Best TWAS P=4.83e-11 · Best GWAS P=3.14e-09 conditioned to 0.169
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | AC026740.1 | 0.08 | 0.06 | lasso | 3 | 0.05 | 1.0e-04 | -5.5 | 5.9 | 3.7e-09 | -0.79 | 0.02 | 0.96 | FALSE |
2 | GTEx | Brain Frontal Cortex BA9 | AC026740.1 | 0.17 | 0.02 | enet | 13 | 0.06 | 9.5e-03 | 2.9 | 5.6 | 2.0e-08 | -0.66 | 0.04 | 0.49 | FALSE |
3 | GTEx | Colon Sigmoid | AC026740.1 | 0.13 | 0.06 | lasso | 3 | 0.03 | 3.8e-02 | -5.3 | 5.5 | 5.0e-08 | -0.75 | 0.04 | 0.74 | FALSE |
4 | GTEx | Esophagus Mucosa | AC026740.1 | 0.17 | 0.07 | lasso | 5 | 0.07 | 2.2e-05 | -5.5 | 5.5 | 2.9e-08 | -0.75 | 0.04 | 0.95 | FALSE |
5 | GTEx | Esophagus Muscularis | AC026740.1 | 0.12 | 0.10 | lasso | 6 | 0.08 | 1.1e-05 | -5.1 | 5.6 | 2.1e-08 | -0.72 | 0.04 | 0.94 | FALSE |
6 | GTEx | Ovary | CTD-2228K2.7 | 0.29 | 0.03 | enet | 26 | 0.08 | 4.8e-03 | -5.3 | -5.4 | 6.2e-08 | 0.75 | 0.03 | 0.83 | FALSE |
7 | GTEx | Pancreas | EXOC3 | 0.15 | 0.09 | lasso | 4 | 0.14 | 2.0e-06 | -4.8 | 5.4 | 7.8e-08 | -0.50 | 0.11 | 0.81 | FALSE |
8 | GTEx | Prostate | EXOC3 | 0.23 | 0.13 | lasso | 14 | 0.06 | 1.1e-02 | -5.3 | 6.6 | 4.8e-11 | -0.77 | 0.02 | 0.90 | TRUE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | AC026740.1 | 0.15 | 0.10 | lasso | 5 | 0.20 | 1.9e-11 | -5.5 | 5.5 | 4.2e-08 | -0.71 | 0.04 | 0.96 | FALSE |
10 | GTEx | Stomach | AC026740.1 | 0.13 | 0.01 | lasso | 4 | 0.03 | 1.5e-02 | -5.5 | 5.4 | 5.9e-08 | -0.71 | 0.02 | 0.83 | FALSE |
11 | GTEx | Testis | AC026740.1 | 0.19 | 0.04 | enet | 8 | 0.06 | 1.3e-03 | -5.5 | 5.5 | 4.4e-08 | -0.67 | 0.02 | 0.96 | FALSE |
12 | GTEx | Whole Blood | EXOC3 | 0.08 | 0.10 | enet | 7 | 0.10 | 1.2e-09 | -4.8 | 5.6 | 2.4e-08 | -0.47 | 0.66 | 0.34 | FALSE |
13 | METSIM | Adipose | TPPP | 0.04 | 0.00 | blup | 355 | 0.01 | 1.2e-02 | -5.9 | 5.7 | 1.1e-08 | -0.69 | 0.01 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC9A3 | 0.04 | 0.02 | blup | 63 | 0.02 | 9.4e-04 | -4.8 | -5.4 | 6.6e-08 | 0.58 | 0.07 | 0.40 | FALSE |