Best TWAS P=1.17e-09 · Best GWAS P=3.12e-09 conditioned to 0.088
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GATAD2A | 0.13 | 0.30 | lasso | 7 | 0.29 | 2.4e-35 | 5.7 | -5.5 | 3.7e-08 | -0.99 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Tibial | MAU2 | 0.07 | 0.05 | lasso | 4 | 0.05 | 1.3e-04 | 5.2 | 5.3 | 8.9e-08 | 0.85 | 0.04 | 0.93 | FALSE |
| 3 | GTEx | Brain Cerebellum | SUGP2 | 0.15 | -0.01 | enet | 27 | 0.00 | 2.3e-01 | 5.2 | 6.1 | 1.2e-09 | 0.70 | 0.03 | 0.62 | TRUE |
| 4 | GTEx | Brain Cerebellum | PBX4 | 0.20 | 0.09 | lasso | 6 | 0.13 | 9.9e-05 | 5.6 | 5.2 | 2.7e-07 | 0.70 | 0.10 | 0.64 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | LPAR2 | 0.04 | 0.05 | lasso | 2 | 0.04 | 5.5e-04 | 5.1 | -5.5 | 2.9e-08 | -0.66 | 0.06 | 0.77 | FALSE |
| 6 | GTEx | Lung | LPAR2 | 0.07 | 0.09 | lasso | 3 | 0.05 | 9.9e-05 | 5.1 | -5.2 | 1.6e-07 | -0.59 | 0.28 | 0.69 | FALSE |
| 7 | GTEx | Nerve Tibial | LPAR2 | 0.14 | 0.05 | lasso | 5 | 0.06 | 2.3e-05 | 5.1 | -5.2 | 2.1e-07 | -0.58 | 0.31 | 0.58 | FALSE |
| 8 | GTEx | Whole Blood | TMEM161A | 0.06 | 0.00 | enet | 2 | 0.00 | 1.4e-01 | 5.7 | -5.7 | 1.1e-08 | -1.00 | 0.03 | 0.84 | FALSE |
| 9 | YFS | Blood | GATAD2A | 0.09 | 0.14 | blup | 365 | 0.14 | 7.5e-44 | 5.7 | 5.7 | 1.3e-08 | 0.92 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | GATAD2A | 0.04 | 0.03 | blup | 61 | 0.05 | 1.3e-03 | 5.7 | 5.3 | 1.4e-07 | 0.94 | 0.03 | 0.84 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GATAD2A | 0.02 | 0.02 | lasso | 1 | 0.02 | 2.1e-03 | 5.7 | 5.7 | 1.1e-08 | 0.99 | 0.02 | 0.78 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GMIP | 0.03 | 0.02 | lasso | 4 | 0.02 | 3.2e-03 | 5.1 | 5.8 | 5.7e-09 | 0.68 | 0.00 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GMIP | 0.07 | 0.04 | blup | 43 | 0.04 | 8.5e-06 | 3.9 | 5.3 | 1.4e-07 | 0.42 | 0.21 | 0.74 | TRUE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSSK6 | 0.02 | 0.02 | blup | 33 | 0.02 | 1.8e-03 | 5.6 | 5.8 | 5.3e-09 | 0.95 | 0.01 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GATAD2A | 0.04 | 0.03 | lasso | 2 | 0.03 | 2.9e-04 | 5.8 | 5.5 | 3.5e-08 | 0.95 | 0.02 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0892 | 0.04 | 0.04 | blup | 43 | 0.02 | 4.1e-03 | 5.0 | -5.6 | 1.7e-08 | -0.94 | 0.05 | 0.90 | FALSE |