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chr1:66,304,567-67,938,108

Best TWAS P=1.99e-17 · Best GWAS P=5e-25 conditioned to 8.53e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Whole Blood	TCTEX1D1	0.05	0.01	enet	10	0.02	9.9e-03	4.1	8.5	2.0e-17	-0.72	0.01	0.94	TRUE
5	GTEx	Heart Left Ventricle	SGIP1	0.24	0.26	lasso	7	0.28	3.1e-15	-8.7	-8.4	5.0e-17	0.92	0.02	0.98	TRUE
6	GTEx	Lung	TCTEX1D1	0.11	0.11	enet	19	0.11	8.3e-09	-5.8	7.4	1.7e-13	-0.58	0.83	0.17	FALSE
4	GTEx	Esophagus Muscularis	TCTEX1D1	0.09	0.02	enet	10	0.01	4.0e-02	-6.2	6.9	4.8e-12	-0.73	0.25	0.33	FALSE
8	GTEx	Muscle Skeletal	TCTEX1D1	0.07	0.01	enet	17	0.02	1.7e-03	-6.7	6.8	1.3e-11	-0.60	0.09	0.62	FALSE
1	GTEx	Adipose Visceral Omentum	SGIP1	0.18	0.02	lasso	5	0.03	6.8e-03	-6.8	-6.6	4.7e-11	0.67	0.13	0.57	FALSE
10	GTEx	Stomach	TCTEX1D1	0.12	0.01	enet	33	0.05	1.9e-03	4.1	6.3	3.5e-10	-0.32	0.40	0.03	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SGIP1	0.06	0.02	blup	240	0.04	5.4e-05	5.6	-6.2	6.0e-10	0.64	0.16	0.71	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	TCTEX1D1	0.03	0.00	blup	72	0.01	4.5e-02	-5.8	6.1	1.0e-09	-0.52	0.01	0.85	FALSE
9	GTEx	Nerve Tibial	TCTEX1D1	0.09	0.00	enet	18	0.02	2.5e-02	-5.8	6.1	1.4e-09	-0.38	0.22	0.04	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCTEX1D1	0.07	0.09	lasso	3	0.08	3.2e-09	-5.8	6.1	1.4e-09	-0.54	0.00	1.00	FALSE
12	METSIM	Adipose	TCTEX1D1	0.10	0.10	lasso	8	0.13	1.6e-18	4.1	5.9	3.6e-09	-0.36	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	TCTEX1D1	0.08	0.00	blup	72	0.00	2.3e-01	1.9	5.9	3.8e-09	-0.39	0.01	0.58	FALSE
2	GTEx	Adrenal Gland	TCTEX1D1	0.28	0.20	enet	31	0.24	3.6e-09	4.1	5.8	4.9e-09	-0.32	0.99	0.00	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	TCTEX1D1	0.04	0.01	blup	72	0.02	3.8e-03	4.1	5.8	5.5e-09	-0.44	0.21	0.32	FALSE
3	GTEx	Cells Transformed fibroblasts	SGIP1	0.19	0.01	enet	22	0.10	3.8e-08	-6.4	-5.7	1.6e-08	0.50	0.52	0.28	FALSE
7	GTEx	Muscle Skeletal	SGIP1	0.07	0.04	enet	15	0.02	3.1e-03	-6.7	-5.7	1.6e-08	0.64	0.53	0.38	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INSL5	0.11	0.00	blup	56	0.01	1.3e-01	-4.8	-5.5	3.1e-08	0.46	0.01	0.71	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCTEX1D1	0.07	0.08	lasso	4	0.09	1.6e-18	4.1	5.5	3.3e-08	-0.32	0.95	0.04	FALSE