Hub : Genes

KIAA1755

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.1408 0.0562 0.00440 -0.003 NA -0.003 NA 0.000 6.3e-01 NA 6.7e-01 NA 3.0e-01
2 GTEx Skin Sun Exposed Lower leg 0.1510 0.0460 0.00013 0.020 NA 0.029 NA 0.044 7.7e-03 NA 1.8e-03 NA 1.5e-04
3 GTEx Testis 0.1930 0.0750 0.00360 0.125 NA 0.089 NA 0.104 3.6e-06 NA 9.5e-05 NA 2.5e-05
4 TCGA Breast Invasive Carcinoma 0.0184 0.0099 0.00740 -0.001 0.002 -0.001 NA -0.001 9.1e-01 0.12 7.9e-01 NA 9.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.9 1.4 4.0 -1.0 2.0 -0.7 0.4
Bipolar Disorder or Schizophrenia 1.7 4.1 5.8 -2.2 2.1 -2.4 1.3
Depressed Affect (Nagel 2018) 0.7 1.6 3.8 0.2 -1.9 -1.2 1.0
Depression (Nagel 2018) 1.1 1.7 5.7 0.1 -0.9 0.6 -2.4
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.5 -1.1 0.3 -1.6 -1.6
Neuroticism (Nagel 2018) 0.5 1.2 3.9 -0.2 -2.0 -0.8 -0.4
Schizophrenia (2018) 1.6 3.3 6.3 -2.1 1.0 -2.5 1.3
Schizophrenia vs Biploar Disorder 0.2 0.2 0.6 0.0 -0.8 -0.5 -0.3
Worry (Nagel 2018) 1.2 2.4 5.3 -0.5 -2.3 -1.5 -1.4
Alzheimer’s Disease (in mother) 1.2 1.4 3.5 1.9 -1.2 0.5 -0.6
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.8 -0.1 0.5 0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 2.1 1.4 -0.6 0.6 -0.1
Crohns Disease (2017) 1.4 3.0 6.2 -1.0 2.5 2.2 -0.3
Irritable Bowel Disease (IBD) 0.2 0.4 0.6 -0.8 0.7 0.7 -0.2
Ulcerative Colitis (UC) 0.5 0.9 1.8 -0.7 -1.4 -1.1 -0.5
Major Depression (MDD) 0.4 0.5 0.9 -0.9 -0.6 -0.9 0.2
Reaction Time 0.3 0.7 1.7 1.3 -0.6 -0.4 0.6
Verbal and Numeric Reasoning (VNR) 0.8 1.9 3.2 -1.3 -1.3 -1.8 -1.0
Breast Cancer 0.4 1.1 1.6 -0.9 -0.5 -1.2 -1.3
Ovarian Cancer 0.4 0.6 1.3 -1.2 0.7 0.7 -0.1
Prostate Cancer 1.1 1.5 4.3 -0.0 0.8 1.0 -2.1
Age at First Birth 0.9 1.3 2.5 -1.1 -1.3 -1.6 -0.2
Bipolar Disorder (2011) 0.4 0.4 0.9 -0.8 -0.1 0.1 -0.9
Body Mass Index (BMI) (2010) 2.2 3.0 6.4 2.5 0.6 1.1 2.0
Coronary Artery Disease (CAD) 1.6 1.9 6.8 0.4 2.6 -0.0 0.8
Crohns Disease (2012) 1.0 1.5 4.0 -1.1 2.0 1.0 -0.4
Mean Putamen Volume 0.5 0.6 1.6 -1.3 0.8 0.2 -0.2
Fasting Glucose 1.8 2.1 6.3 -0.8 2.5 1.2 -0.3
HbA1C 1.0 1.1 2.1 0.3 1.4 1.4 0.7
HDL Cholesterol 1.7 2.8 4.8 -2.0 -1.4 -2.2 -0.5
LDL Cholesterol 0.8 1.3 3.7 1.9 0.5 1.2 -0.1
Lupus 1.9 2.9 6.3 1.5 1.2 2.5 1.2
Neuroticism (2016) 1.7 2.4 7.1 0.1 -2.7 1.0 1.3
Primary Biliary Cirrhosis 1.1 1.5 2.6 -0.9 1.2 -1.2 1.6
Rheumatoid Arthritis 0.5 0.7 2.3 0.5 1.5 0.4 -0.1
Schizophrenia (2014) 1.2 2.7 3.6 -1.8 1.5 -1.9 1.4
Triglycerides 1.4 2.4 3.5 1.8 -0.9 1.9 -1.3
Type 2 Diabetes (T2D) (2012) 1.8 2.1 5.6 -0.8 0.7 2.4 1.3
Ulcerative Colitis 0.3 0.4 1.3 -1.1 -0.4 -0.1 -0.3
Blood Eosinophil Count 0.2 1.8 3.1 0.6 1.8 1.5 -1.2
Blood Platelet Count 1.0 11.4 24.4 3.2 4.9 3.3 0.6
Blood Red Count 0.2 2.3 5.6 1.4 0.3 2.4 -1.2
Blood White Count 0.9 6.7 23.6 -0.2 4.9 1.1 -1.4
Heel T-Score 0.3 2.0 7.7 0.2 0.4 -0.4 -2.8
BMI 0.4 2.3 3.4 0.7 1.8 1.6 1.8
Height 0.3 6.6 10.5 -2.9 -2.3 -3.2 -1.4
Waist Hip Ratio (WHR) 0.3 1.4 2.4 1.0 0.6 1.3 1.6
Systolic Blood Pressure 0.6 2.8 8.2 -1.3 -0.9 -0.7 -2.9
Smoking Status 1.3 3.1 8.6 0.4 1.3 2.9 1.4
Allergy or Eczema 0.6 1.6 5.8 0.6 0.3 0.4 2.4
Cardiovascular Disease 0.2 0.7 1.7 -0.6 -1.3 0.6 -0.4
Hypothyroidism (self reported) 0.9 2.1 6.0 2.4 0.2 1.5 0.4
Respiratory disease 0.6 1.3 2.3 -1.5 -0.4 -0.7 1.5
Type 2 Diabetes (T2D) (2018) 1.4 2.5 6.0 1.0 0.0 2.4 1.8
Lung FEV1/FVC ratio 0.3 1.3 3.0 1.7 0.8 1.1 0.6
Lung FVC 0.2 1.0 2.9 1.7 0.7 0.6 0.4
Neuroticism 0.2 0.5 1.0 -0.3 -1.0 -0.9 -0.1
Chronotype (morning person) 0.8 1.7 2.4 1.5 1.5 1.4 -0.5
Hair Pigment 0.1 4.2 8.2 1.9 2.0 2.9 -1.0
Tanning 0.2 1.9 4.8 -1.1 -0.2 -2.2 1.3
Hand grip strength (left) 1.1 2.8 7.6 -2.8 -0.6 -0.8 -1.6
Number of treatments/medications taken 1.6 2.8 5.4 2.3 -1.9 1.2 1.0
Average weekly spirits intake 1.9 2.4 5.1 2.3 0.5 1.1 1.7
Sensitivity / hurt feelings 0.8 1.4 2.7 -1.6 -0.1 -0.5 -1.6
Frequency of depressed mood in last 2 weeks 1.4 2.0 6.9 0.0 -1.0 -0.5 -2.6
Hearing difficulty/problems: Yes 0.4 0.6 1.2 0.3 -0.9 0.3 1.1
Relative age of first facial hair 1.0 2.1 4.2 -2.1 -0.6 -1.5 -1.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.8 -0.2 -0.3 1.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 -0.5 0.5 -0.4 -0.8
Ever had hysterectomy (womb removed) 0.6 0.6 1.7 -0.1 1.3 0.4 -0.8
Systolic blood pressure, automated reading 0.2 0.7 1.6 -0.9 0.4 0.3 -1.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.6 0.4 -0.1 1.2 -0.1
Angina 0.8 1.1 1.7 1.2 -1.3 1.0 -0.3
Medication for hormone replacement therapy 1.0 1.1 2.2 0.8 0.3 1.2 -1.5
Vitamin and mineral supplements 0.7 0.9 2.1 -0.2 0.8 -1.0 -1.4
Supplements: Zinc 1.1 1.2 2.9 0.9 -1.7 -0.5 -0.9
Medication: Co-codamol 2.0 2.3 7.5 2.7 0.1 -0.4 1.2
Medication: Metformin 1.3 1.8 4.3 0.7 -0.0 2.1 1.5
Diabetes (father) 2.3 2.8 10.6 0.6 0.5 0.2 3.3
Diabetes (mother) 0.2 0.3 0.9 1.0 0.5 -0.3 -0.2
Severe depression (siblings) 1.2 1.4 2.7 1.1 -0.2 1.3 -1.7
Pack years adult smoking proportion 0.8 1.2 2.9 -0.0 -1.4 -0.1 -1.7
Impedance of leg (right) 1.4 6.7 11.9 3.2 2.2 3.5 0.3
Leg fat-free mass (left) 0.9 5.0 8.9 -3.0 -1.7 -2.8 -0.4
Trunk fat percentage 0.6 2.4 3.0 1.2 1.6 1.6 1.7
Hand grip strength (right) 0.4 1.2 2.3 -1.4 0.3 0.5 -1.5
Townsend deprivation index at recruitment 0.7 1.0 1.9 -1.1 -0.3 1.0 -1.4
Current tobacco smoking 0.5 0.8 1.2 -0.8 0.9 1.1 -0.8
Average weekly fortified wine intake 0.5 0.6 1.9 0.4 1.4 0.5 0.2
Maternal smoking around birth 0.7 1.0 2.3 -0.4 -1.5 -0.9 -0.9
Fed-up feelings 0.2 0.4 0.7 0.3 -0.8 -0.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.7 8.9 0.1 -1.0 1.1 -3.0
Relative age voice broke 0.4 0.6 1.8 -0.0 -1.4 -0.7 0.0
Taking other prescription medications 1.0 1.6 3.7 1.2 -0.5 1.0 1.9
Age when periods started (menarche) 0.6 1.5 2.1 -0.5 -1.4 1.4 1.4
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 5.8 0.4 0.9 0.6 -2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.3 -0.7 -1.5 -0.2 -1.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -0.2 1.0 0.5 -0.7
Qualifications: CSEs or equivalent 1.9 2.5 6.2 1.5 0.6 1.0 2.5
Serious illness, injury or assault to yourself 1.0 1.2 3.3 -0.4 0.5 1.8 1.1
High blood pressure 0.3 0.8 2.1 -0.8 -1.4 0.5 -0.5
Hayfever, allergic rhinitis or eczema 0.7 1.5 5.1 0.5 0.7 0.3 2.3
Multivitamins +/- minerals 0.8 1.0 1.8 0.8 -1.0 0.9 1.3
Stomach or abdominal pain in last month 0.6 0.7 2.6 0.2 -1.6 0.3 -0.2
Supplements: Glucosamine 1.0 1.3 2.5 0.8 -0.7 -1.3 1.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.6 0.0 -1.3 -0.1 -0.5
Medication: Atenolol 1.7 2.2 7.2 0.9 -2.7 -0.7 0.5
Medication: Levothyroxine sodium 0.9 1.5 2.5 1.5 1.6 1.1 -0.2
Sitting height 1.4 10.0 19.4 -3.9 -1.8 -4.4 -1.5
Chronic bronchitis/emphysema (father) 0.8 0.9 2.8 0.6 -1.7 -0.1 -0.7
High blood pressure (mother) 0.6 0.9 1.8 -1.3 0.8 -1.0 -0.2
Body mass index (BMI) 0.2 0.7 1.4 -0.6 0.9 0.5 1.2
Impedance of leg (left) 1.1 5.5 9.7 2.9 1.7 3.1 1.0
Leg predicted mass (left) 1.0 5.2 9.4 -3.1 -1.6 -3.0 -0.4
Trunk fat mass 0.3 1.2 2.7 0.2 1.2 0.8 1.6
Waist circumference 0.2 0.8 2.0 -0.5 1.0 0.3 1.4
Number of incorrect matches in round 0.5 0.8 1.8 -0.5 -1.3 0.6 0.8
Past tobacco smoking 1.7 3.2 4.8 -0.9 -1.7 -2.1 -2.2
Alcohol usually taken with meals 0.5 0.9 1.5 -0.6 -1.2 -1.2 -0.4
Nervous feelings 0.8 1.5 6.0 -0.0 -0.1 0.4 -2.4
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 2.9 -1.4 -1.7 -1.6 -0.5
Hearing difficulty/problems with background noise 1.1 1.8 4.4 -0.7 -1.4 -2.1 0.5
Hair/balding pattern: Pattern 2 1.0 1.3 4.7 0.6 -0.4 -0.1 2.2
Had menopause 1.1 1.4 3.6 0.6 1.9 0.8 -1.0
Had other major operations 0.0 0.1 0.2 0.1 0.1 -0.1 0.5
Forced vital capacity (FVC) 0.1 0.4 1.2 -0.5 1.1 -0.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.6 -0.2 -0.3 -0.0 -1.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.4 -1.6 0.1 0.4 -1.5
Qualifications: None of the above 0.1 0.3 0.6 -0.3 0.2 0.7 0.8
Financial difficulties in last 2 years 0.3 0.4 1.1 0.3 -0.7 -1.1 0.2
Mouth/teeth dental problems 1.0 1.6 3.7 -0.1 1.9 0.6 -1.5
Heart attack 0.6 0.7 1.6 0.9 -0.6 1.3 0.2
Allergy 0.6 1.4 5.0 0.6 -0.6 -0.0 -2.2
Pain all over the body in last month 1.1 1.2 2.2 0.6 -1.5 0.2 1.4
Diabetes (self-reported) 1.6 2.5 5.8 1.2 -0.6 2.4 1.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.6 0.7 -1.1 0.9 1.9
Medication: Ramipril 0.2 0.2 0.4 0.2 0.6 -0.3 -0.6
Medication: Simvastatin 0.6 0.9 2.6 0.7 0.6 0.4 1.6
Fluid intelligence score 0.7 1.5 1.9 -1.0 -1.2 -1.4 -1.4
Illnesses of siblings 0.2 0.3 0.7 -0.3 -0.3 -0.8 -0.4
Neuroticism score 0.3 0.6 1.3 -0.4 -1.2 -0.7 -0.7
Weight 0.2 1.1 2.9 -1.7 0.4 -0.8 0.7
Impedance of arm (right) 0.1 0.7 2.0 1.4 0.3 0.7 -0.4
Arm fat percentage (right) 0.3 1.0 2.1 0.3 1.1 0.9 1.4
Trunk fat-free mass 1.0 5.5 12.4 -3.5 -1.3 -2.7 -0.7
Hip circumference 0.2 0.8 2.7 -1.6 0.2 -0.4 0.5
Time employed in main current job 0.2 0.2 0.4 -0.3 0.3 -0.5 0.6
Alcohol intake versus 10 years previously 0.9 1.3 3.7 0.6 0.8 0.8 -1.9
Father’s age at death 0.7 0.9 2.8 -1.7 0.5 -0.2 0.7
Worrier / anxious feelings 0.4 0.7 2.3 0.4 -0.7 -0.3 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 5.3 -0.2 -2.3 0.7 0.1
Falls in the last year 2.2 2.9 6.7 1.3 -1.7 -0.6 2.6
Hair/balding pattern: Pattern 3 1.1 1.6 3.9 -0.7 0.5 -1.4 -2.0
Number of live births 0.3 0.4 0.8 0.9 0.3 0.8 0.1
Forced expiratory volume in 1-second (FEV1) 0.0 0.2 0.6 -0.2 0.7 -0.2 -0.0
Pulse rate 36.7 61.9 88.9 6.9 4.8 9.3 9.4
Happiness 1.0 1.2 4.7 0.3 0.1 -2.2 -0.4
Noisy workplace 1.5 1.8 4.5 2.1 -0.0 1.3 1.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.1 0.2 -1.1 0.5 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.0 -0.6 -1.0 -0.2 0.5
Mouth/teeth dental problems: Dentures 0.4 0.6 1.2 0.4 0.1 -1.1 1.1
Asthma 1.1 2.3 6.1 -1.4 -1.0 -0.3 2.5
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.8 1.3 -0.1 1.1 -0.2
Medication: Cholesterol lowering 0.7 1.1 2.9 0.7 0.7 -0.7 1.7
Depression (self-reported) 1.5 1.8 5.9 0.1 -2.4 -0.4 1.0
Medication: Lansoprazole 0.8 0.9 2.3 0.3 -0.3 1.1 1.5
Prospective memory result 0.1 0.2 0.3 -0.3 0.6 0.4 -0.2
Lung cancer (father) 0.7 0.8 1.6 0.4 -1.3 0.7 -1.0
Illnesses of mother 0.3 0.3 0.4 -0.6 -0.5 0.7 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.5 -0.2 1.6 -0.3 -0.9
Pulse wave Arterial Stiffness index 0.9 1.1 1.2 -1.1 -1.0 -1.0 1.1
Impedance of arm (left) 0.4 1.7 4.0 2.0 0.3 1.4 -0.7
Arm fat mass (right) 0.1 0.5 1.1 -0.7 0.6 -0.0 1.0
Trunk predicted mass 0.9 5.4 12.3 -3.5 -1.3 -2.6 -0.7
Standing height 0.4 3.9 7.1 -2.5 -1.1 -2.7 -1.1
Length of working week for main job 0.3 0.4 0.8 -0.3 0.6 0.2 -0.9
Exposure to tobacco smoke at home 0.4 0.4 0.9 -0.5 -0.9 -0.1 0.7
Breastfed as a baby 0.4 0.5 1.3 -0.4 0.3 -1.1 0.6
Tense / ‘highly strung’ 0.2 0.3 0.6 0.8 -0.6 -0.3 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 3.6 -1.5 -1.9 -1.9 -0.7
Hair/balding pattern: Pattern 4 0.0 0.1 0.3 0.0 0.3 -0.0 -0.6
Birth weight of first child 0.9 1.7 6.0 -0.6 -0.6 -2.4 0.4
Peak expiratory flow (PEF) 1.4 3.2 8.2 -1.9 0.1 -2.9 -1.0
Pulse wave reflection index 14.4 17.8 27.6 -4.1 -3.5 -5.3 -3.8
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.3 0.2 1.5 1.3 1.0
Loud music exposure frequency 1.0 1.1 2.2 -1.2 0.3 1.5 -0.9
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.6 0.6 0.8 -0.5 -1.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.2 -0.3 -1.5 0.2 0.6
Blood clot in the leg (DVT) 0.3 0.4 1.1 0.2 0.6 -0.2 1.0
Medication: Paracetamol 1.9 3.1 6.4 1.8 0.4 2.5 1.6
Headache pain in last month 0.2 0.3 0.6 0.3 -0.1 0.8 0.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.6 -0.3 1.1 0.9 -1.6
Glaucoma (self-reported) 0.3 0.4 0.9 0.6 -0.3 0.4 -1.0
Gout (self-reported) 1.9 2.7 7.2 -0.1 0.5 2.7 -1.8
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 5.0 2.2 0.4 1.2 -0.3
Medication: Amlodipine 0.3 0.5 0.9 -0.5 -0.9 -0.3 0.8
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.6 -0.8 -0.1 -0.3 0.3
Birth weight 1.1 2.3 4.9 -1.1 -1.1 -2.2 1.4
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.0 -0.1 -1.0 -0.2 -1.0
High blood pressure (siblings) 0.4 0.5 1.0 0.5 -0.0 -0.9 1.0
Forced vital capacity (FVC), Best measure 0.2 0.7 1.8 -0.2 1.3 -0.1 -1.1
Body fat percentage 0.8 3.1 4.3 1.3 1.9 1.8 2.1
Leg fat percentage (right) 1.2 4.3 5.2 1.5 2.3 2.3 2.1
Arm fat-free mass (right) 0.7 3.7 8.7 -3.0 -0.9 -2.3 0.1
Exposure to tobacco smoke outside home 1.5 2.0 4.8 -0.3 -2.2 -1.3 1.1
Comparative body size at age 10 0.7 2.0 7.5 -0.8 -2.7 -0.2 -0.1
Number of full brothers 0.7 0.9 1.8 0.2 1.3 -0.3 -1.3
Worry too long after embarrassment 0.5 0.9 2.4 -0.9 -0.6 -0.4 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 -0.5 -0.5 -0.2 0.2
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 -0.0 0.2 0.8 -0.7
Number of children fathered 0.1 0.2 0.4 -0.3 0.4 -0.1 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.1 0.4 0.6 -0.5
Age at first live birth 0.5 1.0 1.8 0.5 -1.2 -0.5 1.4
Pulse wave peak to peak time 0.8 0.9 1.5 0.7 1.0 0.8 -1.2
Health satisfaction 0.8 1.0 2.6 0.9 -1.6 0.7 -0.3
Shortness of breath walking on level ground 0.5 0.6 1.5 -0.1 0.2 1.2 -0.8
Qualifications: College or University degree 0.6 1.8 4.0 -1.1 -2.0 -1.3 -0.7
Eye problems/disorders: None of the above 1.5 1.8 2.8 -1.5 1.3 -1.7 0.5
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.3 -1.5 0.6 0.6 0.1
Emphysema/chronic bronchitis 0.6 0.6 1.4 -1.2 0.8 0.6 -0.3
Medication for pain relief, constipation, heartburn 2.5 4.2 7.3 -2.7 -0.9 -2.6 -1.3
Neck or shoulder pain in last month 1.1 1.6 6.0 -0.3 -2.5 0.1 -0.3
Medication: Blood pressure 0.5 0.9 2.4 0.0 -1.6 -0.3 0.9
Angina (self-reported) 0.8 1.0 1.8 1.1 -1.3 1.0 -0.5
Migraine (self-reported) 1.2 1.4 4.5 2.1 0.6 0.9 0.2
Medication: Ibuprofen 0.4 0.5 1.4 1.2 -0.6 0.3 -0.2
Medication: Allopurinol 1.2 1.6 3.6 -0.4 0.5 1.9 -1.5
Medication: Omeprazole 1.3 1.5 4.7 0.4 -2.2 -0.2 1.1
Medication: Seretide 50 evohaler 0.4 0.5 1.5 -0.2 -1.2 0.7 -0.1
Mean time to correctly identify matches 0.6 1.2 4.3 2.1 -0.0 0.0 0.5
Heart disease (mother) 0.4 0.5 0.9 -0.7 0.9 -0.6 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.6 -0.3 -1.3 -0.5 1.9
Whole body fat mass 0.2 1.0 3.4 0.0 0.8 0.4 1.8
Leg fat mass (right) 0.4 1.4 3.6 0.0 1.2 0.8 1.9
Arm predicted mass (right) 0.8 4.1 10.2 -3.2 -1.1 -2.2 0.2
Pulse rate, automated reading 44.5 143.9 216.1 10.0 7.6 14.2 14.7
Alcohol intake frequency. 1.5 3.5 9.2 1.1 0.2 3.0 -1.9
Comparative height size at age 10 0.1 0.4 1.1 0.4 -0.4 -1.0 -0.5
Number of full sisters 0.6 0.7 2.7 -1.7 0.4 -0.2 -0.1
Suffer from ‘nerves’ 1.4 2.2 5.1 -0.5 -1.8 -0.4 -2.2
Overall health rating 0.6 1.3 2.5 -0.5 -1.6 1.6 0.2
Chest pain or discomfort 1.0 1.4 2.2 0.8 -0.9 1.5 -1.3
Had major operations 0.5 0.6 2.0 0.4 -1.4 -0.3 -0.5
Age at last live birth 1.2 1.8 2.7 1.3 -1.6 -1.3 1.0
Family relationship satisfaction 1.1 1.4 3.8 -1.2 0.3 -1.9 0.6
Leg pain on walking 2.7 3.4 4.2 1.8 1.8 1.7 2.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.5 0.6 0.8 1.2 0.8
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.6 0.6 1.3 0.5 0.4
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.1 0.7 1.5 1.8 -0.4
Medication: Aspirin 1.2 1.6 2.4 1.6 1.1 1.5 0.6
Supplements: Vitamin C 0.4 0.5 1.0 -0.9 -0.3 -0.0 -1.0
Knee pain experienced in last month 0.9 1.5 3.6 1.9 0.2 1.0 1.1
Hypertension (Self-reported) 0.3 0.9 2.9 -0.8 -1.7 0.3 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.5 5.2 1.7 -2.3 -1.1 2.2
Illnesses of father: Heart disease 1.0 1.4 4.9 0.1 0.6 -0.6 -2.2
Illnesses of siblings: Diabetes 0.6 0.7 1.8 0.0 1.3 0.9 0.6
Smoking status: Previous 3.1 4.7 10.1 1.3 1.1 2.4 3.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 5.2 -2.3 -0.3 -0.9 -1.1
Whole body fat-free mass 1.0 5.6 11.4 -3.4 -1.5 -2.9 -0.4
Leg fat-free mass (right) 1.2 6.3 11.1 -3.3 -1.8 -3.3 -0.2
Arm fat percentage (left) 0.3 1.1 1.9 0.5 1.0 1.1 1.4
Average weekly red wine intake 0.1 0.1 0.3 -0.3 -0.2 -0.2 0.5
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.4 -1.8 -1.2 -0.1 -1.5
Mood swings 0.2 0.3 0.5 0.3 -0.7 -0.6 0.5
Loneliness, isolation 0.3 0.4 0.7 -0.8 -0.7 0.3 -0.4
Long-standing illness, disability or infirmity 0.4 0.6 1.1 -0.1 0.3 1.1 1.0
Ever had bowel cancer screening 1.5 1.7 5.0 0.0 -2.2 -1.1 0.8
Diabetes diagnosed by doctor 1.2 2.0 4.2 0.5 -0.4 2.0 1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.2 0.4 -1.1 -0.5 0.5
Friendships satisfaction 0.7 0.9 2.1 -1.0 0.0 -1.5 0.5
Qualifications: nursing, teaching 0.3 0.5 1.5 -0.2 -0.5 0.2 -1.2
Commuting to job workplace: Walk 0.9 1.0 1.8 -1.4 0.7 1.0 -0.8
Eye problems/disorders: Cataract 0.9 1.1 1.9 1.1 -1.4 0.9 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.2 0.8 -0.5 -0.5 1.1
Medication for cholesterol 1.3 2.0 3.6 -1.4 1.6 -0.4 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 4.6 2.1 0.5 1.6 0.7
Back pain experienced in last month 0.2 0.3 0.8 -0.3 -0.5 -0.3 -0.9
Mineral and other dietary supplements 0.1 0.1 0.3 -0.5 0.4 -0.0 0.0
Breast cancer (self-reported) 2.5 2.9 5.4 0.9 2.1 0.9 2.3
Asthma (self-reported) 1.3 2.5 5.5 -1.2 -1.6 -0.7 2.4
Osteoporosis (self-reported) 0.2 0.3 0.7 -0.5 -0.3 -0.2 0.8
Osteoarthritis (self-reported) 5.1 6.6 11.0 2.5 3.3 2.9 1.0
Medication: Aspirin 2.0 2.6 4.7 2.2 1.7 1.6 0.6
Medication: Gliclazide 0.7 0.8 2.7 0.5 0.4 0.2 1.6
Illnesses of father: None of the above (group 1) 0.7 0.8 1.6 -0.5 -0.9 1.3 0.7
Smoking status: Current 0.6 1.0 1.8 -0.6 1.3 1.1 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.7 0.8 0.8 -0.2 0.7
Whole body water mass 1.0 5.7 11.4 -3.4 -1.6 -3.0 -0.5
Leg predicted mass (right) 1.2 6.3 11.5 -3.4 -1.9 -3.2 -0.3
Arm fat mass (left) 0.1 0.5 1.2 -0.7 0.6 0.3 1.1
Number of self-reported non-cancer illnesses 0.4 0.8 1.9 0.7 -1.4 0.1 0.8
Average weekly champagne plus white wine intake 0.3 0.5 1.3 -0.7 -1.1 0.1 -0.2
Miserableness 0.5 0.8 1.8 0.5 -1.3 -1.0 -0.5
Guilty feelings 0.6 1.0 3.8 -0.2 0.1 -0.0 -1.9
Wears glasses or contact lenses 0.1 0.2 0.2 -0.4 0.1 -0.5 -0.4
Ever taken oral contraceptive pill 2.0 2.2 4.3 -1.7 -0.7 -2.1 -1.0
Hearing aid user 1.4 1.6 4.3 0.4 -1.4 2.1 -0.3
Mother’s age at death 0.6 0.7 1.6 -0.9 1.3 0.8 -0.2
Financial situation satisfaction 0.2 0.2 0.8 0.9 0.1 0.2 -0.3
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.7 -0.7 -1.5 -1.6 0.7
Commuting to job workplace: Public transport 1.0 1.2 2.6 0.6 -1.6 1.1 -0.7
Eye problems/disorders: Glaucoma 0.3 0.3 0.8 0.6 0.4 0.9 -0.2
Medication: Blood pressure 0.9 1.7 3.9 0.7 -2.0 0.1 -1.5
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.5 -1.6 -0.7 -0.3 0.7
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.9 -0.3 -1.4 -0.2 0.5
High cholesterol (Self-reported) 0.3 0.5 1.2 0.9 0.0 -0.1 1.1
Medication: Bendroflumethiazide 0.2 0.3 0.6 -0.1 -0.8 0.1 -0.7
Medication: Paracetamol 0.7 1.1 1.5 1.1 -0.4 1.2 1.2
Medication: Lisinopril 1.5 1.9 5.3 -1.3 -2.3 0.5 0.8
Medication: Atorvastatin 0.8 1.0 2.7 0.5 0.2 1.6 -1.0
Illnesses of father: High blood pressure 1.0 1.2 3.6 -0.2 1.1 -1.9 0.4
Alcohol drinker status: Never 0.2 0.2 0.8 0.1 -0.9 -0.2 0.1
Ever smoked 0.5 0.8 1.7 -0.7 1.3 0.5 0.9
Basal metabolic rate 0.8 4.2 9.4 -3.1 -1.1 -2.5 -0.1
Leg fat percentage (left) 1.0 3.6 6.3 1.2 1.8 1.9 2.5
Arm fat-free mass (left) 0.8 4.0 9.6 -3.1 -0.9 -2.4 0.2
Number of operations (self-reported) 0.4 0.5 1.4 1.2 -0.6 0.6 0.1
Average weekly beer plus cider intake 0.3 0.5 1.1 1.0 0.7 -0.4 0.4
Irritability 0.2 0.4 1.2 1.1 0.1 0.4 0.3
Risk taking 0.2 0.3 0.6 -0.8 0.8 0.1 -0.1
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.0 0.4 -1.4 -1.2 -0.1
Fractured/broken bones in last 5 years 0.6 0.8 2.2 -0.6 0.7 -1.5 -0.3
Age started oral contraceptive pill 1.2 1.5 4.9 -0.1 -0.0 -1.1 2.2
Diastolic blood pressure, automated reading 1.6 5.1 11.7 1.5 2.0 3.4 1.6
Ever depressed for a whole week 0.9 1.1 1.8 -1.1 0.4 1.3 -1.0
Unable to work because of sickness or disability 0.7 0.9 2.2 1.5 -0.2 1.0 0.5
Commuting to job workplace: Cycle 2.0 2.4 5.2 0.8 -2.3 -1.7 0.9
Myopia 0.3 0.4 0.9 -0.1 0.9 -0.9 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.4 0.2 1.5 -0.5 0.7
Cholesterol lowering medication 0.2 0.2 0.5 0.7 -0.5 0.4 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.5 0.7 -1.6 0.2 0.7
Pain experienced in last month 0.7 1.1 2.7 -0.7 1.6 -1.1 -0.5
Supplements: Calcium 0.5 0.5 0.9 -0.3 -0.8 0.6 1.0
Basal cell carcinoma (self-reported) 1.3 1.5 2.9 -0.5 1.5 0.7 -1.7
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.7 0.9 -0.6 1.3 0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.1 0.4 0.8 -0.1 1.0
Heart disease (siblings) 0.5 0.6 1.1 0.7 -0.0 1.0 -1.1
Alcohol drinker status: Previous 2.0 2.3 4.4 1.4 1.7 2.1 -0.1
Pack years of smoking 0.8 1.1 1.9 0.8 -1.4 0.2 -1.3
Impedance of whole body 0.6 2.9 5.7 2.4 1.1 2.2 0.1
Leg fat mass (left) 0.4 1.4 4.6 -0.1 0.8 0.6 2.2
Arm predicted mass (left) 0.8 4.0 9.4 -3.1 -0.8 -2.5 0.3