[Hub]/) : Traits : Systolic Blood Pressure :

chr1:40,791,792-44,618,031

Best TWAS P=1.82e-20 · Best GWAS P=2.41e-19 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ELOVL1 0.04 0.01 enet 11 0.01 6.3e-03 8.4 -8.9 3.9e-19 -0.78 0.07 0.91 FALSE
2 CommonMind Brain Pre-frontal Cortex MED8 0.04 0.00 blup 455 0.01 1.1e-02 -3.0 6.7 1.5e-11 0.69 0.04 0.72 FALSE
3 CommonMind Brain Pre-frontal Cortex TIE1 0.04 0.05 lasso 3 0.05 2.1e-06 8.5 -8.5 2.3e-17 -0.82 0.26 0.74 FALSE
4 GTEx Adipose Subcutaneous TIE1 0.10 0.05 lasso 3 0.05 4.4e-05 8.5 -8.5 1.6e-17 -0.84 0.12 0.88 FALSE
5 GTEx Adipose Subcutaneous MED8 0.07 0.00 enet 8 0.01 4.5e-02 9.0 8.0 1.3e-15 0.85 0.03 0.95 FALSE
6 GTEx Adipose Subcutaneous HYI 0.38 0.09 lasso 9 0.07 1.6e-06 -5.7 -5.2 1.5e-07 -0.56 0.79 0.21 FALSE
7 GTEx Adipose Visceral Omentum TIE1 0.13 0.09 lasso 4 0.06 7.5e-04 8.7 -8.5 1.5e-17 -0.86 0.07 0.88 FALSE
8 GTEx Adipose Visceral Omentum HYI 0.35 0.23 enet 25 0.24 2.0e-12 -5.9 -5.3 9.8e-08 -0.59 0.89 0.11 FALSE
9 GTEx Adrenal Gland HYI 0.15 0.18 lasso 1 0.14 8.0e-06 8.7 -8.7 3.2e-18 -0.87 0.06 0.91 FALSE
10 GTEx Artery Aorta MED8 0.10 0.05 enet 13 0.08 4.6e-05 8.2 7.6 2.2e-14 0.86 0.05 0.94 FALSE
11 GTEx Artery Tibial SCMH1 0.09 0.01 lasso 3 0.00 1.4e-01 4.5 5.3 1.4e-07 0.04 0.35 0.10 FALSE
12 GTEx Artery Tibial HYI 0.15 0.09 lasso 4 0.12 6.3e-10 -6.0 -8.0 9.5e-16 -0.73 0.11 0.89 FALSE
13 GTEx Breast Mammary Tissue TIE1 0.08 0.06 lasso 5 0.08 7.1e-05 8.4 -8.9 4.9e-19 -0.92 0.04 0.95 FALSE
14 GTEx Breast Mammary Tissue (Female) TIE1 0.10 0.07 enet 10 0.07 3.5e-03 7.6 -6.6 5.6e-11 -0.81 0.03 0.82 FALSE
15 GTEx Cells Transformed fibroblasts HYI 0.14 0.01 enet 18 0.02 7.0e-03 8.9 -7.1 1.7e-12 -0.82 0.03 0.96 FALSE
16 GTEx Cells Transformed fibroblasts RP1-92O14.6 0.12 0.02 lasso 5 0.03 3.6e-03 8.6 -8.5 1.6e-17 -0.83 0.06 0.93 FALSE
17 GTEx Colon Transverse HYI 0.16 0.05 lasso 6 0.09 6.9e-05 -6.0 -7.7 1.9e-14 -0.66 0.04 0.88 FALSE
18 GTEx Esophagus Mucosa HYI 0.08 0.05 enet 18 0.06 4.9e-05 8.7 -7.3 2.1e-13 -0.77 0.04 0.94 FALSE
19 GTEx Esophagus Mucosa RP1-92O14.6 0.12 0.11 lasso 3 0.09 8.3e-07 8.9 -8.8 8.6e-19 -0.88 0.05 0.95 FALSE
20 GTEx Heart Left Ventricle TIE1 0.22 0.04 lasso 11 0.04 5.3e-03 8.5 -8.2 3.2e-16 -0.88 0.06 0.93 FALSE
21 GTEx Heart Left Ventricle MED8 0.08 0.01 lasso 3 0.01 1.2e-01 2.4 -6.2 6.4e-10 -0.79 0.05 0.74 FALSE
22 GTEx Lung HYI 0.18 0.04 enet 22 0.06 1.8e-05 9.0 -7.7 1.5e-14 -0.76 0.03 0.97 FALSE
23 GTEx Muscle Skeletal TIE1 0.08 0.06 lasso 6 0.05 5.5e-06 8.6 -9.0 2.8e-19 -0.89 0.05 0.95 FALSE
24 GTEx Muscle Skeletal MED8 0.23 0.37 lasso 1 0.37 7.7e-38 8.9 -8.9 8.3e-19 -0.88 0.03 0.97 FALSE
25 GTEx Muscle Skeletal RP1-92O14.6 0.18 0.24 lasso 3 0.24 6.8e-23 8.9 -9.0 2.2e-19 -0.90 0.04 0.96 FALSE
26 GTEx Nerve Tibial TIE1 0.20 0.09 lasso 6 0.13 2.6e-09 8.5 -8.0 9.1e-16 -0.81 0.12 0.88 FALSE
27 GTEx Nerve Tibial MED8 0.13 0.07 enet 11 0.16 3.6e-11 8.9 8.9 4.3e-19 0.85 0.03 0.97 FALSE
28 GTEx Pancreas HYI 0.22 0.16 enet 9 0.20 9.7e-09 -5.9 -6.8 1.1e-11 -0.67 0.47 0.52 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic RP1-92O14.6 0.25 0.09 lasso 12 0.11 1.9e-06 8.9 -8.2 2.6e-16 -0.88 0.03 0.97 FALSE
30 GTEx Skin Sun Exposed Lower leg RP1-92O14.6 0.13 0.07 lasso 5 0.07 1.6e-06 8.7 -9.1 6.0e-20 -0.94 0.04 0.96 FALSE
31 GTEx Stomach HYI 0.16 0.06 lasso 6 0.07 4.1e-04 -6.0 -7.4 1.7e-13 -0.67 0.13 0.71 FALSE
32 GTEx Testis MED8 0.21 0.14 lasso 3 0.20 1.8e-09 -5.7 -8.1 4.6e-16 -0.84 0.09 0.91 FALSE
33 GTEx Testis SLFNL1 0.30 0.17 lasso 14 0.28 5.3e-13 -5.2 -5.8 5.3e-09 -0.03 0.07 0.93 FALSE
34 GTEx Testis SZT2 0.14 0.12 lasso 3 0.09 5.7e-05 8.7 9.1 1.5e-19 0.94 0.03 0.97 FALSE
35 GTEx Thyroid TIE1 0.10 0.05 lasso 3 0.05 1.3e-04 8.7 -8.9 4.2e-19 -0.88 0.04 0.95 FALSE
36 GTEx Thyroid MED8 0.08 0.07 lasso 3 0.06 2.0e-05 8.9 8.8 1.2e-18 0.88 0.08 0.92 FALSE
37 GTEx Thyroid HYI 0.16 0.13 lasso 6 0.12 1.2e-09 -5.9 -7.2 6.9e-13 -0.74 0.57 0.43 FALSE
38 ROSMAP Brain Pre-frontal Cortex TIE1 0.08 0.10 lasso 3 0.10 1.3e-12 8.3 -8.3 7.6e-17 -0.83 0.29 0.71 FALSE
39 ROSMAP Brain Pre-frontal Cortex HYI 0.35 0.35 lasso 7 0.36 8.6e-48 -5.9 -6.4 1.5e-10 -0.60 1.00 0.00 FALSE
40 ROSMAP Brain Pre-frontal Cortex TMEM125 0.02 0.01 lasso 4 0.01 7.4e-03 8.3 -6.4 1.4e-10 -0.75 0.13 0.66 FALSE
41 The Cancer Genome Atlas Bladder Urothelial Carcinoma C1orf84 0.02 0.02 blup 44 0.01 2.0e-02 9.0 -8.9 5.5e-19 -0.98 0.02 0.74 FALSE
42 The Cancer Genome Atlas Bladder Urothelial Carcinoma HYI 0.09 0.02 blup 33 0.02 8.6e-03 -6.0 -7.8 9.0e-15 -0.83 0.01 0.47 FALSE
43 The Cancer Genome Atlas Bladder Urothelial Carcinoma MED8 0.03 0.00 blup 38 0.01 2.1e-02 8.8 -8.5 2.6e-17 -0.95 0.01 0.54 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma C1orf84 0.02 0.03 blup 46 0.03 3.4e-07 8.9 -9.1 8.1e-20 -0.94 0.03 0.97 FALSE
45 The Cancer Genome Atlas Breast Invasive Carcinoma HYI 0.09 0.05 lasso 2 0.05 5.1e-10 -5.9 -6.1 1.0e-09 -0.57 0.99 0.01 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma SLFNL1 0.03 0.01 enet 6 0.02 5.6e-05 4.4 -6.2 7.2e-10 -0.02 0.08 0.77 TRUE
47 The Cancer Genome Atlas Breast Invasive Carcinoma TIE1 0.01 0.02 lasso 1 0.01 1.8e-03 8.3 -8.3 1.5e-16 -0.82 0.02 0.94 FALSE
48 The Cancer Genome Atlas Colon Adenocarcinoma HYI 0.10 0.05 enet 5 0.09 1.1e-05 -6.0 -8.0 1.1e-15 -0.77 0.03 0.93 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1orf84 0.05 0.04 lasso 1 0.03 7.6e-05 -5.7 -5.7 9.4e-09 -0.60 0.17 0.56 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HYI 0.02 0.01 blup 34 0.02 6.1e-03 8.9 -9.0 3.0e-19 -0.99 0.02 0.77 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MED8 0.02 0.03 enet 5 0.02 9.0e-04 8.7 -8.8 1.7e-18 -0.96 0.02 0.94 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KIAA0467 0.03 0.00 blup 54 0.02 2.7e-03 7.5 8.2 3.7e-16 0.91 0.02 0.54 FALSE
53 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ELOVL1 0.06 0.04 blup 36 0.03 4.7e-03 8.9 -8.8 1.8e-18 -0.91 0.01 0.92 FALSE
54 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FOXJ3 0.14 0.02 enet 23 0.05 6.3e-04 -6.8 -6.9 4.7e-12 0.04 0.00 0.95 TRUE
55 The Cancer Genome Atlas Brain Lower Grade Glioma C1orf84 0.01 0.02 blup 45 0.02 3.0e-03 8.9 -9.1 8.5e-20 -0.98 0.02 0.82 FALSE
56 The Cancer Genome Atlas Brain Lower Grade Glioma SCMH1 0.04 0.01 enet 7 0.02 2.5e-03 3.7 5.8 5.0e-09 0.03 0.01 0.80 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma TIE1 0.02 0.02 blup 46 0.02 9.0e-04 8.4 -8.2 2.1e-16 -0.83 0.02 0.87 FALSE
58 The Cancer Genome Atlas Lung Adenocarcinoma C1orf84 0.02 0.02 blup 45 0.02 1.3e-03 8.9 -9.3 1.8e-20 -0.96 0.03 0.86 TRUE
59 The Cancer Genome Atlas Lung Adenocarcinoma CDC20 0.03 0.03 blup 34 0.03 8.8e-05 8.6 -8.4 5.0e-17 -0.82 0.03 0.93 FALSE
60 The Cancer Genome Atlas Lung Adenocarcinoma MED8 0.02 0.02 blup 39 0.01 7.5e-03 8.7 -8.7 3.7e-18 -0.89 0.02 0.60 FALSE
61 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MED8 0.03 0.01 lasso 4 0.02 6.2e-03 -5.7 -8.0 1.2e-15 -0.84 0.02 0.60 FALSE
62 The Cancer Genome Atlas Pancreatic Adenocarcinoma HYI 0.26 0.15 lasso 3 0.13 3.7e-06 -6.0 -5.6 2.4e-08 -0.44 0.34 0.15 FALSE
63 The Cancer Genome Atlas Prostate Adenocarcinoma C1orf210 0.03 0.01 enet 9 0.01 2.6e-02 8.7 -6.6 3.3e-11 -0.53 0.01 0.83 FALSE
64 The Cancer Genome Atlas Prostate Adenocarcinoma C1orf84 0.02 0.02 lasso 2 0.02 8.8e-03 8.6 -8.6 6.5e-18 -0.88 0.02 0.61 FALSE
65 The Cancer Genome Atlas Prostate Adenocarcinoma HYI 0.22 0.14 lasso 2 0.14 1.6e-14 -5.9 -6.0 2.1e-09 -0.60 1.00 0.00 FALSE
66 The Cancer Genome Atlas Prostate Adenocarcinoma SCMH1 0.03 0.03 lasso 2 0.02 6.2e-03 -5.4 5.3 8.7e-08 0.05 0.01 0.94 FALSE
67 The Cancer Genome Atlas Prostate Adenocarcinoma TIE1 0.02 0.01 blup 45 0.01 6.4e-02 8.5 -7.3 2.2e-13 -0.70 0.02 0.69 FALSE
68 The Cancer Genome Atlas Rectum Adenocarcinoma HYI 0.23 0.08 blup 34 0.14 3.1e-04 -5.9 -7.7 1.5e-14 -0.79 0.02 0.52 FALSE
69 The Cancer Genome Atlas Skin Cutaneous Melanoma KIAA0467 0.17 0.08 blup 52 0.13 2.9e-04 8.7 8.9 4.3e-19 0.94 0.03 0.86 FALSE
70 The Cancer Genome Atlas Testicular Germ Cell Tumors HYI 0.24 0.16 lasso 2 0.12 5.7e-05 -5.9 -5.9 4.5e-09 -0.61 0.13 0.54 FALSE
71 The Cancer Genome Atlas Testicular Germ Cell Tumors MED8 0.26 0.18 blup 39 0.24 3.5e-09 8.6 -8.4 5.1e-17 -0.91 0.03 0.97 FALSE
72 The Cancer Genome Atlas Thyroid Carcinoma C1orf210 0.04 0.02 lasso 2 0.01 1.4e-02 8.0 7.9 2.3e-15 0.80 0.02 0.88 FALSE
73 The Cancer Genome Atlas Thyroid Carcinoma C1orf84 0.03 0.02 blup 46 0.03 7.0e-04 8.9 -8.7 4.0e-18 -0.98 0.03 0.91 FALSE
74 The Cancer Genome Atlas Thyroid Carcinoma HYI 0.28 0.22 lasso 2 0.23 5.3e-22 -6.0 -6.1 8.6e-10 -0.55 1.00 0.00 FALSE
75 The Cancer Genome Atlas Thyroid Carcinoma TIE1 0.03 0.03 blup 46 0.03 6.1e-04 8.4 -8.4 6.3e-17 -0.87 0.01 0.97 FALSE