Hub : Traits :

Exposure to tobacco smoke at home

20 significantly associated models · 5 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	49030828	50546340	5	1	3.5e-09	1.6e-06	0.57	99	RNF123

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Qualifications: College or University degree	45.7	1	1	2.2	1	RNF123
Age at First Birth	41.0	1	1	2.2	1	RNF123
Qualifications: A levels/AS levels or equivalent	38.8	1	1	2.2	1	RNF123
Body mass index (BMI)	32.7	1	1	2.2	1	RNF123
Age at last live birth	31.8	1	1	2.2	1	RNF123
Age at first live birth	31.2	1	1	2.2	1	RNF123
Overall health rating	31.1	1	1	2.2	1	RNF123
Miserableness	31.0	1	1	2.2	1	RNF123
Leg fat mass (right)	30.1	1	1	2.2	1	RNF123
Leg fat mass (left)	29.9	1	1	2.2	1	RNF123
Taking other prescription medications	28.4	1	1	2.2	1	RNF123
Qualifications: None of the above	28.4	1	1	2.2	1	RNF123
BMI	28.2	1	1	2.2	1	RNF123
Intelligence (Savage-Jansen 2018)	27.1	1	1	2.2	1	RNF123
Fluid intelligence score	26.8	1	1	2.2	1	RNF123
Leg fat percentage (right)	26.2	1	1	2.2	1	RNF123
Number of treatments/medications taken	25.7	1	1	2.2	1	RNF123
Leg fat percentage (left)	25.4	1	1	2.2	1	RNF123
Arm fat mass (right)	24.8	1	1	2.2	1	RNF123
Arm fat mass (left)	24.8	1	1	2.2	1	RNF123
Verbal and Numeric Reasoning (VNR)	24.4	1	1	2.2	1	RNF123
Impedance of arm (left)	24.3	1	1	2.2	1	RNF123
Impedance of arm (right)	24.1	1	1	2.2	1	RNF123
Whole body fat mass	23.1	1	1	2.2	1	RNF123
Wheeze or whistling in the chest in last year	22.8	1	1	2.2	1	RNF123
Ever highly irritable/argumentative for 2 days	22.1	1	1	2.2	1	RNF123
Medication: Co-codamol	20.7	1	0	0.0	1	RNF123
Mood swings	20.5	1	1	2.2	1	RNF123
Average weekly beer plus cider intake	20.5	1	1	2.2	1	RNF123
Weight	20.3	1	1	2.2	1	RNF123
Impedance of whole body	19.4	1	1	2.2	1	RNF123
Fed-up feelings	19.3	1	1	2.2	1	RNF123
Depressed Affect (Nagel 2018)	19.0	1	1	2.2	1	RNF123
Waist circumference	18.2	1	1	2.2	1	RNF123
Arm fat percentage (right)	18.2	1	1	2.2	1	RNF123
Arm fat percentage (left)	18.2	1	1	2.2	1	RNF123
Medication: Seretide 50 evohaler	17.7	1	0	0.0	1	RNF123
Trunk fat mass	16.9	1	1	2.2	1	RNF123
Body fat percentage	16.7	1	1	2.2	1	RNF123
Ever unenthusiastic/disinterested for a whole week	16.6	1	0	0.0	1	RNF123
Arm fat-free mass (left)	16.6	1	1	2.2	1	RNF123
Arm predicted mass (left)	16.6	1	1	2.2	1	RNF123
Arm predicted mass (right)	16.1	1	1	2.2	1	RNF123
Chronic bronchitis/emphysema (mother)	15.2	1	0	0.0	1	RNF123
Alcohol intake versus 10 years previously	15.1	1	0	0.0	1	RNF123
Arm fat-free mass (right)	15.1	1	1	2.2	1	RNF123
Diabetes (self-reported)	15.0	1	0	0.0	1	RNF123
Financial situation satisfaction	14.8	1	0	0.0	1	RNF123
Health satisfaction	14.3	1	0	0.0	1	RNF123
Mouth/teeth dental problems: Dentures	14.2	1	0	0.0	1	RNF123
Exposure to tobacco smoke outside home	14.2	1	0	0.0	1	RNF123
Pain experienced in last month	14.2	1	0	0.0	1	RNF123
Ulcerative Colitis (UC)	13.7	1	0	0.0	1	RNF123
Basal metabolic rate	13.6	1	1	2.2	1	RNF123
Major Depression (MDD)	13.2	1	0	0.0	1	RNF123
Hip circumference	13.2	1	1	2.2	1	RNF123
Frequency of tenseness / restlessness in last 2 weeks	13.0	1	0	0.0	1	RNF123
Number of full brothers	12.8	1	0	0.0	1	RNF123
Age started oral contraceptive pill	12.8	1	0	0.0	1	RNF123
Neuroticism score	12.6	1	1	2.2	1	RNF123
Guilty feelings	12.5	1	0	0.0	1	RNF123
Ever depressed for a whole week	12.1	1	0	0.0	1	RNF123
Type 2 Diabetes (T2D) (2018)	11.9	1	0	0.0	1	RNF123
Number of operations (self-reported)	11.9	1	0	0.0	1	RNF123
Qualifications: CSEs or equivalent	11.8	1	0	0.0	1	RNF123
Trunk fat percentage	11.7	1	1	2.2	1	RNF123
Irritable Bowel Disease (IBD)	11.6	1	1	2.2	1	RNF123
Pain all over the body in last month	11.6	1	0	0.0	1	RNF123
Leg pain on walking	11.5	1	0	0.0	1	RNF123
Leg fat-free mass (left)	11.2	1	1	2.2	1	RNF123
Leg predicted mass (left)	11.1	1	1	2.2	1	RNF123
Medication: Ventolin 100micrograms inhaler	11.1	1	0	0.0	1	RNF123
Loneliness, isolation	11.1	1	0	0.0	1	RNF123
Ever had bowel cancer screening	11.1	1	0	0.0	1	RNF123
Whole body water mass	11.1	1	1	2.2	1	RNF123
Prostate Cancer	10.9	1	0	0.0	1	RNF123
Frequency of unenthusiasm / disinterest in last 2 weeks	10.8	1	0	0.0	1	RNF123
Neuroticism	10.7	1	0	0.0	1	RNF123
Maternal smoking around birth	10.7	1	0	0.0	1	RNF123
Whole body fat-free mass	10.7	1	1	2.2	1	RNF123
Qualifications: nursing, teaching	10.7	1	0	0.0	1	RNF123
Diabetes diagnosed by doctor	10.6	1	0	0.0	1	RNF123
Qualifications: O levels/GCSEs or equivalent	10.4	1	0	0.0	1	RNF123
Impedance of leg (left)	10.3	1	1	2.2	1	RNF123
Medication: Paracetamol	10.2	1	0	0.0	1	RNF123
Medication for cholesterol, blood pressure or diabetes	10.1	1	0	0.0	1	RNF123
Medication: Paracetamol	9.8	1	0	0.0	1	RNF123
Chest pain or discomfort	9.6	1	0	0.0	1	RNF123
Schizophrenia vs Biploar Disorder	9.5	1	0	0.0	1	RNF123
Smoking Status	9.5	1	0	0.0	1	RNF123
Father's age at death	9.5	1	0	0.0	1	RNF123
Neck or shoulder pain in last month	9.5	1	0	0.0	1	RNF123
Had major operations	9.4	1	0	0.0	1	RNF123
Respiratory disease	9.2	1	0	0.0	1	RNF123
Trunk fat-free mass	9.2	1	1	2.2	1	RNF123
Knee pain experienced in last month	9.2	1	0	0.0	1	RNF123
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.2	1	0	0.0	1	RNF123
Forced expiratory volume in 1-second (FEV1), Best measure	9.1	1	1	2.2	1	RNF123
Trunk predicted mass	9.1	1	1	2.2	1	RNF123
Forced expiratory volume in 1-second (FEV1)	9.0	1	1	2.2	1	RNF123
Leg fat-free mass (right)	9.0	1	1	2.2	1	RNF123
Impedance of leg (right)	8.8	1	1	2.2	1	RNF123
Long-standing illness, disability or infirmity	8.8	1	0	0.0	1	RNF123
Leg predicted mass (right)	8.8	1	1	2.2	1	RNF123
Medication: Omeprazole	8.7	1	0	0.0	1	RNF123
Age when periods started (menarche)	8.6	1	0	0.0	1	RNF123
Number of full sisters	8.6	1	0	0.0	1	RNF123
Mother's age at death	8.6	1	0	0.0	1	RNF123
Medication for pain relief, constipation, heartburn	8.5	1	0	0.0	1	RNF123
Neuroticism (Nagel 2018)	8.4	1	0	0.0	1	RNF123
Bilateral oophorectomy (both ovaries removed)	8.4	1	0	0.0	1	RNF123
Number of live births	8.4	1	0	0.0	1	RNF123
Basal cell carcinoma (self-reported)	7.8	1	0	0.0	1	RNF123
Average weekly red wine intake	7.7	1	0	0.0	1	RNF123
Blood White Count	7.6	1	1	2.2	1	RNF123
Seen doctor (GP) for nerves, anxiety, tension or depression	7.6	1	0	0.0	1	RNF123
Medication: Blood pressure	7.6	1	0	0.0	1	RNF123
Number of self-reported non-cancer illnesses	7.6	1	0	0.0	1	RNF123
Diastolic blood pressure, automated reading	7.5	1	0	0.0	1	RNF123
Neuroticism (2016)	7.1	1	0	0.0	1	RNF123
Alcohol usually taken with meals	6.9	1	0	0.0	1	RNF123
Alcohol intake frequency.	6.9	1	0	0.0	1	RNF123
Forced vital capacity (FVC), Best measure	6.8	1	0	0.0	1	RNF123
Body Mass Index (BMI) (2010)	6.7	1	0	0.0	1	RNF123
Asthma (self-reported)	6.6	1	0	0.0	1	RNF123
Asthma	6.5	1	0	0.0	1	RNF123
Crohns Disease (2017)	6.2	1	0	0.0	1	RNF123
Forced vital capacity (FVC)	6.1	1	0	0.0	1	RNF123
Lung FVC	6.0	1	1	2.2	1	RNF123
Systolic blood pressure, automated reading	5.3	1	0	0.0	1	RNF123
Chronotype (morning person)	5.2	1	0	0.0	1	RNF123
Peak expiratory flow (PEF)	5.2	1	0	0.0	1	RNF123
Breast Cancer	4.8	1	0	0.0	1	RNF123
Vascular/heart problems diagnosed by doctor	3.6	1	0	0.0	1	RNF123
Systolic Blood Pressure	3.3	1	0	0.0	1	RNF123
Lung FEV1/FVC ratio	3.2	1	0	0.0	1	RNF123
Comparative height size at age 10	1.9	1	0	0.0	1	RNF123
Blood Eosinophil Count	1.8	1	0	0.0	1	RNF123
Height	0.5	1	0	0.0	1	RNF123

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Adipose Subcutaneous	1	0.029	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	1	0.109	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	1	0.108	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	1	0.051	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Colon Sigmoid	1	0.068	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Thyroid	1	0.025	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Aorta	0	0.000	1.1
GTEx	Artery Tibial	1	0.027	1.1
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.1
GTEx	Brain Cerebellum	1	0.050	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.1
GTEx	Cells Transformed fibroblasts	0	0.000	1.1
GTEx	Esophagus Mucosa	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
GTEx	Lung	0	0.000	1.1
GTEx	Muscle Skeletal	0	0.000	1.1
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Ovary	0	0.000	1.1
GTEx	Pancreas	0	0.000	1.1
GTEx	Pituitary	0	0.000	1.1
GTEx	Prostate	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
GTEx	Stomach	1	0.069	1.1
GTEx	Testis	0	0.000	1.1
GTEx	Whole Blood	0	0.000	1.1
METSIM	Adipose	1	0.022	1.1
NTR	Blood	0	0.000	1.1
YFS	Blood	0	0.000	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.0