Hub : Genes

LRRN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2400	0.095	0.00140	0.010	NA	0.013	NA	0.038	1.6e-01	NA	0.1300	NA	0.02700
2	GTEx	Lung	0.0598	0.032	0.00670	0.002	NA	0.006	NA	0.000	2.1e-01	NA	0.1100	NA	0.31000
3	GTEx	Thyroid	0.0980	0.041	0.00038	0.062	NA	0.022	NA	0.037	1.7e-05	NA	0.0077	NA	0.00075
4	TCGA	Cervical Squamous Cell Carcinoma	0.1490	0.085	0.00920	0.022	0.012	0.000	NA	0.011	2.9e-02	0.084	0.3200	NA	0.08600
5	TCGA	Pancreatic Adenocarcinoma	0.1450	0.075	0.00890	0.004	0.035	0.027	NA	0.021	2.2e-01	0.013	0.0260	NA	0.04500

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	3.0	-1.7	-0.1	-0.9	-0.3	-1.7
Bipolar Disorder or Schizophrenia	1.3	3.1	12.7	0.8	-3.6	-0.0	-1.2	-0.9
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	0.1	0.3	1.0	0.6	0.1
Depression (Nagel 2018)	0.3	0.5	1.3	1.1	-0.7	0.7	0.3	0.2
Intelligence (Savage-Jansen 2018)	2.8	8.7	14.4	-3.2	3.4	-3.8	-2.6	-0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.0	-0.5	0.5	-0.1	-0.6
Schizophrenia (2018)	2.7	5.7	20.5	2.3	-4.5	0.7	-1.3	0.2
Schizophrenia vs Biploar Disorder	3.1	4.1	11.1	3.3	-2.5	1.7	-0.4	0.6
Worry (Nagel 2018)	0.6	1.4	2.9	1.4	-1.7	1.1	-0.8	0.4
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	0.2	0.2	0.2	0.9	-0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.5	0.3	0.5	-0.3	0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	1.1	-0.6	1.0	0.1	-0.0
Crohns Disease (2017)	1.0	2.1	3.8	-1.4	-1.2	-1.8	-2.0	-0.5
Irritable Bowel Disease (IBD)	0.9	2.1	6.6	0.3	-2.6	-0.4	-1.9	-0.4
Ulcerative Colitis (UC)	1.0	1.9	4.8	1.5	-2.2	1.2	-1.1	-0.3
Major Depression (MDD)	0.4	0.5	2.2	-0.5	0.2	-0.2	1.5	0.3
Reaction Time	1.3	2.4	8.7	1.1	-3.0	0.4	-1.5	0.1
Verbal and Numeric Reasoning (VNR)	1.8	4.4	7.3	-2.6	2.7	-2.4	-1.5	-0.3
Breast Cancer	0.3	0.8	1.8	0.4	0.7	0.9	1.3	0.8
Ovarian Cancer	0.2	0.3	1.0	-0.3	0.4	0.3	0.2	1.0
Prostate Cancer	0.6	0.8	2.3	-0.9	0.3	-1.5	-0.0	-1.0
Age at First Birth	0.4	0.5	1.4	0.8	-1.2	-0.1	0.5	0.6
Bipolar Disorder (2011)	1.0	1.0	4.2	-0.7	0.1	0.2	2.0	-0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	-0.1	0.9	0.2	-0.3	0.5
Coronary Artery Disease (CAD)	3.8	4.5	7.1	2.3	-0.5	2.7	2.5	-1.9
Crohns Disease (2012)	0.6	1.0	2.9	-0.9	-0.7	-0.6	-0.6	-1.7
Mean Putamen Volume	0.9	1.0	2.3	0.1	1.5	-0.7	-1.3	0.7
Fasting Glucose	0.6	0.8	1.8	-0.3	0.7	-1.4	-0.1	1.2
HbA1C	1.0	1.1	2.2	-1.0	0.4	-1.5	-1.3	-0.7
HDL Cholesterol	0.8	1.3	3.0	-1.6	0.2	-1.7	-0.2	-0.8
LDL Cholesterol	0.3	0.4	1.1	0.1	0.8	-0.5	1.0	0.3
Lupus	0.5	0.7	1.4	-0.9	0.1	-1.2	-0.7	-0.9
Neuroticism (2016)	0.5	0.8	2.2	-0.8	0.5	0.5	1.5	-0.8
Primary Biliary Cirrhosis	0.2	0.2	1.1	0.1	1.0	0.1	-0.2	0.3
Rheumatoid Arthritis	0.6	0.8	2.5	-1.6	-0.0	-1.2	-0.4	-0.3
Schizophrenia (2014)	4.2	9.2	33.5	3.0	-5.8	1.5	-1.0	-0.8
Triglycerides	1.0	1.6	4.9	2.2	-0.4	1.4	-0.8	0.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.8	0.5	1.2	1.0	1.3	-0.4
Ulcerative Colitis	0.4	0.6	2.1	-0.1	0.1	-0.2	-1.0	-1.5
Blood Eosinophil Count	0.1	0.9	2.3	1.5	-0.7	1.1	0.0	-0.6
Blood Platelet Count	0.0	0.5	2.1	-0.1	0.1	-0.7	-1.5	-0.3
Blood Red Count	0.1	1.3	4.7	2.2	-0.6	0.6	1.1	0.1
Blood White Count	0.1	0.9	1.8	0.3	-1.4	1.1	1.0	-0.7
Heel T-Score	0.2	1.8	3.5	1.9	0.2	1.3	1.8	-0.9
BMI	0.1	0.7	2.6	-0.6	1.6	0.4	0.8	0.0
Height	0.2	4.1	12.9	-3.6	0.6	-1.9	-0.7	-1.9
Waist Hip Ratio (WHR)	0.2	0.8	1.3	1.0	-0.2	0.6	-1.1	1.1
Systolic Blood Pressure	0.2	1.0	1.8	1.0	-0.4	1.3	-0.6	1.3
Smoking Status	1.3	3.2	11.5	-0.4	3.4	1.0	1.7	-0.4
Allergy or Eczema	0.2	0.5	0.9	-0.6	-0.1	-0.8	-1.0	-0.7
Cardiovascular Disease	0.1	0.4	1.0	0.1	0.8	1.0	0.3	0.1
Hypothyroidism (self reported)	0.2	0.5	1.2	0.2	-0.1	1.0	1.1	0.2
Respiratory disease	0.4	0.8	3.3	0.3	1.8	0.4	0.4	0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.1	-1.7	0.6	-0.2	0.1	-1.8
Lung FEV1/FVC ratio	0.9	4.7	6.9	-2.1	1.6	-2.6	-2.1	-2.4
Lung FVC	0.3	1.3	3.3	1.7	0.3	0.4	-0.5	1.8
Neuroticism	0.0	0.1	0.3	-0.0	-0.0	0.5	-0.3	0.5
Chronotype (morning person)	0.3	0.6	2.4	-0.3	-0.6	0.1	-0.3	1.6
Hair Pigment	0.0	0.6	1.8	-1.3	-0.2	0.1	-0.8	-0.8
Tanning	0.0	0.5	1.2	-0.4	0.7	0.2	1.1	-0.6
Hand grip strength (left)	0.4	0.9	2.8	-1.7	0.4	-1.1	-0.2	0.6
Number of treatments/medications taken	0.6	1.1	2.8	-0.4	-0.4	-0.8	-1.7	-1.3
Average weekly spirits intake	0.4	0.5	1.3	-0.4	0.5	-0.6	-1.1	-0.5
Sensitivity / hurt feelings	1.2	2.1	5.1	0.7	-0.5	1.9	2.2	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	0.5	0.6	0.3	0.8	-0.9
Hearing difficulty/problems: Yes	1.5	2.3	7.0	-2.7	1.2	-1.1	-0.3	-1.3
Relative age of first facial hair	1.8	3.7	11.6	1.6	-3.4	1.9	-0.7	0.6
Other serious medical condition/disability diagnosed by doctor	2.8	3.7	10.1	-2.2	3.2	-1.7	-0.0	-0.4
Ever used hormone-replacement therapy (HRT)	3.6	4.6	7.9	-2.8	1.7	-2.2	-1.6	-2.2
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	-0.9	0.9	-0.5	-0.2	-0.9
Systolic blood pressure, automated reading	0.6	1.8	5.1	2.3	-1.3	1.3	0.2	-0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.3	0.5	0.8	0.1	0.6
Angina	0.2	0.3	0.6	-0.4	-0.0	-0.8	-0.6	-0.4
Medication for hormone replacement therapy	0.2	0.3	0.9	-0.2	-0.9	-0.1	-0.5	0.5
Vitamin and mineral supplements	1.6	2.1	4.0	2.0	-1.0	1.6	1.5	0.8
Supplements: Zinc	1.3	1.4	3.9	-0.6	1.0	-0.6	-1.2	2.0
Medication: Co-codamol	0.8	0.9	2.8	-0.2	1.7	-0.4	-0.4	-1.1
Medication: Metformin	1.2	1.7	5.7	-2.4	0.7	-1.3	-0.9	-0.4
Diabetes (father)	0.9	1.1	3.1	0.2	0.4	-1.3	-0.7	1.8
Diabetes (mother)	0.7	0.8	1.9	-0.1	0.6	0.8	1.4	1.1
Severe depression (siblings)	0.5	0.6	1.0	-1.0	1.0	-0.4	-0.2	0.9
Pack years adult smoking proportion	1.7	2.7	5.5	0.6	2.3	1.4	2.3	0.7
Impedance of leg (right)	0.4	1.9	7.2	1.2	-2.7	0.2	-0.6	-0.5
Leg fat-free mass (left)	0.3	1.4	4.8	-1.5	2.2	-0.1	0.5	-0.0
Trunk fat percentage	0.3	1.0	1.7	0.8	-1.3	1.3	0.7	-0.8
Hand grip strength (right)	0.2	0.6	1.6	-0.7	1.3	-0.8	0.2	0.5
Townsend deprivation index at recruitment	0.5	0.7	1.5	-0.3	-0.8	1.2	0.2	-1.2
Current tobacco smoking	1.6	2.7	7.5	0.3	2.7	1.5	1.7	-0.9
Average weekly fortified wine intake	1.0	1.2	4.3	0.2	-0.9	-0.8	-2.1	0.3
Maternal smoking around birth	0.6	0.8	2.9	0.6	0.4	0.6	0.6	1.7
Fed-up feelings	0.5	0.8	3.4	-0.3	1.9	0.6	0.5	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.1	0.8	0.3	1.4	0.3	1.3
Relative age voice broke	0.9	1.4	4.9	-0.5	-2.2	-0.5	-1.3	0.1
Taking other prescription medications	0.4	0.5	1.8	-0.5	-0.2	-0.3	-0.7	-1.3
Age when periods started (menarche)	0.3	0.7	2.3	0.8	-1.5	0.1	-0.8	0.1
Bilateral oophorectomy (both ovaries removed)	4.3	5.0	9.7	-1.7	3.1	-1.4	-2.5	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.4	-0.2	0.8	-0.2	1.5	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.3	-1.5	0.7	-0.3	-0.3	-0.7
Qualifications: CSEs or equivalent	3.3	4.4	10.9	1.7	1.2	2.6	3.3	0.5
Serious illness, injury or assault to yourself	1.1	1.4	3.6	-1.7	1.9	-0.5	-0.4	0.2
High blood pressure	0.4	1.0	2.8	0.8	-0.8	1.0	0.1	-1.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.4	-1.0	0.3	-1.3	-1.6	-0.2
Multivitamins +/- minerals	1.1	1.4	2.2	-1.5	1.4	-1.4	-0.8	-0.2
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.4	1.2	0.5	0.7	-0.9
Supplements: Glucosamine	1.3	1.7	4.8	-1.5	0.2	-2.2	-1.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.9	-0.8	-0.6	-0.3	-0.9	-0.6
Medication: Atenolol	0.3	0.4	0.8	-0.3	-0.0	-0.9	-0.9	0.6
Medication: Levothyroxine sodium	0.5	0.8	1.4	1.0	-0.5	0.8	1.2	-0.9
Sitting height	0.3	1.9	4.3	-2.1	1.8	-1.3	-0.3	-0.3
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-1.2	1.2	-0.8	0.4	-0.5
High blood pressure (mother)	0.8	1.2	3.7	-0.7	1.0	0.7	1.9	0.3
Body mass index (BMI)	0.1	0.4	1.2	-0.5	1.1	0.1	0.6	-0.6
Impedance of leg (left)	0.4	2.1	9.0	0.8	-3.0	0.3	-0.6	-0.8
Leg predicted mass (left)	0.3	1.5	4.8	-1.5	2.2	-0.1	0.6	-0.1
Trunk fat mass	0.1	0.5	1.0	0.1	-0.3	0.9	0.7	-1.0
Waist circumference	0.0	0.2	0.4	0.1	0.3	0.6	0.4	-0.5
Number of incorrect matches in round	0.1	0.2	0.8	-0.2	-0.9	-0.4	0.1	-0.1
Past tobacco smoking	0.7	1.3	3.1	1.8	-0.8	1.6	0.1	-0.3
Alcohol usually taken with meals	0.4	0.6	1.2	-1.0	-0.5	-1.1	-0.4	-0.8
Nervous feelings	1.3	2.4	8.4	1.2	-2.9	0.7	-0.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	4.4	-0.4	0.5	-0.4	-2.1	0.4
Hearing difficulty/problems with background noise	2.3	3.7	7.4	-2.7	1.3	-1.8	-0.9	-2.3
Hair/balding pattern: Pattern 2	0.8	1.0	4.8	0.3	-2.2	0.2	-0.1	0.5
Had menopause	0.9	1.2	5.6	-0.3	-0.1	-0.4	0.2	-2.4
Had other major operations	3.1	3.8	8.1	-2.8	0.7	-2.6	-0.4	-1.8
Forced vital capacity (FVC)	0.2	0.7	2.5	0.6	1.6	0.4	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.4	-0.2	0.3	0.0	1.8	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	-1.2	0.7	-0.6	-1.2	0.2
Qualifications: None of the above	1.2	2.5	6.7	1.6	-1.8	2.6	0.1	0.5
Financial difficulties in last 2 years	2.9	3.9	7.6	-2.7	2.4	-1.5	-1.5	-1.3
Mouth/teeth dental problems	0.4	0.7	2.5	-0.5	0.5	0.2	1.6	-0.5
Heart attack	0.5	0.6	1.8	0.5	0.2	-0.0	-0.9	1.4
Allergy	0.3	0.6	1.2	0.6	0.3	1.1	0.9	0.9
Pain all over the body in last month	0.9	1.0	2.8	-1.7	-0.2	-0.6	-0.6	-1.1
Diabetes (self-reported)	0.5	0.7	2.4	-1.0	1.6	0.2	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.4	0.5	-0.2	-0.4	-0.1
Medication: Ramipril	0.3	0.4	0.9	-0.9	0.6	-0.9	0.3	-0.2
Medication: Simvastatin	0.2	0.3	1.0	-0.3	-0.2	-0.1	-0.5	-1.0
Fluid intelligence score	2.1	4.5	6.5	-2.4	2.6	-2.2	-2.2	0.0
Illnesses of siblings	1.0	1.4	4.8	-0.3	0.5	-2.2	-1.3	-0.4
Neuroticism score	0.1	0.2	0.8	-0.1	-0.0	0.9	0.1	-0.6
Weight	0.2	0.8	1.7	-1.2	1.3	-0.0	0.5	-0.9
Impedance of arm (right)	0.6	3.0	9.2	1.9	-3.0	1.0	-0.9	0.7
Arm fat percentage (right)	0.1	0.5	0.8	0.7	-0.9	0.9	0.3	-0.4
Trunk fat-free mass	0.4	2.5	6.9	-2.1	2.6	-0.7	0.4	-0.7
Hip circumference	0.1	0.6	1.6	-0.6	0.2	0.7	1.3	-0.6
Time employed in main current job	0.5	0.6	2.6	-0.4	-0.3	-0.6	0.1	-1.6
Alcohol intake versus 10 years previously	1.5	2.2	7.1	0.8	-2.7	1.7	0.5	0.2
Father’s age at death	1.1	1.5	5.2	0.1	-0.7	0.2	1.2	-2.3
Worrier / anxious feelings	0.2	0.3	0.5	-0.5	0.5	0.4	0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.7	-0.4	1.9	0.3	-0.4	-1.1
Falls in the last year	3.4	4.6	10.4	-3.2	1.1	-2.7	-2.0	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.5	0.5	0.2	-0.2	0.4
Number of live births	0.6	0.9	2.6	-0.4	0.1	-1.1	0.7	-1.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	3.0	0.1	1.7	-0.6	-0.4	0.0
Pulse rate	0.3	0.4	1.0	-0.5	0.4	-0.1	-0.9	-1.0
Happiness	0.5	0.6	2.1	-0.4	0.8	0.4	0.5	-1.4
Noisy workplace	0.6	0.7	3.1	-0.3	0.0	0.2	1.8	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.9	-0.9	-1.7	-0.8	0.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.9	-0.1	0.5	-1.0	-0.4	2.2
Mouth/teeth dental problems: Dentures	0.8	1.3	3.1	1.8	-0.5	1.6	0.2	-1.0
Asthma	0.3	0.7	1.4	-0.2	0.7	-1.2	-0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-0.2	1.2	0.9	1.0	0.9
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.2	0.7	-0.1	-0.8	-0.4
Depression (self-reported)	1.1	1.4	3.1	-1.3	0.5	-1.3	-1.8	-0.2
Medication: Lansoprazole	1.0	1.2	2.9	1.5	0.7	1.7	0.3	-0.4
Prospective memory result	1.4	1.8	4.3	2.1	-1.0	1.3	0.3	1.3
Lung cancer (father)	0.8	0.9	1.9	-0.8	1.4	0.0	0.8	-1.3
Illnesses of mother	2.9	3.6	10.4	0.8	-1.3	-1.6	-3.2	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.4	-0.2	2.1	-0.9	-0.7	-0.0
Pulse wave Arterial Stiffness index	1.8	2.1	7.1	-0.1	-1.0	-0.5	-2.7	1.4
Impedance of arm (left)	0.7	3.4	12.2	1.7	-3.5	1.0	-0.6	0.6
Arm fat mass (right)	0.1	0.2	0.5	-0.1	0.2	0.6	0.5	-0.7
Trunk predicted mass	0.4	2.5	7.1	-2.1	2.7	-0.7	0.3	-0.7
Standing height	0.0	0.3	1.3	-1.1	0.3	0.1	0.1	-0.5
Length of working week for main job	2.7	3.0	7.7	-2.8	1.0	-2.0	-1.3	0.6
Exposure to tobacco smoke at home	1.0	1.1	3.5	1.1	-0.8	1.9	0.0	-0.2
Breastfed as a baby	3.3	4.1	10.2	-1.8	0.5	-3.2	-2.5	0.1
Tense / ‘highly strung’	0.4	0.6	2.2	0.1	-0.0	0.2	-1.5	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.4	-0.6	-0.5	-1.1	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	3.5	0.1	0.2	0.2	1.9	-0.5
Birth weight of first child	0.4	0.7	1.9	1.1	0.4	-0.1	1.4	0.1
Peak expiratory flow (PEF)	0.7	1.6	3.4	-1.0	1.6	-1.8	-0.9	-0.5
Pulse wave reflection index	1.5	1.9	4.3	0.2	-1.2	-0.9	-1.6	2.1
Ever highly irritable/argumentative for 2 days	2.7	3.3	10.4	-1.7	3.2	-0.8	-0.7	1.4
Loud music exposure frequency	0.2	0.3	0.7	-0.4	-0.5	0.4	-0.8	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.1	0.7	-0.1	0.5	0.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.6	0.2	0.1	-0.9	-1.9	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.0	-0.9	-0.2	-0.6	0.4
Medication: Paracetamol	0.8	1.4	2.8	-0.9	1.3	0.5	1.2	-1.7
Headache pain in last month	0.2	0.3	1.1	-0.3	1.1	0.0	-0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	0.3	-0.5	-0.4	0.2	0.9
Glaucoma (self-reported)	0.1	0.2	0.5	0.7	0.4	0.1	-0.2	-0.2
Gout (self-reported)	0.4	0.5	2.1	-0.0	-1.5	-0.3	-0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	0.8	-0.4	0.8	1.2	0.1
Medication: Amlodipine	0.7	1.0	2.6	0.0	0.0	1.0	1.2	-1.6
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.4	-0.3	-1.3	-2.1	-2.0	0.5
Birth weight	0.2	0.4	1.5	0.6	0.1	0.3	0.5	-1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.1	-0.8	1.1	0.5	1.5	-0.9
High blood pressure (siblings)	1.1	1.6	4.0	0.2	0.6	2.0	1.9	0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	4.3	0.4	2.1	0.1	-0.5	0.5
Body fat percentage	0.2	0.9	1.5	0.6	-1.2	1.0	0.6	-1.0
Leg fat percentage (right)	0.1	0.4	1.5	0.0	-0.6	-0.0	-0.0	-1.2
Arm fat-free mass (right)	0.5	2.7	7.3	-2.1	2.7	-0.6	0.7	-1.0
Exposure to tobacco smoke outside home	0.4	0.5	0.9	0.7	1.0	0.4	-0.8	-0.4
Comparative body size at age 10	1.7	4.6	6.1	-2.5	2.5	0.2	2.5	-2.2
Number of full brothers	0.8	1.0	3.0	-1.7	0.9	-0.6	-0.6	0.5
Worry too long after embarrassment	0.8	1.3	4.9	-0.6	-0.8	-0.6	0.2	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.6	-1.3	-0.3	-1.4	-1.3	-1.6
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	-0.2	0.2	0.8	0.7	-1.5
Number of children fathered	0.5	0.5	1.9	1.4	0.2	0.9	0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	7.7	-0.3	-1.7	-2.1	-2.8	1.8
Age at first live birth	0.8	1.4	3.5	-0.8	-1.9	-0.9	-1.4	0.5
Pulse wave peak to peak time	1.8	2.1	6.9	-0.1	1.1	0.5	2.6	-1.5
Health satisfaction	1.3	1.7	4.6	-2.1	1.2	-1.0	-1.1	0.2
Shortness of breath walking on level ground	0.8	1.0	2.3	-1.5	-0.2	-0.9	-0.8	-1.1
Qualifications: College or University degree	1.0	3.1	6.2	-2.1	0.7	-2.5	-1.9	0.9
Eye problems/disorders: None of the above	0.7	0.8	2.6	-1.1	-0.0	-0.1	-0.0	-1.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.4	0.7	-0.7	-0.3	-0.5
Emphysema/chronic bronchitis	0.5	0.6	1.3	1.0	-0.8	0.0	-1.1	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.8	-0.0	-0.4	-0.4	0.1	1.3
Neck or shoulder pain in last month	1.0	1.4	4.3	-1.0	2.1	-0.4	-1.0	-0.7
Medication: Blood pressure	0.2	0.4	1.1	0.5	0.2	1.0	-0.0	-0.6
Angina (self-reported)	0.2	0.2	0.5	-0.2	-0.2	-0.7	-0.6	-0.3
Migraine (self-reported)	0.2	0.3	0.5	0.2	-0.6	0.3	0.5	-0.7
Medication: Ibuprofen	0.5	0.6	1.4	0.2	0.2	1.0	0.7	1.2
Medication: Allopurinol	0.4	0.5	1.8	-0.1	-1.3	-0.6	-0.7	0.1
Medication: Omeprazole	0.1	0.1	0.2	0.3	-0.1	-0.4	-0.1	-0.4
Medication: Seretide 50 evohaler	1.5	1.7	5.6	1.1	-2.4	0.2	-1.2	0.3
Mean time to correctly identify matches	2.4	4.5	15.9	1.8	-4.0	0.9	-1.5	-0.6
Heart disease (mother)	0.2	0.3	0.6	-0.5	0.4	0.8	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	-0.9	0.5	-1.2	-0.0	0.5
Whole body fat mass	0.1	0.5	1.0	-0.0	-0.3	0.8	0.9	-1.0
Leg fat mass (right)	0.1	0.4	1.5	-0.5	0.1	0.2	0.6	-1.2
Arm predicted mass (right)	0.6	3.1	8.4	-2.1	2.9	-0.4	1.0	-1.0
Pulse rate, automated reading	0.2	0.8	2.2	0.0	0.7	0.5	-1.5	-0.9
Alcohol intake frequency.	0.4	0.8	2.0	0.1	0.7	1.4	-0.0	-1.3
Comparative height size at age 10	0.3	1.7	3.5	0.9	0.2	1.1	1.9	-1.6
Number of full sisters	1.2	1.5	2.5	-0.7	1.6	-1.5	0.8	1.2
Suffer from ‘nerves’	1.2	2.0	3.3	1.8	-1.8	1.3	-0.7	-1.2
Overall health rating	0.6	1.2	4.3	-0.7	0.7	0.8	-0.3	-2.1
Chest pain or discomfort	0.9	1.3	3.7	-0.4	1.9	-0.5	0.8	-1.3
Had major operations	1.6	1.9	4.0	-1.9	0.9	-1.0	0.2	-2.0
Age at last live birth	0.8	1.2	2.2	-0.3	-1.0	-1.0	-1.5	1.2
Family relationship satisfaction	1.2	1.4	3.4	-1.1	-0.3	-1.4	-1.9	0.5
Leg pain on walking	0.4	0.5	2.2	-0.4	0.6	0.1	0.0	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	8.2	-1.7	2.9	-0.8	0.3	-0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.4	0.2	1.9	-0.7	-1.0	1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.1	0.2	-1.4	-0.8	-0.5	-0.6
Medication: Aspirin	0.3	0.4	1.0	0.6	-0.2	-0.0	-0.7	-1.0
Supplements: Vitamin C	0.2	0.3	0.5	-0.7	-0.1	-0.6	-0.7	-0.2
Knee pain experienced in last month	0.2	0.2	0.5	-0.5	0.2	0.0	0.7	-0.6
Hypertension (Self-reported)	0.4	1.1	3.6	0.8	-0.6	1.0	-0.1	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	3.5	1.9	-1.6	1.2	1.2	-1.8
Illnesses of father: Heart disease	1.1	1.5	3.7	-0.8	1.9	0.6	1.1	-1.2
Illnesses of siblings: Diabetes	0.5	0.6	1.7	-0.2	0.1	1.3	0.7	-0.7
Smoking status: Previous	0.6	0.9	2.4	-1.0	0.1	-1.5	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	-0.4	0.5	0.4	0.3	0.3
Whole body fat-free mass	0.4	2.4	6.9	-2.1	2.6	-0.6	0.4	-0.6
Leg fat-free mass (right)	0.3	1.6	4.6	-1.8	2.1	-0.2	0.5	-0.1
Arm fat percentage (left)	0.2	0.6	1.0	0.7	-0.9	1.0	0.7	-0.6
Average weekly red wine intake	0.2	0.2	0.9	0.3	-0.9	-0.4	0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.4	0.9	0.5	0.9	0.6	-1.5
Mood swings	0.2	0.3	1.1	-0.0	0.6	-0.1	-1.0	0.0
Loneliness, isolation	0.7	1.0	2.6	-0.7	0.1	0.5	1.3	-1.6
Long-standing illness, disability or infirmity	2.4	3.7	10.9	-3.3	0.9	-1.6	-1.9	-0.7
Ever had bowel cancer screening	0.3	0.4	0.9	0.9	-0.2	-0.0	-0.6	-0.7
Diabetes diagnosed by doctor	0.3	0.5	1.4	-0.9	1.2	0.4	0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.0	-0.4	0.8	0.7	-0.5
Friendships satisfaction	0.4	0.5	1.7	-0.3	0.5	0.1	-0.6	-1.3
Qualifications: nursing, teaching	0.5	0.7	2.1	-1.1	-0.2	-1.5	-0.6	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.4	0.2	-0.4	0.1	0.1	0.7
Eye problems/disorders: Cataract	0.5	0.6	1.5	0.8	-1.2	-0.1	0.2	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.4	-1.9	0.6	-0.9	0.1	-1.2
Medication for cholesterol	1.6	2.4	5.6	1.4	0.1	2.4	2.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.4	-0.5	-0.5	0.2	-1.0
Back pain experienced in last month	0.5	0.7	2.7	-0.6	1.6	-0.2	0.7	-0.3
Mineral and other dietary supplements	1.4	1.9	3.6	1.0	0.5	1.7	1.9	-1.3
Breast cancer (self-reported)	1.4	1.6	3.5	-1.9	-0.2	-0.5	0.9	-1.9
Asthma (self-reported)	0.2	0.4	1.0	-0.0	1.0	-0.8	-0.3	-0.6
Osteoporosis (self-reported)	1.4	1.8	4.4	1.8	-2.1	0.5	-0.5	0.8
Osteoarthritis (self-reported)	0.7	1.0	1.8	-1.3	1.3	-1.0	-0.2	-0.5
Medication: Aspirin	0.4	0.5	1.9	0.5	-0.1	-0.0	-0.5	-1.4
Medication: Gliclazide	1.0	1.2	2.7	-1.7	1.0	-0.9	-0.9	-0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	1.5	-1.2	-0.2	-1.2	-1.1	0.1
Smoking status: Current	1.7	2.7	5.8	0.5	2.4	1.8	1.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	1.0	0.5	-0.3	-1.0	0.2
Whole body water mass	0.4	2.5	7.5	-2.0	2.7	-0.5	0.5	-0.5
Leg predicted mass (right)	0.3	1.6	4.7	-1.8	2.2	-0.2	0.4	-0.1
Arm fat mass (left)	0.1	0.3	0.5	-0.1	-0.0	0.6	0.6	-0.7
Number of self-reported non-cancer illnesses	0.7	1.2	2.6	0.1	-1.0	-1.1	-1.1	-1.6
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.8	-0.1	-0.5	-0.5	-0.3
Miserableness	0.2	0.4	1.0	-1.0	0.3	0.2	0.7	0.4
Guilty feelings	0.2	0.4	0.8	-0.2	-0.9	0.3	-0.2	-0.9
Wears glasses or contact lenses	0.1	0.2	0.4	0.6	0.2	-0.2	0.4	0.4
Ever taken oral contraceptive pill	1.6	1.8	4.7	-1.8	2.2	-0.5	-0.7	-0.5
Hearing aid user	0.9	1.0	2.0	0.1	-1.1	0.2	-1.4	1.4
Mother’s age at death	2.5	3.2	6.3	1.8	-0.8	2.5	2.4	0.0
Financial situation satisfaction	2.1	2.6	7.5	-1.6	2.7	-1.1	0.8	-0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.5	0.4	-0.2	0.6	0.4
Commuting to job workplace: Public transport	0.5	0.6	1.8	0.0	-0.1	1.3	0.8	-0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	1.1	0.1	-0.2	-1.2	1.0
Medication: Blood pressure	1.1	2.2	3.7	-1.7	0.8	-1.9	-1.6	-0.9
Pain type(s) experienced in last month: Hip pain	1.4	1.8	5.6	0.9	0.6	0.7	1.3	-2.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.5	-0.3	-1.1	-0.6	-1.2	0.6
High cholesterol (Self-reported)	0.7	1.3	3.3	-1.3	1.0	-0.6	0.4	-1.8
Medication: Bendroflumethiazide	0.3	0.5	1.5	0.2	0.9	0.2	-0.1	1.2
Medication: Paracetamol	0.5	0.8	1.9	-1.2	0.5	0.1	0.4	-1.4
Medication: Lisinopril	0.7	1.0	3.4	0.6	0.9	-0.5	-1.8	0.2
Medication: Atorvastatin	0.6	0.7	3.1	-0.0	0.0	-1.8	-0.6	0.3
Illnesses of father: High blood pressure	2.7	3.4	7.0	2.5	1.1	2.6	0.9	1.3
Alcohol drinker status: Never	0.8	0.9	4.2	0.4	0.4	0.2	-2.0	0.1
Ever smoked	2.0	3.6	6.8	-2.6	1.2	-2.4	-1.9	0.4
Basal metabolic rate	0.3	1.9	5.3	-1.9	2.3	-0.4	0.5	-0.5
Leg fat percentage (left)	0.1	0.4	1.6	-0.2	-0.6	-0.0	-0.2	-1.3
Arm fat-free mass (left)	0.6	3.0	8.4	-2.3	2.9	-0.6	0.5	-0.7
Number of operations (self-reported)	1.2	1.8	6.1	-2.5	0.4	-0.7	-0.4	-1.4
Average weekly beer plus cider intake	0.7	1.0	1.7	-0.3	0.9	1.2	1.3	0.9
Irritability	0.9	1.6	5.8	-1.1	2.4	-0.6	-0.6	-0.1
Risk taking	0.7	1.0	4.7	-0.4	2.2	-0.4	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	1.3	1.6	5.3	2.3	-0.8	0.9	0.8	-0.7
Fractured/broken bones in last 5 years	3.7	4.8	7.5	-2.7	0.4	-2.7	-2.7	1.3
Age started oral contraceptive pill	0.9	1.2	3.5	0.6	-1.9	-0.4	-1.0	-0.9
Diastolic blood pressure, automated reading	0.1	0.4	1.0	1.0	-0.0	0.1	-0.7	0.6
Ever depressed for a whole week	1.3	1.6	3.0	-1.4	0.3	-1.7	-1.5	-0.7
Unable to work because of sickness or disability	0.8	1.1	2.7	0.6	-1.4	1.6	0.2	0.6
Commuting to job workplace: Cycle	1.0	1.3	3.4	-1.9	1.6	-0.5	0.2	0.0
Myopia	0.5	0.8	1.8	-1.4	-0.3	0.5	0.7	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.0	-1.3	0.8	-0.9	0.1	1.4
Cholesterol lowering medication	0.8	1.2	3.8	-0.9	0.3	-2.0	-0.8	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.6	0.0	-0.2	0.2	-0.7
Pain experienced in last month	0.9	1.5	5.3	1.0	-2.3	0.1	0.5	1.1
Supplements: Calcium	1.0	1.1	3.7	0.1	-0.1	0.4	-1.2	1.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	0.0	0.2	-0.7	-0.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.6	0.4	-0.1	-0.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-0.4	-0.9	-0.2	-0.9	0.8
Heart disease (siblings)	0.3	0.3	0.9	-0.1	-0.7	-0.0	-0.6	0.9
Alcohol drinker status: Previous	0.5	0.6	1.2	-0.7	1.1	-0.3	-0.9	-0.4
Pack years of smoking	2.0	3.0	6.8	1.1	1.8	1.8	2.6	0.8
Impedance of whole body	0.5	2.6	9.8	1.4	-3.1	0.8	-0.9	0.1
Leg fat mass (left)	0.1	0.5	1.7	-0.5	0.1	0.3	0.6	-1.3
Arm predicted mass (left)	0.4	2.3	6.0	-2.0	2.4	-0.5	0.6	-0.9