Best TWAS P=2.98e-09 · Best GWAS P=1.6e-08 conditioned to 0.45
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-380L11.3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.4e-03 | -5.4 | -5.9 | 3.0e-09 | 0.90 | 0.04 | 0.95 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | CCDC92 | 0.19 | 0.02 | lasso | 8 | 0.09 | 3.3e-05 | -5.7 | -5.5 | 4.6e-08 | 0.65 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-380L11.4 | 0.14 | 0.12 | lasso | 4 | 0.12 | 2.2e-09 | -5.4 | -5.3 | 9.6e-08 | 0.99 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | CCDC92 | 0.05 | -0.01 | enet | 2 | -0.01 | 6.2e-01 | -5.2 | -5.2 | 1.6e-07 | 0.95 | 0.03 | 0.36 | FALSE |
| 5 | GTEx | Colon Sigmoid | RP11-380L11.4 | 0.21 | 0.12 | lasso | 3 | 0.08 | 1.1e-03 | -5.3 | -5.7 | 1.1e-08 | 0.96 | 0.02 | 0.94 | FALSE |
| 6 | GTEx | Esophagus Mucosa | CCDC92 | 0.11 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | -5.3 | -5.2 | 1.6e-07 | 0.95 | 0.03 | 0.92 | FALSE |
| 7 | GTEx | Esophagus Muscularis | RP11-380L11.4 | 0.27 | 0.29 | lasso | 8 | 0.27 | 1.0e-16 | -5.2 | -5.3 | 1.5e-07 | 0.99 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | CCDC92 | 0.12 | 0.11 | enet | 9 | 0.11 | 1.1e-05 | -4.6 | -5.2 | 1.7e-07 | 0.86 | 0.04 | 0.95 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | RP11-380L11.4 | 0.18 | 0.11 | lasso | 7 | 0.12 | 6.5e-06 | -5.7 | -5.8 | 5.1e-09 | 0.99 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Heart Left Ventricle | CCDC92 | 0.26 | 0.19 | lasso | 4 | 0.21 | 1.9e-11 | -5.3 | -5.7 | 9.4e-09 | 0.92 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Lung | RP11-380L11.4 | 0.07 | 0.07 | lasso | 3 | 0.07 | 8.2e-06 | -5.5 | -5.4 | 6.3e-08 | 0.99 | 0.03 | 0.97 | FALSE |
| 12 | GTEx | Muscle Skeletal | RP11-380L11.4 | 0.14 | 0.03 | lasso | 8 | 0.03 | 4.0e-04 | -5.4 | -5.2 | 1.6e-07 | 0.93 | 0.02 | 0.97 | FALSE |
| 13 | GTEx | Thyroid | CCDC92 | 0.06 | 0.03 | lasso | 3 | 0.02 | 1.1e-02 | -5.4 | -5.4 | 7.5e-08 | 0.94 | 0.03 | 0.94 | FALSE |
| 14 | GTEx | Thyroid | ZNF664 | 0.13 | 0.06 | lasso | 11 | 0.08 | 6.7e-07 | -5.2 | 5.9 | 4.3e-09 | -0.93 | 0.02 | 0.98 | FALSE |
| 15 | METSIM | Adipose | RP11-214K3.24 | 0.05 | 0.03 | bslmm | 444 | 0.02 | 2.7e-04 | -5.3 | -5.7 | 1.0e-08 | 0.78 | 0.02 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC92 | 0.07 | 0.02 | blup | 52 | 0.04 | 1.8e-02 | -5.2 | -5.3 | 8.9e-08 | 0.98 | 0.02 | 0.75 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DNAH10 | 0.07 | 0.03 | lasso | 3 | 0.05 | 7.4e-06 | -5.2 | -5.3 | 9.7e-08 | 0.88 | 0.02 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAH10 | 0.04 | 0.03 | lasso | 5 | 0.02 | 4.6e-03 | -4.7 | -5.6 | 2.3e-08 | 0.90 | 0.03 | 0.69 | FALSE |