Best TWAS P=6.18e-09 · Best GWAS P=1.83e-14 conditioned to 4.23e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MED20 | 0.15 | 0.11 | blup | 471 | 0.13 | 3.1e-15 | 5.3 | -5.8 | 6.2e-09 | -0.14 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | MED20 | 0.08 | 0.07 | enet | 9 | 0.05 | 4.7e-05 | -5.4 | -5.3 | 1.3e-07 | -0.09 | 0.97 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | MED20 | 0.14 | 0.11 | lasso | 2 | 0.09 | 9.7e-08 | -5.2 | -5.2 | 1.6e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | MED20 | 0.25 | 0.01 | lasso | 5 | 0.07 | 3.0e-03 | 5.1 | -5.2 | 2.6e-07 | -0.13 | 0.14 | 0.18 | FALSE |
| 5 | GTEx | Esophagus Muscularis | MED20 | 0.15 | 0.05 | lasso | 7 | 0.04 | 1.0e-03 | 5.1 | -5.5 | 4.7e-08 | -0.14 | 0.88 | 0.01 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | MED20 | 0.14 | 0.12 | enet | 11 | 0.09 | 5.9e-05 | -5.8 | -5.6 | 1.9e-08 | -0.10 | 0.92 | 0.01 | FALSE |
| 7 | GTEx | Heart Left Ventricle | PRICKLE4 | 0.11 | 0.05 | lasso | 4 | 0.03 | 9.8e-03 | -5.0 | 5.3 | 8.6e-08 | 0.09 | 0.26 | 0.04 | FALSE |
| 8 | GTEx | Heart Left Ventricle | MED20 | 0.22 | 0.19 | enet | 8 | 0.12 | 5.8e-07 | -5.2 | -5.2 | 1.5e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Nerve Tibial | MED20 | 0.13 | 0.11 | enet | 8 | 0.10 | 1.5e-07 | -5.8 | -5.6 | 2.2e-08 | -0.09 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MED20 | 0.09 | 0.08 | enet | 12 | 0.09 | 5.5e-10 | -5.2 | -5.3 | 1.4e-07 | -0.12 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MED20 | 0.04 | 0.06 | enet | 6 | 0.05 | 2.6e-06 | -5.0 | -5.4 | 6.7e-08 | -0.10 | 0.01 | 0.98 | FALSE |