Best TWAS P=1.46e-09 · Best GWAS P=2.32e-42 conditioned to 6.22e-40
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pancreas | ZSWIM5 | 0.14 | 0.02 | lasso | 3 | 0.03 | 1.4e-02 | 5.1 | 6.0 | 1.5e-09 | 0.06 | 0.23 | 0.04 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | GPBP1L1 | 0.03 | 0.00 | lasso | 5 | 0.00 | 4.8e-01 | 5.6 | -5.8 | 8.5e-09 | -0.03 | 0.14 | 0.12 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | MUTYH | 0.04 | 0.04 | blup | 282 | 0.03 | 3.7e-05 | 2.9 | 5.8 | 7.3e-09 | 0.05 | 0.72 | 0.21 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MMACHC | 0.07 | 0.05 | enet | 12 | 0.09 | 3.1e-09 | -3.2 | 5.5 | 4.1e-08 | 0.06 | 0.18 | 0.80 | FALSE |
| 4 | GTEx | Uterus | UROD | 0.19 | -0.01 | enet | 15 | 0.00 | 3.3e-01 | -5.6 | -5.3 | 9.0e-08 | -0.21 | 0.08 | 0.08 | FALSE |
| 3 | GTEx | Small Intestine Terminal Ileum | CCDC163P | 0.63 | 0.40 | enet | 35 | 0.42 | 1.7e-10 | 3.3 | 5.2 | 2.0e-07 | 0.02 | 0.92 | 0.03 | FALSE |