Best TWAS P=1.99e-17 · Best GWAS P=5e-25 conditioned to 8.53e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | SGIP1 | 0.18 | 0.02 | lasso | 5 | 0.03 | 6.8e-03 | -6.8 | -6.6 | 4.7e-11 | 0.67 | 0.13 | 0.57 | FALSE |
| 2 | GTEx | Adrenal Gland | TCTEX1D1 | 0.28 | 0.20 | enet | 31 | 0.24 | 3.6e-09 | 4.1 | 5.8 | 4.9e-09 | -0.32 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | SGIP1 | 0.19 | 0.01 | enet | 22 | 0.10 | 3.8e-08 | -6.4 | -5.7 | 1.6e-08 | 0.50 | 0.52 | 0.28 | FALSE |
| 4 | GTEx | Esophagus Muscularis | TCTEX1D1 | 0.09 | 0.02 | enet | 10 | 0.01 | 4.0e-02 | -6.2 | 6.9 | 4.8e-12 | -0.73 | 0.25 | 0.33 | FALSE |
| 5 | GTEx | Heart Left Ventricle | SGIP1 | 0.24 | 0.26 | lasso | 7 | 0.28 | 3.1e-15 | -8.7 | -8.4 | 5.0e-17 | 0.92 | 0.02 | 0.98 | TRUE |
| 6 | GTEx | Lung | TCTEX1D1 | 0.11 | 0.11 | enet | 19 | 0.11 | 8.3e-09 | -5.8 | 7.4 | 1.7e-13 | -0.58 | 0.83 | 0.17 | FALSE |
| 7 | GTEx | Muscle Skeletal | SGIP1 | 0.07 | 0.04 | enet | 15 | 0.02 | 3.1e-03 | -6.7 | -5.7 | 1.6e-08 | 0.64 | 0.53 | 0.38 | FALSE |
| 8 | GTEx | Muscle Skeletal | TCTEX1D1 | 0.07 | 0.01 | enet | 17 | 0.02 | 1.7e-03 | -6.7 | 6.8 | 1.3e-11 | -0.60 | 0.09 | 0.62 | FALSE |
| 9 | GTEx | Nerve Tibial | TCTEX1D1 | 0.09 | 0.00 | enet | 18 | 0.02 | 2.5e-02 | -5.8 | 6.1 | 1.4e-09 | -0.38 | 0.22 | 0.04 | FALSE |
| 10 | GTEx | Stomach | TCTEX1D1 | 0.12 | 0.01 | enet | 33 | 0.05 | 1.9e-03 | 4.1 | 6.3 | 3.5e-10 | -0.32 | 0.40 | 0.03 | FALSE |
| 11 | GTEx | Whole Blood | TCTEX1D1 | 0.05 | 0.01 | enet | 10 | 0.02 | 9.9e-03 | 4.1 | 8.5 | 2.0e-17 | -0.72 | 0.01 | 0.94 | TRUE |
| 12 | METSIM | Adipose | TCTEX1D1 | 0.10 | 0.10 | lasso | 8 | 0.13 | 1.6e-18 | 4.1 | 5.9 | 3.6e-09 | -0.36 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCTEX1D1 | 0.07 | 0.08 | lasso | 4 | 0.09 | 1.6e-18 | 4.1 | 5.5 | 3.3e-08 | -0.32 | 0.95 | 0.04 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | TCTEX1D1 | 0.08 | 0.00 | blup | 72 | 0.00 | 2.3e-01 | 1.9 | 5.9 | 3.8e-09 | -0.39 | 0.01 | 0.58 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGIP1 | 0.06 | 0.02 | blup | 240 | 0.04 | 5.4e-05 | 5.6 | -6.2 | 6.0e-10 | 0.64 | 0.16 | 0.71 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TCTEX1D1 | 0.07 | 0.09 | lasso | 3 | 0.08 | 3.2e-09 | -5.8 | 6.1 | 1.4e-09 | -0.54 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INSL5 | 0.11 | 0.00 | blup | 56 | 0.01 | 1.3e-01 | -4.8 | -5.5 | 3.1e-08 | 0.46 | 0.01 | 0.71 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TCTEX1D1 | 0.04 | 0.01 | blup | 72 | 0.02 | 3.8e-03 | 4.1 | 5.8 | 5.5e-09 | -0.44 | 0.21 | 0.32 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | TCTEX1D1 | 0.03 | 0.00 | blup | 72 | 0.01 | 4.5e-02 | -5.8 | 6.1 | 1.0e-09 | -0.52 | 0.01 | 0.85 | FALSE |