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chr2:26,653,457-28,414,302

Best TWAS P=7.53e-29 · Best GWAS P=1.23e-27 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	10.9	-11.1	7.5e-29	-0.99	0.00	0.95	TRUE
59	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	-5.8	-8.6	6.6e-18	-0.70	0.43	0.57	FALSE
32	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	-5.0	8.4	3.3e-17	0.85	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	-5.6	-8.3	1.0e-16	-0.64	0.89	0.11	FALSE
21	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	-6.0	8.3	1.4e-16	0.82	0.02	0.96	FALSE
33	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	-5.6	-8.2	2.1e-16	-0.69	0.64	0.36	FALSE
31	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	-6.0	7.9	3.0e-15	0.80	0.03	0.96	FALSE
27	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	-4.9	7.5	6.2e-14	0.77	0.05	0.77	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	-5.0	-7.5	7.4e-14	-0.75	0.43	0.57	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	-6.6	-7.4	1.3e-13	-0.54	0.02	0.29	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	-5.4	7.0	3.4e-12	0.72	0.34	0.66	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	-6.0	6.9	5.6e-12	0.65	0.04	0.71	FALSE
35	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	-4.9	6.8	7.2e-12	0.72	0.09	0.52	FALSE
20	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	-6.0	6.6	3.3e-11	0.74	0.93	0.07	FALSE
26	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	-6.0	6.6	5.4e-11	0.61	0.34	0.53	FALSE
28	GTEx	Pituitary	AC074117.10	0.23	0.23	lasso	8	0.29	5.6e-08	-5.2	6.5	7.6e-11	0.66	0.40	0.50	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	-4.9	-6.4	1.2e-10	-0.40	0.19	0.14	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	-5.4	6.4	1.6e-10	0.64	0.46	0.26	FALSE
8	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	-5.5	6.4	1.7e-10	0.66	0.28	0.14	FALSE
3	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	-6.0	6.3	3.0e-10	0.65	0.49	0.22	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	7.4	6.2	4.1e-10	0.54	0.01	0.95	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	-5.0	-6.2	4.8e-10	-0.63	0.43	0.49	FALSE
38	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	-6.0	6.2	5.0e-10	0.67	1.00	0.00	FALSE
22	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	-6.0	6.1	1.1e-09	0.65	0.78	0.20	FALSE
16	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	-6.0	6.0	1.4e-09	0.66	0.91	0.09	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	-6.0	6.0	1.9e-09	0.67	0.02	0.18	FALSE
44	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	-5.0	6.0	2.6e-09	0.61	0.99	0.00	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	-5.5	5.8	5.0e-09	0.66	0.03	0.57	FALSE
12	GTEx	Breast Mammary Tissue (Female)	ABHD1	0.17	0.01	enet	28	0.07	5.3e-03	-2.2	-5.8	7.1e-09	-0.52	0.02	0.73	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	-4.9	5.8	8.8e-09	0.64	0.39	0.47	FALSE
24	GTEx	Lung	AC074117.10	0.07	0.06	lasso	6	0.05	6.6e-05	-5.5	5.7	1.1e-08	0.63	0.78	0.22	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	-2.2	-5.7	1.4e-08	-0.55	0.01	0.69	FALSE
23	GTEx	Lung	NRBP1	0.05	0.05	enet	9	0.05	1.7e-04	-5.5	5.7	1.5e-08	0.61	0.75	0.15	FALSE
30	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	-6.0	-5.7	1.5e-08	-0.36	0.20	0.07	FALSE
36	GTEx	Whole Blood	KRTCAP3	0.12	0.05	enet	10	0.05	9.9e-06	-4.9	-5.6	2.8e-08	-0.63	0.97	0.01	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	NRBP1	0.11	0.01	enet	23	0.02	7.7e-02	-3.7	5.5	2.9e-08	0.53	0.12	0.21	FALSE
14	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	-5.0	5.5	3.3e-08	0.61	0.96	0.04	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	-6.0	5.5	3.6e-08	0.62	0.18	0.47	FALSE
4	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	-4.9	5.5	3.9e-08	0.64	0.11	0.28	FALSE
43	YFS	Blood	EIF2B4	0.01	0.00	enet	9	0.00	8.5e-02	-2.1	-5.5	4.3e-08	-0.52	0.04	0.04	FALSE
10	GTEx	Brain Cerebellum	AC074117.10	0.13	0.08	enet	6	0.07	4.4e-03	-5.5	-5.4	5.4e-08	-0.60	0.10	0.41	FALSE
39	METSIM	Adipose	SLC5A6	0.03	0.02	bslmm	298	0.01	3.9e-03	-3.0	5.4	5.4e-08	0.43	0.25	0.06	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1G	0.03	0.02	blup	32	0.02	2.4e-03	-5.4	5.4	5.5e-08	0.61	0.05	0.71	FALSE
5	GTEx	Adipose Visceral Omentum	KRTCAP3	0.10	0.07	lasso	4	0.06	5.2e-04	-5.4	-5.4	5.8e-08	-0.61	0.68	0.10	FALSE
15	GTEx	Cells Transformed fibroblasts	IFT172	0.04	0.04	lasso	2	0.02	8.1e-03	-5.5	-5.4	6.6e-08	-0.60	0.18	0.32	FALSE
34	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	-5.4	5.4	6.9e-08	0.61	1.00	0.00	FALSE
25	GTEx	Muscle Skeletal	SNX17	0.18	0.24	lasso	6	0.26	6.2e-26	-5.4	5.4	7.0e-08	0.61	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SLC4A1AP	0.17	0.05	blup	26	0.08	4.4e-03	7.4	-5.3	1.1e-07	-0.47	0.01	0.72	FALSE
9	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	-5.0	5.3	1.2e-07	0.62	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC4A1AP	0.02	0.03	lasso	2	0.03	3.7e-04	2.9	-5.2	1.5e-07	-0.47	0.01	0.83	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	-5.0	5.2	1.6e-07	0.62	0.57	0.10	FALSE
37	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	-4.9	-5.2	1.7e-07	-0.52	0.96	0.03	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX17	0.02	0.01	blup	26	0.01	2.1e-02	-5.1	-5.2	1.7e-07	-0.62	0.09	0.43	FALSE
7	GTEx	Adrenal Gland	KRTCAP3	0.11	0.16	lasso	4	0.15	4.9e-06	-5.0	-5.2	1.8e-07	-0.60	0.48	0.45	FALSE
17	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	-5.0	5.2	2.2e-07	0.60	0.87	0.06	FALSE
11	GTEx	Brain Cortex	KRTCAP3	0.19	0.10	lasso	2	0.12	3.7e-04	-4.9	-5.2	2.5e-07	-0.54	0.26	0.30	FALSE
6	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	-5.0	5.2	2.6e-07	0.60	0.86	0.06	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	43	0.02	2.7e-03	-5.0	5.2	2.6e-07	0.60	0.10	0.12	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	SNX17	0.27	0.35	lasso	10	0.34	7.9e-46	-5.1	-5.1	2.7e-07	-0.60	1.00	0.00	FALSE
29	GTEx	Prostate	AC074117.10	0.14	0.01	lasso	5	0.02	8.8e-02	-6.0	5.1	2.9e-07	0.61	0.07	0.55	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBP1	0.03	0.03	blup	29	0.03	1.2e-06	-5.0	5.1	3.0e-07	0.57	0.82	0.18	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBP1	0.05	0.06	lasso	2	0.05	6.0e-05	-5.1	5.1	3.1e-07	0.60	0.68	0.19	FALSE