TWAS
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Usage
Models
Genes
Traits
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Traits
:
Ulcerative Colitis (UC)
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chr16:23,149,956-24,929,475
Best TWAS P=4.2e-08 · Best GWAS P=1.83e-08 conditioned to 0.0676
23.2M
23.4M
23.6M
23.8M
24M
24.2M
24.4M
24.6M
24.8M
25M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Artery Aorta
PRKCB
0.16
0.13
lasso
4
0.10
4.0e-06
-5.5
-5.5
4.2e-08
0.85
0.01
0.99
TRUE
3
GTEx
Esophagus Muscularis
PRKCB
0.29
0.26
lasso
5
0.25
1.4e-15
-5.5
-5.4
6.1e-08
0.87
0.00
1.00
FALSE
1
GTEx
Adrenal Gland
PRKCB
0.27
0.11
lasso
4
0.03
2.9e-02
-5.2
5.3
1.0e-07
-0.52
0.02
0.84
FALSE