Best TWAS P=6.49e-08 · Best GWAS P=4.24e-07 conditioned to 0.854
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CCDC101 | 0.09 | 0.00 | enet | 7 | 0.01 | 1.1e-01 | 5.1 | -5.1 | 2.8e-07 | -0.93 | 0.01 | 0.95 | FALSE |
2 | GTEx | Artery Coronary | SH2B1 | 0.10 | 0.09 | lasso | 6 | 0.03 | 4.5e-02 | 5.1 | -5.3 | 1.5e-07 | -0.98 | 0.02 | 0.59 | FALSE |
3 | GTEx | Artery Coronary | RP11-1348G14.4 | 0.12 | 0.11 | lasso | 2 | 0.09 | 7.6e-04 | 5.1 | -5.2 | 1.6e-07 | -0.97 | 0.02 | 0.94 | FALSE |
4 | GTEx | Artery Tibial | EIF3CL | 0.05 | 0.03 | lasso | 2 | 0.04 | 8.3e-04 | 4.6 | 5.2 | 1.8e-07 | 0.77 | 0.08 | 0.86 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | SULT1A1 | 0.05 | 0.05 | enet | 9 | 0.04 | 4.5e-04 | 4.5 | -5.3 | 9.9e-08 | -0.79 | 0.06 | 0.92 | FALSE |
6 | GTEx | Colon Transverse | NFATC2IP | 0.07 | 0.08 | lasso | 6 | 0.09 | 3.5e-05 | 4.5 | 5.3 | 1.5e-07 | 0.73 | 0.07 | 0.89 | FALSE |
7 | GTEx | Esophagus Muscularis | CCDC101 | 0.07 | 0.07 | enet | 5 | 0.04 | 2.2e-03 | 5.0 | -5.3 | 1.0e-07 | -0.97 | 0.01 | 0.93 | FALSE |
8 | GTEx | Esophagus Muscularis | SULT1A1 | 0.10 | 0.09 | enet | 16 | 0.08 | 1.0e-05 | 5.1 | -5.4 | 8.6e-08 | -0.94 | 0.02 | 0.98 | FALSE |
9 | GTEx | Heart Atrial Appendage | SULT1A1 | 0.14 | 0.08 | enet | 13 | 0.09 | 5.5e-05 | 5.1 | -5.4 | 6.5e-08 | -0.92 | 0.02 | 0.97 | TRUE |
10 | GTEx | Lung | SULT1A1 | 0.07 | 0.09 | lasso | 3 | 0.07 | 8.6e-06 | 5.0 | -5.1 | 3.0e-07 | -0.97 | 0.01 | 0.99 | FALSE |
11 | GTEx | Muscle Skeletal | CCDC101 | 0.12 | 0.08 | enet | 7 | 0.10 | 9.9e-10 | 5.1 | -5.2 | 1.9e-07 | -0.93 | 0.01 | 0.99 | FALSE |
12 | GTEx | Muscle Skeletal | SULT1A1 | 0.10 | 0.04 | enet | 20 | 0.05 | 7.5e-06 | 4.6 | -5.4 | 6.8e-08 | -0.80 | 0.03 | 0.96 | FALSE |
13 | GTEx | Pancreas | SULT1A1 | 0.12 | 0.13 | enet | 13 | 0.11 | 2.1e-05 | 4.9 | -5.4 | 6.8e-08 | -0.86 | 0.02 | 0.97 | FALSE |
14 | GTEx | Stomach | EIF3C | 0.11 | 0.07 | enet | 12 | 0.06 | 8.6e-04 | 3.1 | 5.2 | 2.4e-07 | 0.71 | 0.13 | 0.70 | FALSE |
15 | GTEx | Stomach | EIF3CL | 0.09 | 0.06 | lasso | 3 | 0.12 | 2.5e-06 | -4.4 | 5.1 | 3.0e-07 | 0.74 | 0.10 | 0.83 | FALSE |
16 | ROSMAP | Brain Pre-frontal Cortex | RP11-1348G14.1 | 0.03 | 0.01 | blup | 175 | 0.02 | 3.6e-03 | -4.2 | -5.1 | 2.8e-07 | -0.86 | 0.04 | 0.89 | FALSE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | EIF3C | 0.09 | 0.03 | blup | 10 | 0.03 | 8.6e-03 | -4.0 | 5.2 | 2.1e-07 | 0.70 | 0.01 | 0.71 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUPR1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.8e-05 | 5.1 | 5.2 | 1.8e-07 | 0.96 | 0.01 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC101 | 0.06 | 0.08 | lasso | 4 | 0.07 | 6.4e-08 | 5.1 | -5.1 | 2.9e-07 | -0.98 | 0.00 | 1.00 | FALSE |