Best TWAS P=6.16e-13 · Best GWAS P=1.16e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MET | 0.08 | 0.07 | lasso | 4 | 0.07 | 4.5e-09 | -7.3 | 7.2 | 6.3e-13 | -0.99 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Aorta | MET | 0.21 | 0.23 | lasso | 5 | 0.22 | 3.0e-12 | 5.9 | -6.1 | 9.2e-10 | 0.64 | 0.86 | 0.14 | FALSE |
| 3 | GTEx | Artery Tibial | MET | 0.13 | 0.11 | lasso | 8 | 0.10 | 6.4e-08 | 5.9 | -6.5 | 7.5e-11 | 0.72 | 0.22 | 0.78 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | MET | 0.39 | 0.35 | enet | 25 | 0.30 | 2.1e-09 | -7.1 | 7.1 | 1.0e-12 | -0.99 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Brain Putamen basal ganglia | MET | 0.21 | 0.12 | lasso | 1 | 0.05 | 2.0e-02 | -7.2 | 7.2 | 6.2e-13 | -0.99 | 0.02 | 0.91 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | MET | 0.07 | 0.02 | bslmm | 398 | 0.02 | 5.5e-04 | -7.2 | 5.2 | 1.6e-07 | -0.78 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MET | 0.06 | 0.08 | enet | 18 | 0.08 | 3.3e-09 | -7.1 | 7.1 | 1.5e-12 | -0.97 | 0.02 | 0.98 | FALSE |