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chr6:36,014,161-37,590,303

Best TWAS P=1.09e-13 · Best GWAS P=5.51e-23 conditioned to 2.13e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C6orf89	0.05	0.01	lasso	5	0.01	1.5e-02	-5.3	5.1	3.0e-07	-0.58	0.01	0.90	FALSE
2	GTEx	Cells Transformed fibroblasts	PPIL1	0.20	0.06	lasso	7	0.08	2.4e-06	-4.8	-5.8	6.0e-09	0.68	0.36	0.60	FALSE
3	GTEx	Esophagus Mucosa	PPIL1	0.09	0.01	lasso	4	0.02	3.1e-02	7.2	-6.8	9.2e-12	0.50	0.04	0.81	TRUE
4	GTEx	Nerve Tibial	CPNE5	0.20	0.18	enet	8	0.15	6.5e-11	5.3	5.5	4.8e-08	-0.56	1.00	0.00	FALSE
5	GTEx	Thyroid	PPIL1	0.10	0.08	lasso	3	0.05	9.1e-05	5.5	-5.5	4.0e-08	0.67	0.44	0.32	FALSE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPIL1	0.08	0.09	lasso	6	0.09	2.9e-08	-5.2	-7.4	1.1e-13	0.89	0.05	0.95	TRUE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPIL1	0.05	0.04	lasso	3	0.04	2.6e-08	-5.2	-6.5	5.6e-11	0.84	0.56	0.44	FALSE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	PPIL1	0.19	0.11	blup	77	0.08	1.7e-05	-5.4	-6.3	3.0e-10	0.71	0.26	0.63	FALSE
9	The Cancer Genome Atlas	Esophageal Carcinoma	PPIL1	0.12	0.03	enet	7	0.02	8.3e-02	-5.4	-5.6	2.4e-08	0.63	0.04	0.40	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PPIL1	0.11	0.06	blup	77	0.09	5.3e-10	-5.2	-5.4	7.7e-08	0.59	0.36	0.64	FALSE
11	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIL1	0.06	0.10	lasso	1	0.08	9.9e-05	-5.2	-5.2	1.9e-07	0.77	0.04	0.70	FALSE
12	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PPIL1	0.08	0.04	blup	77	0.07	2.3e-08	-5.2	-6.8	1.3e-11	0.78	0.05	0.95	FALSE
13	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PPIL1	0.17	0.09	lasso	1	0.06	1.2e-03	-5.1	-5.1	2.9e-07	0.66	0.17	0.46	FALSE
14	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PPIL1	0.20	0.10	lasso	2	0.07	5.2e-03	5.9	-6.6	4.1e-11	0.54	0.02	0.12	FALSE
15	The Cancer Genome Atlas	Stomach Adenocarcinoma	PPIL1	0.11	0.06	enet	10	0.07	6.5e-06	-5.4	-5.8	8.3e-09	0.73	0.12	0.85	FALSE
16	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PPIL1	0.12	0.09	lasso	4	0.07	1.9e-03	5.3	-6.4	1.9e-10	0.71	0.09	0.41	FALSE