Best TWAS P=1.59e-13 · Best GWAS P=1.77e-14 conditioned to 0.276
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C19orf47 | 0.05 | 0.04 | lasso | 3 | 0.04 | 2.4e-05 | 6.9 | 6.9 | 3.9e-12 | -0.68 | 0.07 | 0.88 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | C19orf54 | 0.06 | 0.02 | bslmm | 432 | 0.02 | 6.6e-04 | 0.7 | 5.1 | 2.8e-07 | -0.23 | 0.28 | 0.22 | TRUE |
3 | GTEx | Adipose Subcutaneous | MAP3K10 | 0.18 | 0.15 | enet | 27 | 0.19 | 2.6e-15 | 4.6 | -5.8 | 8.3e-09 | 0.44 | 1.00 | 0.00 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | MAP3K10 | 0.42 | 0.15 | lasso | 9 | 0.10 | 5.6e-04 | 4.6 | -5.9 | 3.0e-09 | 0.50 | 0.15 | 0.25 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | MAP3K10 | 0.28 | 0.15 | lasso | 6 | 0.16 | 9.0e-06 | -6.6 | -6.6 | 3.3e-11 | 0.82 | 0.15 | 0.80 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | C19orf47 | 0.10 | 0.02 | enet | 11 | 0.02 | 1.0e-02 | -7.7 | 6.1 | 9.5e-10 | -0.73 | 0.00 | 0.98 | FALSE |
7 | GTEx | Esophagus Mucosa | C19orf47 | 0.09 | 0.06 | lasso | 6 | 0.04 | 6.1e-04 | -7.7 | 6.8 | 9.1e-12 | -0.94 | 0.01 | 0.95 | FALSE |
8 | GTEx | Esophagus Muscularis | PLD3 | 0.09 | 0.09 | lasso | 5 | 0.09 | 3.1e-06 | 6.8 | 6.7 | 2.4e-11 | -0.73 | 0.01 | 0.98 | FALSE |
9 | GTEx | Lung | MAP3K10 | 0.13 | 0.13 | lasso | 5 | 0.13 | 4.6e-10 | 4.6 | -5.9 | 3.9e-09 | 0.61 | 0.75 | 0.25 | FALSE |
10 | GTEx | Muscle Skeletal | PLD3 | 0.11 | 0.09 | lasso | 4 | 0.10 | 7.7e-10 | -5.9 | 7.3 | 2.4e-13 | -0.91 | 0.02 | 0.98 | FALSE |
11 | GTEx | Testis | C19orf47 | 0.22 | 0.14 | lasso | 3 | 0.15 | 3.0e-07 | -6.5 | 7.4 | 1.6e-13 | -0.93 | 0.01 | 0.98 | TRUE |
12 | GTEx | Whole Blood | MAP3K10 | 0.12 | 0.03 | lasso | 6 | 0.02 | 5.6e-03 | -6.5 | -6.0 | 2.4e-09 | 0.75 | 0.28 | 0.68 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C19orf47 | 0.04 | 0.01 | blup | 53 | 0.02 | 8.9e-04 | 6.6 | 6.6 | 3.9e-11 | -0.76 | 0.01 | 0.73 | TRUE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | C19orf47 | 0.03 | 0.02 | blup | 53 | 0.01 | 1.3e-02 | 7.6 | 5.5 | 4.8e-08 | -0.54 | 0.01 | 0.88 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C19orf47 | 0.13 | 0.05 | lasso | 5 | 0.08 | 1.1e-08 | -2.7 | 5.4 | 6.3e-08 | -0.65 | 0.22 | 0.78 | FALSE |