Best TWAS P=6.06e-49 · Best GWAS P=3.89e-59 conditioned to 0
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NEO1 | 0.05 | 0.00 | bslmm | 373 | 0.02 | 1.5e-03 | 0.58 | -9.2 | 4.4e-20 | 0.27 | 0.06 | 0.11 | FALSE |
2 | GTEx | Adipose Subcutaneous | MYO9A | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.7e-02 | -5.36 | 5.2 | 2.1e-07 | -0.06 | 0.04 | 0.88 | FALSE |
3 | GTEx | Artery Tibial | MYO9A | 0.07 | 0.08 | enet | 11 | 0.09 | 2.5e-07 | -5.45 | 5.2 | 2.1e-07 | -0.07 | 0.03 | 0.97 | TRUE |
4 | GTEx | Breast Mammary Tissue | MYO9A | 0.19 | 0.02 | lasso | 8 | 0.03 | 9.4e-03 | -5.36 | 5.8 | 6.5e-09 | -0.03 | 0.03 | 0.91 | TRUE |
5 | GTEx | Heart Atrial Appendage | RP11-1006G14.4 | 0.12 | 0.06 | lasso | 11 | 0.05 | 2.3e-03 | -5.36 | -6.0 | 2.3e-09 | 0.18 | 0.10 | 0.25 | TRUE |
6 | GTEx | Nerve Tibial | MYO9A | 0.13 | 0.13 | lasso | 3 | 0.11 | 2.1e-08 | -5.44 | 5.6 | 1.8e-08 | -0.02 | 0.00 | 1.00 | FALSE |
7 | GTEx | Nerve Tibial | NEO1 | 0.07 | 0.09 | lasso | 2 | 0.09 | 3.9e-07 | -5.96 | -5.9 | 4.4e-09 | 0.11 | 0.95 | 0.00 | TRUE |
8 | GTEx | Pituitary | BBS4 | 0.27 | 0.02 | enet | 21 | 0.05 | 2.1e-02 | -5.10 | -7.5 | 8.3e-14 | 0.07 | 0.09 | 0.15 | FALSE |
9 | GTEx | Pituitary | HEXA | 0.15 | 0.02 | enet | 30 | 0.03 | 4.7e-02 | 2.38 | -5.6 | 2.0e-08 | 0.02 | 0.12 | 0.10 | TRUE |
10 | GTEx | Spleen | NEO1 | 0.39 | 0.00 | lasso | 9 | 0.01 | 2.0e-01 | 12.05 | -10.7 | 1.3e-26 | 0.22 | 0.06 | 0.05 | TRUE |
11 | NTR | Blood | NEO1 | 0.04 | 0.01 | lasso | 4 | 0.02 | 4.1e-06 | 9.86 | -11.3 | 8.4e-30 | 0.33 | 0.92 | 0.02 | TRUE |
12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NR2E3 | 0.07 | 0.02 | blup | 38 | 0.05 | 4.4e-03 | -4.48 | 5.3 | 1.1e-07 | -0.04 | 0.01 | 0.28 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | HCN4 | 0.03 | 0.00 | blup | 52 | 0.02 | 2.0e-03 | 2.72 | 14.7 | 6.1e-49 | -0.52 | 0.01 | 0.45 | TRUE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | NEO1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 6.2e-03 | 12.18 | -11.1 | 7.2e-29 | 0.29 | 0.05 | 0.50 | TRUE |