Hub : Genes

IMMP2L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0460 0.0220 8.7e-03 0.003 0.005 -0.001 0.004 -0.002 1.1e-01 7.9e-02 5.2e-01 8.4e-02 9.2e-01
2 GTEx Cells Transformed fibroblasts 0.1040 0.0380 1.6e-04 0.059 NA 0.047 NA 0.010 3.1e-05 NA 2.0e-04 NA 5.2e-02
3 GTEx Colon Sigmoid 0.1230 0.0490 4.8e-03 0.047 NA 0.029 NA 0.048 9.0e-03 NA 3.4e-02 NA 8.5e-03
4 GTEx Colon Transverse 0.2170 0.0740 3.4e-04 0.024 NA 0.016 NA 0.008 2.5e-02 NA 5.4e-02 NA 1.2e-01
5 GTEx Esophagus Gastroesophageal Junction 0.2140 0.0730 1.8e-04 0.142 NA 0.091 NA -0.008 8.4e-06 NA 3.5e-04 NA 9.1e-01
6 GTEx Esophagus Mucosa 0.0990 0.0400 1.5e-03 0.078 NA 0.086 NA 0.058 6.3e-06 NA 2.4e-06 NA 1.0e-04
7 GTEx Esophagus Muscularis 0.1370 0.0490 1.5e-04 0.052 NA 0.070 NA 0.049 4.1e-04 NA 4.8e-05 NA 5.8e-04
8 GTEx Skin Sun Exposed Lower leg 0.0620 0.0220 3.7e-04 0.063 NA 0.058 NA 0.057 6.0e-06 NA 1.5e-05 NA 1.6e-05
9 GTEx Testis 0.1720 0.0580 5.2e-04 0.087 NA 0.064 NA 0.107 1.1e-04 NA 8.4e-04 NA 1.8e-05
10 GTEx Thyroid 0.1570 0.0520 3.4e-05 0.078 NA 0.065 NA 0.067 1.3e-06 NA 1.1e-05 NA 8.1e-06
11 GTEx Vagina 0.2960 0.1120 9.5e-03 0.012 NA 0.037 NA 0.010 1.7e-01 NA 5.0e-02 NA 1.9e-01
12 GTEx Whole Blood 0.0580 0.0230 2.1e-03 0.058 NA 0.011 NA 0.040 4.5e-06 NA 3.0e-02 NA 1.4e-04
13 METSIM Adipose 0.0331 0.0144 1.8e-03 0.025 0.018 0.013 0.017 0.022 9.2e-05 7.9e-04 3.7e-03 1.2e-03 2.6e-04
14 YFS Blood 0.1523 0.0230 0.0e+00 0.244 0.257 0.272 0.259 0.266 5.0e-79 9.2e-84 4.1e-89 2.6e-84 5.3e-87
15 TCGA Breast Invasive Carcinoma 0.0328 0.0124 1.4e-06 0.032 0.032 0.025 NA 0.031 3.5e-07 3.3e-07 5.4e-06 NA 5.6e-07
16 TCGA Head and Neck Squamous Cell Carcinoma 0.0433 0.0217 1.6e-03 0.018 0.028 0.017 NA 0.016 3.4e-03 3.8e-04 4.3e-03 NA 5.3e-03
17 TCGA Kidney Renal Clear Cell Carcinoma 0.0356 0.0165 2.8e-03 0.019 0.027 0.012 NA 0.014 2.8e-03 4.1e-04 1.5e-02 NA 8.0e-03
18 TCGA Kidney Renal Papillary Cell Carcinoma 0.0800 0.0350 1.5e-03 -0.004 0.028 -0.003 NA -0.004 7.0e-01 1.0e-02 4.9e-01 NA 6.1e-01
19 TCGA Brain Lower Grade Glioma 0.0385 0.0175 1.0e-03 0.006 0.024 0.013 NA 0.010 5.6e-02 8.4e-04 1.2e-02 NA 2.5e-02
20 TCGA Lung Adenocarcinoma 0.0506 0.0213 1.5e-04 0.021 0.036 0.019 NA 0.022 1.4e-03 4.5e-05 2.1e-03 NA 1.3e-03
21 TCGA Ovarian Serous Cystadenocarcinoma 0.0920 0.0460 3.2e-03 -0.004 0.043 0.008 NA 0.002 9.3e-01 6.4e-04 9.1e-02 NA 2.1e-01
22 TCGA Pancreatic Adenocarcinoma 0.0890 0.0420 5.6e-03 0.046 0.064 0.000 NA 0.016 5.0e-03 1.2e-03 3.4e-01 NA 6.6e-02
23 TCGA Thyroid Carcinoma 0.1180 0.0370 1.8e-06 0.057 0.073 0.060 NA 0.049 2.9e-06 1.3e-07 1.7e-06 NA 1.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bipolar Disorder (2018) 0.4 0.6 2.9 -0.2 -0.3 0.1 -0.9 1.4 -0.1 -0.2 -1.1 -0.3 -0.2 -0.4 -1.7 -1.5 -0.4 0.0 -0.2 -1.7 -0.3 -1.0 -0.2 0.9 -0.2 0.5
Bipolar Disorder or Schizophrenia 4.9 12.0 26.6 -1.7 -4.0 4.2 -4.1 -0.7 -1.2 -2.5 -4.5 -4.2 -4.6 -1.1 -5.2 -3.1 -4.0 -3.2 -3.5 -4.2 -3.2 -4.0 -4.2 -2.2 -3.4 -1.2
Depressed Affect (Nagel 2018) 1.3 2.7 12.3 -0.9 1.1 -1.0 2.4 0.5 0.6 0.8 1.9 1.6 0.8 1.2 2.4 3.5 1.5 1.4 1.6 1.9 1.2 2.2 2.1 1.4 0.7 1.7
Depression (Nagel 2018) 0.4 0.6 2.8 -1.2 -0.8 0.9 -0.2 -0.4 1.7 -0.2 0.1 -0.4 -0.2 0.2 0.2 0.8 -0.3 -0.9 0.5 -0.3 -1.0 1.0 0.7 -0.3 -1.1 1.0
Intelligence (Savage-Jansen 2018) 2.7 8.3 28.8 5.4 3.3 -4.4 3.9 4.2 1.4 2.3 1.9 2.7 4.2 0.4 1.2 0.8 3.5 4.4 3.2 -1.3 1.4 -0.7 1.1 0.8 2.8 2.3
Neuroticism (Nagel 2018) 0.4 1.0 8.6 -1.3 0.1 -0.1 1.5 0.1 -0.5 -0.4 0.8 0.6 0.3 0.2 0.8 2.9 0.4 0.5 0.9 0.6 -0.3 1.3 1.3 1.0 -0.6 0.9
Schizophrenia (2018) 8.1 16.8 32.2 -2.0 -5.0 5.3 -4.5 -2.1 -1.4 -3.1 -5.0 -5.1 -5.7 -1.2 -5.3 -2.8 -4.8 -4.2 -4.3 -4.1 -3.9 -4.3 -5.2 -3.5 -4.2 -1.9
Schizophrenia vs Biploar Disorder 5.8 7.7 14.2 -1.4 -3.6 3.6 -2.6 -2.4 -2.3 -1.8 -3.5 -3.5 -3.8 -1.8 -2.9 -0.4 -3.1 -3.3 -2.7 -1.7 -3.2 -1.9 -3.2 -3.3 -3.1 -1.3
Worry (Nagel 2018) 0.9 1.9 5.2 -1.7 -1.4 1.6 -0.1 -0.5 -2.1 -2.0 -1.3 -1.2 -1.2 -1.1 -1.5 1.2 -1.3 -1.4 -0.5 -1.2 -2.3 -0.8 -1.0 -0.8 -2.1 0.1
Alzheimer’s Disease (in mother) 0.4 0.5 2.9 0.6 -0.4 0.5 -0.7 0.4 -0.9 -0.7 -0.6 -0.7 -1.0 -0.4 -0.3 -1.0 -0.9 -0.7 -1.0 -0.3 0.5 -1.7 -0.8 0.5 0.3 0.0
Alzheimer’s Disease (in father) 0.4 0.4 3.2 0.7 0.5 0.1 -0.1 0.8 0.0 1.0 0.0 0.7 -0.7 1.8 0.1 -0.3 0.5 0.1 0.8 0.2 0.4 0.4 0.5 -0.0 0.6 1.2
Alzheimer’s Disease (including proxy) 0.9 1.2 5.3 0.2 -1.0 1.6 -1.7 -0.5 -1.2 -0.7 -1.2 -1.1 -2.3 0.7 -0.6 -1.2 -1.5 -1.3 -1.4 -0.3 -0.2 -1.5 -1.0 -0.3 -0.5 -0.0
Crohns Disease (2017) 1.0 2.3 6.1 -0.4 -0.9 0.9 -0.9 -0.4 -1.1 -0.7 -1.6 -1.8 -1.0 -0.7 -1.8 -2.4 -1.2 0.0 -1.4 -2.5 -1.8 -2.0 -2.5 -0.6 -1.7 -2.4
Irritable Bowel Disease (IBD) 2.4 5.6 13.0 -2.2 -2.4 2.5 -2.4 -1.8 -1.3 -2.2 -2.6 -2.9 -2.4 -1.0 -2.2 -2.2 -2.6 -1.1 -2.4 -2.5 -2.9 -2.2 -3.6 -1.6 -3.1 -2.9
Ulcerative Colitis (UC) 2.0 3.8 7.2 -2.6 -2.3 2.4 -2.3 -2.0 -0.8 -2.0 -1.7 -2.2 -2.2 -1.2 -1.3 -1.1 -2.2 -1.3 -2.0 -1.0 -2.2 -1.0 -2.5 -1.6 -2.7 -2.2
Major Depression (MDD) 1.8 2.2 9.3 -0.6 0.7 -0.7 1.4 1.0 1.4 1.4 1.4 1.0 0.4 2.6 1.4 3.0 1.2 0.1 1.1 1.3 1.8 1.9 2.4 1.0 1.2 1.3
Reaction Time 6.5 12.3 22.3 -3.6 -4.0 4.4 -3.8 -4.7 -2.6 -3.5 -3.6 -3.8 -4.1 -3.3 -2.9 -3.5 -4.0 -2.6 -3.2 -2.3 -3.6 -2.0 -4.2 -1.9 -3.9 -3.5
Verbal and Numeric Reasoning (VNR) 2.5 6.0 19.9 4.5 2.2 -3.5 3.0 3.4 0.4 2.4 2.1 2.3 3.5 -0.2 1.8 0.7 3.0 3.8 2.5 -0.1 1.6 -0.1 1.5 1.6 2.5 2.4
Breast Cancer 0.6 1.5 4.3 1.4 1.4 -1.4 0.7 1.6 1.6 1.7 1.1 1.1 1.6 0.9 0.7 0.5 1.0 0.7 0.3 1.0 2.1 0.5 1.0 0.7 1.7 1.3
Ovarian Cancer 0.2 0.2 1.8 -0.7 -0.2 -0.0 -0.7 0.5 -0.1 0.2 -0.4 -0.4 -0.1 -0.0 0.1 -0.5 -0.3 -0.8 -0.7 0.2 -0.7 0.1 -0.4 -0.3 -0.4 -1.4
Prostate Cancer 0.4 0.6 2.9 0.6 0.7 -0.6 0.0 1.2 1.7 1.0 0.4 0.4 0.6 1.1 0.8 -0.6 1.1 0.9 0.8 0.1 0.7 0.7 1.0 -0.0 0.4 0.1
Age at First Birth 1.1 1.7 4.4 -0.8 -1.2 0.9 -1.6 -1.0 -0.1 -1.2 -1.6 -1.3 -0.7 -1.0 -1.4 -2.1 -1.2 -0.9 -1.9 -0.4 -1.0 -0.9 -0.6 -1.9 -1.6 -2.0
Bipolar Disorder (2011) 0.2 0.2 1.2 0.1 -0.2 -0.6 -0.1 1.1 -0.4 0.1 -0.0 0.4 0.5 0.1 0.4 -0.2 0.4 -0.7 0.3 0.2 0.7 -0.2 0.2 0.6 1.0 0.3
Body Mass Index (BMI) (2010) 1.1 1.5 2.9 0.5 0.9 -1.1 1.6 1.5 0.8 1.2 1.7 1.1 0.7 0.8 1.4 1.7 1.2 0.7 0.7 1.4 1.1 1.6 1.6 1.2 1.2 1.3
Coronary Artery Disease (CAD) 0.5 0.7 3.7 0.6 -0.2 -0.1 0.2 -0.7 -1.5 0.7 0.2 0.0 -0.4 -0.3 1.3 1.3 -0.2 -1.0 -0.1 1.1 0.9 0.5 0.2 0.4 0.5 1.9
Crohns Disease (2012) 1.5 2.4 9.1 -0.9 -1.6 1.5 -1.0 -0.3 -1.1 -0.5 -2.3 -1.8 -1.5 -0.7 -1.4 -1.3 -1.6 -0.9 -1.5 -1.5 -1.9 -1.3 -1.9 -1.2 -2.1 -3.0
Mean Putamen Volume 1.0 1.2 3.1 0.4 1.6 -1.6 1.4 0.4 0.6 1.0 1.0 1.3 1.5 0.9 1.1 0.4 1.6 1.8 0.9 0.8 1.3 0.5 1.2 -0.3 0.8 0.5
Fasting Glucose 0.3 0.4 3.4 0.9 0.1 -0.6 0.4 0.1 -1.9 -0.0 0.5 0.7 0.2 0.3 0.3 0.2 0.6 0.4 0.4 0.5 0.6 -0.2 0.6 0.2 0.9 0.6
HbA1C 0.3 0.4 2.1 -0.1 0.4 -0.6 1.4 0.1 0.2 -0.3 0.1 0.3 0.6 1.5 0.2 0.6 0.4 0.9 0.3 -0.2 -0.1 -0.3 0.2 0.5 -0.3 -1.1
HDL Cholesterol 0.5 0.8 3.7 1.1 0.3 -0.9 -0.3 1.9 1.3 0.3 -0.1 0.0 1.1 0.7 -0.3 -1.9 0.6 1.0 -0.2 -1.4 0.1 -1.2 -0.4 -0.1 0.4 -0.6
LDL Cholesterol 1.2 1.9 4.3 0.8 1.8 -1.3 1.3 1.4 1.3 2.0 1.3 1.5 1.5 0.8 1.2 0.9 1.8 1.1 1.0 1.4 2.1 1.2 1.8 0.2 1.5 1.5
Lupus 0.5 0.7 3.1 1.8 0.3 -0.7 0.4 1.1 0.4 0.9 0.0 0.1 0.7 -0.9 -1.2 -1.2 0.6 0.8 0.5 -1.6 -0.8 -0.7 -0.3 -0.2 -0.2 1.0
Neuroticism (2016) 1.3 1.8 4.2 -0.7 1.8 -1.2 1.8 -0.3 0.7 0.4 1.6 1.3 1.3 -0.1 2.0 1.6 1.3 0.7 1.1 2.0 1.1 1.9 1.8 1.6 0.8 1.0
Primary Biliary Cirrhosis 0.6 0.8 2.9 -0.6 -1.1 0.6 -1.0 -0.8 -0.8 -1.3 -1.2 -1.2 -0.8 -1.7 -0.7 -1.1 -0.9 -0.5 -0.6 -1.2 -0.8 -1.0 -0.8 -0.2 -0.4 -0.4
Rheumatoid Arthritis 0.4 0.5 2.1 1.4 0.5 -0.7 -0.0 -0.0 0.3 -0.2 0.0 0.4 1.0 0.0 0.9 0.2 0.5 1.0 0.9 -0.3 0.4 -0.7 0.0 1.4 1.0 0.7
Schizophrenia (2014) 11.2 24.6 42.4 -3.3 -6.0 6.4 -5.8 -2.8 -2.5 -4.3 -6.2 -6.0 -6.5 -3.0 -6.0 -3.2 -5.9 -5.2 -5.1 -4.5 -5.2 -4.5 -5.7 -4.1 -5.7 -2.5
Triglycerides 0.6 0.9 4.8 -0.8 -0.9 0.9 -0.0 -1.4 -0.7 -1.0 -1.0 -0.7 -1.1 0.4 -0.4 1.5 -0.7 -1.2 -0.6 0.1 -0.9 0.0 -0.0 -2.2 -1.4 -0.5
Type 2 Diabetes (T2D) (2012) 0.6 0.6 4.0 -0.3 0.5 -0.3 0.4 0.7 2.0 1.2 1.0 0.1 0.6 -0.8 1.2 -0.4 0.5 -0.4 0.1 1.1 1.0 0.9 0.5 0.2 0.7 -0.6
Ulcerative Colitis 0.6 0.8 2.5 -0.9 -1.3 0.9 -0.8 -0.8 -0.5 -0.8 -1.3 -1.1 -0.8 -0.8 -0.7 -0.3 -1.0 0.2 -1.0 -0.9 -1.0 -0.9 -1.4 0.0 -1.6 -0.6
Blood Eosinophil Count 0.1 0.5 4.3 1.5 -0.3 -0.3 1.0 -0.0 0.2 -0.2 -0.2 0.2 0.9 0.0 1.0 2.1 0.1 -0.3 -0.1 0.5 -0.2 -0.6 -0.1 -0.7 0.1 1.2
Blood Platelet Count 0.0 0.4 1.3 0.4 0.5 -0.5 0.8 -0.6 1.0 0.9 0.3 0.6 0.2 0.4 0.7 0.8 0.5 1.2 0.6 0.1 0.3 0.3 0.6 -0.3 -0.1 1.0
Blood Red Count 0.1 1.0 3.4 -0.2 -0.9 0.9 -0.0 -0.7 0.1 -0.7 -1.5 -1.2 -0.9 0.8 -1.4 0.6 -1.0 -1.1 -1.7 -0.9 -0.6 -0.8 -0.4 -1.9 -1.0 0.2
Blood White Count 0.1 0.8 3.5 -1.4 -0.7 1.4 -0.1 -1.9 0.8 0.6 -0.5 -0.8 -1.1 -0.8 0.3 1.3 -1.2 -0.5 -0.8 0.8 0.4 0.4 -0.5 0.3 -0.6 -0.2
Heel T-Score 0.1 0.4 2.0 -0.5 -0.5 0.4 -0.5 -0.5 0.1 -1.1 -0.9 -0.3 -0.5 0.8 -0.9 -0.8 -0.4 -1.4 -1.0 0.2 0.4 -0.2 0.2 -0.9 -0.2 -0.4
BMI 0.9 5.2 15.4 0.1 2.0 -2.8 3.4 1.6 1.1 0.9 2.5 1.9 2.5 2.5 3.9 3.6 2.7 1.0 1.7 2.6 2.0 2.5 2.8 0.3 1.8 -0.3
Height 0.2 4.3 8.5 1.7 2.8 -2.0 1.6 2.1 1.7 1.9 2.6 2.5 2.6 1.3 2.1 0.5 2.1 2.9 2.7 1.0 1.9 1.4 1.4 2.8 2.0 1.7
Waist Hip Ratio (WHR) 0.1 0.4 1.4 -0.6 -0.1 0.6 -0.0 -0.8 -0.8 -0.2 -0.7 -0.2 -0.6 -0.8 -0.7 -0.4 -0.5 -0.4 -0.0 0.0 -0.9 0.4 -0.0 -1.0 -1.2 -0.1
Systolic Blood Pressure 0.6 2.8 9.9 -2.0 -2.0 1.5 -1.1 -1.3 -2.1 -1.4 -1.8 -1.7 -1.8 -3.1 -1.3 -1.1 -1.2 -1.6 -1.6 -1.1 -2.2 -1.1 -1.6 -1.1 -1.7 -1.3
Smoking Status 6.0 14.4 26.8 2.9 3.8 -3.8 3.8 1.6 1.7 4.6 4.7 3.9 3.8 2.8 5.2 3.9 4.0 3.0 3.1 4.6 4.6 3.7 4.4 3.4 4.2 3.6
Allergy or Eczema 0.3 0.9 4.6 1.2 1.1 -0.7 0.1 0.4 -1.3 -0.3 0.7 1.1 0.4 0.1 0.7 0.7 0.9 1.2 1.4 -0.4 0.5 -0.1 0.2 1.6 1.1 2.1
Cardiovascular Disease 0.2 0.7 3.1 -1.8 -0.4 0.2 -0.1 0.2 -1.4 0.2 0.5 -0.2 -0.5 -0.9 1.2 0.3 0.2 -0.8 0.6 1.0 -1.3 1.7 0.8 -0.4 -0.8 -1.1
Hypothyroidism (self reported) 0.2 0.4 1.1 0.4 0.7 -0.6 0.7 0.0 -0.4 -0.3 0.9 0.6 0.1 0.7 0.8 1.0 0.3 -0.1 0.2 1.0 0.8 0.5 1.0 0.4 0.6 0.3
Respiratory disease 0.9 2.1 11.9 0.9 1.4 -1.1 1.9 0.7 -1.9 0.3 0.5 1.6 0.4 1.3 1.4 3.4 1.5 0.6 1.9 1.0 0.8 1.0 1.6 0.2 1.3 1.9
Type 2 Diabetes (T2D) (2018) 2.0 3.8 10.6 0.4 1.8 -2.1 2.8 0.6 -0.4 0.4 2.1 1.8 1.9 2.8 3.3 3.2 1.7 1.3 1.6 2.4 1.3 2.1 2.3 2.2 1.2 0.0
Lung FEV1/FVC ratio 0.6 3.2 8.5 1.1 1.2 -2.3 2.3 1.0 -1.1 1.0 2.7 1.7 2.5 2.1 2.3 2.3 2.2 2.9 1.6 1.1 0.6 1.7 1.8 1.4 0.6 0.1
Lung FVC 0.1 0.5 3.2 -0.6 -0.4 0.8 -0.8 -0.6 -0.3 0.5 -1.1 -0.7 -1.2 -0.1 -0.8 -0.1 -0.6 -0.1 -1.0 -0.8 0.2 -0.6 -0.7 -1.8 -0.3 0.1
Neuroticism 0.3 0.8 8.4 -1.6 0.1 -0.1 1.3 -0.1 -1.0 -0.7 0.4 0.2 0.0 0.8 0.3 2.9 0.2 0.4 0.6 0.5 -0.7 0.8 0.7 0.3 -0.9 0.1
Chronotype (morning person) 0.1 0.2 0.8 -0.3 0.2 0.3 -0.6 -0.4 0.4 -0.5 -0.2 0.0 -0.3 -0.4 -0.5 -0.2 -0.3 -0.5 -0.0 -0.2 0.2 -0.9 -0.9 0.4 0.5 -0.2
Hair Pigment 0.0 0.5 5.5 -0.1 0.1 -0.1 0.1 0.2 0.7 -0.2 0.8 0.3 0.3 0.3 1.2 -0.2 0.3 0.3 0.9 0.2 -0.2 0.8 0.6 2.4 0.2 0.7
Tanning 0.1 1.4 4.9 -0.3 1.1 -0.2 0.7 0.1 1.9 1.9 1.3 1.3 0.6 0.6 0.9 0.5 0.9 0.8 0.8 2.2 1.9 1.8 1.3 -0.4 1.0 -0.5
Hand grip strength (left) 0.7 1.8 4.1 1.7 2.0 -1.3 1.2 -0.1 1.0 1.0 1.4 1.7 1.7 1.8 1.2 0.8 1.4 1.6 2.0 0.4 1.5 0.6 1.0 0.7 1.8 1.2
Number of treatments/medications taken 0.2 0.3 1.5 -0.5 0.4 -0.2 0.3 0.0 -0.6 -1.2 0.0 0.6 -0.2 -0.0 -0.6 0.2 0.4 0.7 1.1 -0.8 -0.9 0.1 0.2 -0.0 -0.8 -0.5
Average weekly spirits intake 0.2 0.3 1.3 0.2 0.7 -0.8 0.9 -0.2 -1.1 -0.4 0.2 0.3 0.5 -0.5 -0.6 0.7 0.4 0.7 0.7 -0.4 -0.3 -0.2 0.4 -0.4 -0.4 -0.3
Sensitivity / hurt feelings 0.4 0.8 4.3 -2.1 -0.3 0.5 0.6 -1.1 -0.2 -0.6 0.8 0.2 -0.2 0.1 0.7 1.8 -0.2 -0.9 -0.1 1.5 0.0 1.4 0.6 0.7 -0.4 -0.1
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.1 -1.0 -0.3 0.4 0.5 -0.2 1.4 0.1 0.5 0.0 0.2 -0.2 0.2 1.0 0.1 -0.6 0.9 -0.1 -0.9 1.4 0.6 -0.2 -0.6 0.7
Hearing difficulty/problems: Yes 3.2 4.8 8.7 1.0 2.8 -2.1 2.7 1.1 1.6 1.2 2.4 2.7 1.5 1.1 2.8 2.7 2.5 2.0 3.0 1.5 2.0 1.9 2.9 2.5 2.3 2.0
Relative age of first facial hair 3.5 7.2 13.8 -2.2 -3.2 3.3 -3.3 -3.7 -2.0 -3.1 -2.5 -2.9 -3.1 -2.2 -2.4 -1.9 -3.7 -2.5 -3.0 -1.4 -2.4 -2.2 -3.1 -1.2 -2.6 -1.4
Other serious medical condition/disability diagnosed by doctor 3.8 5.0 9.3 2.4 2.7 -3.0 2.8 1.6 0.6 1.9 2.3 2.3 2.5 1.7 1.9 1.8 2.7 2.1 3.0 0.5 1.7 1.8 2.6 2.7 2.4 2.4
Ever used hormone-replacement therapy (HRT) 3.1 3.9 10.2 2.8 2.2 -2.3 1.6 2.4 2.1 1.7 1.6 2.3 2.4 1.4 1.3 0.4 2.1 3.2 2.4 -0.1 1.8 0.1 1.1 2.4 1.9 1.8
Ever had hysterectomy (womb removed) 0.3 0.4 1.9 -0.4 0.3 -0.4 -0.1 1.4 -0.3 0.9 0.1 0.5 0.5 -0.4 0.1 -0.6 0.7 0.0 0.9 0.3 -0.4 1.0 0.9 0.7 -0.2 -0.4
Systolic blood pressure, automated reading 2.6 7.4 13.0 -2.3 -3.3 2.8 -2.5 -1.5 -2.8 -2.0 -3.6 -3.5 -2.9 -3.4 -2.5 -1.8 -2.6 -3.2 -3.3 -1.9 -2.6 -2.6 -3.0 -2.3 -2.8 -2.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 4.7 1.0 0.9 -0.5 1.1 -0.2 0.9 0.3 1.1 1.3 0.4 2.2 1.1 0.9 0.7 0.5 1.4 1.7 0.7 1.4 1.0 0.5 1.0 0.8
Angina 0.2 0.3 0.8 0.9 0.5 -0.3 0.2 0.4 -0.6 -0.1 0.0 0.3 -0.1 0.9 -0.7 -0.9 0.4 0.5 0.5 -0.6 0.1 0.1 0.4 0.4 0.0 0.6
Medication for hormone replacement therapy 0.3 0.4 2.5 -0.4 -0.1 0.5 -0.4 -0.3 1.1 -0.8 0.2 0.2 -0.6 0.4 -0.6 -0.4 -0.4 0.3 -0.7 0.2 0.1 -0.5 -0.5 -0.7 -0.6 -1.6
Vitamin and mineral supplements 0.3 0.5 1.6 -0.2 -1.2 0.8 -0.8 -0.5 0.3 -0.2 -0.8 -0.5 -0.8 0.1 -0.4 0.4 -0.4 -1.1 -1.1 -0.1 0.0 -0.6 -0.9 -1.2 0.0 0.4
Supplements: Zinc 0.7 0.8 2.7 -0.3 -0.4 -0.1 0.0 0.8 -1.6 -1.2 -0.6 -0.8 -0.2 -0.5 -1.1 -1.2 -0.5 -0.8 0.3 -1.2 -1.3 -1.3 -0.5 -0.7 -0.4 -1.4
Medication: Co-codamol 0.6 0.7 3.1 -1.4 1.0 -0.8 1.2 0.1 -0.8 -0.7 0.9 0.7 0.9 0.0 0.7 1.0 0.6 0.4 0.8 0.7 0.1 1.4 1.8 0.9 -0.1 0.3
Medication: Metformin 1.0 1.4 3.2 0.1 1.5 -1.7 1.3 0.7 0.5 0.6 1.3 1.0 1.5 1.2 1.8 0.5 1.3 1.7 1.0 1.0 0.3 1.6 1.4 1.4 0.5 -0.8
Diabetes (father) 0.4 0.4 4.2 0.1 -0.0 -0.3 0.8 0.9 -0.7 0.2 -0.5 -0.6 0.3 2.0 -0.4 0.8 -0.0 0.3 -0.5 -0.3 0.3 -0.4 0.2 -1.1 -0.3 -0.6
Diabetes (mother) 0.4 0.5 2.0 -0.9 0.2 -0.4 0.9 0.8 0.7 0.0 0.5 0.3 0.3 -1.0 0.7 1.3 0.4 -0.2 0.5 0.5 0.4 1.2 1.4 -0.2 -0.1 -0.8
Severe depression (siblings) 1.5 1.7 3.7 0.4 1.3 -0.9 1.2 0.4 1.3 0.9 1.4 1.5 0.8 1.9 1.6 1.8 1.3 1.4 1.3 0.7 1.5 1.0 1.2 1.3 1.5 1.9
Pack years adult smoking proportion 1.7 2.6 7.6 0.0 1.2 -0.6 1.2 0.2 1.8 1.4 1.5 1.3 0.9 1.8 2.7 1.8 0.9 -0.5 1.8 2.8 1.8 2.6 2.5 1.6 1.4 1.0
Impedance of leg (right) 0.9 4.6 10.3 -1.4 -1.9 3.1 -2.6 -2.0 -0.4 -1.3 -2.7 -1.9 -3.0 -1.8 -2.7 -1.5 -2.6 -1.4 -2.4 -1.3 -2.3 -1.1 -2.2 -2.2 -3.2 -1.4
Leg fat-free mass (left) 0.9 4.8 11.1 1.1 2.0 -2.5 2.5 1.5 1.1 1.0 2.9 2.1 2.6 1.9 3.3 2.9 2.5 1.6 2.6 1.3 2.2 1.9 2.4 2.1 2.8 1.6
Trunk fat percentage 0.2 0.7 2.4 -1.3 -0.3 0.7 0.1 -1.3 0.6 -0.7 0.3 -0.3 -0.3 0.5 1.0 1.0 -0.4 -0.9 -0.7 1.4 -0.1 1.3 0.3 -1.2 -1.0 -1.5
Hand grip strength (right) 1.0 2.6 4.9 2.0 2.2 -2.0 1.8 0.4 1.3 1.1 1.7 2.1 2.1 1.9 1.2 1.4 1.8 1.9 1.8 0.9 2.0 1.1 1.7 0.5 1.7 1.0
Townsend deprivation index at recruitment 0.5 0.8 2.8 0.1 -0.3 -0.5 1.6 -0.3 -0.4 0.5 0.9 0.4 0.4 1.3 1.3 1.7 0.6 0.4 0.8 0.9 0.3 1.6 1.3 0.9 -0.1 -0.1
Current tobacco smoking 5.0 8.2 16.4 1.1 2.0 -1.6 2.8 0.1 2.2 3.3 3.5 3.0 1.6 1.8 3.8 3.8 2.4 1.9 2.4 3.9 3.2 4.0 3.4 3.5 2.6 3.5
Average weekly fortified wine intake 0.8 0.9 5.6 0.9 -0.1 0.4 -1.6 -0.5 -0.5 -0.8 -0.2 0.1 -0.4 -2.2 -1.2 -2.4 -0.1 0.4 0.5 -1.3 -0.7 -0.7 -0.4 0.1 -0.2 1.1
Maternal smoking around birth 0.5 0.8 1.6 0.6 1.0 -0.8 1.0 0.8 0.6 0.5 0.7 0.8 1.0 1.0 0.9 1.1 1.1 0.3 0.7 0.8 0.8 0.7 1.3 0.9 0.9 1.2
Fed-up feelings 3.2 5.8 17.7 -0.4 2.4 -2.1 3.4 1.0 0.8 2.2 2.9 2.5 2.0 1.1 3.1 4.2 2.5 2.3 2.7 2.8 2.0 3.0 2.7 1.5 1.7 2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.9 -1.3 -0.3 0.3 0.7 -0.3 1.2 0.5 1.1 -0.1 0.2 0.3 1.0 1.1 0.3 -0.7 0.8 0.8 -0.6 1.7 1.0 -0.7 -0.5 0.1
Relative age voice broke 2.9 4.4 14.0 -1.3 -2.3 1.7 -3.3 -1.5 -1.8 -2.3 -1.6 -2.1 -1.7 -2.2 -2.1 -3.7 -2.3 -0.9 -1.9 -2.0 -2.4 -2.3 -2.7 0.2 -1.8 -1.3
Taking other prescription medications 0.4 0.7 2.0 -0.1 1.4 -0.6 1.0 -0.3 -0.3 -0.4 0.6 1.2 0.4 0.2 0.2 0.7 0.8 0.8 1.4 0.2 0.3 1.0 1.0 1.4 0.3 1.4
Age when periods started (menarche) 1.0 2.3 5.9 0.4 -1.4 1.8 -1.3 -1.4 -1.4 -0.5 -1.8 -1.3 -1.6 -1.7 -2.4 -1.2 -1.4 -0.8 -0.8 -1.4 -2.2 -1.4 -2.2 -1.7 -2.0 -1.3
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 5.2 1.5 1.5 -2.3 1.0 1.7 0.8 1.0 1.0 1.0 2.1 0.1 0.7 -0.8 1.4 2.1 1.6 -1.1 0.3 -0.6 0.1 1.4 1.6 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 5.4 1.0 1.4 -1.1 1.7 1.2 1.2 1.4 1.2 1.3 1.2 1.0 1.7 2.3 1.7 0.5 1.0 1.3 1.4 1.5 1.4 0.7 1.1 0.6
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 3.1 -0.5 0.7 -1.1 1.8 0.3 -0.0 0.2 0.9 0.6 0.6 1.1 1.4 1.2 0.6 0.9 0.3 0.9 0.6 0.8 1.0 1.1 0.1 -0.7
Qualifications: CSEs or equivalent 2.0 2.6 11.9 -2.0 0.9 -0.1 0.9 -0.4 2.6 0.0 1.5 1.3 0.5 1.5 2.7 1.7 0.6 -1.1 0.2 3.5 2.1 2.5 1.9 0.6 1.3 0.1
Serious illness, injury or assault to yourself 1.4 1.7 5.5 0.5 1.2 -1.3 0.2 -0.2 0.2 0.7 2.0 1.5 1.3 0.7 2.0 -0.3 1.1 1.3 1.9 1.1 1.2 1.6 1.6 2.3 1.7 1.1
High blood pressure 0.8 2.2 8.5 -1.9 -1.5 1.4 -1.2 -0.9 -2.9 -1.5 -1.1 -1.3 -1.8 -0.7 0.5 -0.5 -0.8 -1.9 -0.4 0.1 -2.5 0.5 -0.5 -1.5 -2.1 -1.8
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.9 1.4 1.3 -1.1 0.8 1.1 -0.7 0.1 1.0 1.1 0.8 -0.2 0.5 1.0 1.2 1.7 1.5 -0.8 0.3 -0.4 0.1 1.1 1.0 1.5
Multivitamins +/- minerals 0.5 0.7 2.1 0.0 1.5 -0.8 1.4 0.5 0.4 0.5 1.0 0.6 1.0 1.1 0.5 -0.1 0.5 1.1 0.9 0.4 0.7 0.8 0.9 1.3 0.5 0.4
Stomach or abdominal pain in last month 1.6 2.0 6.0 0.4 1.4 -1.2 2.4 0.8 0.6 1.4 1.1 1.6 0.7 1.1 1.7 2.4 1.9 1.0 2.0 1.3 0.6 2.1 1.9 0.2 0.8 0.8
Supplements: Glucosamine 0.7 0.9 3.6 0.6 0.7 -1.0 0.5 1.6 0.6 -0.6 -0.1 -0.3 1.2 0.4 -1.3 -1.1 0.3 1.0 -0.5 -1.7 -0.5 -1.9 -0.4 -1.0 -0.4 -1.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 2.2 -1.5 -0.1 0.5 -0.8 -0.9 -0.2 -0.7 -0.2 -0.3 -0.8 -1.1 -0.1 -0.8 -0.0 -0.2 -0.1 -0.3 -0.8 0.1 -0.0 -0.6 -0.8 -1.2
Medication: Atenolol 0.3 0.4 1.5 -0.3 -0.2 0.5 -0.2 -0.4 -0.2 -0.9 -0.9 -0.5 -0.5 -1.2 -1.1 -1.2 -0.2 -0.8 -0.1 -0.7 -0.4 -0.8 -0.5 -0.3 -0.3 -0.7
Medication: Levothyroxine sodium 0.3 0.4 2.7 0.4 -0.5 0.6 0.6 -0.9 -0.4 -0.2 -0.4 -0.7 -0.9 -0.6 0.7 1.6 -0.7 -0.8 -0.8 0.7 0.3 -0.2 -0.3 -0.7 -0.4 -0.2
Sitting height 0.4 2.9 5.4 1.9 1.9 -2.2 1.8 2.1 0.9 1.8 2.2 1.8 2.2 1.5 1.4 1.3 1.9 2.3 2.2 -0.0 1.3 0.9 1.1 1.5 1.7 1.1
Chronic bronchitis/emphysema (father) 2.2 2.6 8.5 1.6 1.2 -1.7 1.4 2.0 0.4 1.0 1.2 1.3 1.5 1.0 1.4 1.2 1.7 1.1 1.8 0.1 1.8 0.7 1.9 2.7 2.2 2.9
High blood pressure (mother) 1.6 2.2 5.5 0.5 0.9 -0.9 1.0 0.7 2.3 1.3 2.1 1.5 0.8 1.9 1.9 2.1 0.9 0.7 1.2 1.5 2.3 0.4 0.7 1.8 2.3 1.4
Body mass index (BMI) 0.5 2.0 7.6 -0.1 1.2 -1.7 2.1 0.8 0.6 0.1 1.5 0.9 1.6 1.3 2.8 2.2 1.7 0.3 1.1 1.3 1.2 1.6 2.0 0.4 1.1 -0.2
Impedance of leg (left) 1.0 4.8 11.0 -1.8 -1.9 3.3 -2.8 -2.2 -0.3 -1.0 -2.6 -1.9 -3.3 -1.8 -2.6 -2.0 -2.8 -1.3 -2.3 -0.9 -2.2 -0.7 -2.3 -1.9 -3.3 -1.5
Leg predicted mass (left) 1.0 5.1 11.9 1.1 2.0 -2.5 2.6 1.5 1.1 1.1 3.0 2.1 2.7 1.8 3.5 3.0 2.6 1.6 2.7 1.4 2.2 2.0 2.5 2.3 2.8 1.6
Trunk fat mass 0.2 0.8 3.3 -0.6 0.5 -0.3 0.9 -0.4 0.7 -0.2 1.1 0.5 0.6 0.8 1.8 1.6 0.6 -0.2 0.3 1.6 0.6 1.7 1.1 -0.2 0.0 -0.6
Waist circumference 0.1 0.5 3.3 -0.3 0.4 -0.6 1.2 0.2 0.2 -0.2 0.6 -0.0 0.6 0.3 1.8 1.7 0.5 -0.4 0.2 0.9 0.4 0.9 0.7 -0.2 0.1 -0.7
Number of incorrect matches in round 0.3 0.5 4.1 1.3 -0.2 0.2 -0.7 0.3 0.6 -0.5 -0.5 -0.1 0.2 -0.7 -0.9 -2.0 -0.5 -0.6 0.2 -0.4 -0.6 -0.9 -0.4 0.6 -0.2 -0.1
Past tobacco smoking 2.0 3.8 11.5 -2.1 -2.3 3.3 -2.3 -2.9 0.7 -1.9 -2.0 -1.4 -3.4 -2.7 -1.6 -0.2 -2.4 -1.7 -1.3 -0.5 -1.4 -0.5 -2.0 -1.0 -1.8 -0.2
Alcohol usually taken with meals 0.4 0.7 3.5 -0.1 -0.6 0.3 -1.2 0.2 0.9 -0.5 -0.5 -0.6 0.0 -0.9 -1.4 -1.9 -0.5 -0.1 -0.8 -1.1 -0.9 -1.2 -1.2 0.1 -0.7 -0.5
Nervous feelings 2.8 5.2 13.0 -3.6 -2.2 3.3 -1.2 -2.2 -2.3 -2.7 -2.4 -2.0 -3.0 -2.1 -2.6 0.0 -2.7 -2.2 -1.6 -1.1 -2.6 -0.5 -1.5 -1.8 -3.4 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 3.2 -1.3 -0.2 0.2 0.7 -0.7 -0.2 -0.8 0.2 -0.4 0.2 0.7 0.1 1.8 -0.2 0.4 0.4 -0.5 -1.5 0.9 0.5 -0.1 -1.4 0.0
Hearing difficulty/problems with background noise 2.9 4.6 9.0 2.3 2.1 -2.1 2.6 1.4 0.6 1.7 2.6 2.7 1.3 -0.2 2.8 2.2 2.6 2.2 2.8 1.8 1.6 2.2 3.0 2.4 1.8 1.3
Hair/balding pattern: Pattern 2 0.2 0.2 1.3 -0.9 -0.4 0.5 -0.7 -0.1 0.4 0.1 -0.5 -0.1 -0.5 0.2 -1.1 -1.0 -0.2 -0.2 -0.0 -0.5 0.2 -0.3 0.0 -0.2 0.2 0.5
Had menopause 0.3 0.4 1.5 -0.4 -0.2 0.6 -0.4 -0.2 0.8 0.2 -1.0 -0.6 -0.4 -0.1 -1.0 -0.9 -0.2 -0.4 -0.5 -0.5 -0.7 -0.1 0.0 -0.7 -1.2 -0.6
Had other major operations 1.2 1.5 3.4 1.7 1.4 -1.3 0.3 1.6 1.6 0.9 0.9 1.1 1.4 1.4 0.5 -1.4 1.2 1.7 1.6 -0.4 0.5 0.3 0.8 1.8 0.9 0.6
Forced vital capacity (FVC) 0.2 0.8 1.9 0.1 0.8 -0.6 0.4 0.4 1.3 1.2 1.1 1.2 0.6 1.4 0.8 1.3 1.0 1.0 0.7 0.4 1.3 0.6 0.6 -0.8 0.8 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.3 1.1 1.4 -1.1 1.6 1.0 0.4 0.9 1.1 1.3 0.8 0.5 1.9 2.1 1.6 0.6 1.1 1.5 1.4 0.9 0.8 0.7 1.4 0.6
Ever unenthusiastic/disinterested for a whole week 2.9 3.6 10.2 0.9 2.0 -1.7 3.0 0.6 1.8 0.8 1.9 1.9 1.7 2.1 2.1 3.2 2.1 1.9 2.4 1.1 1.4 1.6 2.6 0.8 1.1 1.9
Qualifications: None of the above 1.1 2.3 11.6 -3.4 -1.4 2.1 -1.5 -3.0 0.4 -0.8 -0.4 -0.8 -2.2 -1.2 0.3 -0.2 -1.2 -2.0 -0.8 1.3 -0.9 1.5 0.2 -0.5 -1.7 -1.4
Financial difficulties in last 2 years 1.9 2.6 6.0 0.2 1.8 -1.8 2.5 1.1 0.1 1.7 1.9 1.4 1.4 0.8 2.2 1.7 1.9 2.2 1.9 1.3 1.3 1.8 2.1 0.8 0.8 -1.5
Mouth/teeth dental problems 0.2 0.3 1.4 0.4 -0.6 0.0 -1.0 0.7 -0.2 0.3 0.1 -0.2 -0.3 -1.1 -1.1 -1.2 -0.3 -0.5 -0.4 -0.6 -0.3 -0.5 -0.2 0.5 0.5 -0.0
Heart attack 0.4 0.5 5.1 -0.3 -0.4 -0.2 0.6 -0.2 -0.4 -0.6 -0.1 -0.3 -0.2 2.3 -0.6 1.2 -0.1 -0.7 0.5 -0.2 -0.7 0.6 0.6 -0.4 -0.6 -0.2
Allergy 0.3 0.6 2.4 -1.1 -0.8 0.6 -0.6 -1.4 0.9 0.1 -0.4 -0.9 -0.1 0.4 -0.1 -1.5 -1.0 -1.0 -1.2 0.7 0.2 0.2 -0.2 -0.4 -0.4 -1.1
Pain all over the body in last month 1.6 1.8 5.0 1.1 0.9 -1.1 1.1 -0.0 1.3 0.4 1.7 1.4 1.4 1.6 2.2 2.0 1.5 0.9 1.6 1.0 0.4 1.9 1.7 1.4 1.0 0.4
Diabetes (self-reported) 1.9 3.0 7.1 -0.0 1.8 -1.9 2.4 0.9 0.3 0.6 1.8 1.8 1.8 2.7 2.4 2.6 1.7 1.5 1.8 1.7 1.1 2.0 2.1 1.5 1.2 1.0
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.7 -1.3 -0.5 1.1 -1.1 -0.5 -1.4 -1.2 -1.5 -0.8 -1.6 -0.8 -1.2 -0.8 -1.2 -0.7 -0.8 -1.1 -1.1 -0.9 -1.6 -0.6 -1.0 -1.5
Medication: Ramipril 1.4 1.8 3.2 0.2 1.8 -1.3 1.4 0.2 -0.1 1.0 1.6 1.7 1.1 1.6 1.5 1.4 1.8 1.2 1.8 1.3 1.2 1.5 1.7 0.9 1.4 0.8
Medication: Simvastatin 0.2 0.2 1.6 1.2 -0.4 -0.2 -0.1 0.2 -0.3 0.1 0.4 0.3 0.3 0.8 -0.6 -0.1 0.1 0.2 0.8 -0.5 -0.3 0.1 0.3 0.6 0.2 0.7
Fluid intelligence score 1.6 3.2 13.4 3.7 1.6 -2.4 2.4 2.2 0.2 1.2 1.3 1.7 2.2 -0.1 1.2 0.7 2.0 3.2 2.2 -0.6 0.8 -0.5 0.5 1.2 1.9 1.9
Illnesses of siblings 0.5 0.7 3.0 1.4 0.6 -0.8 0.3 1.5 0.4 0.1 -0.9 0.1 0.9 0.2 -1.3 -0.8 0.2 1.1 -0.1 -1.7 0.0 -1.2 0.1 -0.4 0.0 0.9
Neuroticism score 0.5 1.1 8.2 -1.6 0.3 -0.1 1.4 -0.3 -0.3 -0.3 1.1 0.8 0.3 0.8 0.8 2.9 0.4 0.4 1.1 1.1 -0.1 1.7 1.3 1.1 -0.3 0.7
Weight 0.6 3.1 9.2 0.5 1.7 -2.0 2.3 1.1 1.1 0.5 2.2 1.6 2.1 1.4 3.0 2.6 2.1 1.0 1.9 1.4 1.7 1.8 2.0 1.3 1.8 0.7
Impedance of arm (right) 1.9 9.0 16.0 -2.4 -3.1 3.9 -3.8 -2.8 -0.8 -2.3 -3.0 -3.0 -3.5 -2.3 -4.0 -2.8 -3.6 -2.2 -3.4 -1.8 -3.1 -2.2 -3.5 -3.1 -3.7 -2.3
Arm fat percentage (right) 0.2 0.7 2.2 -1.4 -0.2 0.2 0.5 -0.8 0.1 -1.0 0.2 -0.5 -0.1 -0.1 1.2 1.1 0.1 -0.9 -0.6 1.0 -0.3 1.1 0.6 -1.3 -0.8 -1.5
Trunk fat-free mass 1.0 5.9 11.4 1.5 2.5 -2.7 2.5 2.0 1.3 1.2 2.9 2.6 2.7 1.4 3.2 2.4 2.8 2.0 3.4 0.9 2.4 1.9 2.5 3.0 3.1 2.6
Hip circumference 0.2 1.0 5.7 -0.4 0.6 -0.9 1.5 0.3 0.5 0.0 1.2 0.4 1.0 0.6 2.4 2.1 0.8 -0.1 0.7 1.2 0.9 1.3 1.0 0.4 0.6 -0.6
Time employed in main current job 0.4 0.4 1.4 -0.5 -0.6 0.7 -0.7 -0.6 0.7 0.9 -0.5 -0.7 -0.7 0.6 -0.5 -0.5 -0.6 -0.5 -0.5 0.2 -0.5 0.7 -0.2 0.2 -1.1 -1.2
Alcohol intake versus 10 years previously 0.6 0.9 3.3 -1.8 -0.7 1.5 -0.3 -0.5 0.7 -0.8 -0.6 -0.9 -1.5 1.7 0.1 0.9 -1.1 -1.1 -0.6 0.2 -0.1 0.1 -0.9 -0.5 -0.8 -0.8
Father’s age at death 0.1 0.1 0.8 -0.2 0.1 0.2 0.0 0.3 0.9 -0.0 0.3 -0.1 0.3 -0.1 -0.6 -0.5 -0.3 -0.4 -0.5 0.2 0.1 0.1 0.2 0.4 -0.7 -0.1
Worrier / anxious feelings 0.1 0.2 1.3 -1.1 -0.0 -0.1 0.2 0.8 0.3 -0.2 0.3 0.1 0.3 0.1 -0.4 0.7 0.0 -0.0 0.4 -0.3 -0.1 0.1 0.2 1.0 -0.3 0.3
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.5 13.6 -0.0 1.9 -1.8 2.4 0.3 1.0 1.7 2.4 2.2 1.8 1.8 3.2 3.3 2.2 1.8 2.7 1.8 0.7 3.7 3.1 1.4 1.0 1.9
Falls in the last year 2.0 2.7 8.0 2.0 1.9 -2.0 1.6 2.2 1.3 0.6 1.5 1.8 1.6 2.2 0.5 0.5 1.9 2.8 2.0 -1.1 1.3 -0.3 0.5 1.9 2.0 1.0
Hair/balding pattern: Pattern 3 0.3 0.5 1.7 0.4 -0.5 0.4 0.3 0.1 -1.3 -1.1 -0.3 -0.3 -0.3 -1.3 0.1 0.7 -0.5 -0.6 -0.4 0.1 -1.0 -0.4 -0.5 -0.7 -0.7 -1.2
Number of live births 1.1 1.6 8.9 -0.2 -1.4 0.7 -0.8 0.0 0.1 -0.9 -1.3 -1.6 -1.1 -0.4 -0.3 -0.8 -1.1 -0.8 -1.9 -0.8 -0.8 -2.1 -2.1 -1.1 -1.1 -3.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 3.1 0.3 1.0 -1.2 0.9 0.7 0.8 1.2 1.6 1.3 1.2 1.8 1.4 1.7 1.5 1.4 0.9 0.7 1.3 0.7 0.9 -0.6 1.1 0.5
Pulse rate 0.3 0.5 4.7 0.5 0.5 -0.4 0.9 0.5 -0.8 -0.0 0.7 0.3 0.2 0.3 0.5 2.2 0.2 1.0 0.8 0.1 -0.2 0.1 -0.0 0.4 0.2 1.2
Happiness 0.3 0.4 2.8 -0.2 -0.4 0.4 0.7 0.2 0.4 0.9 0.5 -0.2 -0.4 1.2 0.9 1.7 -0.1 -0.2 0.2 0.7 0.5 0.6 0.3 0.8 0.1 -0.0
Noisy workplace 2.3 2.8 6.6 0.1 1.8 -0.6 0.9 0.0 2.4 2.0 1.5 1.6 0.6 1.7 1.9 2.0 1.5 0.7 1.4 1.9 2.4 2.6 2.4 1.6 1.5 1.8
Qualifications: A levels/AS levels or equivalent 1.0 2.1 9.0 0.3 -0.7 0.3 -1.0 1.4 -1.2 -0.5 -1.6 -1.4 -0.1 -1.2 -2.6 -3.0 -1.1 -0.4 -1.4 -2.2 -1.4 -2.0 -1.6 -1.1 -1.1 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.6 0.3 -0.0 -0.3 0.3 0.7 -0.9 -0.4 -1.1 -0.3 -0.1 1.2 -0.9 0.2 -0.1 -0.3 0.2 -1.0 -0.3 -1.2 -0.2 0.2 0.3 0.2
Mouth/teeth dental problems: Dentures 0.5 0.8 2.6 -1.6 -0.9 0.9 0.3 -1.6 -0.8 -1.2 -1.2 -0.7 -0.7 -0.4 0.7 1.3 -0.3 -1.2 -0.6 0.4 -1.0 0.4 -0.2 -0.3 -1.4 0.1
Asthma 0.6 1.2 6.9 1.2 1.1 -1.0 1.4 1.1 -0.6 0.3 0.7 1.2 0.5 0.7 0.6 2.6 1.4 1.3 1.5 -0.1 0.4 0.5 1.1 0.3 0.7 1.8
Medication: Ibuprofen (e.g. Nurofen) 2.3 3.0 5.5 1.8 1.8 -1.8 1.7 1.1 1.0 1.9 2.0 2.0 1.5 1.6 1.5 2.0 1.5 1.3 1.8 1.2 2.3 1.7 2.0 1.5 1.9 1.9
Medication: Cholesterol lowering 0.6 0.9 3.5 1.4 0.7 -0.8 1.3 1.4 -0.5 0.7 0.8 1.1 0.5 1.0 0.7 1.9 0.9 0.9 1.3 0.7 0.6 0.3 0.8 0.4 0.8 0.5
Depression (self-reported) 0.4 0.5 2.1 0.1 0.8 0.1 -0.1 -0.8 0.9 -0.1 0.9 1.0 -0.1 -0.5 1.3 -0.0 0.2 1.2 1.4 0.4 0.2 0.8 0.4 1.3 0.3 0.2
Medication: Lansoprazole 0.5 0.6 3.6 0.2 0.3 0.0 1.5 -0.3 0.7 0.7 0.3 0.7 -0.1 -0.0 0.5 1.9 0.8 0.5 0.5 1.2 0.3 0.8 0.6 -0.6 -0.3 1.2
Prospective memory result 2.1 2.6 6.7 -2.6 -1.6 1.7 -1.4 -1.3 -1.9 -1.7 -1.9 -1.6 -2.0 -2.0 -1.0 -0.1 -1.3 -2.2 -1.3 -0.9 -1.9 -0.4 -0.8 -1.7 -1.9 -1.7
Lung cancer (father) 2.0 2.4 6.4 0.9 1.4 -1.6 1.7 1.5 0.1 1.6 1.9 1.5 1.6 0.3 2.5 2.1 1.8 0.6 1.7 1.8 1.4 1.5 1.5 1.0 1.9 1.1
Illnesses of mother 2.0 2.4 8.4 -1.1 -0.3 0.7 -0.8 -1.1 -2.2 -1.4 -2.0 -1.5 -0.9 -1.4 -2.9 -2.1 -1.2 -0.3 -1.4 -1.9 -2.2 -0.7 -1.3 -1.8 -2.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 3.1 -0.1 1.0 -1.2 0.9 0.3 0.9 0.8 1.6 1.4 1.3 0.9 1.3 1.8 1.3 1.4 0.8 0.7 1.2 0.5 0.8 0.1 1.2 0.7
Pulse wave Arterial Stiffness index 0.8 1.0 3.9 1.1 -0.1 0.0 -0.0 -0.3 -0.9 -0.7 -0.7 -0.5 -0.2 -1.4 -1.6 -1.7 -0.2 1.1 -0.2 -2.0 -1.1 -1.5 -0.9 -1.1 -0.7 0.4
Impedance of arm (left) 1.7 7.8 14.7 -2.5 -2.6 3.8 -3.4 -3.0 0.1 -1.8 -2.8 -2.6 -3.3 -2.1 -3.8 -2.7 -3.5 -2.0 -3.3 -1.1 -2.6 -1.6 -3.3 -3.0 -3.6 -2.6
Arm fat mass (right) 0.2 0.8 4.2 -0.6 0.5 -0.7 1.3 -0.2 0.4 -0.3 1.1 0.4 0.7 0.6 2.0 1.8 1.0 -0.1 0.5 1.1 0.5 1.5 1.3 -0.1 0.3 -0.4
Trunk predicted mass 1.1 6.2 12.2 1.6 2.6 -2.8 2.5 2.1 1.3 1.3 3.0 2.7 2.8 1.3 3.2 2.5 3.0 2.1 3.5 0.9 2.4 1.9 2.6 3.0 3.2 2.7
Standing height 0.1 0.9 3.8 0.9 0.9 -0.3 -0.1 0.3 1.2 0.5 1.5 1.2 0.7 -0.0 0.5 0.6 0.4 1.3 1.5 0.2 1.0 0.3 -0.1 1.7 1.2 1.9
Length of working week for main job 1.8 2.0 5.5 1.2 1.7 -2.1 1.7 0.9 1.8 1.4 1.5 1.1 2.3 0.9 0.4 1.3 1.8 2.3 1.6 -0.9 0.7 0.5 1.3 0.8 1.2 0.3
Exposure to tobacco smoke at home 0.7 0.8 3.8 -1.4 -0.8 0.9 -0.2 -1.1 -0.2 -0.7 0.5 0.4 -0.9 -1.4 0.3 1.2 0.1 -1.4 0.4 1.0 -1.0 2.0 0.6 -0.1 -0.5 0.2
Breastfed as a baby 0.7 0.8 3.9 1.7 -0.0 -0.6 0.2 1.4 -1.0 0.2 -0.7 -0.6 0.5 0.3 -1.5 -1.6 -0.3 1.0 0.0 -2.0 -0.1 -1.3 -0.0 0.4 -0.1 -0.1
Tense / ‘highly strung’ 0.3 0.5 3.1 -0.2 -0.2 0.4 0.8 -0.1 -1.8 -1.2 -0.2 -0.3 -0.2 -0.1 -0.2 1.4 -0.4 -0.7 0.6 -0.5 -1.4 -0.5 -0.3 -0.0 -0.7 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.5 -0.0 0.4 0.4 0.9 0.1 1.2 0.8 0.6 0.8 -0.6 -0.4 0.2 0.3 0.1 0.7 1.0 0.6 1.0 0.4 0.2 0.6 0.7 0.7
Hair/balding pattern: Pattern 4 0.6 1.4 5.5 -0.4 0.9 -0.8 0.2 0.2 1.5 1.1 1.1 1.0 0.5 1.0 2.4 1.0 1.2 -0.2 0.5 2.1 1.1 2.1 2.2 1.0 0.5 0.5
Birth weight of first child 0.3 0.5 2.8 0.5 0.7 -0.7 0.9 1.1 0.3 0.2 0.3 0.6 1.0 -0.1 0.8 0.9 0.8 -0.3 0.1 0.5 1.1 -0.1 0.9 -1.7 0.5 0.0
Peak expiratory flow (PEF) 1.7 3.9 9.5 0.9 2.0 -2.2 1.9 1.6 0.6 2.0 2.2 2.1 1.6 3.1 2.0 2.5 2.6 2.8 1.7 0.9 2.4 1.8 2.0 0.5 1.9 1.4
Pulse wave reflection index 2.0 2.5 7.7 0.7 -1.0 0.7 -1.1 -0.6 -1.0 -1.0 -1.8 -1.6 -0.9 -0.5 -2.2 -2.7 -0.9 -0.7 -1.4 -2.8 -1.3 -2.8 -1.7 -2.5 -1.1 -1.3
Ever highly irritable/argumentative for 2 days 2.8 3.4 10.8 0.3 2.2 -2.2 2.2 1.8 1.6 1.6 1.9 1.7 2.6 3.3 1.4 1.9 1.8 1.9 2.0 1.0 1.9 0.9 2.0 1.2 1.6 -0.2
Loud music exposure frequency 0.5 0.6 5.7 -0.1 0.0 0.1 1.2 -0.9 0.3 0.1 0.7 0.4 0.1 0.3 1.3 2.4 0.4 0.7 0.7 0.2 -0.2 0.5 -0.3 0.8 0.1 0.7
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 3.8 1.2 0.5 -1.0 1.4 1.9 0.0 1.3 0.2 0.2 1.2 1.2 -1.1 0.1 0.7 0.4 -0.1 -0.4 0.8 -0.4 0.1 -0.4 0.8 0.6
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 3.3 0.1 1.0 -0.2 0.5 -0.5 1.2 1.1 1.2 0.9 0.4 1.3 1.2 0.8 0.6 1.7 0.5 1.5 1.1 0.8 0.1 -1.8 -0.0 -0.9
Blood clot in the leg (DVT) 0.2 0.2 2.2 -0.9 -0.1 -0.1 -0.3 0.5 0.5 -1.5 0.1 0.4 -0.0 -0.6 -0.4 -0.6 0.2 0.1 0.0 -0.1 -0.3 -0.4 0.1 -0.4 -0.0 0.2
Medication: Paracetamol 2.2 3.7 9.5 -0.1 1.4 -1.8 1.7 1.6 1.3 1.8 2.0 1.9 1.3 2.1 2.8 2.0 1.8 1.2 1.9 2.0 2.2 2.1 2.5 3.1 1.9 1.7
Headache pain in last month 1.3 2.3 9.1 -1.2 1.6 -0.7 1.3 1.4 1.9 1.0 1.6 2.1 -0.0 0.4 1.4 1.8 1.5 1.2 1.9 1.6 0.9 3.0 2.0 1.5 0.9 1.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.9 -0.1 -0.7 0.4 -1.2 -0.4 -0.1 -0.7 -1.0 -1.2 -0.3 -0.4 -1.0 -1.7 -0.9 -0.5 -1.6 -1.4 -0.4 -1.6 -1.4 -0.9 -0.3 -0.3
Glaucoma (self-reported) 0.4 0.5 2.0 -0.3 -0.6 0.0 -0.0 -0.0 -0.8 0.2 -1.1 -0.7 0.0 -0.3 -0.3 0.5 -0.0 -0.9 -0.8 -0.4 -1.3 0.1 0.6 -1.2 -1.4 -0.6
Gout (self-reported) 0.1 0.2 0.7 0.7 -0.2 0.1 -0.1 0.6 -0.2 0.5 -0.0 0.1 0.3 -0.1 -0.8 -0.6 0.0 0.3 0.2 -0.6 -0.0 -0.6 -0.4 -0.1 -0.1 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.5 -0.0 0.2 0.2 0.1 -0.7 -0.4 -0.7 -0.3 -0.5 -0.8 -0.8 -0.1 0.3 -0.5 -0.7 -0.6 0.3 0.2 -0.6 -0.3 -1.2 -0.3 -0.6
Medication: Amlodipine 0.3 0.5 1.6 -0.8 -0.3 0.3 -0.1 -1.3 -0.6 -1.0 0.6 0.7 -0.5 -0.6 1.2 0.3 0.2 -0.2 0.5 1.3 0.2 0.9 0.5 0.8 0.2 0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.8 0.8 0.3 -0.1 0.2 -0.2 0.7 -0.5 -0.3 0.2 -0.5 1.0 -0.5 0.7 0.3 0.7 0.4 -1.3 -0.6 -0.4 0.1 -0.1 -0.3 1.3
Birth weight 0.2 0.3 2.5 0.2 -0.6 0.1 0.0 1.6 -1.5 0.0 -0.1 -0.3 -0.5 0.2 -0.3 0.7 -0.2 -0.2 -0.1 -0.8 0.0 -0.7 -0.3 0.3 0.2 0.8
Chronic bronchitis/emphysema (mother) 0.3 0.3 2.2 -0.1 -0.4 0.0 0.5 -0.1 1.0 0.1 0.1 -0.6 0.0 1.5 0.6 0.5 -0.4 -0.2 -0.7 0.2 0.0 0.2 0.1 0.2 -0.3 -1.4
High blood pressure (siblings) 0.8 1.2 5.6 -0.8 0.2 0.2 0.6 -1.4 0.2 0.3 1.6 0.7 -0.1 0.4 2.0 1.9 0.6 -0.6 0.7 2.4 0.7 2.0 1.4 0.7 0.4 0.0
Forced vital capacity (FVC), Best measure 0.3 1.1 2.6 0.0 1.2 -0.7 0.5 0.1 1.2 1.0 1.4 1.5 0.8 0.6 1.0 1.6 1.1 1.2 1.2 0.6 1.4 0.7 0.8 -0.1 1.4 1.5
Body fat percentage 0.2 0.7 2.6 -1.2 -0.2 0.4 0.5 -0.9 0.3 -0.6 0.3 -0.3 -0.1 0.3 1.1 1.3 -0.1 -0.9 -0.6 1.3 -0.1 1.4 0.6 -1.3 -1.0 -1.6
Leg fat percentage (right) 0.2 0.6 2.5 -0.7 0.0 -0.2 0.8 0.2 -0.2 -0.8 0.1 -0.4 0.2 0.2 1.2 1.5 0.3 -0.8 -0.5 0.6 -0.4 1.0 0.9 -1.1 -0.9 -1.6
Arm fat-free mass (right) 1.7 8.6 16.2 1.7 3.1 -3.1 3.2 2.1 2.0 2.1 3.6 3.2 3.0 2.0 4.0 3.2 3.3 2.4 3.6 1.9 3.1 2.9 3.3 3.2 3.4 2.6
Exposure to tobacco smoke outside home 1.3 1.7 7.3 -0.6 0.4 -0.6 1.6 -0.6 -0.2 0.4 1.2 1.4 0.6 1.2 2.1 2.7 1.2 0.3 1.6 1.9 0.7 2.1 1.9 0.3 0.8 0.8
Comparative body size at age 10 2.4 6.7 15.1 -0.2 2.5 -1.7 1.9 0.9 3.4 3.1 3.4 2.4 1.4 3.5 3.6 1.8 2.0 1.9 1.8 3.8 3.9 3.2 2.4 2.9 2.8 0.1
Number of full brothers 1.4 1.7 6.0 0.3 0.7 -1.8 1.2 1.4 0.2 1.2 1.5 1.2 1.2 -0.2 1.9 0.1 1.7 1.4 1.3 0.5 1.3 0.8 1.3 2.4 2.0 1.2
Worry too long after embarrassment 0.3 0.5 1.3 -1.1 -0.6 0.9 -0.1 -1.1 0.8 -0.9 0.2 -0.1 -0.2 0.5 0.2 0.8 -0.5 -0.2 -0.1 0.3 -0.6 0.9 0.5 1.0 -1.1 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 3.1 -1.8 -0.3 0.9 0.4 -1.3 1.1 -0.6 0.4 -0.4 -0.9 -1.2 0.6 -0.4 -0.5 0.1 -0.4 0.2 0.0 0.6 0.1 1.0 -0.8 -0.7
Wheeze or whistling in the chest in last year 0.4 0.6 3.4 -1.0 0.2 0.3 0.3 -0.8 0.2 -0.1 0.2 0.4 -1.0 1.0 0.7 1.9 0.1 -0.2 0.6 0.7 -0.3 1.6 1.4 0.3 -0.9 0.1
Number of children fathered 0.3 0.4 1.1 -0.6 -0.0 0.6 -1.0 -0.6 -0.6 -0.5 0.1 -0.3 -0.7 -0.1 -0.1 -0.6 -0.6 -0.8 -1.1 0.3 0.8 -0.9 -0.3 0.2 0.2 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 6.7 0.7 0.4 -0.1 0.6 -0.2 -1.1 -0.4 -0.7 -0.4 -0.1 -2.6 -1.4 -0.1 0.1 0.5 0.1 -1.1 -1.5 -0.7 -0.5 -1.8 -1.2 -0.6
Age at first live birth 1.1 2.0 9.4 -0.0 -1.0 0.9 -2.0 -0.4 -1.5 -1.6 -1.4 -0.9 -0.5 -0.8 -2.4 -3.1 -1.1 -0.0 -0.9 -1.9 -1.7 -1.5 -1.6 -0.6 -1.2 -1.0
Pulse wave peak to peak time 1.0 1.1 4.4 -1.1 0.2 -0.2 0.2 0.4 1.1 0.7 0.9 0.7 0.5 1.4 1.8 1.8 0.4 -0.9 0.4 2.1 1.2 1.6 1.1 1.2 0.9 -0.1
Health satisfaction 3.3 4.2 8.1 1.8 2.2 -2.0 2.6 2.1 1.4 2.0 2.4 2.1 1.9 0.8 1.9 2.8 2.3 2.7 2.8 0.8 1.6 2.1 2.3 2.0 1.7 1.3
Shortness of breath walking on level ground 0.7 0.8 2.7 0.8 0.7 -0.4 0.6 -0.2 -0.5 -0.2 0.5 1.0 0.1 -0.1 0.7 1.4 1.0 1.3 1.6 -0.3 -0.1 1.2 1.5 1.6 0.1 1.4
Qualifications: College or University degree 0.4 1.1 4.8 2.2 0.5 -1.5 0.5 1.6 0.1 0.8 0.2 0.5 1.7 -0.4 -1.0 -1.2 0.7 1.7 0.7 -1.5 0.1 -1.4 -0.1 0.4 1.0 0.2
Eye problems/disorders: None of the above 0.5 0.5 2.8 -1.0 0.2 0.2 0.3 -0.3 0.4 0.9 0.6 0.3 -0.3 -0.8 1.0 0.7 -0.2 0.8 0.2 0.9 1.0 1.1 -0.2 1.7 0.6 0.4
Mouth/teeth dental problems: Loose teeth 1.4 1.7 5.3 2.3 0.8 -1.2 1.8 1.4 1.6 2.2 0.3 1.0 1.2 0.7 0.4 1.2 1.4 1.1 1.1 0.5 1.4 0.8 1.2 0.8 1.2 2.0
Emphysema/chronic bronchitis 2.7 3.0 7.2 -1.1 -1.7 1.7 -2.3 -1.2 -0.8 -1.7 -2.3 -1.7 -2.0 -0.9 -2.3 -1.9 -1.7 -1.6 -1.1 -2.7 -1.9 -1.6 -1.7 -1.6 -1.7 -1.3
Medication for pain relief, constipation, heartburn 0.9 1.5 4.2 -0.1 -1.0 1.1 -0.9 -1.7 -0.2 -1.1 -1.2 -1.5 -0.7 -1.2 -1.0 -1.1 -1.3 -1.3 -1.5 -1.0 -1.5 -1.8 -2.1 -1.4 -0.8 -1.2
Neck or shoulder pain in last month 1.3 1.9 6.8 0.7 1.7 -1.4 1.1 1.3 1.6 0.7 1.5 1.8 1.5 2.6 0.9 0.7 1.3 1.4 2.0 0.8 0.8 1.6 1.9 0.8 0.9 0.5
Medication: Blood pressure 0.3 0.6 2.6 -1.1 -0.6 0.7 0.1 -1.6 -0.8 -0.7 0.2 0.1 -0.6 -0.1 0.8 1.1 -0.1 -0.8 0.5 1.0 -0.8 0.9 0.3 -0.1 -0.7 -1.0
Angina (self-reported) 0.2 0.2 0.8 0.8 0.3 -0.1 -0.0 0.3 -0.7 -0.2 -0.1 0.0 -0.5 0.7 -0.7 -0.9 0.3 0.4 0.4 -0.7 0.2 -0.0 0.3 0.3 -0.1 0.7
Migraine (self-reported) 0.2 0.3 1.2 -0.3 0.6 -0.0 0.4 0.4 0.0 0.1 0.2 0.4 -0.2 0.8 0.1 0.4 0.5 -0.3 0.6 0.4 0.5 0.7 0.9 0.6 0.2 1.1
Medication: Ibuprofen 0.8 0.9 2.1 0.9 0.8 -1.0 0.9 0.4 0.4 1.0 1.0 1.1 0.8 0.3 0.7 1.4 0.9 0.7 1.1 0.3 1.4 1.1 1.4 0.6 1.0 1.4
Medication: Allopurinol 0.2 0.3 1.2 0.7 -0.2 0.5 -0.5 0.7 -0.0 -0.1 -0.5 -0.1 -0.2 0.6 -0.9 -0.1 -0.5 0.2 0.4 -0.9 -0.1 -0.7 -0.6 0.3 -0.1 1.1
Medication: Omeprazole 0.2 0.2 1.2 0.9 0.3 -0.4 0.3 0.9 0.7 0.1 -0.1 0.0 0.8 1.1 -0.7 0.2 -0.1 -0.3 0.2 -0.6 -0.2 -0.3 -0.0 -0.4 -0.1 0.2
Medication: Seretide 50 evohaler 1.1 1.2 3.4 -1.1 -1.1 1.6 -0.9 -1.3 -0.3 -1.1 -1.5 -1.1 -1.8 -0.1 -1.0 -0.1 -1.1 -0.7 -1.0 -1.0 -1.1 -0.9 -1.1 -1.2 -1.5 -0.6
Mean time to correctly identify matches 8.9 17.0 25.7 -3.3 -4.8 5.1 -4.9 -5.0 -3.3 -4.0 -4.3 -4.5 -4.8 -3.9 -3.9 -4.5 -4.8 -3.3 -4.1 -2.8 -4.2 -2.7 -4.8 -2.2 -4.7 -3.2
Heart disease (mother) 0.4 0.5 2.6 0.6 0.0 -0.2 -0.3 -0.3 -1.4 -0.3 1.0 0.8 0.1 0.3 1.6 0.8 0.5 0.0 1.1 0.7 -0.1 0.7 0.6 1.0 0.6 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 1.2 -0.4 0.1 -0.4 0.3 0.1 1.1 -0.3 0.4 -0.3 0.6 0.9 0.2 -0.5 0.2 0.1 0.0 -0.2 -0.0 0.1 0.5 0.7 -0.1 -0.2
Whole body fat mass 0.2 0.8 3.8 -0.8 0.4 -0.4 0.9 -0.2 0.4 -0.3 1.0 0.3 0.5 0.7 1.9 1.8 0.7 -0.4 0.3 1.4 0.4 1.6 1.1 -0.2 -0.0 -0.8
Leg fat mass (right) 0.3 1.0 5.0 -0.3 0.7 -0.9 1.4 0.5 0.3 -0.2 1.1 0.4 0.9 0.8 2.2 2.2 1.1 -0.2 0.6 1.1 0.5 1.5 1.5 0.2 0.3 -0.5
Arm predicted mass (right) 1.7 8.7 15.9 1.7 3.0 -3.0 3.2 2.0 1.8 2.0 3.6 3.2 3.0 2.1 4.0 3.2 3.3 2.3 3.6 2.0 3.2 2.9 3.3 3.3 3.5 2.7
Pulse rate, automated reading 0.2 0.7 5.3 -0.2 -0.2 -0.1 1.2 1.2 -2.3 0.0 -0.3 -0.3 -0.0 0.1 0.2 1.7 -0.1 0.3 0.3 -0.4 -1.5 0.3 -0.5 -0.5 -0.9 -0.2
Alcohol intake frequency. 0.4 1.0 5.5 -2.2 0.2 0.5 0.6 -0.3 -0.1 0.3 0.2 0.2 -0.9 1.1 1.3 1.8 0.1 -0.1 0.7 0.9 0.7 2.4 1.3 1.2 -0.2 0.2
Comparative height size at age 10 0.1 0.4 2.8 -0.3 -0.2 0.4 -0.5 -1.0 0.7 -0.0 0.5 0.5 0.1 1.7 0.5 0.5 -0.1 -0.2 0.2 0.9 0.6 1.1 0.3 -0.1 0.2 0.6
Number of full sisters 1.2 1.5 3.5 -0.8 1.8 -1.5 0.8 1.3 1.6 0.9 1.2 1.2 1.3 1.9 0.8 -0.3 1.6 0.5 0.8 1.2 1.8 0.6 1.8 0.1 1.3 -0.9
Suffer from ‘nerves’ 1.9 3.0 7.2 -2.2 -2.0 2.4 -0.6 -2.3 -2.4 -2.1 -1.4 -1.6 -2.3 -1.7 -1.5 0.7 -2.2 -1.5 -1.2 -0.2 -2.2 0.2 -1.1 -1.4 -2.7 -0.3
Overall health rating 1.2 2.5 12.0 -1.3 1.0 -0.5 1.8 0.2 -0.4 0.6 1.7 1.5 -0.0 1.4 2.1 2.7 1.4 0.9 2.0 1.5 0.3 3.5 2.5 1.6 0.0 1.4
Chest pain or discomfort 0.4 0.6 2.9 -0.1 0.5 -0.8 1.7 0.8 -0.7 -0.2 0.2 0.6 -0.2 1.1 -0.1 1.3 1.0 -0.0 1.1 -0.4 0.3 0.7 1.3 0.8 0.3 1.1
Had major operations 1.3 1.5 3.7 0.3 1.1 -1.0 1.0 1.4 1.9 0.9 1.3 1.6 1.2 1.1 0.8 -0.0 1.5 1.6 1.4 0.5 0.8 1.9 1.8 1.6 0.5 0.6
Age at last live birth 1.7 2.4 6.4 0.4 -1.5 0.8 -1.5 -0.1 -2.0 -1.8 -1.7 -1.4 -0.7 -0.2 -2.1 -2.5 -1.5 -0.4 -1.4 -2.1 -2.2 -2.4 -2.1 -1.1 -1.2 -1.1
Family relationship satisfaction 0.2 0.3 1.3 1.0 0.3 -0.2 0.5 1.2 0.6 0.7 0.1 0.2 0.1 0.1 -0.0 -0.2 0.5 0.7 1.1 -0.6 -0.0 0.3 0.9 -0.1 -0.1 0.3
Leg pain on walking 1.0 1.3 4.1 0.9 -0.0 -1.1 0.8 1.4 1.0 0.5 0.8 0.5 1.2 2.0 1.4 1.7 1.6 0.6 1.2 -0.5 -0.0 1.4 1.9 1.3 0.1 1.0
Qualifications: NVQ or HND or HNC or equivalent 6.0 7.2 10.8 2.9 2.7 -2.7 3.3 2.9 1.6 2.9 2.7 2.9 2.7 2.2 2.6 3.0 3.1 2.5 2.8 2.1 3.0 2.2 3.3 1.7 2.8 2.1
Commuting to job workplace: Car/motor vehicle 1.6 1.8 5.4 2.3 1.6 -1.4 1.4 1.6 0.9 1.4 1.1 1.6 1.7 0.3 1.1 0.9 1.5 1.6 2.1 0.2 0.9 0.4 0.9 0.2 1.6 1.8
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.7 0.7 -0.7 0.1 -0.5 1.4 -0.8 0.3 -0.9 -0.8 -0.0 -1.3 -1.1 -0.8 -0.1 -0.4 -0.9 -1.6 -1.1 -1.2 -1.0 -1.0 -0.8 -0.1
Medication: Aspirin 0.5 0.7 4.7 -0.7 -1.1 0.4 -1.0 0.3 -2.2 -0.9 -0.8 -0.5 -0.7 1.2 -0.9 -0.9 -0.3 -0.1 -0.2 -0.9 -0.4 -0.1 -0.1 -0.5 -0.7 -0.5
Supplements: Vitamin C 1.4 1.6 7.1 -1.3 -0.9 0.7 -1.2 -0.5 -2.7 -1.5 -0.8 -1.0 -1.1 -1.6 -0.8 -1.5 -0.8 -1.1 -0.4 -0.7 -1.6 -0.7 -0.7 -1.1 -1.5 -2.3
Knee pain experienced in last month 0.3 0.5 1.7 -1.2 0.1 -0.4 -0.6 1.2 0.9 -0.3 0.3 0.0 1.1 0.2 1.0 0.1 0.6 -0.6 0.4 -0.3 -0.0 0.8 1.3 0.7 0.0 0.5
Hypertension (Self-reported) 0.7 1.9 8.0 -1.9 -1.5 1.5 -1.3 -0.9 -2.8 -1.2 -1.0 -1.2 -1.8 -0.7 0.5 -0.5 -0.7 -1.6 -0.4 0.2 -2.4 0.6 -0.5 -1.2 -2.0 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.2 -0.4 -1.8 1.4 -0.9 -0.8 0.1 -0.6 -1.3 -1.3 -1.5 0.7 0.0 0.4 -1.3 -1.6 -1.6 -0.1 -0.9 0.0 -0.9 -1.6 -1.6 -1.1
Illnesses of father: Heart disease 3.8 5.2 12.7 0.6 2.3 -1.6 2.2 1.1 0.6 2.8 3.2 2.5 1.3 1.6 2.2 2.5 2.2 1.2 2.9 3.5 2.4 3.6 3.3 2.2 1.7 1.8
Illnesses of siblings: Diabetes 0.8 1.0 3.7 -1.8 -1.1 0.9 -0.3 -0.4 -1.7 -0.4 -0.6 -1.4 -1.3 -0.4 0.4 0.3 -1.1 -0.9 -1.3 0.4 -0.4 -0.4 -1.4 -0.5 -0.8 -1.9
Smoking status: Previous 1.3 1.9 8.2 1.6 1.7 -2.6 1.3 2.5 -1.0 1.2 1.1 0.5 2.9 1.5 0.5 -0.9 1.6 1.0 0.5 -0.3 0.8 -0.8 0.9 -0.1 1.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.6 0.3 0.9 -0.6 0.6 0.4 1.6 0.6 1.2 1.2 0.6 0.3 1.3 1.4 0.7 0.9 0.9 1.0 1.0 1.2 0.9 1.4 1.1 1.1
Whole body fat-free mass 1.2 6.7 12.5 1.6 2.6 -2.9 2.7 2.0 1.4 1.4 3.2 2.7 3.0 1.7 3.5 2.8 3.0 2.2 3.4 1.2 2.6 2.1 2.7 3.0 3.3 2.5
Leg fat-free mass (right) 1.0 5.4 11.8 0.9 2.2 -2.5 2.6 1.5 1.3 1.4 3.2 2.3 2.7 1.9 3.4 2.7 2.6 1.8 2.8 1.6 2.5 2.1 2.4 2.6 3.0 1.7
Arm fat percentage (left) 0.2 0.8 2.3 -1.5 -0.1 0.2 0.6 -0.8 0.7 -0.7 0.4 -0.3 -0.0 0.1 1.2 1.2 0.1 -0.9 -0.6 1.4 0.0 1.5 0.9 -1.1 -0.7 -1.5
Average weekly red wine intake 0.3 0.4 3.8 0.2 -0.6 0.4 -0.9 -0.1 -0.4 -0.3 -0.2 -0.3 0.4 -1.4 -0.6 -1.9 -0.3 0.1 -0.8 -0.0 -0.5 -0.6 -0.7 -0.3 -0.4 0.0
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.4 -0.3 -1.5 1.1 -1.3 -0.5 -0.2 -0.6 -1.2 -1.0 -1.0 0.0 -1.2 -1.9 -1.4 -1.3 -0.9 -0.7 0.0 -1.6 -1.2 0.4 0.3 -0.2
Mood swings 0.4 0.7 4.1 -1.2 0.2 0.0 1.2 -0.3 0.5 0.1 0.8 0.6 0.3 -0.1 0.6 2.0 0.2 1.1 0.5 0.4 0.6 1.5 1.2 1.1 -0.2 0.9
Loneliness, isolation 2.7 3.7 8.6 -0.3 1.6 -1.1 2.2 0.5 1.7 1.4 2.3 2.1 0.8 1.6 2.9 2.9 1.8 1.2 2.3 2.5 1.5 2.9 2.5 1.6 1.2 2.2
Long-standing illness, disability or infirmity 3.3 5.1 11.2 1.3 3.0 -2.9 3.3 1.2 -0.2 1.4 2.6 2.8 2.2 1.8 2.1 2.5 3.0 2.4 3.3 0.6 0.6 2.7 3.0 2.1 1.3 0.9
Ever had bowel cancer screening 0.8 0.9 4.4 -0.0 -0.6 0.4 -0.8 0.1 -2.1 -0.4 -0.7 -1.0 -0.2 -1.9 -1.3 -1.6 -0.5 -0.8 -0.9 -0.8 -1.2 -1.1 -0.7 -0.1 -1.0 0.4
Diabetes diagnosed by doctor 1.1 1.9 4.5 -0.4 1.5 -1.5 1.9 0.7 0.1 0.3 1.2 1.3 1.4 2.0 2.0 2.1 1.3 0.9 1.6 1.4 0.6 1.8 1.8 1.4 0.9 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.9 -1.3 -0.8 0.8 0.6 -1.2 -0.6 -0.4 -0.3 -0.4 -0.7 -1.0 0.4 1.4 -0.6 -0.5 -0.5 0.7 -0.2 -0.0 -0.4 0.0 -0.7 -1.3
Friendships satisfaction 0.2 0.3 1.7 1.3 -0.4 0.3 0.3 0.6 0.3 0.7 -0.3 -0.4 -0.7 -0.7 0.2 0.2 -0.1 0.0 0.4 -0.8 -0.2 -0.6 -0.4 0.1 -0.1 0.5
Qualifications: nursing, teaching 0.3 0.5 3.8 0.5 0.1 -0.2 -0.5 0.4 -0.0 -0.2 -0.6 -0.1 0.3 -1.5 -1.4 -1.9 -0.0 0.6 0.1 -1.1 -0.5 -0.6 -0.3 0.2 -0.2 -0.3
Commuting to job workplace: Walk 0.3 0.4 1.7 -0.6 -0.5 -0.3 0.0 0.4 -0.2 0.0 -0.4 -0.6 -0.4 -0.4 -0.9 -1.3 -0.2 -1.0 -0.5 -0.2 -0.9 -0.0 0.0 -0.7 -0.6 -1.1
Eye problems/disorders: Cataract 2.7 3.1 7.8 -0.2 -2.1 1.3 -1.8 -0.1 -1.0 -1.7 -1.9 -2.2 -1.3 -0.1 -2.6 -2.0 -1.8 -1.8 -1.9 -2.1 -1.6 -2.8 -1.8 -1.8 -1.5 -1.9
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.2 0.6 1.8 -1.6 1.4 1.5 0.4 0.4 1.5 1.3 1.7 1.7 0.8 0.7 1.3 1.2 1.5 0.2 1.6 0.6 1.4 1.7 1.2 1.1
Medication for cholesterol 0.4 0.6 2.5 -0.1 -0.5 0.8 0.4 -1.3 0.2 0.5 -0.0 -0.3 -0.5 0.4 1.2 1.6 -0.8 -1.3 -0.4 1.3 0.8 0.7 -0.1 0.5 0.5 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.7 -0.9 0.3 0.2 -0.7 -0.2 1.2 -0.3 0.3 0.3 -0.6 -1.1 0.3 -0.8 0.0 -0.4 -0.5 1.3 0.8 0.4 0.4 0.3 -0.1 -0.7
Back pain experienced in last month 0.6 0.8 3.0 -0.7 0.7 -0.9 0.9 0.9 1.2 0.5 1.1 0.6 0.7 1.0 1.0 1.2 0.7 0.1 0.5 1.0 1.2 0.9 1.7 1.0 0.4 0.2
Mineral and other dietary supplements 2.2 3.0 13.0 0.1 0.7 -0.5 1.5 -0.3 1.0 2.0 1.4 1.6 0.3 0.8 2.5 3.6 1.4 0.4 1.1 2.6 1.9 2.9 1.9 1.5 1.4 2.6
Breast cancer (self-reported) 0.9 1.1 3.5 0.0 0.7 -1.3 0.5 0.6 1.0 1.4 1.6 0.7 1.4 0.5 1.9 0.7 0.9 0.8 0.5 1.6 0.8 1.2 1.0 1.7 0.2 -0.1
Asthma (self-reported) 0.9 1.7 9.0 1.2 1.4 -1.1 1.7 1.1 -0.8 0.5 0.9 1.4 0.6 1.0 0.9 3.0 1.6 1.3 1.7 0.1 0.6 0.8 1.4 0.4 0.9 2.1
Osteoporosis (self-reported) 1.8 2.2 7.1 -0.4 -1.1 1.2 -0.2 -0.3 -0.5 -0.9 -2.2 -1.7 -1.2 -1.2 -2.6 0.2 -1.3 -1.8 -1.2 -2.0 -1.8 -1.5 -1.1 -2.7 -2.2 -0.9
Osteoarthritis (self-reported) 1.9 2.4 8.6 0.5 2.1 -1.8 1.5 0.7 0.6 0.4 1.8 2.0 2.0 2.9 1.2 1.0 1.9 1.7 1.5 0.7 1.6 1.0 2.0 1.5 1.1 1.4
Medication: Aspirin 0.4 0.6 5.7 -0.7 -1.0 0.2 -0.5 0.1 -2.4 -0.8 -0.6 -0.5 -0.8 1.2 -0.6 -0.2 -0.1 0.0 -0.1 -0.7 -0.3 0.1 0.1 -0.5 -0.7 -0.5
Medication: Gliclazide 2.0 2.2 5.4 2.2 1.6 -2.1 1.6 1.7 0.3 0.3 1.3 1.7 1.7 0.9 1.2 1.3 1.4 1.7 2.0 -0.2 0.4 0.7 1.2 2.3 1.7 1.8
Illnesses of father: None of the above (group 1) 0.9 1.2 4.3 2.1 0.4 -0.8 -0.4 -0.1 -0.0 -0.3 -0.2 0.1 1.3 -1.8 -0.8 -1.5 0.1 1.4 -0.2 -2.0 -0.6 -2.0 -1.6 -0.2 0.6 0.2
Smoking status: Current 4.3 6.9 16.3 0.8 1.7 -1.3 2.5 -0.2 1.6 2.9 3.2 2.7 1.2 1.8 3.7 3.8 2.0 1.6 2.0 3.9 2.9 4.0 3.1 3.3 2.1 3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 3.1 -1.5 -0.5 0.4 -0.8 -0.2 -0.3 -1.0 -0.5 -0.2 -0.5 1.0 -0.3 0.0 -0.3 -0.2 -1.0 -0.3 -0.0 -0.9 -0.6 -1.8 -0.4 -1.2
Whole body water mass 1.2 7.0 12.7 1.5 2.6 -2.9 2.8 2.0 1.4 1.5 3.3 2.8 3.0 1.8 3.6 2.9 3.1 2.2 3.4 1.3 2.6 2.2 2.8 3.0 3.3 2.6
Leg predicted mass (right) 1.0 5.5 11.5 1.0 2.2 -2.5 2.6 1.5 1.2 1.4 3.2 2.3 2.7 1.9 3.4 2.7 2.6 1.9 2.9 1.6 2.5 2.2 2.5 2.6 3.0 1.8
Arm fat mass (left) 0.2 0.9 4.4 -0.8 0.6 -0.7 1.3 -0.2 0.6 -0.3 1.0 0.5 0.7 0.6 2.1 1.9 1.0 -0.1 0.5 1.2 0.6 1.7 1.4 -0.1 0.3 -0.4
Number of self-reported non-cancer illnesses 0.2 0.3 1.1 -0.3 -0.1 0.3 -0.8 -0.1 -1.0 -0.9 -0.3 -0.0 -0.8 0.4 -0.5 -0.9 -0.0 -0.1 0.4 -0.7 -0.6 -0.2 -0.1 -0.3 -0.7 -0.2
Average weekly champagne plus white wine intake 0.5 0.7 4.2 0.5 -0.9 0.2 -1.3 0.7 -0.6 -0.5 -0.4 -0.6 0.2 0.8 -1.0 -2.0 -1.0 0.1 -0.5 -1.0 -0.5 -1.3 -1.0 0.0 -0.3 -0.8
Miserableness 1.6 2.7 15.6 -0.7 1.6 -1.3 2.9 0.5 0.5 1.5 2.0 1.6 0.9 0.6 2.0 3.9 1.6 1.5 1.2 1.9 1.6 1.8 1.6 0.8 0.9 0.0
Guilty feelings 0.4 0.5 2.7 -1.3 -0.2 0.1 0.7 -0.1 -0.4 -0.2 0.6 0.2 -0.1 -0.0 0.6 1.6 0.1 0.1 0.3 0.8 -0.6 1.6 1.2 0.4 -1.0 -0.1
Wears glasses or contact lenses 0.8 0.9 4.2 1.4 0.4 -0.9 0.2 2.1 0.2 0.7 -0.2 -0.4 1.0 -0.5 -0.8 -0.3 0.1 -0.2 -0.8 -0.2 -0.2 -1.8 -1.1 -2.0 -0.1 -1.0
Ever taken oral contraceptive pill 4.0 4.4 8.6 2.1 2.8 -2.6 2.1 0.7 1.4 0.9 2.8 2.5 2.9 2.8 2.5 1.1 2.1 2.1 2.7 1.8 2.3 0.7 0.9 1.7 2.9 0.2
Hearing aid user 0.5 0.6 1.9 -0.6 0.0 0.7 -0.5 -1.2 -0.5 -0.9 -0.9 -0.7 -1.1 -0.1 -0.9 -0.7 -0.6 -0.4 -0.5 -0.7 -1.4 -0.4 -0.7 -1.1 -1.0 -0.6
Mother’s age at death 0.4 0.5 2.0 -0.9 0.2 0.9 0.1 -1.3 0.7 -0.0 0.1 0.3 -0.5 -1.0 0.1 0.7 -0.1 -0.9 -0.5 1.4 0.1 0.7 -0.1 -0.8 -0.4 0.8
Financial situation satisfaction 4.1 5.1 10.4 0.9 2.2 -1.9 2.6 2.2 2.5 2.7 2.6 2.1 1.8 2.3 2.6 2.7 2.2 1.6 2.2 2.0 3.0 2.4 3.2 1.5 2.2 1.0
Tinnitus: Yes, now most or all of the time 0.7 0.9 3.6 -0.6 1.3 -0.6 0.0 1.0 1.9 0.6 1.4 0.8 0.7 0.6 0.3 -1.0 0.8 0.4 0.2 1.0 0.9 1.4 1.5 0.5 0.6 0.7
Commuting to job workplace: Public transport 0.8 1.0 2.8 -0.9 -1.5 0.9 -1.2 -1.5 -1.0 -1.7 -0.5 -1.1 -1.3 -0.1 -0.7 -0.3 -1.4 -1.2 -1.0 -0.5 -0.8 -0.7 -0.8 0.2 -0.8 -0.6
Eye problems/disorders: Glaucoma 0.6 0.7 3.9 0.6 -0.6 -0.2 0.4 0.0 -1.3 -0.0 -1.3 -0.5 0.0 0.2 -1.1 0.1 0.1 -0.5 -0.5 -1.2 -1.7 -0.3 0.4 -2.0 -1.2 -0.3
Medication: Blood pressure 0.4 0.7 2.3 0.4 1.0 -1.0 0.0 1.4 -0.9 -0.3 0.3 0.6 0.5 -0.1 -0.4 -0.9 1.2 1.5 1.4 -1.3 -0.9 0.3 0.4 0.5 -0.2 0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.7 -0.9 -0.2 0.4 -0.1 -0.0 1.0 0.0 0.4 0.1 -0.3 1.0 0.3 0.0 0.0 -0.4 -0.5 1.1 0.7 1.0 1.3 -0.7 -0.7 -0.6
Supplements: Fish oil (including cod liver oil) 2.1 2.7 9.6 -0.6 -0.8 1.2 -1.8 -1.3 -1.3 -2.1 -1.2 -1.5 -0.9 -1.4 -2.4 -3.1 -1.9 -0.8 -1.2 -1.8 -1.4 -2.3 -2.0 -0.9 -1.4 -1.8
High cholesterol (Self-reported) 1.0 1.8 6.9 1.2 1.3 -1.3 0.1 2.6 1.3 2.2 1.5 1.5 1.3 0.2 0.4 -0.7 1.5 1.1 1.8 0.6 1.2 1.1 1.5 1.3 1.3 1.2
Medication: Bendroflumethiazide 0.2 0.3 2.4 0.8 -0.4 -0.8 0.1 0.7 -1.6 -0.4 0.1 0.2 0.3 0.3 0.5 -0.4 0.6 -0.5 0.6 -0.2 -0.7 0.3 0.8 0.4 0.3 0.4
Medication: Paracetamol 1.1 1.8 7.4 -1.0 0.7 -1.3 0.9 1.1 0.7 1.0 1.4 1.4 1.0 1.0 1.9 1.0 1.5 1.2 1.6 1.1 1.0 1.7 1.6 2.7 1.1 0.8
Medication: Lisinopril 0.4 0.6 2.2 -0.3 0.1 -0.1 -0.4 -0.4 -1.2 -1.1 -0.1 0.3 -0.2 -0.9 -0.6 -1.2 0.3 -0.0 0.8 -0.6 -1.5 -0.2 -0.1 -1.4 -0.6 -1.3
Medication: Atorvastatin 0.5 0.6 5.2 -0.9 0.8 -0.5 0.1 2.3 1.0 -0.1 -0.4 0.1 0.3 0.6 -1.1 0.2 0.5 0.4 0.1 -0.5 -0.0 -0.3 0.4 -1.7 -0.7 -0.4
Illnesses of father: High blood pressure 0.7 0.9 4.2 -1.3 -1.0 0.7 0.7 0.2 1.1 0.3 0.3 -0.3 -0.8 1.7 1.0 2.0 -0.4 -1.2 -0.7 1.6 0.7 1.0 0.8 -0.7 0.0 0.3
Alcohol drinker status: Never 1.3 1.5 4.8 -1.5 -1.1 1.1 -0.7 -1.7 -2.2 -1.7 -1.1 -0.9 -1.4 -1.7 -1.1 -0.2 -1.1 -0.7 -0.8 -0.6 -1.6 -0.8 -1.0 -0.4 -1.6 -1.1
Ever smoked 1.8 3.1 9.2 2.2 2.0 -3.0 1.8 2.5 -0.0 1.3 1.9 1.4 3.0 2.1 1.4 -0.3 2.1 2.2 1.4 -0.1 0.8 0.5 1.8 1.6 1.6 0.2
Basal metabolic rate 1.0 5.8 12.7 1.1 2.4 -2.7 2.7 1.7 1.3 1.2 3.0 2.4 2.8 1.7 3.6 2.9 2.8 1.9 3.1 1.3 2.3 2.2 2.6 2.5 2.9 1.9
Leg fat percentage (left) 0.2 0.6 2.4 -0.9 0.1 -0.2 0.8 0.2 -0.1 -0.5 0.3 -0.2 0.2 0.5 1.4 1.2 0.4 -0.5 -0.3 0.9 -0.2 1.4 1.0 -0.8 -0.9 -1.5
Arm fat-free mass (left) 1.6 8.0 14.4 1.9 2.9 -3.3 3.3 2.3 1.3 1.7 3.3 2.9 3.3 1.7 3.8 3.2 3.3 2.5 3.6 1.2 2.7 2.3 3.0 3.1 3.4 2.8
Number of operations (self-reported) 1.3 1.9 11.0 1.0 1.6 -1.2 0.2 1.4 3.3 0.6 0.8 1.5 1.7 1.4 0.2 -1.8 1.3 1.8 1.8 -0.5 0.1 0.9 0.9 1.7 0.6 0.6
Average weekly beer plus cider intake 2.1 3.1 5.7 0.4 1.4 -1.0 1.4 0.0 2.0 1.9 2.1 1.9 1.5 1.7 2.4 1.6 1.4 1.0 1.6 2.1 2.4 2.2 2.2 2.0 2.0 1.8
Irritability 1.1 1.8 6.0 1.5 1.1 -1.7 1.7 1.6 0.3 0.9 1.7 1.2 2.4 1.3 1.3 1.4 1.2 1.5 1.6 0.5 1.1 0.8 1.4 0.7 1.4 0.4
Risk taking 0.9 1.4 5.3 1.6 1.1 -1.5 2.3 -0.3 0.3 1.0 1.0 0.8 1.3 1.4 0.8 1.7 1.3 1.3 1.4 0.5 1.0 0.3 1.0 0.6 1.1 0.9
Ever had prostate specific antigen (PSA) test 0.8 1.0 2.6 0.7 -0.8 1.1 -0.8 -0.8 -0.6 0.1 -1.5 -1.2 -0.8 -1.6 -1.4 -1.1 -1.2 -1.5 -0.9 -0.6 -0.4 -0.7 -0.7 -0.9 -0.7 0.8
Fractured/broken bones in last 5 years 1.3 1.7 6.9 2.4 1.1 -1.5 1.3 1.4 0.9 0.8 0.9 0.8 1.3 1.9 0.2 0.1 1.3 2.6 1.3 -1.4 1.0 -1.1 0.3 0.2 1.4 -0.6
Age started oral contraceptive pill 3.8 4.8 16.4 0.2 -2.2 2.1 -2.2 -0.8 -1.2 -2.3 -3.2 -2.0 -2.1 -0.8 -4.0 -2.8 -2.0 -1.5 -1.1 -3.4 -2.5 -2.4 -2.3 -1.6 -2.2 -0.2
Diastolic blood pressure, automated reading 0.6 1.7 3.9 -1.0 -1.4 1.1 -0.6 0.0 -1.9 -0.5 -1.4 -2.0 -1.2 -1.3 -1.2 0.0 -1.0 -1.2 -1.7 -1.2 -1.5 -1.3 -1.6 -1.7 -1.4 -1.7
Ever depressed for a whole week 3.2 3.9 10.0 1.1 2.2 -1.3 2.4 0.7 3.2 0.9 1.8 2.3 1.6 3.0 1.6 2.6 1.8 2.3 2.7 0.9 1.3 2.2 2.6 1.2 0.8 1.9
Unable to work because of sickness or disability 0.9 1.2 5.2 -2.3 -1.3 1.4 -1.4 -1.3 0.1 -1.6 -0.2 -0.7 -1.9 1.6 -0.2 0.0 -1.1 -1.6 -0.5 0.0 -1.0 0.6 0.2 0.2 -1.0 -0.1
Commuting to job workplace: Cycle 1.1 1.3 4.4 0.8 0.7 -1.4 0.7 1.7 1.2 0.5 1.1 0.8 1.9 1.1 1.0 -0.8 1.2 0.8 0.8 -0.3 0.7 0.4 1.3 2.1 1.5 1.4
Myopia 0.4 0.6 2.7 -0.4 -1.2 0.6 -1.0 -0.2 -0.4 -0.5 0.1 -0.6 -0.2 -1.0 0.6 -0.6 -0.5 -1.1 -0.8 0.7 -0.9 0.0 -0.6 1.2 -0.6 -1.6
Vascular/heart problems diagnosed by doctor 0.9 2.5 9.8 2.0 1.5 -1.3 1.4 0.9 3.1 1.8 1.2 1.4 1.8 0.4 -0.2 0.8 0.8 2.0 0.5 -0.1 2.7 -0.5 0.6 1.9 2.2 2.1
Cholesterol lowering medication 0.5 0.8 2.8 0.9 0.7 -1.4 -0.1 1.7 0.5 0.7 0.7 0.5 1.4 0.9 -1.0 -1.2 1.0 1.4 0.5 -0.9 0.5 -0.2 0.7 0.0 0.3 0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 4.5 0.8 0.2 -0.2 0.6 1.0 0.7 0.2 -0.1 0.0 0.5 2.1 -0.5 0.9 -0.0 -0.3 0.2 -0.2 0.0 -0.2 0.1 -0.6 -0.1 0.3
Pain experienced in last month 2.5 4.2 8.8 -0.3 -1.8 1.9 -1.6 -2.9 -2.6 -1.4 -2.1 -2.2 -2.0 -2.0 -2.5 -2.0 -2.4 -1.0 -2.6 -1.2 -1.0 -2.6 -3.0 -2.2 -1.6 -1.6
Supplements: Calcium 0.7 0.8 2.7 -0.9 -0.3 0.2 -0.0 -0.0 -1.2 -0.9 -0.6 -1.0 -0.3 -1.4 -1.1 -0.9 -0.7 -0.5 -0.2 -1.0 -1.7 -1.0 -1.1 -0.9 -0.9 -1.0
Basal cell carcinoma (self-reported) 0.5 0.6 4.2 0.6 -0.4 0.2 -0.4 -0.2 -0.4 -0.6 -1.1 -0.8 -0.1 -2.0 -0.6 -0.3 -0.5 -0.3 -0.6 -1.4 -0.5 -1.3 -1.0 -0.4 -0.2 0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 4.8 -0.0 -0.3 -0.4 0.7 0.1 -0.5 -0.4 0.0 -0.2 -0.1 2.2 -0.4 1.2 0.1 -0.6 0.6 0.0 -0.5 0.6 0.7 -0.3 -0.5 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 1.4 -0.7 0.2 -0.3 0.1 0.6 0.8 -1.2 0.3 0.7 0.3 -0.4 -0.3 -0.6 0.5 0.5 0.3 -0.1 -0.2 -0.0 0.4 0.1 0.2 0.6
Heart disease (siblings) 0.2 0.3 1.1 -0.5 -1.0 0.2 -1.1 0.4 -0.7 0.6 -0.2 -0.4 -0.7 -0.0 -0.1 -1.0 -0.2 -0.2 0.5 -0.2 -0.4 0.2 -0.7 0.5 0.1 -0.1
Alcohol drinker status: Previous 0.8 0.9 4.4 -1.1 0.7 -0.6 1.1 0.2 0.1 1.1 1.0 0.5 0.7 0.1 1.2 0.9 0.7 1.0 1.1 1.0 0.8 2.1 1.5 1.0 0.2 0.3
Pack years of smoking 1.0 1.5 6.0 -0.2 0.6 -0.2 0.6 0.1 1.5 1.0 0.8 0.8 0.4 1.6 2.1 0.9 0.4 -1.0 1.2 2.4 1.5 2.0 1.9 1.0 1.1 0.8
Impedance of whole body 1.2 6.3 13.1 -1.9 -2.3 3.5 -3.0 -2.6 -0.4 -1.4 -2.6 -2.2 -3.2 -1.9 -3.4 -2.3 -3.2 -1.5 -2.8 -1.1 -2.7 -1.3 -2.9 -2.7 -3.6 -2.0
Leg fat mass (left) 0.3 1.1 5.8 -0.4 0.6 -0.8 1.4 0.4 0.3 -0.0 1.2 0.5 0.8 0.9 2.4 2.1 1.1 -0.1 0.6 1.3 0.7 1.7 1.6 0.3 0.3 -0.5
Arm predicted mass (left) 1.2 6.1 11.9 1.4 2.5 -2.8 2.8 1.9 1.2 1.4 2.9 2.5 2.8 1.6 3.5 2.8 2.9 2.0 3.2 1.1 2.4 2.2 2.8 2.7 2.9 2.4