Best TWAS P=2.36e-10 · Best GWAS P=9.87e-09 conditioned to 0.00124
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BTBD1 | 0.07 | 0.01 | bslmm | 356 | 0.04 | 1.7e-05 | 3.4 | 6.3 | 2.4e-10 | -0.45 | 0.16 | 0.79 | TRUE |
| 2 | GTEx | Artery Tibial | C15orf40 | 0.17 | 0.08 | lasso | 5 | 0.07 | 2.7e-06 | -5.7 | -5.6 | 2.4e-08 | 0.59 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Cortex | BTBD1 | 0.33 | 0.13 | lasso | 5 | 0.22 | 7.9e-07 | -4.7 | 5.7 | 1.0e-08 | -0.47 | 0.14 | 0.34 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | BTBD1 | 0.12 | 0.01 | enet | 19 | 0.02 | 8.4e-02 | -5.7 | 5.4 | 5.4e-08 | -0.53 | 0.05 | 0.62 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | C15orf40 | 0.36 | 0.21 | lasso | 6 | 0.18 | 5.4e-07 | 5.5 | -5.5 | 3.7e-08 | 0.41 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Lung | C15orf40 | 0.12 | 0.10 | lasso | 5 | 0.09 | 1.6e-07 | -5.4 | -5.1 | 3.0e-07 | 0.51 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Nerve Tibial | C15orf40 | 0.20 | 0.14 | lasso | 5 | 0.14 | 4.6e-10 | -5.7 | -5.5 | 4.1e-08 | 0.49 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | C15orf40 | 0.21 | 0.04 | lasso | 7 | 0.09 | 1.5e-05 | 4.2 | -5.5 | 3.0e-08 | 0.39 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | BTBD1 | 0.13 | 0.12 | lasso | 3 | 0.13 | 2.8e-04 | -4.7 | 5.7 | 1.4e-08 | -0.56 | 0.02 | 0.52 | FALSE |