[Hub]/) : Traits : Exposure to tobacco smoke at home :

chr3:49,030,828-50,546,340

Best TWAS P=3.47e-09 · Best GWAS P=1.59e-06 conditioned to 0.572

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	4.7	5.4	5.5e-08	0.94	0.03	0.96	FALSE
2	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	4.7	5.2	1.5e-07	0.93	0.03	0.96	FALSE
3	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	4.8	5.2	1.9e-07	0.97	0.04	0.83	FALSE
4	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	4.8	5.9	3.5e-09	0.86	0.03	0.96	TRUE
5	GTEx	Brain Frontal Cortex BA9	RNF123	0.25	0.28	enet	34	0.05	2.3e-02	4.7	5.4	6.7e-08	0.89	0.04	0.94	FALSE
6	GTEx	Breast Mammary Tissue	RNF123	0.11	0.07	enet	14	0.02	3.2e-02	4.7	5.1	2.7e-07	0.88	0.04	0.94	FALSE
7	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	4.5	5.2	2.3e-07	0.84	0.05	0.93	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	UBA7	0.07	0.03	lasso	6	0.06	2.9e-04	4.4	-5.2	1.6e-07	-0.77	0.07	0.88	FALSE
9	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	4.5	5.4	7.3e-08	0.83	0.06	0.92	FALSE
10	GTEx	Thyroid	UBA7	0.04	0.01	enet	22	0.02	9.2e-03	4.5	-5.2	2.4e-07	-0.64	0.07	0.57	FALSE
11	METSIM	Adipose	RNF123	0.03	0.02	lasso	12	0.02	2.0e-04	4.8	5.1	2.8e-07	0.97	0.03	0.95	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	4.4	5.2	2.4e-07	0.93	0.03	0.96	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBA7	0.01	0.01	enet	5	0.01	6.6e-04	4.8	-5.2	2.6e-07	-0.96	0.01	0.96	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMIGO3	0.11	0.09	enet	10	0.11	2.2e-12	4.5	5.4	6.3e-08	0.71	0.04	0.93	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNF123	0.07	0.05	enet	19	0.05	3.1e-06	4.7	5.5	4.5e-08	0.89	0.02	0.97	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	4.7	5.3	1.4e-07	0.95	0.01	0.69	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	4.8	5.5	4.4e-08	0.91	0.01	0.59	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	IP6K1	0.03	0.04	blup	55	0.04	9.2e-05	4.4	5.3	1.2e-07	0.70	0.06	0.85	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	4.8	-5.1	3.0e-07	-0.97	0.01	0.97	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	4.8	-5.3	1.2e-07	-0.92	0.01	0.78	FALSE