83	0.02	0.87	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf84	0.02	0.02	blup	45	0.02	1.3e-03	8.9	-9.3	1.8e-20	-0.96	0.03	0.86	TRUE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	CDC20	0.03	0.03	blup	34	0.03	8.8e-05	8.6	-8.4	5.0e-17	-0.82	0.03	0.93	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	MED8	0.02	0.02	blup	39	0.01	7.5e-03	8.7	-8.7	3.7e-18	-0.89	0.02	0.60	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED8	0.03	0.01	lasso	4	0.02	6.2e-03	-5.7	-8.0	1.2e-15	-0.84	0.02	0.60	FALSE
62	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HYI	0.26	0.15	lasso	3	0.13	3.7e-06	-6.0	-5.6	2.4e-08	-0.44	0.34	0.15	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf210	0.03	0.01	enet	9	0.01	2.6e-02	8.7	-6.6	3.3e-11	-0.53	0.01	0.83	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf84	0.02	0.02	lasso	2	0.02	8.8e-03	8.6	-8.6	6.5e-18	-0.88	0.02	0.61	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	HYI	0.22	0.14	lasso	2	0.14	1.6e-14	-5.9	-6.0	2.1e-09	-0.60	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	SCMH1	0.03	0.03	lasso	2	0.02	6.2e-03	-5.4	5.3	8.7e-08	0.05	0.01	0.94	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	TIE1	0.02	0.01	blup	45	0.01	6.4e-02	8.5	-7.3	2.2e-13	-0.70	0.02	0.69	FALSE
68	The Cancer Genome Atlas	Rectum Adenocarcinoma	HYI	0.23	0.08	blup	34	0.14	3.1e-04	-5.9	-7.7	1.5e-14	-0.79	0.02	0.52	FALSE
69	The Cancer Genome Atlas	Skin Cutaneous Melanoma	KIAA0467	0.17	0.08	blup	52	0.13	2.9e-04	8.7	8.9	4.3e-19	0.94	0.03	0.86	FALSE
70	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HYI	0.24	0.16	lasso	2	0.12	5.7e-05	-5.9	-5.9	4.5e-09	-0.61	0.13	0.54	FALSE
71	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED8	0.26	0.18	blup	39	0.24	3.5e-09	8.6	-8.4	5.1e-17	-0.91	0.03	0.97	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	C1orf210	0.04	0.02	lasso	2	0.01	1.4e-02	8.0	7.9	2.3e-15	0.80	0.02	0.88	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	C1orf84	0.03	0.02	blup	46	0.03	7.0e-04	8.9	-8.7	4.0e-18	-0.98	0.03	0.91	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	HYI	0.28	0.22	lasso	2	0.23	5.3e-22	-6.0	-6.1	8.6e-10	-0.55	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	TIE1	0.03	0.03	blup	46	0.03	6.1e-04	8.4	-8.4	6.3e-17	-0.87	0.01	0.97	FALSE