Hub : Traits :

Exposure to tobacco smoke at home

20 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49030828 50546340 5 1 3.5e-09 1.6e-06 0.57 99 RNF123

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 19.0 1 1 2.2 0 1 RNF123
Intelligence (Savage-Jansen 2018) 27.1 1 1 2.2 0 1 RNF123
Neuroticism (Nagel 2018) 8.4 1 0 0.0 0 1 RNF123
Schizophrenia vs Biploar Disorder 9.5 1 0 0.0 0 1 RNF123
Crohns Disease (2017) 6.2 1 0 0.0 0 1 RNF123
Irritable Bowel Disease (IBD) 11.6 1 1 2.2 0 1 RNF123
Ulcerative Colitis (UC) 13.7 1 0 0.0 0 1 RNF123
Major Depression (MDD) 13.2 1 0 0.0 0 1 RNF123
Verbal and Numeric Reasoning (VNR) 24.4 1 1 2.2 0 1 RNF123
Breast Cancer 4.8 1 0 0.0 0 1 RNF123
Prostate Cancer 10.9 1 0 0.0 0 1 RNF123
Age at First Birth 41.0 1 1 2.2 0 1 RNF123
Body Mass Index (BMI) (2010) 6.7 1 0 0.0 0 1 RNF123
Neuroticism (2016) 7.1 1 0 0.0 0 1 RNF123
Blood Eosinophil Count 1.8 1 0 0.0 0 1 RNF123
Blood White Count 7.6 1 1 2.2 0 1 RNF123
BMI 28.2 1 1 2.2 0 1 RNF123
Height 0.5 1 0 0.0 0 1 RNF123
Systolic Blood Pressure 3.3 1 0 0.0 0 1 RNF123
Smoking Status 9.5 1 0 0.0 0 1 RNF123
Respiratory disease 9.2 1 0 0.0 0 1 RNF123
Type 2 Diabetes (T2D) (2018) 11.9 1 0 0.0 0 1 RNF123
Lung FEV1/FVC ratio 3.2 1 0 0.0 0 1 RNF123
Lung FVC 6.0 1 1 2.2 0 1 RNF123
Neuroticism 10.7 1 0 0.0 0 1 RNF123
Chronotype (morning person) 5.2 1 0 0.0 0 1 RNF123
Number of treatments/medications taken 25.7 1 1 2.2 0 1 RNF123
Systolic blood pressure, automated reading 5.3 1 0 0.0 0 1 RNF123
Medication: Co-codamol 20.7 1 0 0.0 0 1 RNF123
Impedance of leg (right) 8.8 1 1 2.2 0 1 RNF123
Leg fat-free mass (left) 11.2 1 1 2.2 0 1 RNF123
Trunk fat percentage 11.7 1 1 2.2 0 1 RNF123
Maternal smoking around birth 10.7 1 0 0.0 0 1 RNF123
Fed-up feelings 19.3 1 1 2.2 0 1 RNF123
Frequency of unenthusiasm / disinterest in last 2 weeks 10.8 1 0 0.0 0 1 RNF123
Taking other prescription medications 28.4 1 1 2.2 0 1 RNF123
Age when periods started (menarche) 8.6 1 0 0.0 0 1 RNF123
Bilateral oophorectomy (both ovaries removed) 8.4 1 0 0.0 0 1 RNF123
Qualifications: CSEs or equivalent 11.8 1 0 0.0 0 1 RNF123
Body mass index (BMI) 32.7 1 1 2.2 0 1 RNF123
Impedance of leg (left) 10.3 1 1 2.2 0 1 RNF123
Leg predicted mass (left) 11.1 1 1 2.2 0 1 RNF123
Trunk fat mass 16.9 1 1 2.2 0 1 RNF123
Waist circumference 18.2 1 1 2.2 0 1 RNF123
Alcohol usually taken with meals 6.9 1 0 0.0 0 1 RNF123
Frequency of tenseness / restlessness in last 2 weeks 13.0 1 0 0.0 0 1 RNF123
Forced vital capacity (FVC) 6.1 1 0 0.0 0 1 RNF123
Ever unenthusiastic/disinterested for a whole week 16.6 1 0 0.0 0 1 RNF123
Qualifications: None of the above 28.4 1 1 2.2 0 1 RNF123
Pain all over the body in last month 11.6 1 0 0.0 0 1 RNF123
Diabetes (self-reported) 15.0 1 0 0.0 0 1 RNF123
Fluid intelligence score 26.8 1 1 2.2 0 1 RNF123
Neuroticism score 12.6 1 1 2.2 0 1 RNF123
Weight 20.3 1 1 2.2 0 1 RNF123
Impedance of arm (right) 24.1 1 1 2.2 0 1 RNF123
Arm fat percentage (right) 18.2 1 1 2.2 0 1 RNF123
Trunk fat-free mass 9.2 1 1 2.2 0 1 RNF123
Hip circumference 13.2 1 1 2.2 0 1 RNF123
Alcohol intake versus 10 years previously 15.1 1 0 0.0 0 1 RNF123
Father's age at death 9.5 1 0 0.0 0 1 RNF123
Number of live births 8.4 1 0 0.0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1) 9.0 1 1 2.2 0 1 RNF123
Qualifications: A levels/AS levels or equivalent 38.8 1 1 2.2 0 1 RNF123
Mouth/teeth dental problems: Dentures 14.2 1 0 0.0 0 1 RNF123
Asthma 6.5 1 0 0.0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1), Best measure 9.1 1 1 2.2 0 1 RNF123
Impedance of arm (left) 24.3 1 1 2.2 0 1 RNF123
Arm fat mass (right) 24.8 1 1 2.2 0 1 RNF123
Trunk predicted mass 9.1 1 1 2.2 0 1 RNF123
Seen doctor (GP) for nerves, anxiety, tension or depression 7.6 1 0 0.0 0 1 RNF123
Peak expiratory flow (PEF) 5.2 1 0 0.0 0 1 RNF123
Ever highly irritable/argumentative for 2 days 22.1 1 1 2.2 0 1 RNF123
Qualifications: O levels/GCSEs or equivalent 10.4 1 0 0.0 0 1 RNF123
Medication: Paracetamol 9.8 1 0 0.0 0 1 RNF123
Medication for cholesterol, blood pressure or diabetes 10.1 1 0 0.0 0 1 RNF123
Medication: Ventolin 100micrograms inhaler 11.1 1 0 0.0 0 1 RNF123
Chronic bronchitis/emphysema (mother) 15.2 1 0 0.0 0 1 RNF123
Forced vital capacity (FVC), Best measure 6.8 1 0 0.0 0 1 RNF123
Body fat percentage 16.7 1 1 2.2 0 1 RNF123
Leg fat percentage (right) 26.2 1 1 2.2 0 1 RNF123
Arm fat-free mass (right) 15.1 1 1 2.2 0 1 RNF123
Exposure to tobacco smoke outside home 14.2 1 0 0.0 0 1 RNF123
Number of full brothers 12.8 1 0 0.0 0 1 RNF123
Wheeze or whistling in the chest in last year 22.8 1 1 2.2 0 1 RNF123
Age at first live birth 31.2 1 1 2.2 0 1 RNF123
Health satisfaction 14.3 1 0 0.0 0 1 RNF123
Qualifications: College or University degree 45.7 1 1 2.2 0 1 RNF123
Medication for pain relief, constipation, heartburn 8.5 1 0 0.0 0 1 RNF123
Neck or shoulder pain in last month 9.5 1 0 0.0 0 1 RNF123
Medication: Blood pressure 7.6 1 0 0.0 0 1 RNF123
Medication: Omeprazole 8.7 1 0 0.0 0 1 RNF123
Medication: Seretide 50 evohaler 17.7 1 0 0.0 0 1 RNF123
Whole body fat mass 23.1 1 1 2.2 0 1 RNF123
Leg fat mass (right) 30.1 1 1 2.2 0 1 RNF123
Arm predicted mass (right) 16.1 1 1 2.2 0 1 RNF123
Alcohol intake frequency. 6.9 1 0 0.0 0 1 RNF123
Comparative height size at age 10 1.9 1 0 0.0 0 1 RNF123
Number of full sisters 8.6 1 0 0.0 0 1 RNF123
Overall health rating 31.1 1 1 2.2 0 1 RNF123
Chest pain or discomfort 9.6 1 0 0.0 0 1 RNF123
Had major operations 9.4 1 0 0.0 0 1 RNF123
Age at last live birth 31.8 1 1 2.2 0 1 RNF123
Leg pain on walking 11.5 1 0 0.0 0 1 RNF123
Knee pain experienced in last month 9.2 1 0 0.0 0 1 RNF123
Whole body fat-free mass 10.7 1 1 2.2 0 1 RNF123
Leg fat-free mass (right) 9.0 1 1 2.2 0 1 RNF123
Arm fat percentage (left) 18.2 1 1 2.2 0 1 RNF123
Average weekly red wine intake 7.7 1 0 0.0 0 1 RNF123
Mood swings 20.5 1 1 2.2 0 1 RNF123
Loneliness, isolation 11.1 1 0 0.0 0 1 RNF123
Long-standing illness, disability or infirmity 8.8 1 0 0.0 0 1 RNF123
Ever had bowel cancer screening 11.1 1 0 0.0 0 1 RNF123
Diabetes diagnosed by doctor 10.6 1 0 0.0 0 1 RNF123
Qualifications: nursing, teaching 10.7 1 0 0.0 0 1 RNF123
Asthma (self-reported) 6.6 1 0 0.0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.2 1 0 0.0 0 1 RNF123
Whole body water mass 11.1 1 1 2.2 0 1 RNF123
Leg predicted mass (right) 8.8 1 1 2.2 0 1 RNF123
Arm fat mass (left) 24.8 1 1 2.2 0 1 RNF123
Number of self-reported non-cancer illnesses 7.6 1 0 0.0 0 1 RNF123
Miserableness 31.0 1 1 2.2 0 1 RNF123
Guilty feelings 12.5 1 0 0.0 0 1 RNF123
Mother's age at death 8.6 1 0 0.0 0 1 RNF123
Financial situation satisfaction 14.8 1 0 0.0 0 1 RNF123
Medication: Paracetamol 10.2 1 0 0.0 0 1 RNF123
Basal metabolic rate 13.6 1 1 2.2 0 1 RNF123
Leg fat percentage (left) 25.4 1 1 2.2 0 1 RNF123
Arm fat-free mass (left) 16.6 1 1 2.2 0 1 RNF123
Number of operations (self-reported) 11.9 1 0 0.0 0 1 RNF123
Average weekly beer plus cider intake 20.5 1 1 2.2 0 1 RNF123
Age started oral contraceptive pill 12.8 1 0 0.0 0 1 RNF123
Diastolic blood pressure, automated reading 7.5 1 0 0.0 0 1 RNF123
Ever depressed for a whole week 12.1 1 0 0.0 0 1 RNF123
Vascular/heart problems diagnosed by doctor 3.6 1 0 0.0 0 1 RNF123
Pain experienced in last month 14.2 1 0 0.0 0 1 RNF123
Basal cell carcinoma (self-reported) 7.8 1 0 0.0 0 1 RNF123
Impedance of whole body 19.4 1 1 2.2 0 1 RNF123
Leg fat mass (left) 29.9 1 1 2.2 0 1 RNF123
Arm predicted mass (left) 16.6 1 1 2.2 0 1 RNF123

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 1 0.027 1.1
GTEx Brain Caudate basal ganglia 1 0.109 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 1 0.050 1.1
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 1 0.108 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 1 0.051 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.1
GTEx Cells Transformed fibroblasts 0 0.000 1.1
GTEx Colon Sigmoid 1 0.068 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.1
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.1
GTEx Lung 0 0.000 1.1
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.1
GTEx Ovary 0 0.000 1.1
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.1
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.1
GTEx Stomach 1 0.069 1.1
GTEx Testis 0 0.000 1.1
GTEx Thyroid 1 0.025 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.1
METSIM Adipose 1 0.022 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.0
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1