Hub : Genes

KIAA1755

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1408	0.0562	0.00440	-0.003	NA	-0.003	NA	0.000	6.3e-01	NA	6.7e-01	NA	3.0e-01
2	GTEx	Skin Sun Exposed Lower leg	0.1510	0.0460	0.00013	0.020	NA	0.029	NA	0.044	7.7e-03	NA	1.8e-03	NA	1.5e-04
3	GTEx	Testis	0.1930	0.0750	0.00360	0.125	NA	0.089	NA	0.104	3.6e-06	NA	9.5e-05	NA	2.5e-05
4	TCGA	Breast Invasive Carcinoma	0.0184	0.0099	0.00740	-0.001	0.002	-0.001	NA	-0.001	9.1e-01	0.12	7.9e-01	NA	9.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	4.0	-1.0	2.0	-0.7	0.4
Bipolar Disorder or Schizophrenia	1.7	4.1	5.8	-2.2	2.1	-2.4	1.3
Depressed Affect (Nagel 2018)	0.7	1.6	3.8	0.2	-1.9	-1.2	1.0
Depression (Nagel 2018)	1.1	1.7	5.7	0.1	-0.9	0.6	-2.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.5	-1.1	0.3	-1.6	-1.6
Neuroticism (Nagel 2018)	0.5	1.2	3.9	-0.2	-2.0	-0.8	-0.4
Schizophrenia (2018)	1.6	3.3	6.3	-2.1	1.0	-2.5	1.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.0	-0.8	-0.5	-0.3
Worry (Nagel 2018)	1.2	2.4	5.3	-0.5	-2.3	-1.5	-1.4
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	1.9	-1.2	0.5	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.8	-0.1	0.5	0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.1	1.4	-0.6	0.6	-0.1
Crohns Disease (2017)	1.4	3.0	6.2	-1.0	2.5	2.2	-0.3
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	-0.8	0.7	0.7	-0.2
Ulcerative Colitis (UC)	0.5	0.9	1.8	-0.7	-1.4	-1.1	-0.5
Major Depression (MDD)	0.4	0.5	0.9	-0.9	-0.6	-0.9	0.2
Reaction Time	0.3	0.7	1.7	1.3	-0.6	-0.4	0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.2	-1.3	-1.3	-1.8	-1.0
Breast Cancer	0.4	1.1	1.6	-0.9	-0.5	-1.2	-1.3
Ovarian Cancer	0.4	0.6	1.3	-1.2	0.7	0.7	-0.1
Prostate Cancer	1.1	1.5	4.3	-0.0	0.8	1.0	-2.1
Age at First Birth	0.9	1.3	2.5	-1.1	-1.3	-1.6	-0.2
Bipolar Disorder (2011)	0.4	0.4	0.9	-0.8	-0.1	0.1	-0.9
Body Mass Index (BMI) (2010)	2.2	3.0	6.4	2.5	0.6	1.1	2.0
Coronary Artery Disease (CAD)	1.6	1.9	6.8	0.4	2.6	-0.0	0.8
Crohns Disease (2012)	1.0	1.5	4.0	-1.1	2.0	1.0	-0.4
Mean Putamen Volume	0.5	0.6	1.6	-1.3	0.8	0.2	-0.2
Fasting Glucose	1.8	2.1	6.3	-0.8	2.5	1.2	-0.3
HbA1C	1.0	1.1	2.1	0.3	1.4	1.4	0.7
HDL Cholesterol	1.7	2.8	4.8	-2.0	-1.4	-2.2	-0.5
LDL Cholesterol	0.8	1.3	3.7	1.9	0.5	1.2	-0.1
Lupus	1.9	2.9	6.3	1.5	1.2	2.5	1.2
Neuroticism (2016)	1.7	2.4	7.1	0.1	-2.7	1.0	1.3
Primary Biliary Cirrhosis	1.1	1.5	2.6	-0.9	1.2	-1.2	1.6
Rheumatoid Arthritis	0.5	0.7	2.3	0.5	1.5	0.4	-0.1
Schizophrenia (2014)	1.2	2.7	3.6	-1.8	1.5	-1.9	1.4
Triglycerides	1.4	2.4	3.5	1.8	-0.9	1.9	-1.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	5.6	-0.8	0.7	2.4	1.3
Ulcerative Colitis	0.3	0.4	1.3	-1.1	-0.4	-0.1	-0.3
Blood Eosinophil Count	0.2	1.8	3.1	0.6	1.8	1.5	-1.2
Blood Platelet Count	1.0	11.4	24.4	3.2	4.9	3.3	0.6
Blood Red Count	0.2	2.3	5.6	1.4	0.3	2.4	-1.2
Blood White Count	0.9	6.7	23.6	-0.2	4.9	1.1	-1.4
Heel T-Score	0.3	2.0	7.7	0.2	0.4	-0.4	-2.8
BMI	0.4	2.3	3.4	0.7	1.8	1.6	1.8
Height	0.3	6.6	10.5	-2.9	-2.3	-3.2	-1.4
Waist Hip Ratio (WHR)	0.3	1.4	2.4	1.0	0.6	1.3	1.6
Systolic Blood Pressure	0.6	2.8	8.2	-1.3	-0.9	-0.7	-2.9
Smoking Status	1.3	3.1	8.6	0.4	1.3	2.9	1.4
Allergy or Eczema	0.6	1.6	5.8	0.6	0.3	0.4	2.4
Cardiovascular Disease	0.2	0.7	1.7	-0.6	-1.3	0.6	-0.4
Hypothyroidism (self reported)	0.9	2.1	6.0	2.4	0.2	1.5	0.4
Respiratory disease	0.6	1.3	2.3	-1.5	-0.4	-0.7	1.5
Type 2 Diabetes (T2D) (2018)	1.4	2.5	6.0	1.0	0.0	2.4	1.8
Lung FEV1/FVC ratio	0.3	1.3	3.0	1.7	0.8	1.1	0.6
Lung FVC	0.2	1.0	2.9	1.7	0.7	0.6	0.4
Neuroticism	0.2	0.5	1.0	-0.3	-1.0	-0.9	-0.1
Chronotype (morning person)	0.8	1.7	2.4	1.5	1.5	1.4	-0.5
Hair Pigment	0.1	4.2	8.2	1.9	2.0	2.9	-1.0
Tanning	0.2	1.9	4.8	-1.1	-0.2	-2.2	1.3
Hand grip strength (left)	1.1	2.8	7.6	-2.8	-0.6	-0.8	-1.6
Number of treatments/medications taken	1.6	2.8	5.4	2.3	-1.9	1.2	1.0
Average weekly spirits intake	1.9	2.4	5.1	2.3	0.5	1.1	1.7
Sensitivity / hurt feelings	0.8	1.4	2.7	-1.6	-0.1	-0.5	-1.6
Frequency of depressed mood in last 2 weeks	1.4	2.0	6.9	0.0	-1.0	-0.5	-2.6
Hearing difficulty/problems: Yes	0.4	0.6	1.2	0.3	-0.9	0.3	1.1
Relative age of first facial hair	1.0	2.1	4.2	-2.1	-0.6	-1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.2	-0.3	1.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.6	-0.5	0.5	-0.4	-0.8
Ever had hysterectomy (womb removed)	0.6	0.6	1.7	-0.1	1.3	0.4	-0.8
Systolic blood pressure, automated reading	0.2	0.7	1.6	-0.9	0.4	0.3	-1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	0.4	-0.1	1.2	-0.1
Angina	0.8	1.1	1.7	1.2	-1.3	1.0	-0.3
Medication for hormone replacement therapy	1.0	1.1	2.2	0.8	0.3	1.2	-1.5
Vitamin and mineral supplements	0.7	0.9	2.1	-0.2	0.8	-1.0	-1.4
Supplements: Zinc	1.1	1.2	2.9	0.9	-1.7	-0.5	-0.9
Medication: Co-codamol	2.0	2.3	7.5	2.7	0.1	-0.4	1.2
Medication: Metformin	1.3	1.8	4.3	0.7	-0.0	2.1	1.5
Diabetes (father)	2.3	2.8	10.6	0.6	0.5	0.2	3.3
Diabetes (mother)	0.2	0.3	0.9	1.0	0.5	-0.3	-0.2
Severe depression (siblings)	1.2	1.4	2.7	1.1	-0.2	1.3	-1.7
Pack years adult smoking proportion	0.8	1.2	2.9	-0.0	-1.4	-0.1	-1.7
Impedance of leg (right)	1.4	6.7	11.9	3.2	2.2	3.5	0.3
Leg fat-free mass (left)	0.9	5.0	8.9	-3.0	-1.7	-2.8	-0.4
Trunk fat percentage	0.6	2.4	3.0	1.2	1.6	1.6	1.7
Hand grip strength (right)	0.4	1.2	2.3	-1.4	0.3	0.5	-1.5
Townsend deprivation index at recruitment	0.7	1.0	1.9	-1.1	-0.3	1.0	-1.4
Current tobacco smoking	0.5	0.8	1.2	-0.8	0.9	1.1	-0.8
Average weekly fortified wine intake	0.5	0.6	1.9	0.4	1.4	0.5	0.2
Maternal smoking around birth	0.7	1.0	2.3	-0.4	-1.5	-0.9	-0.9
Fed-up feelings	0.2	0.4	0.7	0.3	-0.8	-0.6	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.7	8.9	0.1	-1.0	1.1	-3.0
Relative age voice broke	0.4	0.6	1.8	-0.0	-1.4	-0.7	0.0
Taking other prescription medications	1.0	1.6	3.7	1.2	-0.5	1.0	1.9
Age when periods started (menarche)	0.6	1.5	2.1	-0.5	-1.4	1.4	1.4
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	5.8	0.4	0.9	0.6	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.3	-0.7	-1.5	-0.2	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.2	1.0	0.5	-0.7
Qualifications: CSEs or equivalent	1.9	2.5	6.2	1.5	0.6	1.0	2.5
Serious illness, injury or assault to yourself	1.0	1.2	3.3	-0.4	0.5	1.8	1.1
High blood pressure	0.3	0.8	2.1	-0.8	-1.4	0.5	-0.5
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.1	0.5	0.7	0.3	2.3
Multivitamins +/- minerals	0.8	1.0	1.8	0.8	-1.0	0.9	1.3
Stomach or abdominal pain in last month	0.6	0.7	2.6	0.2	-1.6	0.3	-0.2
Supplements: Glucosamine	1.0	1.3	2.5	0.8	-0.7	-1.3	1.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	0.0	-1.3	-0.1	-0.5
Medication: Atenolol	1.7	2.2	7.2	0.9	-2.7	-0.7	0.5
Medication: Levothyroxine sodium	0.9	1.5	2.5	1.5	1.6	1.1	-0.2
Sitting height	1.4	10.0	19.4	-3.9	-1.8	-4.4	-1.5
Chronic bronchitis/emphysema (father)	0.8	0.9	2.8	0.6	-1.7	-0.1	-0.7
High blood pressure (mother)	0.6	0.9	1.8	-1.3	0.8	-1.0	-0.2
Body mass index (BMI)	0.2	0.7	1.4	-0.6	0.9	0.5	1.2
Impedance of leg (left)	1.1	5.5	9.7	2.9	1.7	3.1	1.0
Leg predicted mass (left)	1.0	5.2	9.4	-3.1	-1.6	-3.0	-0.4
Trunk fat mass	0.3	1.2	2.7	0.2	1.2	0.8	1.6
Waist circumference	0.2	0.8	2.0	-0.5	1.0	0.3	1.4
Number of incorrect matches in round	0.5	0.8	1.8	-0.5	-1.3	0.6	0.8
Past tobacco smoking	1.7	3.2	4.8	-0.9	-1.7	-2.1	-2.2
Alcohol usually taken with meals	0.5	0.9	1.5	-0.6	-1.2	-1.2	-0.4
Nervous feelings	0.8	1.5	6.0	-0.0	-0.1	0.4	-2.4
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.9	-1.4	-1.7	-1.6	-0.5
Hearing difficulty/problems with background noise	1.1	1.8	4.4	-0.7	-1.4	-2.1	0.5
Hair/balding pattern: Pattern 2	1.0	1.3	4.7	0.6	-0.4	-0.1	2.2
Had menopause	1.1	1.4	3.6	0.6	1.9	0.8	-1.0
Had other major operations	0.0	0.1	0.2	0.1	0.1	-0.1	0.5
Forced vital capacity (FVC)	0.1	0.4	1.2	-0.5	1.1	-0.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	-0.2	-0.3	-0.0	-1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.4	-1.6	0.1	0.4	-1.5
Qualifications: None of the above	0.1	0.3	0.6	-0.3	0.2	0.7	0.8
Financial difficulties in last 2 years	0.3	0.4	1.1	0.3	-0.7	-1.1	0.2
Mouth/teeth dental problems	1.0	1.6	3.7	-0.1	1.9	0.6	-1.5
Heart attack	0.6	0.7	1.6	0.9	-0.6	1.3	0.2
Allergy	0.6	1.4	5.0	0.6	-0.6	-0.0	-2.2
Pain all over the body in last month	1.1	1.2	2.2	0.6	-1.5	0.2	1.4
Diabetes (self-reported)	1.6	2.5	5.8	1.2	-0.6	2.4	1.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.6	0.7	-1.1	0.9	1.9
Medication: Ramipril	0.2	0.2	0.4	0.2	0.6	-0.3	-0.6
Medication: Simvastatin	0.6	0.9	2.6	0.7	0.6	0.4	1.6
Fluid intelligence score	0.7	1.5	1.9	-1.0	-1.2	-1.4	-1.4
Illnesses of siblings	0.2	0.3	0.7	-0.3	-0.3	-0.8	-0.4
Neuroticism score	0.3	0.6	1.3	-0.4	-1.2	-0.7	-0.7
Weight	0.2	1.1	2.9	-1.7	0.4	-0.8	0.7
Impedance of arm (right)	0.1	0.7	2.0	1.4	0.3	0.7	-0.4
Arm fat percentage (right)	0.3	1.0	2.1	0.3	1.1	0.9	1.4
Trunk fat-free mass	1.0	5.5	12.4	-3.5	-1.3	-2.7	-0.7
Hip circumference	0.2	0.8	2.7	-1.6	0.2	-0.4	0.5
Time employed in main current job	0.2	0.2	0.4	-0.3	0.3	-0.5	0.6
Alcohol intake versus 10 years previously	0.9	1.3	3.7	0.6	0.8	0.8	-1.9
Father’s age at death	0.7	0.9	2.8	-1.7	0.5	-0.2	0.7
Worrier / anxious feelings	0.4	0.7	2.3	0.4	-0.7	-0.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.3	-0.2	-2.3	0.7	0.1
Falls in the last year	2.2	2.9	6.7	1.3	-1.7	-0.6	2.6
Hair/balding pattern: Pattern 3	1.1	1.6	3.9	-0.7	0.5	-1.4	-2.0
Number of live births	0.3	0.4	0.8	0.9	0.3	0.8	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.6	-0.2	0.7	-0.2	-0.0
Pulse rate	36.7	61.9	88.9	6.9	4.8	9.3	9.4
Happiness	1.0	1.2	4.7	0.3	0.1	-2.2	-0.4
Noisy workplace	1.5	1.8	4.5	2.1	-0.0	1.3	1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.1	0.2	-1.1	0.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.0	-0.6	-1.0	-0.2	0.5
Mouth/teeth dental problems: Dentures	0.4	0.6	1.2	0.4	0.1	-1.1	1.1
Asthma	1.1	2.3	6.1	-1.4	-1.0	-0.3	2.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	1.3	-0.1	1.1	-0.2
Medication: Cholesterol lowering	0.7	1.1	2.9	0.7	0.7	-0.7	1.7
Depression (self-reported)	1.5	1.8	5.9	0.1	-2.4	-0.4	1.0
Medication: Lansoprazole	0.8	0.9	2.3	0.3	-0.3	1.1	1.5
Prospective memory result	0.1	0.2	0.3	-0.3	0.6	0.4	-0.2
Lung cancer (father)	0.7	0.8	1.6	0.4	-1.3	0.7	-1.0
Illnesses of mother	0.3	0.3	0.4	-0.6	-0.5	0.7	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.5	-0.2	1.6	-0.3	-0.9
Pulse wave Arterial Stiffness index	0.9	1.1	1.2	-1.1	-1.0	-1.0	1.1
Impedance of arm (left)	0.4	1.7	4.0	2.0	0.3	1.4	-0.7
Arm fat mass (right)	0.1	0.5	1.1	-0.7	0.6	-0.0	1.0
Trunk predicted mass	0.9	5.4	12.3	-3.5	-1.3	-2.6	-0.7
Standing height	0.4	3.9	7.1	-2.5	-1.1	-2.7	-1.1
Length of working week for main job	0.3	0.4	0.8	-0.3	0.6	0.2	-0.9
Exposure to tobacco smoke at home	0.4	0.4	0.9	-0.5	-0.9	-0.1	0.7
Breastfed as a baby	0.4	0.5	1.3	-0.4	0.3	-1.1	0.6
Tense / ‘highly strung’	0.2	0.3	0.6	0.8	-0.6	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	3.6	-1.5	-1.9	-1.9	-0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.0	0.3	-0.0	-0.6
Birth weight of first child	0.9	1.7	6.0	-0.6	-0.6	-2.4	0.4
Peak expiratory flow (PEF)	1.4	3.2	8.2	-1.9	0.1	-2.9	-1.0
Pulse wave reflection index	14.4	17.8	27.6	-4.1	-3.5	-5.3	-3.8
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	0.2	1.5	1.3	1.0
Loud music exposure frequency	1.0	1.1	2.2	-1.2	0.3	1.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	0.6	0.8	-0.5	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.2	-0.3	-1.5	0.2	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.2	0.6	-0.2	1.0
Medication: Paracetamol	1.9	3.1	6.4	1.8	0.4	2.5	1.6
Headache pain in last month	0.2	0.3	0.6	0.3	-0.1	0.8	0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	-0.3	1.1	0.9	-1.6
Glaucoma (self-reported)	0.3	0.4	0.9	0.6	-0.3	0.4	-1.0
Gout (self-reported)	1.9	2.7	7.2	-0.1	0.5	2.7	-1.8
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.0	2.2	0.4	1.2	-0.3
Medication: Amlodipine	0.3	0.5	0.9	-0.5	-0.9	-0.3	0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.8	-0.1	-0.3	0.3
Birth weight	1.1	2.3	4.9	-1.1	-1.1	-2.2	1.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.1	-1.0	-0.2	-1.0
High blood pressure (siblings)	0.4	0.5	1.0	0.5	-0.0	-0.9	1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	-0.2	1.3	-0.1	-1.1
Body fat percentage	0.8	3.1	4.3	1.3	1.9	1.8	2.1
Leg fat percentage (right)	1.2	4.3	5.2	1.5	2.3	2.3	2.1
Arm fat-free mass (right)	0.7	3.7	8.7	-3.0	-0.9	-2.3	0.1
Exposure to tobacco smoke outside home	1.5	2.0	4.8	-0.3	-2.2	-1.3	1.1
Comparative body size at age 10	0.7	2.0	7.5	-0.8	-2.7	-0.2	-0.1
Number of full brothers	0.7	0.9	1.8	0.2	1.3	-0.3	-1.3
Worry too long after embarrassment	0.5	0.9	2.4	-0.9	-0.6	-0.4	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.5	-0.5	-0.2	0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.0	0.2	0.8	-0.7
Number of children fathered	0.1	0.2	0.4	-0.3	0.4	-0.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.1	0.4	0.6	-0.5
Age at first live birth	0.5	1.0	1.8	0.5	-1.2	-0.5	1.4
Pulse wave peak to peak time	0.8	0.9	1.5	0.7	1.0	0.8	-1.2
Health satisfaction	0.8	1.0	2.6	0.9	-1.6	0.7	-0.3
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.1	0.2	1.2	-0.8
Qualifications: College or University degree	0.6	1.8	4.0	-1.1	-2.0	-1.3	-0.7
Eye problems/disorders: None of the above	1.5	1.8	2.8	-1.5	1.3	-1.7	0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.3	-1.5	0.6	0.6	0.1
Emphysema/chronic bronchitis	0.6	0.6	1.4	-1.2	0.8	0.6	-0.3
Medication for pain relief, constipation, heartburn	2.5	4.2	7.3	-2.7	-0.9	-2.6	-1.3
Neck or shoulder pain in last month	1.1	1.6	6.0	-0.3	-2.5	0.1	-0.3
Medication: Blood pressure	0.5	0.9	2.4	0.0	-1.6	-0.3	0.9
Angina (self-reported)	0.8	1.0	1.8	1.1	-1.3	1.0	-0.5
Migraine (self-reported)	1.2	1.4	4.5	2.1	0.6	0.9	0.2
Medication: Ibuprofen	0.4	0.5	1.4	1.2	-0.6	0.3	-0.2
Medication: Allopurinol	1.2	1.6	3.6	-0.4	0.5	1.9	-1.5
Medication: Omeprazole	1.3	1.5	4.7	0.4	-2.2	-0.2	1.1
Medication: Seretide 50 evohaler	0.4	0.5	1.5	-0.2	-1.2	0.7	-0.1
Mean time to correctly identify matches	0.6	1.2	4.3	2.1	-0.0	0.0	0.5
Heart disease (mother)	0.4	0.5	0.9	-0.7	0.9	-0.6	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.6	-0.3	-1.3	-0.5	1.9
Whole body fat mass	0.2	1.0	3.4	0.0	0.8	0.4	1.8
Leg fat mass (right)	0.4	1.4	3.6	0.0	1.2	0.8	1.9
Arm predicted mass (right)	0.8	4.1	10.2	-3.2	-1.1	-2.2	0.2
Pulse rate, automated reading	44.5	143.9	216.1	10.0	7.6	14.2	14.7
Alcohol intake frequency.	1.5	3.5	9.2	1.1	0.2	3.0	-1.9
Comparative height size at age 10	0.1	0.4	1.1	0.4	-0.4	-1.0	-0.5
Number of full sisters	0.6	0.7	2.7	-1.7	0.4	-0.2	-0.1
Suffer from ‘nerves’	1.4	2.2	5.1	-0.5	-1.8	-0.4	-2.2
Overall health rating	0.6	1.3	2.5	-0.5	-1.6	1.6	0.2
Chest pain or discomfort	1.0	1.4	2.2	0.8	-0.9	1.5	-1.3
Had major operations	0.5	0.6	2.0	0.4	-1.4	-0.3	-0.5
Age at last live birth	1.2	1.8	2.7	1.3	-1.6	-1.3	1.0
Family relationship satisfaction	1.1	1.4	3.8	-1.2	0.3	-1.9	0.6
Leg pain on walking	2.7	3.4	4.2	1.8	1.8	1.7	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	0.6	0.8	1.2	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	0.6	1.3	0.5	0.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.1	0.7	1.5	1.8	-0.4
Medication: Aspirin	1.2	1.6	2.4	1.6	1.1	1.5	0.6
Supplements: Vitamin C	0.4	0.5	1.0	-0.9	-0.3	-0.0	-1.0
Knee pain experienced in last month	0.9	1.5	3.6	1.9	0.2	1.0	1.1
Hypertension (Self-reported)	0.3	0.9	2.9	-0.8	-1.7	0.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	5.2	1.7	-2.3	-1.1	2.2
Illnesses of father: Heart disease	1.0	1.4	4.9	0.1	0.6	-0.6	-2.2
Illnesses of siblings: Diabetes	0.6	0.7	1.8	0.0	1.3	0.9	0.6
Smoking status: Previous	3.1	4.7	10.1	1.3	1.1	2.4	3.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.2	-2.3	-0.3	-0.9	-1.1
Whole body fat-free mass	1.0	5.6	11.4	-3.4	-1.5	-2.9	-0.4
Leg fat-free mass (right)	1.2	6.3	11.1	-3.3	-1.8	-3.3	-0.2
Arm fat percentage (left)	0.3	1.1	1.9	0.5	1.0	1.1	1.4
Average weekly red wine intake	0.1	0.1	0.3	-0.3	-0.2	-0.2	0.5
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.4	-1.8	-1.2	-0.1	-1.5
Mood swings	0.2	0.3	0.5	0.3	-0.7	-0.6	0.5
Loneliness, isolation	0.3	0.4	0.7	-0.8	-0.7	0.3	-0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.1	-0.1	0.3	1.1	1.0
Ever had bowel cancer screening	1.5	1.7	5.0	0.0	-2.2	-1.1	0.8
Diabetes diagnosed by doctor	1.2	2.0	4.2	0.5	-0.4	2.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.2	0.4	-1.1	-0.5	0.5
Friendships satisfaction	0.7	0.9	2.1	-1.0	0.0	-1.5	0.5
Qualifications: nursing, teaching	0.3	0.5	1.5	-0.2	-0.5	0.2	-1.2
Commuting to job workplace: Walk	0.9	1.0	1.8	-1.4	0.7	1.0	-0.8
Eye problems/disorders: Cataract	0.9	1.1	1.9	1.1	-1.4	0.9	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	0.8	-0.5	-0.5	1.1
Medication for cholesterol	1.3	2.0	3.6	-1.4	1.6	-0.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.6	2.1	0.5	1.6	0.7
Back pain experienced in last month	0.2	0.3	0.8	-0.3	-0.5	-0.3	-0.9
Mineral and other dietary supplements	0.1	0.1	0.3	-0.5	0.4	-0.0	0.0
Breast cancer (self-reported)	2.5	2.9	5.4	0.9	2.1	0.9	2.3
Asthma (self-reported)	1.3	2.5	5.5	-1.2	-1.6	-0.7	2.4
Osteoporosis (self-reported)	0.2	0.3	0.7	-0.5	-0.3	-0.2	0.8
Osteoarthritis (self-reported)	5.1	6.6	11.0	2.5	3.3	2.9	1.0
Medication: Aspirin	2.0	2.6	4.7	2.2	1.7	1.6	0.6
Medication: Gliclazide	0.7	0.8	2.7	0.5	0.4	0.2	1.6
Illnesses of father: None of the above (group 1)	0.7	0.8	1.6	-0.5	-0.9	1.3	0.7
Smoking status: Current	0.6	1.0	1.8	-0.6	1.3	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.7	0.8	0.8	-0.2	0.7
Whole body water mass	1.0	5.7	11.4	-3.4	-1.6	-3.0	-0.5
Leg predicted mass (right)	1.2	6.3	11.5	-3.4	-1.9	-3.2	-0.3
Arm fat mass (left)	0.1	0.5	1.2	-0.7	0.6	0.3	1.1
Number of self-reported non-cancer illnesses	0.4	0.8	1.9	0.7	-1.4	0.1	0.8
Average weekly champagne plus white wine intake	0.3	0.5	1.3	-0.7	-1.1	0.1	-0.2
Miserableness	0.5	0.8	1.8	0.5	-1.3	-1.0	-0.5
Guilty feelings	0.6	1.0	3.8	-0.2	0.1	-0.0	-1.9
Wears glasses or contact lenses	0.1	0.2	0.2	-0.4	0.1	-0.5	-0.4
Ever taken oral contraceptive pill	2.0	2.2	4.3	-1.7	-0.7	-2.1	-1.0
Hearing aid user	1.4	1.6	4.3	0.4	-1.4	2.1	-0.3
Mother’s age at death	0.6	0.7	1.6	-0.9	1.3	0.8	-0.2
Financial situation satisfaction	0.2	0.2	0.8	0.9	0.1	0.2	-0.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.7	-0.7	-1.5	-1.6	0.7
Commuting to job workplace: Public transport	1.0	1.2	2.6	0.6	-1.6	1.1	-0.7
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.6	0.4	0.9	-0.2
Medication: Blood pressure	0.9	1.7	3.9	0.7	-2.0	0.1	-1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-1.6	-0.7	-0.3	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.9	-0.3	-1.4	-0.2	0.5
High cholesterol (Self-reported)	0.3	0.5	1.2	0.9	0.0	-0.1	1.1
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.1	-0.8	0.1	-0.7
Medication: Paracetamol	0.7	1.1	1.5	1.1	-0.4	1.2	1.2
Medication: Lisinopril	1.5	1.9	5.3	-1.3	-2.3	0.5	0.8
Medication: Atorvastatin	0.8	1.0	2.7	0.5	0.2	1.6	-1.0
Illnesses of father: High blood pressure	1.0	1.2	3.6	-0.2	1.1	-1.9	0.4
Alcohol drinker status: Never	0.2	0.2	0.8	0.1	-0.9	-0.2	0.1
Ever smoked	0.5	0.8	1.7	-0.7	1.3	0.5	0.9
Basal metabolic rate	0.8	4.2	9.4	-3.1	-1.1	-2.5	-0.1
Leg fat percentage (left)	1.0	3.6	6.3	1.2	1.8	1.9	2.5
Arm fat-free mass (left)	0.8	4.0	9.6	-3.1	-0.9	-2.4	0.2
Number of operations (self-reported)	0.4	0.5	1.4	1.2	-0.6	0.6	0.1
Average weekly beer plus cider intake	0.3	0.5	1.1	1.0	0.7	-0.4	0.4
Irritability	0.2	0.4	1.2	1.1	0.1	0.4	0.3
Risk taking	0.2	0.3	0.6	-0.8	0.8	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.0	0.4	-1.4	-1.2	-0.1
Fractured/broken bones in last 5 years	0.6	0.8	2.2	-0.6	0.7	-1.5	-0.3
Age started oral contraceptive pill	1.2	1.5	4.9	-0.1	-0.0	-1.1	2.2
Diastolic blood pressure, automated reading	1.6	5.1	11.7	1.5	2.0	3.4	1.6
Ever depressed for a whole week	0.9	1.1	1.8	-1.1	0.4	1.3	-1.0
Unable to work because of sickness or disability	0.7	0.9	2.2	1.5	-0.2	1.0	0.5
Commuting to job workplace: Cycle	2.0	2.4	5.2	0.8	-2.3	-1.7	0.9
Myopia	0.3	0.4	0.9	-0.1	0.9	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.4	0.2	1.5	-0.5	0.7
Cholesterol lowering medication	0.2	0.2	0.5	0.7	-0.5	0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.5	0.7	-1.6	0.2	0.7
Pain experienced in last month	0.7	1.1	2.7	-0.7	1.6	-1.1	-0.5
Supplements: Calcium	0.5	0.5	0.9	-0.3	-0.8	0.6	1.0
Basal cell carcinoma (self-reported)	1.3	1.5	2.9	-0.5	1.5	0.7	-1.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.7	0.9	-0.6	1.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.4	0.8	-0.1	1.0
Heart disease (siblings)	0.5	0.6	1.1	0.7	-0.0	1.0	-1.1
Alcohol drinker status: Previous	2.0	2.3	4.4	1.4	1.7	2.1	-0.1
Pack years of smoking	0.8	1.1	1.9	0.8	-1.4	0.2	-1.3
Impedance of whole body	0.6	2.9	5.7	2.4	1.1	2.2	0.1
Leg fat mass (left)	0.4	1.4	4.6	-0.1	0.8	0.6	2.2
Arm predicted mass (left)	0.8	4.0	9.4	-3.1	-0.8	-2.5	0.3