Best TWAS P=1.88e-31 · Best GWAS P=3.05e-42 conditioned to 0.152
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | OTUD3 | 0.25 | 0.14 | lasso | 9 | 0.19 | 2.1e-22 | -2.5 | -5.8 | 6.6e-09 | 0.42 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | OTUD3 | 0.13 | 0.03 | enet | 28 | 0.05 | 1.7e-04 | -4.3 | -5.2 | 2.2e-07 | 0.30 | 0.40 | 0.07 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | PLA2G5 | 0.21 | 0.02 | lasso | 3 | 0.02 | 2.7e-02 | -13.6 | -11.7 | 1.9e-31 | 0.74 | 0.00 | 0.98 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Male) | PLA2G5 | 0.55 | 0.03 | lasso | 18 | 0.01 | 1.9e-01 | 11.4 | 8.7 | 2.5e-18 | -0.51 | 0.03 | 0.54 | TRUE |
| 5 | GTEx | Esophagus Muscularis | OTUD3 | 0.21 | 0.17 | lasso | 2 | 0.14 | 6.1e-09 | -4.3 | -6.2 | 6.0e-10 | 0.43 | 0.93 | 0.07 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | OTUD3 | 0.17 | 0.01 | lasso | 5 | 0.04 | 3.0e-03 | -4.3 | -6.0 | 1.9e-09 | 0.34 | 0.26 | 0.03 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | OTUD3 | 0.16 | 0.04 | enet | 13 | 0.13 | 1.1e-12 | -9.3 | 6.8 | 8.5e-12 | -0.44 | 0.99 | 0.01 | TRUE |