TWAS hub - UTP11L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.1620	0.0710	6.8e-03	0.044	NA	0.025	NA	0.048	1.4e-02	NA	4.8e-02	NA	9.8e-03
2	GTEx	Artery Tibial	0.0923	0.0341	3.7e-04	0.138	NA	0.117	NA	0.120	6.3e-11	NA	2.0e-09	NA	1.1e-09
3	GTEx	Nerve Tibial	0.1066	0.0438	5.9e-03	-0.004	NA	-0.004	NA	-0.004	9.1e-01	NA	7.9e-01	NA	1.0e+00
4	YFS	Blood	0.0893	0.0216	1.6e-12	0.052	0.042	0.064	0.057	0.066	1.2e-16	8.9e-14	4.7e-20	6.6e-18	8.6e-21
5	TCGA	Prostate Adenocarcinoma	0.0470	0.0250	9.3e-03	-0.001	0.010	0.004	NA	-0.002	4.3e-01	2.5e-02	1.0e-01	NA	5.2e-01
6	TCGA	Thyroid Carcinoma	0.0800	0.0410	2.0e-03	0.029	-0.001	0.007	NA	0.028	7.2e-04	4.0e-01	6.8e-02	NA	8.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	8.5	67.3	130.0	-7.0	-11.4	-10.5	-8.4	-6.3	-2.2
Sitting height	5.8	41.3	71.7	5.4	8.5	7.1	7.8	4.8	3.5
Illnesses of father: Heart disease	5.7	7.9	14.4	-2.6	-3.8	-3.6	-1.7	-3.2	-0.5
Diastolic blood pressure, automated reading	5.5	17.0	23.9	4.3	4.8	4.9	3.6	4.2	2.5
Coronary Artery Disease (CAD)	5.3	6.3	11.6	-1.6	-3.4	-3.2	-2.5	-2.7	-0.2
Migraine (self-reported)	5.3	6.5	10.9	-2.5	-2.7	-3.0	-2.3	-3.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	5.3	11.0	18.1	3.6	4.3	3.5	3.4	2.8	1.7
Alzheimer’s Disease (in father)	5.2	5.6	11.1	-3.3	-2.6	-2.8	-1.1	-2.4	1.1
Hypothyroidism (self reported)	5.2	12.0	28.7	2.1	4.9	5.4	3.6	1.1	0.8
Height	5.0	95.5	179.6	8.6	13.4	12.3	10.8	6.2	3.6
Standing height	5.0	49.3	83.9	6.2	9.2	8.0	8.4	5.1	3.7
Heel bone mineral density (BMD) T-score, automated (left)	4.6	10.4	23.6	-3.2	-4.9	-3.8	-3.6	-1.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	4.6	10.4	23.9	-3.1	-4.9	-3.9	-3.5	-1.3	-0.2
Frequency of depressed mood in last 2 weeks	4.5	6.3	10.6	3.0	3.2	3.1	2.5	0.8	1.4
Medication: Amlodipine	4.3	6.1	10.6	-1.4	-2.8	-2.5	-3.3	-2.7	-1.4
Depression (Nagel 2018)	4.0	6.0	10.6	2.2	3.2	3.1	2.5	-0.7	1.9
Systolic blood pressure, automated reading	3.9	11.2	22.3	-2.9	-4.7	-4.2	-3.6	-2.2	-1.3
Had other major operations	3.8	4.7	7.1	1.8	2.1	2.3	2.7	2.6	1.3
Depression (self-reported)	3.6	4.3	10.0	2.0	3.2	2.7	1.8	0.6	0.9
Medication: Bendroflumethiazide	3.6	5.5	12.0	0.1	-3.0	-2.7	-3.5	-1.6	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.5	8.3	2.4	2.9	2.6	2.3	0.3	1.0
Forced vital capacity (FVC)	3.4	13.2	26.3	2.1	4.2	3.8	5.1	2.9	2.9
Medication: Cholesterol lowering	3.4	5.3	9.4	-2.9	-3.0	-3.1	-1.6	-1.7	0.0
Hair/balding pattern: Pattern 4	3.3	8.0	17.8	-2.8	-3.9	-4.2	-1.7	-1.3	-1.6
Peak expiratory flow (PEF)	3.3	7.7	13.4	2.9	3.1	2.4	3.7	2.5	1.6
Forced vital capacity (FVC), Best measure	3.3	12.2	24.7	2.1	4.1	3.8	5.0	2.5	2.5
Rheumatoid Arthritis	3.0	4.1	12.7	-0.2	2.4	3.6	2.2	1.1	-0.3
Systolic Blood Pressure	3.0	14.9	31.8	-2.6	-5.6	-5.1	-4.8	-1.4	-0.6
Father’s age at death	3.0	4.1	5.9	1.5	2.4	2.3	2.4	1.9	1.2
Forced expiratory volume in 1-second (FEV1)	3.0	10.1	23.2	2.3	3.6	2.8	4.8	2.3	2.3
Medication for cholesterol, blood pressure or diabetes	3.0	4.9	10.5	1.9	3.2	2.9	2.1	1.6	-0.2
Hypothyroidism/myxoedema (self-reported)	3.0	5.9	13.1	1.6	3.3	3.6	2.8	1.1	0.8
Medication: Gliclazide	3.0	3.4	6.0	-2.1	-1.9	-2.5	-0.9	-2.1	-1.0
Miserableness	3.0	5.2	9.5	2.7	3.1	2.6	2.1	0.8	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.3	22.9	2.0	3.5	2.8	4.8	2.1	2.1
Medication: Ibuprofen	2.9	3.5	6.8	2.6	2.0	1.9	1.6	1.4	1.4
Medication: Simvastatin	2.8	4.1	5.6	-2.0	-1.8	-1.8	-2.2	-2.4	-2.0
Glaucoma (self-reported)	2.8	3.4	6.5	-1.5	-1.9	-1.7	-2.5	-0.4	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.8	3.6	7.9	0.5	2.8	2.1	2.3	1.8	0.8
Leg fat-free mass (right)	2.8	15.1	35.2	3.2	5.9	4.7	4.5	1.6	0.6
Medication: Aspirin	2.8	3.6	7.3	-2.7	-2.4	-2.3	-1.2	-1.5	0.0
Leg predicted mass (right)	2.8	14.9	34.9	3.3	5.9	4.7	4.4	1.5	0.6
Age at First Birth	2.7	3.9	7.1	-2.7	-2.2	-2.0	-1.3	-1.9	-1.3
Heart attack	2.7	3.4	4.9	-2.2	-2.2	-2.2	-1.3	-1.9	-0.6
Eye problems/disorders: Glaucoma	2.7	3.2	6.0	-1.1	-2.2	-2.0	-2.5	-0.6	-1.7
Heart attack/myocardial infarction (self-reported)	2.7	3.5	5.3	-2.1	-2.3	-2.3	-1.2	-2.0	-0.5
Leg fat-free mass (left)	2.6	13.7	32.3	3.2	5.7	4.5	4.2	1.4	0.5
Medication: Levothyroxine sodium	2.6	4.4	7.3	1.2	2.7	2.7	2.6	1.9	0.1
Leg predicted mass (left)	2.6	13.7	32.3	3.2	5.7	4.5	4.2	1.4	0.5
Guilty feelings	2.6	3.9	7.3	2.7	2.7	2.0	1.7	1.4	-0.1
Whole body fat-free mass	2.5	14.1	33.9	3.1	5.8	4.6	4.2	1.3	0.5
Number of operations (self-reported)	2.5	3.7	6.2	2.5	2.0	1.6	2.1	2.0	0.8
Trunk fat-free mass	2.4	13.9	33.3	3.0	5.8	4.6	4.1	1.3	0.8
Alcohol intake versus 10 years previously	2.4	3.6	7.9	1.2	2.8	2.1	1.7	2.1	0.4
Whole body water mass	2.4	13.8	33.5	3.1	5.8	4.6	4.1	1.3	0.5
Severe depression (siblings)	2.3	2.6	3.5	1.1	1.8	1.7	1.9	1.6	1.5
Trunk predicted mass	2.3	13.4	31.9	3.0	5.7	4.5	4.1	1.3	0.8
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	6.4	-1.9	-2.5	-2.1	-0.6	-0.2	1.3
Angina	2.2	2.9	5.9	-0.5	-2.4	-2.4	-2.2	-0.7	-0.1
Number of incorrect matches in round	2.2	3.7	12.9	0.4	-0.3	-0.4	-2.3	-1.8	-3.6
Angina (self-reported)	2.2	2.9	5.9	-0.5	-2.4	-2.4	-2.3	-0.7	-0.2
Qualifications: nursing, teaching	2.2	3.3	10.9	-0.3	-1.3	-1.1	1.7	1.9	3.3
Basal metabolic rate	2.2	12.3	30.1	3.0	5.5	4.2	3.9	1.2	0.2
Major Depression (MDD)	2.1	2.6	4.3	1.8	1.8	1.5	2.1	1.1	1.2
Had menopause	2.1	2.6	6.1	-1.6	-1.4	-1.5	-1.1	-1.3	-2.5
Birth weight of first child	2.1	3.7	7.5	-2.7	-1.3	-1.2	-2.0	-2.2	-1.8
Comparative height size at age 10	2.1	11.5	20.0	2.9	4.5	3.9	4.0	2.2	2.1
High cholesterol (Self-reported)	2.1	3.7	5.6	-1.8	-1.7	-2.0	-1.6	-2.4	-2.1
Alcohol drinker status: Previous	2.1	2.4	6.0	1.3	2.4	2.5	0.3	-0.7	0.3
Arm fat-free mass (right)	2.0	10.2	25.0	2.7	5.0	3.8	3.6	1.1	0.5
Medication: Blood pressure	2.0	3.5	7.8	-1.2	-2.8	-2.5	-1.6	-1.4	1.0
Medication: Aspirin	2.0	2.7	5.2	-2.3	-2.1	-1.9	-1.2	-1.2	-0.2
Heart disease (siblings)	2.0	2.4	6.4	-1.3	-1.6	-1.8	-0.6	-2.5	-0.7
Fed-up feelings	1.9	3.5	8.1	2.8	2.7	2.2	0.8	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	6.9	2.6	2.1	1.9	1.3	0.1	1.0
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.3	1.2	1.4	1.9	1.5	1.2	2.1
Prospective memory result	1.9	2.3	5.1	1.5	2.3	1.9	1.3	1.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	6.6	1.0	2.6	1.9	2.3	1.0	-0.1
Arm predicted mass (right)	1.9	9.7	24.3	2.7	4.9	3.7	3.4	1.2	0.5
Number of treatments/medications taken	1.8	3.3	6.2	-0.6	-1.9	-1.9	-2.5	-1.9	-1.5
Overall health rating	1.8	3.8	13.7	0.8	0.2	-0.7	-2.2	-1.7	-3.7
Number of self-reported non-cancer illnesses	1.8	3.2	9.2	-0.3	-0.8	-1.1	-2.1	-1.9	-3.0
Financial situation satisfaction	1.8	2.2	4.6	2.0	2.1	1.9	0.9	0.4	-0.1
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.6	-1.0	-1.3	-1.5	-2.1	-0.5	-1.9
Alcohol drinker status: Never	1.8	2.1	4.2	-0.9	-1.5	-1.3	-1.7	-0.9	-2.0
Schizophrenia (2018)	1.7	3.6	12.8	3.6	0.7	-0.3	1.2	2.5	0.3
Fasting Glucose	1.7	2.0	5.4	1.0	2.0	2.3	1.1	0.6	0.5
Lung cancer (father)	1.7	2.0	4.8	2.2	1.6	1.2	0.7	1.6	0.5
Depressed Affect (Nagel 2018)	1.6	3.3	6.9	2.3	2.6	2.0	1.6	0.1	0.9
Primary Biliary Cirrhosis	1.6	2.3	5.0	2.2	1.9	1.8	0.5	1.1	-0.4
Handedness (chirality/laterality): Left-handed	1.6	2.0	3.4	-1.3	-1.9	-1.5	-1.3	-1.6	-0.3
Triglycerides	1.5	2.5	7.4	2.7	1.8	0.9	1.1	1.3	0.9
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.4	0.4	1.4	1.5	2.1	0.2	1.1
Supplements: Glucosamine	1.5	2.0	6.3	-1.1	-0.5	-0.4	-1.6	-1.1	-2.5
Hair/balding pattern: Pattern 3	1.5	2.3	4.6	-1.8	-2.1	-1.6	-1.2	-1.4	-0.3
Tense / ‘highly strung’	1.5	2.5	3.6	1.4	1.8	1.3	1.7	1.3	1.9
Number of full brothers	1.5	1.8	4.7	1.0	2.2	1.7	1.0	0.6	1.1
Number of children fathered	1.5	1.6	4.7	0.6	-1.6	-2.2	-0.3	0.4	1.4
Age at first live birth	1.5	2.6	5.5	-1.6	-1.7	-1.9	0.7	-0.5	2.3
Arm fat-free mass (left)	1.5	7.8	20.7	2.3	4.5	3.2	3.2	0.5	-0.2
Arm predicted mass (left)	1.5	7.9	20.6	2.3	4.5	3.2	3.3	0.6	-0.2
HDL Cholesterol	1.4	2.3	3.7	-1.9	-1.8	-1.9	-0.9	-0.8	-1.3
Neuroticism (2016)	1.4	2.0	6.5	2.5	1.3	0.6	0.7	1.8	0.4
Blood White Count	1.4	10.4	17.4	-2.8	-4.2	-3.8	-3.1	-3.5	-1.0
Relative age voice broke	1.4	2.2	4.0	-1.4	-1.8	-2.0	0.4	-1.4	1.4
Age at last live birth	1.4	2.1	8.4	0.4	0.5	0.4	1.7	0.8	2.9
Fractured/broken bones in last 5 years	1.4	1.8	3.6	1.1	1.9	1.9	1.4	0.9	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	6.4	-0.8	0.1	0.2	-1.7	-0.7	-2.5
Neuroticism (Nagel 2018)	1.3	3.1	6.1	2.5	2.4	1.6	1.8	0.4	0.9
Ever had hysterectomy (womb removed)	1.3	1.4	2.6	1.4	1.6	1.6	0.4	-0.8	-1.0
Pain all over the body in last month	1.3	1.4	3.9	0.9	1.4	1.2	-0.5	0.5	-2.0
Illnesses of siblings	1.3	1.8	4.2	0.8	0.2	-0.0	1.4	2.0	2.0
Weight	1.3	6.4	16.4	2.4	4.0	3.0	2.5	0.6	-0.7
Qualifications: A levels/AS levels or equivalent	1.3	3.0	7.6	-0.4	0.2	0.5	2.2	2.2	2.8
Blood clot in the leg (DVT)	1.3	1.7	5.6	-1.0	-0.3	-0.3	-1.7	-0.6	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.4	-1.1	-1.1	-0.8	-1.8	-0.4	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.9	-1.7	-1.1	-1.1	-1.4	-0.8	-1.1
Bipolar Disorder or Schizophrenia	1.2	2.8	7.6	2.8	1.1	0.2	1.3	2.5	0.4
Medication for hormone replacement therapy	1.2	1.3	2.0	1.1	1.4	1.2	1.2	1.2	0.3
Alcohol usually taken with meals	1.2	2.0	7.6	-0.2	-0.5	-0.4	1.8	0.5	2.8
Medication: Lansoprazole	1.2	1.4	2.6	-0.2	-1.5	-1.6	-1.3	-1.2	0.6
Comparative body size at age 10	1.2	3.4	5.4	-0.8	-1.5	-1.4	-2.3	-2.2	-2.3
Health satisfaction	1.2	1.6	6.2	1.1	0.8	0.3	-1.1	-0.4	-2.5
Shortness of breath walking on level ground	1.2	1.4	3.4	0.5	1.8	1.9	-0.6	-0.7	-0.8
Average weekly red wine intake	1.2	1.8	5.1	0.5	-1.0	-0.6	1.0	2.3	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	2.4	1.0	1.1	0.5	1.4	-0.7	1.6
Back pain experienced in last month	1.2	1.7	4.9	1.6	2.2	1.3	0.3	0.1	-1.1
Average weekly champagne plus white wine intake	1.2	1.7	5.1	-0.9	-2.3	-1.7	-0.4	0.2	1.1
Age started oral contraceptive pill	1.2	1.5	2.4	-1.5	-1.2	-1.2	-1.1	-1.3	-0.9
Commuting to job workplace: Cycle	1.2	1.4	4.2	-1.4	0.2	0.3	2.0	0.2	1.4
Sensitivity / hurt feelings	1.1	1.8	4.0	2.0	1.3	0.8	0.9	1.9	-0.4
Townsend deprivation index at recruitment	1.1	1.5	3.0	1.2	1.4	1.7	-1.0	1.0	-0.9
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.9	2.2	1.1	0.7	-0.1	1.2	0.1
Falls in the last year	1.1	1.4	2.7	0.6	1.6	1.0	1.6	1.2	-0.8
Osteoporosis (self-reported)	1.1	1.3	2.0	0.8	1.4	1.4	1.1	1.4	0.4
Ovarian Cancer	1.0	1.3	5.7	-1.3	0.2	0.4	0.7	-0.2	2.4
Lupus	1.0	1.5	2.5	1.6	1.2	1.2	1.5	1.2	0.3
Hand grip strength (right)	1.0	2.7	4.7	0.4	2.0	1.7	2.2	0.7	2.0
Qualifications: CSEs or equivalent	1.0	1.3	3.6	1.2	1.9	1.6	-0.0	0.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.8	1.7	1.3	1.3	0.5	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.4	-1.6	-1.4	-0.9	-1.2	-0.6	0.1
Mineral and other dietary supplements	1.0	1.4	2.9	1.1	1.1	0.7	1.2	1.0	1.7
Cholesterol lowering medication	1.0	1.4	3.2	-1.3	-0.2	0.0	-1.0	-1.6	-1.8
Alzheimer’s Disease (in mother)	0.9	1.1	4.4	2.1	0.6	0.8	0.3	0.8	-0.5
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.0	-0.9	1.3	1.2	2.2	1.2	1.5
Schizophrenia (2014)	0.9	1.9	7.4	2.7	0.5	-0.5	0.4	1.9	-0.1
Neuroticism	0.9	2.1	4.7	2.2	1.7	1.1	1.5	0.9	1.0
Chronotype (morning person)	0.9	2.1	3.4	1.6	1.9	1.6	1.9	0.7	0.5
Taking other prescription medications	0.9	1.4	2.4	-0.9	-1.2	-1.2	-1.4	-0.4	-1.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.3	-1.4	-0.6	-0.2	-0.4	-1.8	0.3
Neuroticism score	0.9	2.0	4.7	2.2	1.7	1.3	1.2	0.8	0.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.2	1.5	0.9	0.8	-1.4	-0.2	-0.7
Leg fat percentage (right)	0.9	3.3	6.0	-0.8	-1.5	-1.5	-2.4	-1.6	-2.4
Wheeze or whistling in the chest in last year	0.9	1.6	7.1	-1.1	-0.2	-0.0	-0.9	-2.7	-0.5
Eye problems/disorders: None of the above	0.9	1.0	4.6	-0.2	0.6	0.9	0.5	-0.1	2.1
Medication for pain relief, constipation, heartburn	0.9	1.6	4.2	0.8	0.5	0.3	2.1	1.6	1.3
Family relationship satisfaction	0.9	1.2	3.1	1.0	0.9	0.7	1.8	0.2	1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.1	0.7	1.4	1.0	0.9	1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	6.8	0.4	1.2	0.6	2.6	0.6	1.3
Diabetes (father)	0.8	1.0	1.6	1.0	1.3	1.3	-0.9	0.8	-0.4
Chronic bronchitis/emphysema (father)	0.8	1.0	3.0	1.7	1.1	1.1	-0.1	0.6	-0.2
Hip circumference	0.8	3.4	8.2	1.9	2.9	2.2	1.2	0.0	-1.6
Qualifications: College or University degree	0.8	2.6	6.8	-0.8	-0.9	-0.3	1.6	2.6	2.1
Alcohol intake frequency.	0.8	1.8	5.2	1.7	1.0	0.7	-1.1	-0.2	-2.3
Loneliness, isolation	0.8	1.1	2.6	1.6	1.2	1.3	-0.4	-0.3	-0.7
Ever had bowel cancer screening	0.8	0.9	2.0	-1.2	-0.8	-0.6	-0.4	-1.4	-1.0
Ever taken oral contraceptive pill	0.8	0.8	2.9	1.3	-0.2	-0.4	0.1	0.5	1.7
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	-0.6	-1.4	-1.4	-0.9	-0.2	-1.1
Leg fat percentage (left)	0.8	3.0	6.4	-0.8	-1.3	-1.4	-2.3	-1.5	-2.5
Irritability	0.8	1.4	3.2	1.4	0.9	0.5	1.0	1.0	1.8
Reaction Time	0.7	1.3	3.4	0.8	1.3	1.9	-0.6	1.0	-0.9
Body Mass Index (BMI) (2010)	0.7	1.0	1.7	-1.3	-0.7	-0.3	-1.3	-1.1	-0.8
Serious illness, injury or assault to yourself	0.7	0.9	2.8	1.1	0.7	0.1	0.6	1.7	-0.7
Financial difficulties in last 2 years	0.7	1.0	2.6	0.9	1.6	1.6	0.1	-0.1	-0.1
Time employed in main current job	0.7	0.8	3.8	-2.0	0.3	0.8	-0.4	-0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	0.9	1.6	1.2	0.4	-1.1	-0.4
Number of live births	0.7	1.0	2.0	1.1	1.4	1.2	0.8	0.0	-0.7
Medication: Paracetamol	0.7	1.2	1.7	1.1	1.1	0.7	-1.3	-1.1	-1.1
Exposure to tobacco smoke outside home	0.7	0.9	3.3	-0.3	-0.3	-0.8	0.5	-1.8	-0.9
Knee pain experienced in last month	0.7	1.2	2.0	1.3	1.4	1.2	1.1	-0.5	-0.7
Illnesses of siblings: Diabetes	0.7	0.8	2.5	0.2	1.6	1.2	0.9	-0.4	-0.3
Commuting to job workplace: Walk	0.7	0.8	2.0	-0.3	0.9	1.4	0.6	1.0	0.3
Eye problems/disorders: Cataract	0.7	0.8	1.5	0.9	0.7	0.5	0.5	1.2	-1.2
Medication: Atorvastatin	0.7	0.9	2.2	-1.5	-1.0	-0.9	-0.9	-0.6	-0.2
Average weekly beer plus cider intake	0.7	1.0	3.6	-0.4	0.6	0.4	-0.8	-1.9	-1.1
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.2	0.4	1.6	1.7	2.0	0.2	0.9
Basal cell carcinoma (self-reported)	0.7	0.8	2.1	0.8	0.4	0.5	0.5	1.2	1.4
Prostate Cancer	0.6	0.8	1.9	-1.4	-1.3	-0.4	-0.6	-0.9	0.1
Blood Eosinophil Count	0.6	4.7	14.4	-3.8	-1.9	-0.8	-0.3	-2.5	-1.9
Lung FEV1/FVC ratio	0.6	3.0	8.7	2.3	0.5	-1.2	3.0	1.0	1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.3	0.7	1.2	0.7	1.1	-0.3	0.6
Supplements: Zinc	0.6	0.6	1.4	0.5	1.2	1.2	-0.3	0.3	-0.8
Maternal smoking around birth	0.6	0.9	2.5	1.1	0.5	0.4	-1.6	-0.1	-1.1
Age when periods started (menarche)	0.6	1.5	3.4	0.9	1.8	1.9	0.4	-0.9	-0.6
Body mass index (BMI)	0.6	2.4	7.4	-0.5	-0.2	-0.7	-1.5	-1.9	-2.7
Waist circumference	0.6	2.2	4.8	1.1	2.0	1.2	0.3	-1.3	-2.2
Qualifications: None of the above	0.6	1.2	3.6	0.2	0.3	0.1	-1.6	-1.0	-1.9
Diabetes (self-reported)	0.6	1.0	3.6	0.2	1.2	0.5	0.5	-0.4	-1.9
Breastfed as a baby	0.6	0.7	1.7	-0.8	0.1	0.3	1.3	1.0	1.0
Pulse wave peak to peak time	0.6	0.7	2.3	1.5	0.7	0.9	0.6	0.1	0.7
Mean time to correctly identify matches	0.6	1.2	3.7	-0.1	0.8	1.4	-0.8	0.1	-1.9
Suffer from ‘nerves’	0.6	0.9	2.2	1.1	1.5	1.0	0.3	-0.4	-1.0
Diabetes diagnosed by doctor	0.6	1.0	4.8	-0.1	0.6	0.1	-0.2	-1.0	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.8	-0.7	-0.3	-0.2	-1.0	-1.1	-1.3
Osteoarthritis (self-reported)	0.6	0.8	2.7	1.6	0.3	-0.4	1.0	0.8	-0.5
Hearing aid user	0.6	0.7	1.1	0.8	0.6	0.9	-0.0	1.1	-1.0
Medication: Blood pressure	0.6	1.2	3.4	-0.8	-1.1	-0.9	-1.9	-0.7	-0.9
Medication: Lisinopril	0.6	0.7	2.2	-0.3	-0.8	-0.6	-0.9	-1.5	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-0.7	-1.0	-1.0	-0.2	-1.2	-0.1
HbA1C	0.5	0.6	1.0	1.0	0.7	0.8	-0.9	0.6	0.3
Lung FVC	0.5	2.6	9.4	-0.3	1.1	1.4	3.1	1.5	0.6
Medication: Co-codamol	0.5	0.5	1.0	-0.3	0.8	0.5	1.0	-0.7	-0.8
Medication: Metformin	0.5	0.7	2.7	-0.3	-0.5	-0.9	-0.2	-0.5	-1.6
Pack years adult smoking proportion	0.5	0.7	1.9	0.7	0.2	-0.2	-1.2	-0.4	-1.4
Impedance of leg (right)	0.5	2.2	6.6	-0.4	-2.6	-1.8	-1.8	0.1	0.5
Average weekly fortified wine intake	0.5	0.6	1.6	0.5	0.2	0.3	1.3	0.5	1.1
Multivitamins +/- minerals	0.5	0.6	1.1	0.7	1.0	0.9	1.1	0.3	0.4
Stomach or abdominal pain in last month	0.5	0.6	3.7	0.3	-0.2	0.1	0.3	0.0	1.9
High blood pressure (mother)	0.5	0.7	1.6	-0.7	1.3	0.9	1.0	-0.5	0.1
Impedance of leg (left)	0.5	2.2	6.3	-0.3	-2.5	-1.8	-1.8	0.4	0.4
Hearing difficulty/problems with background noise	0.5	0.7	2.3	1.5	0.7	0.4	0.9	-0.7	-0.5
Fluid intelligence score	0.5	1.1	2.3	-0.4	0.4	0.6	1.5	1.5	1.2
Mouth/teeth dental problems: Dentures	0.5	0.9	2.0	1.0	1.4	0.8	0.8	0.4	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.4	0.7	-0.1	-0.4	-0.9	-1.0	-1.2
Number of full sisters	0.5	0.6	1.8	0.4	1.4	1.0	0.6	0.1	0.2
Mood swings	0.5	0.8	3.7	1.9	0.9	0.2	0.3	-0.0	0.4
Commuting to job workplace: Public transport	0.5	0.6	1.8	-0.9	-0.1	-0.0	-0.2	1.4	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.8	0.9	1.1	0.6	0.9	-0.3
Unable to work because of sickness or disability	0.5	0.7	1.6	-0.2	1.2	0.9	-0.8	-0.1	-1.0
Allergy or Eczema	0.4	1.2	4.3	-0.1	0.8	0.8	2.1	-0.9	0.7
Cardiovascular Disease	0.4	1.3	2.9	-1.0	-1.3	-1.2	-1.7	-1.0	-0.1
Respiratory disease	0.4	0.8	2.5	-0.2	0.8	1.2	0.5	-0.2	1.6
Relative age of first facial hair	0.4	0.8	1.8	-0.5	-1.1	-1.3	0.2	0.3	1.3
Vitamin and mineral supplements	0.4	0.5	1.3	-0.2	-0.9	-0.7	-1.2	-0.4	-0.3
Current tobacco smoking	0.4	0.6	1.7	0.4	0.2	0.3	-1.3	-1.0	-0.8
High blood pressure	0.4	1.0	2.7	0.2	-1.2	-1.3	-1.6	-0.1	-0.5
Medication: Atenolol	0.4	0.5	0.9	-0.7	-0.9	-0.9	-0.1	-0.4	0.6
Allergy	0.4	1.0	2.9	1.7	0.2	-0.2	-0.7	1.4	-0.8
Arm fat percentage (right)	0.4	1.5	5.5	-0.0	-0.1	-0.6	-1.0	-1.5	-2.3
Exposure to tobacco smoke at home	0.4	0.5	2.0	1.4	-0.1	-0.3	-0.3	-0.4	-0.7
Pulse wave reflection index	0.4	0.5	0.9	-0.1	0.5	0.9	0.4	0.9	1.0
Loud music exposure frequency	0.4	0.4	1.6	0.5	-0.3	-0.2	0.4	-0.4	1.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.1	0.8	1.2	-0.3	-0.9	0.2
Body fat percentage	0.4	1.5	5.1	0.2	-0.5	-1.0	-1.3	-1.1	-2.3
Emphysema/chronic bronchitis	0.4	0.4	1.2	0.6	0.3	-0.1	-0.8	-1.1	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.5	0.2	-0.4	-0.7	-1.2	-0.8	-0.5
Leg pain on walking	0.4	0.5	1.0	1.0	1.0	0.7	0.4	-0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	1.0	-0.0	-0.6	0.4	-0.6	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	1.1	-0.1	-0.3	-0.2	-1.0	0.8
Arm fat percentage (left)	0.4	1.4	4.9	-0.0	-0.3	-0.6	-1.2	-1.3	-2.2
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.5	1.3	0.4	1.0	0.7	-0.2
Friendships satisfaction	0.4	0.4	1.8	-1.3	-0.4	0.1	0.1	-0.7	0.4
Smoking status: Current	0.4	0.7	1.5	0.1	0.5	0.6	-1.2	-1.0	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	-0.9	0.5	0.8	-0.1	-0.5	-1.1
Medication: Paracetamol	0.4	0.6	1.7	1.3	0.8	0.5	-0.6	-0.8	-0.3
Myopia	0.4	0.6	2.7	-0.0	-0.8	-0.5	0.1	1.6	-0.0
Pain experienced in last month	0.4	0.6	1.2	-1.1	-0.8	-0.5	0.5	0.5	1.1
Supplements: Calcium	0.4	0.4	1.7	-0.1	0.9	1.3	0.1	-0.2	0.1
Pack years of smoking	0.4	0.7	2.1	0.6	0.2	-0.2	-1.1	-0.4	-1.5
Bipolar Disorder (2018)	0.3	0.4	1.0	0.2	1.0	0.8	0.5	0.8	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.2	-0.6	-1.2	-0.2	0.2	-0.7
Worry (Nagel 2018)	0.3	0.6	0.8	0.9	0.9	0.6	0.8	0.3	0.8
Ulcerative Colitis (UC)	0.3	0.5	1.0	-0.6	-1.0	-0.5	-0.9	0.4	0.3
Breast Cancer	0.3	0.8	2.0	0.9	0.7	0.8	-0.4	1.4	-0.8
Ulcerative Colitis	0.3	0.4	0.9	-0.9	0.0	-0.7	0.5	0.4	0.9
Hearing difficulty/problems: Yes	0.3	0.5	1.4	1.2	0.4	0.1	1.0	0.4	-0.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	0.7	0.5	0.0	1.1	0.2	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.7	-0.3	-0.8	0.6	0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	-0.8	0.0	0.2	1.4	-0.8	0.7
Trunk fat mass	0.3	1.2	2.6	1.6	1.5	0.7	0.6	-0.2	-1.2
Mouth/teeth dental problems	0.3	0.4	0.8	-0.8	-0.9	-0.6	-0.5	-0.3	0.5
Medication: Ramipril	0.3	0.4	0.8	0.4	-0.8	-0.8	-0.9	0.3	-0.1
Impedance of arm (right)	0.3	1.4	3.2	1.2	0.2	0.7	1.0	1.8	1.4
Pulse rate	0.3	0.5	0.9	-0.8	-0.5	-0.7	-0.6	-0.5	-0.9
Illnesses of mother	0.3	0.3	1.0	1.0	0.3	0.6	0.1	0.6	0.4
Arm fat mass (right)	0.3	1.2	3.5	0.8	1.4	0.6	0.3	-1.0	-1.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-1.0	-0.2	-0.0	0.7	0.8	0.7
Headache pain in last month	0.3	0.5	1.6	1.0	-0.1	0.1	-1.3	0.1	0.6
Birth weight	0.3	0.6	1.0	0.6	1.0	0.8	1.0	0.5	0.4
High blood pressure (siblings)	0.3	0.4	1.2	0.4	1.0	1.1	-0.1	-0.4	-0.2
Whole body fat mass	0.3	1.2	2.4	1.5	1.5	0.7	0.5	-0.1	-1.4
Chest pain or discomfort	0.3	0.5	1.2	-0.2	-0.5	-0.9	-1.1	-0.2	-0.7
Had major operations	0.3	0.3	1.0	1.0	-0.1	0.2	0.1	0.7	0.6
Supplements: Vitamin C	0.3	0.4	1.3	-1.1	-0.5	-0.2	-0.7	-0.5	-0.2
Hypertension (Self-reported)	0.3	0.8	2.4	0.6	-0.9	-1.0	-1.6	-0.3	-0.2
Smoking status: Previous	0.3	0.4	1.6	-0.1	0.6	0.4	1.3	0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	-0.1	1.0	1.1	0.5	0.3	-0.6
Arm fat mass (left)	0.3	1.1	3.5	0.8	1.2	0.4	0.1	-0.9	-1.9
Mother’s age at death	0.3	0.3	0.5	-0.7	0.5	0.7	0.5	0.7	0.2
Ever smoked	0.3	0.5	1.4	0.4	1.2	1.0	0.5	-0.1	-0.3
Ever depressed for a whole week	0.3	0.4	1.3	0.1	-0.7	-0.4	-0.0	-1.2	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.6	-0.6	-0.8	-0.7	-0.7	0.3	0.8
LDL Cholesterol	0.2	0.3	0.9	0.7	0.5	-0.2	0.3	0.6	-0.9
Blood Red Count	0.2	2.0	9.2	-1.2	0.3	0.2	3.0	0.2	0.9
Hand grip strength (left)	0.2	0.5	2.0	-0.3	0.7	0.6	0.5	-0.2	1.4
Average weekly spirits intake	0.2	0.3	0.4	-0.6	-0.5	-0.5	0.3	-0.6	-0.5
Trunk fat percentage	0.2	1.0	3.6	0.7	-0.2	-0.6	-0.8	-0.8	-1.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.8	0.4	0.8	0.3	-0.1	0.2
Past tobacco smoking	0.2	0.3	0.7	0.4	-0.8	-0.6	-0.4	0.3	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	0.2	-0.1	-0.2	0.2	-1.0	0.8
Happiness	0.2	0.2	0.4	-0.6	0.3	0.3	0.2	-0.6	-0.6
Noisy workplace	0.2	0.2	1.2	-0.1	-0.1	-0.2	-0.2	-1.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.3	-0.3	-0.1	0.4	0.3	0.8
Asthma	0.2	0.5	0.9	-0.7	0.1	0.8	0.4	-0.7	1.0
Pulse wave Arterial Stiffness index	0.2	0.2	1.0	-1.0	-0.0	-0.3	0.0	0.4	-0.4
Impedance of arm (left)	0.2	1.1	3.2	1.0	-0.3	0.3	0.8	1.8	1.3
Length of working week for main job	0.2	0.3	0.6	0.5	0.4	0.0	0.8	0.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.1	-0.3	0.6	0.5	1.1	-0.2	-0.4
Gout (self-reported)	0.2	0.3	1.0	1.0	-0.2	-0.5	-0.5	0.6	-0.4
Worry too long after embarrassment	0.2	0.4	1.1	1.0	0.4	0.1	0.6	-0.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.2	-0.6	-0.6	-0.8	0.3	-0.3
Neck or shoulder pain in last month	0.2	0.3	0.8	0.9	0.6	-0.1	0.7	0.3	-0.0
Medication: Allopurinol	0.2	0.3	0.7	0.5	0.1	-0.0	-0.7	0.7	-0.8
Medication: Omeprazole	0.2	0.3	0.5	-0.4	0.6	0.7	-0.3	-0.3	-0.6
Leg fat mass (right)	0.2	0.6	1.6	0.8	0.9	0.2	-0.2	-0.7	-1.3
Medication for cholesterol	0.2	0.3	1.1	0.2	-0.2	-0.4	0.5	-0.1	1.0
Breast cancer (self-reported)	0.2	0.3	0.6	0.2	0.4	0.6	-0.1	-0.8	0.6
Asthma (self-reported)	0.2	0.4	1.0	-0.5	0.3	1.0	0.3	-0.7	0.8
Risk taking	0.2	0.3	1.0	0.7	-0.3	-0.6	0.2	0.2	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.7	0.0	0.2	-0.5	-0.4	-0.3
Impedance of whole body	0.2	1.1	2.3	0.5	-1.5	-0.9	-0.3	1.5	1.0
Leg fat mass (left)	0.2	0.7	2.0	0.9	1.1	0.3	-0.1	-0.5	-1.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.5	0.3	0.3	0.7	0.5	0.5
Crohns Disease (2017)	0.1	0.2	0.8	-0.1	0.1	-0.2	-0.2	0.2	0.9
Mean Putamen Volume	0.1	0.1	0.4	-0.1	0.5	-0.1	0.7	-0.1	0.4
Blood Platelet Count	0.1	0.6	1.9	-1.4	-0.8	-0.3	-0.5	-0.9	-0.2
BMI	0.1	0.8	2.9	-0.1	0.3	-0.5	-1.0	-0.8	-1.7
Waist Hip Ratio (WHR)	0.1	0.3	0.9	0.1	1.0	0.6	0.5	-0.4	0.3
Smoking Status	0.1	0.3	1.0	0.1	1.0	0.8	0.2	-0.5	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.8	-0.5	0.7	0.2	0.1	-0.3	-0.9
Hair Pigment	0.1	3.0	5.8	0.9	2.4	2.2	1.6	1.4	1.4
Diabetes (mother)	0.1	0.1	0.6	0.2	-0.3	-0.8	0.0	-0.1	0.2
Nervous feelings	0.1	0.2	1.0	1.0	-0.0	-0.0	-0.5	0.5	-0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.3	-0.4	0.0	-0.0	-0.5	0.2
Worrier / anxious feelings	0.1	0.1	0.5	0.2	-0.7	-0.2	-0.3	-0.3	-0.0
Heart disease (mother)	0.1	0.1	0.3	0.0	-0.4	-0.6	-0.1	0.1	0.3
Pulse rate, automated reading	0.1	0.5	1.7	1.0	-0.1	-0.3	-1.3	0.2	-0.2
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	-0.5	-0.2	-0.1	-0.4	-0.3
Illnesses of father: High blood pressure	0.1	0.2	0.6	-0.4	-0.3	0.1	-0.3	0.8	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.3	-0.2	0.0	-0.2	-0.3	-0.5	0.2
Tanning	0.0	0.3	0.8	0.1	-0.8	-0.9	-0.1	-0.7	0.3

Hub : Genes

UTP11L

Models

Trait associations