Best TWAS P=1.9e-08 · Best GWAS P=2.55e-08 conditioned to 0.36
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TOM1L2 | 0.04 | 0.04 | lasso | 3 | 0.04 | 5.3e-04 | 5.1 | -5.3 | 1.2e-07 | -0.92 | 0.13 | 0.85 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | TOM1L2 | 0.15 | 0.13 | lasso | 4 | 0.11 | 3.6e-06 | 5.2 | -5.3 | 1.3e-07 | -0.87 | 0.14 | 0.86 | FALSE |
| 3 | GTEx | Esophagus Muscularis | TOM1L2 | 0.06 | 0.07 | enet | 12 | 0.05 | 4.3e-04 | 5.2 | -5.4 | 5.8e-08 | -0.92 | 0.09 | 0.90 | FALSE |
| 4 | GTEx | Muscle Skeletal | TOM1L2 | 0.08 | 0.11 | lasso | 6 | 0.10 | 5.3e-10 | 5.1 | -5.2 | 1.8e-07 | -0.86 | 0.20 | 0.80 | FALSE |
| 5 | GTEx | Muscle Skeletal | AC122129.1 | 0.13 | 0.14 | lasso | 4 | 0.13 | 7.3e-13 | 5.1 | -5.3 | 9.7e-08 | -0.89 | 0.11 | 0.89 | FALSE |
| 6 | GTEx | Whole Blood | SREBF1 | 0.04 | 0.06 | lasso | 5 | 0.05 | 2.4e-05 | 5.3 | -5.3 | 1.2e-07 | -0.89 | 0.15 | 0.85 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TOM1L2 | 0.01 | 0.01 | blup | 83 | 0.01 | 1.8e-03 | 4.8 | -5.6 | 2.7e-08 | -0.92 | 0.08 | 0.76 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRRC48 | 0.07 | 0.05 | enet | 12 | 0.04 | 7.0e-03 | 5.3 | 5.6 | 1.9e-08 | 0.93 | 0.03 | 0.70 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf39 | 0.05 | 0.05 | blup | 49 | 0.05 | 5.8e-06 | 5.4 | 5.6 | 2.6e-08 | 0.98 | 0.02 | 0.97 | FALSE |