Best TWAS P=6.08e-13 · Best GWAS P=4.03e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-390E23.6 | 0.05 | 0.07 | lasso | 1 | 0.06 | 2.3e-05 | 5.8 | 5.8 | 5.2e-09 | -0.58 | 0.79 | 0.03 | FALSE |
| 2 | GTEx | Esophagus Mucosa | RP11-390E23.6 | 0.06 | 0.03 | enet | 14 | 0.07 | 2.9e-05 | 5.0 | 6.9 | 4.1e-12 | -0.63 | 0.06 | 0.84 | FALSE |
| 3 | GTEx | Lung | WASL | 0.10 | 0.03 | lasso | 5 | 0.02 | 1.5e-02 | -7.5 | -7.2 | 6.1e-13 | 0.97 | 0.01 | 0.98 | TRUE |
| 4 | GTEx | Nerve Tibial | RP11-390E23.6 | 0.19 | 0.09 | lasso | 5 | 0.09 | 7.1e-07 | 5.8 | 5.7 | 1.2e-08 | -0.55 | 0.99 | 0.01 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LMOD2 | 0.04 | 0.01 | blup | 38 | 0.02 | 7.1e-03 | -7.4 | 6.5 | 5.7e-11 | -0.83 | 0.00 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | HYAL4 | 0.14 | 0.08 | lasso | 1 | 0.03 | 3.8e-02 | -6.5 | 6.5 | 9.2e-11 | -0.78 | 0.01 | 0.88 | FALSE |