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chr5:176,043,333-177,426,530

Best TWAS P=2.13e-08 · Best GWAS P=4.48e-08 conditioned to 0.533

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Heart Atrial Appendage	RGS14	0.18	0.18	lasso	2	0.20	2.5e-09	5.5	-5.6	2.2e-08	-0.94	0.00	1.00	TRUE
22	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RGS14	0.13	0.13	lasso	2	0.14	1.1e-09	5.5	-5.6	2.1e-08	-0.92	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RGS14	0.05	0.03	enet	5	0.05	7.2e-06	5.5	-5.6	2.8e-08	-0.87	0.00	1.00	FALSE
13	GTEx	Pituitary	RGS14	0.48	0.34	lasso	6	0.35	1.4e-09	5.5	-5.5	3.1e-08	-0.94	0.00	1.00	FALSE
14	GTEx	Skin Sun Exposed Lower leg	RGS14	0.15	0.16	lasso	3	0.15	9.1e-13	5.5	-5.5	3.1e-08	-0.95	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	RGS14	0.03	0.03	lasso	2	0.04	1.3e-03	5.5	-5.5	3.1e-08	-0.95	0.00	0.96	FALSE
12	GTEx	Nerve Tibial	RGS14	0.22	0.10	lasso	6	0.08	1.8e-06	5.3	-5.5	3.3e-08	-0.91	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RGS14	0.29	0.16	lasso	7	0.20	2.2e-23	5.5	-5.5	3.4e-08	-0.92	0.00	1.00	FALSE
3	GTEx	Adrenal Gland	RGS14	0.28	0.24	lasso	4	0.24	3.7e-09	5.3	-5.5	3.9e-08	-0.86	0.00	1.00	FALSE
16	GTEx	Thyroid	RGS14	0.15	0.14	enet	9	0.13	2.2e-10	5.3	-5.5	4.4e-08	-0.86	0.00	1.00	FALSE
6	GTEx	Breast Mammary Tissue	RGS14	0.13	0.14	lasso	1	0.11	2.0e-06	5.5	-5.5	4.8e-08	-0.96	0.00	1.00	FALSE
11	GTEx	Lung	RGS14	0.12	0.11	lasso	1	0.08	5.5e-07	5.5	-5.5	4.8e-08	-0.96	0.00	1.00	FALSE
15	GTEx	Testis	RGS14	0.63	0.47	enet	9	0.47	4.8e-23	5.5	-5.5	4.8e-08	-0.92	0.00	1.00	FALSE
10	GTEx	Heart Left Ventricle	RGS14	0.20	0.11	lasso	2	0.08	3.6e-05	5.5	-5.5	5.2e-08	-0.95	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS14	0.14	0.12	lasso	3	0.13	2.1e-14	5.3	-5.4	5.5e-08	-0.85	0.01	0.99	FALSE
7	GTEx	Cells Transformed fibroblasts	RGS14	0.52	0.39	lasso	6	0.47	4.9e-39	5.5	-5.3	8.7e-08	-0.93	0.00	1.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	RGS14	0.32	0.35	enet	12	0.38	1.1e-51	4.7	-5.3	8.7e-08	-0.91	0.13	0.87	FALSE
4	GTEx	Artery Aorta	RGS14	0.35	0.31	lasso	6	0.29	1.5e-16	5.5	-5.3	9.1e-08	-0.96	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGS14	0.09	0.08	enet	7	0.10	1.2e-08	5.5	-5.3	1.1e-07	-0.92	0.00	1.00	FALSE
8	GTEx	Esophagus Muscularis	RGS14	0.13	0.12	enet	3	0.15	3.7e-09	5.5	-5.3	1.2e-07	-0.92	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RGS14	0.31	0.10	lasso	3	0.10	2.8e-08	5.3	-5.2	1.5e-07	-0.89	0.00	1.00	FALSE
17	GTEx	Uterus	MXD3	0.51	0.10	enet	30	0.24	1.1e-05	4.0	-5.3	1.5e-07	-0.52	0.05	0.34	FALSE
5	GTEx	Artery Tibial	RGS14	0.49	0.12	enet	10	0.14	6.2e-11	5.5	-5.2	2.2e-07	-0.93	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	RGS14	0.26	0.18	lasso	5	0.19	4.5e-18	4.5	-5.1	3.1e-07	-0.92	0.03	0.97	FALSE