Best TWAS P=5.77e-11 · Best GWAS P=8.84e-10 conditioned to 0.089
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | MSH6 | 0.09 | 0.04 | lasso | 2 | 0.03 | 4.1e-03 | 5.3 | 5.9 | 3.2e-09 | 0.74 | 0.03 | 0.95 | FALSE |
| 2 | GTEx | Thyroid | MSH6 | 0.15 | 0.17 | enet | 12 | 0.16 | 3.5e-12 | 5.3 | 5.3 | 1.1e-07 | 0.59 | 0.14 | 0.86 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MSH6 | 0.07 | 0.02 | blup | 26 | 0.06 | 6.2e-07 | 6.1 | 5.6 | 2.2e-08 | 0.68 | 0.00 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MSH6 | 0.03 | 0.01 | blup | 26 | 0.01 | 1.5e-02 | 5.0 | 6.5 | 5.8e-11 | 0.77 | 0.01 | 0.92 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | MSH6 | 0.11 | 0.06 | enet | 6 | 0.12 | 5.3e-12 | 5.3 | 5.5 | 4.3e-08 | 0.51 | 0.17 | 0.83 | FALSE |