Best TWAS P=9.89e-51 · Best GWAS P=4.14e-116 conditioned to 2.34e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | VSTM2L | 0.24 | -0.01 | enet | 6 | -0.01 | 9.4e-01 | -2.33 | -15.0 | 9.9e-51 | 0.60 | 0.04 | 0.34 | TRUE |
| 2 | GTEx | Nerve Tibial | KIAA1755 | 0.14 | 0.00 | lasso | 5 | 0.00 | 3.0e-01 | -13.61 | 10.0 | 1.5e-23 | -0.46 | 0.05 | 0.12 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | KIAA1755 | 0.15 | 0.02 | lasso | 6 | 0.04 | 1.5e-04 | 0.40 | 7.6 | 2.9e-14 | -0.17 | 0.20 | 0.22 | TRUE |
| 4 | GTEx | Testis | KIAA1755 | 0.19 | 0.12 | lasso | 3 | 0.10 | 2.5e-05 | -13.52 | 14.2 | 6.9e-46 | -0.36 | 0.68 | 0.03 | TRUE |
| 5 | METSIM | Adipose | BPI | 0.08 | 0.00 | bslmm | 494 | 0.03 | 3.4e-05 | -0.41 | 5.8 | 8.4e-09 | -0.22 | 0.14 | 0.02 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1755 | 0.02 | 0.00 | blup | 84 | 0.00 | 1.2e-01 | -22.76 | 14.7 | 6.5e-49 | -0.76 | 0.01 | 0.71 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | TGM2 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.8e-04 | 5.63 | 6.5 | 8.1e-11 | -0.23 | 0.63 | 0.02 | TRUE |