Best TWAS P=7.35e-11 · Best GWAS P=3.96e-12 conditioned to 0.00113
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | IMMP2L | 0.10 | 0.06 | enet | 14 | 0.05 | 2.0e-04 | 6.5 | -6.0 | 2.7e-09 | 0.75 | 0.10 | 0.88 | FALSE |
2 | GTEx | Colon Sigmoid | IMMP2L | 0.12 | 0.05 | lasso | 3 | 0.05 | 8.5e-03 | 6.2 | 6.4 | 1.6e-10 | -0.71 | 0.08 | 0.83 | FALSE |
3 | GTEx | Colon Transverse | IMMP2L | 0.22 | 0.02 | enet | 14 | 0.02 | 5.4e-02 | 6.6 | -5.8 | 8.8e-09 | 0.72 | 0.07 | 0.87 | FALSE |
4 | GTEx | Lung | LRRN3 | 0.06 | 0.00 | enet | 11 | 0.01 | 1.1e-01 | 6.6 | -5.8 | 7.2e-09 | 0.62 | 0.04 | 0.87 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | IMMP2L | 0.06 | 0.06 | enet | 13 | 0.06 | 1.5e-05 | -6.6 | -6.2 | 6.1e-10 | 0.87 | 0.02 | 0.98 | FALSE |
6 | GTEx | Testis | IMMP2L | 0.17 | 0.09 | lasso | 3 | 0.11 | 1.8e-05 | -6.0 | -6.0 | 2.1e-09 | 0.85 | 0.06 | 0.93 | FALSE |
7 | GTEx | Thyroid | IMMP2L | 0.16 | 0.08 | lasso | 6 | 0.07 | 8.1e-06 | 6.4 | -6.5 | 7.4e-11 | 0.72 | 0.08 | 0.92 | TRUE |
8 | GTEx | Whole Blood | IMMP2L | 0.06 | 0.06 | lasso | 4 | 0.04 | 1.4e-04 | -5.8 | -6.0 | 1.9e-09 | 0.90 | 0.03 | 0.96 | FALSE |
9 | YFS | Blood | IMMP2L | 0.15 | 0.24 | enet | 34 | 0.27 | 4.1e-89 | 6.3 | -5.9 | 4.3e-09 | 0.78 | 0.24 | 0.76 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IMMP2L | 0.03 | 0.03 | blup | 313 | 0.03 | 3.3e-07 | 6.3 | -5.2 | 1.6e-07 | 0.60 | 0.07 | 0.93 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IMMP2L | 0.08 | 0.00 | blup | 313 | 0.03 | 1.0e-02 | -2.6 | -5.2 | 1.9e-07 | 0.73 | 0.21 | 0.54 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | IMMP2L | 0.05 | 0.02 | blup | 312 | 0.04 | 4.5e-05 | -4.7 | -5.7 | 1.5e-08 | 0.80 | 0.09 | 0.87 | FALSE |
13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IMMP2L | 0.09 | 0.05 | blup | 314 | 0.06 | 1.2e-03 | 6.2 | -5.7 | 1.5e-08 | 0.74 | 0.05 | 0.84 | FALSE |