TWAS hub - IP6K1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0349	0.0187	0.00210	0.001	NA	0.014	NA	0.004	2.4e-01	NA	0.02500	NA	0.1500
2	TCGA	Prostate Adenocarcinoma	0.0330	0.0198	0.00031	0.039	0.037	0.030	NA	0.030	5.5e-05	9.2e-05	0.00035	NA	0.0004

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Qualifications: College or University degree	32.9	103.6	123.2	-11.1	-9.2
Age at First Birth	29.3	42.5	49.5	-7.0	-6.0
Age at last live birth	25.5	37.0	41.0	-6.4	-5.7
Qualifications: A levels/AS levels or equivalent	23.5	52.0	54.5	-7.4	-7.0
Overall health rating	23.3	50.0	51.4	7.2	7.0
Age at first live birth	22.8	40.4	47.4	-6.9	-5.8
Intelligence (Savage-Jansen 2018)	21.7	66.7	75.9	-8.7	-7.6
Miserableness	20.9	36.2	38.8	5.8	6.2
Ulcerative Colitis	20.7	30.1	50.4	-7.1	-3.1
Ulcerative Colitis (UC)	20.6	38.7	57.6	-7.6	-4.4
Leg pain on walking	18.3	22.9	32.9	5.7	3.6
Qualifications: None of the above	18.1	38.8	38.9	6.2	6.2
Impedance of arm (left)	17.5	81.1	90.4	-8.5	-9.5
Taking other prescription medications	17.4	26.8	27.6	5.1	5.3
Irritable Bowel Disease (IBD)	17.3	41.3	68.6	-8.3	-3.7
Verbal and Numeric Reasoning (VNR)	17.3	41.5	41.7	-6.5	-6.4
Body mass index (BMI)	16.7	71.0	73.8	8.6	8.3
Exposure to tobacco smoke at home	16.6	18.6	28.1	3.0	5.3
Impedance of arm (right)	16.4	76.3	88.7	-8.0	-9.4
Ever highly irritable/argumentative for 2 days	16.1	19.3	21.5	4.6	4.1
Age when periods started (menarche)	15.7	37.6	42.0	6.5	5.8
Fed-up feelings	15.5	28.1	33.4	5.8	4.8
BMI	14.7	85.0	85.0	9.2	9.2
Pain experienced in last month	14.6	24.3	27.6	-5.3	-4.6
Impedance of whole body	14.6	74.1	85.6	-7.9	-9.2
Frequency of tenseness / restlessness in last 2 weeks	14.5	22.5	23.1	4.7	4.8
Wheeze or whistling in the chest in last year	14.5	25.9	30.8	4.6	5.5
Depressed Affect (Nagel 2018)	14.3	30.1	30.8	5.4	5.5
Number of treatments/medications taken	14.1	25.4	28.8	4.7	5.4
Medication: Co-codamol	14.1	16.3	17.9	4.2	3.8
Fluid intelligence score	14.1	29.2	33.8	-5.0	-5.8
Medication: Paracetamol	14.1	21.9	22.9	4.6	4.8
Average weekly beer plus cider intake	14.0	20.3	22.2	4.3	4.7
Ever unenthusiastic/disinterested for a whole week	13.9	17.0	23.0	3.3	4.8
Leg fat mass (right)	13.6	52.6	54.2	7.4	7.1
Leg fat mass (left)	13.6	53.1	55.4	7.4	7.1
Mood swings	13.3	24.0	25.7	4.7	5.1
Pain all over the body in last month	13.1	14.0	15.3	3.6	3.9
Frequency of tiredness / lethargy in last 2 weeks	12.5	20.4	25.3	5.0	3.9
Number of operations (self-reported)	12.0	17.9	18.1	4.3	4.2
Ever depressed for a whole week	12.0	14.8	19.3	3.2	4.4
Medication: Paracetamol	11.9	19.7	21.6	4.2	4.6
Leg fat percentage (right)	11.8	42.7	49.0	7.0	6.0
Prostate Cancer	11.7	16.5	17.1	4.0	4.1
Exposure to tobacco smoke outside home	11.7	15.6	17.2	4.1	3.7
Arm fat mass (right)	11.3	46.4	50.7	7.1	6.5
Leg fat percentage (left)	11.3	41.1	47.9	6.9	5.8
Qualifications: CSEs or equivalent	11.2	14.9	18.9	4.3	3.3
Arm fat mass (left)	11.0	45.2	47.5	6.9	6.5
Knee pain experienced in last month	10.6	16.5	23.8	4.9	3.0
Weight	10.2	50.0	52.9	6.9	7.3
Arm fat-free mass (left)	10.0	50.7	59.0	6.5	7.7
Arm predicted mass (left)	10.0	50.8	58.4	6.6	7.6
Alcohol intake versus 10 years previously	9.9	14.7	23.4	4.8	2.5
Whole body fat mass	9.9	41.3	45.2	6.7	6.1
Chest pain or discomfort	9.9	14.2	17.3	3.3	4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.5	20.1	25.1	-3.9	-5.0
Chronic bronchitis/emphysema (mother)	9.3	10.9	10.9	3.3	3.3
Arm predicted mass (right)	9.3	47.3	56.7	6.2	7.5
Financial situation satisfaction	9.3	11.6	15.3	2.8	3.9
Guilty feelings	9.1	13.7	15.9	3.4	4.0
Number of full brothers	8.8	11.1	13.1	3.0	3.6
Neck or shoulder pain in last month	8.8	12.4	12.6	3.5	3.6
Smoking Status	8.7	20.8	26.9	3.8	5.2
Mouth/teeth dental problems: Dentures	8.7	14.7	14.7	3.8	3.8
Arm fat-free mass (right)	8.7	44.6	54.5	5.9	7.4
Crohns Disease (2012)	8.6	13.8	24.4	-4.9	-1.8
Loneliness, isolation	8.6	11.8	13.0	3.6	3.3
Mother’s age at death	8.5	10.7	12.7	-2.9	-3.6
Major Depression (MDD)	8.4	10.3	15.4	2.3	3.9
Crohns Disease (2017)	8.3	18.3	32.9	-5.7	-1.9
Father’s age at death	8.2	11.0	11.5	-3.4	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	8.1	12.4	13.7	3.3	3.7
Had major operations	8.1	9.5	13.0	2.5	3.6
Osteoarthritis (self-reported)	8.1	10.5	16.2	4.0	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	7.8	25.0	28.5	-4.6	-5.3
Basal metabolic rate	7.8	43.1	50.4	6.0	7.1
Arm fat percentage (right)	7.6	30.1	36.2	6.0	4.9
Impedance of leg (left)	7.5	36.4	45.2	-5.2	-6.7
Health satisfaction	7.4	9.6	15.8	1.8	4.0
Chronotype (morning person)	7.2	16.7	19.4	-4.4	-3.7
Hip circumference	7.2	31.1	32.0	5.7	5.5
Arm fat percentage (left)	7.1	28.4	33.6	5.8	4.8
Forced expiratory volume in 1-second (FEV1)	6.9	23.4	31.4	-3.9	-5.6
Shortness of breath walking on level ground	6.8	8.0	9.3	3.0	2.6
Whole body water mass	6.7	38.3	47.4	5.4	6.9
Neuroticism	6.6	15.9	18.0	3.7	4.2
Impedance of leg (right)	6.6	31.8	38.9	-5.0	-6.2
Whole body fat-free mass	6.6	37.5	46.2	5.4	6.8
Neuroticism score	6.5	13.7	16.3	3.3	4.0
Qualifications: O levels/GCSEs or equivalent	6.5	10.4	12.3	-2.9	-3.5
Medication for pain relief, constipation, heartburn	6.5	11.1	13.4	-3.0	-3.7
Waist circumference	6.4	23.4	23.6	4.8	4.9
Trunk fat mass	6.3	26.9	29.6	5.4	4.9
Body fat percentage	6.3	24.9	31.5	5.6	4.3
Number of self-reported non-cancer illnesses	6.3	10.9	12.5	3.1	3.5
Leg fat-free mass (left)	6.2	33.0	37.9	5.3	6.2
Leg predicted mass (left)	6.2	33.1	37.7	5.3	6.1
Medication: Omeprazole	6.2	7.4	9.6	3.1	2.3
Maternal smoking around birth	6.1	8.8	10.6	2.6	3.3
Trunk fat-free mass	6.0	34.4	45.0	4.9	6.7
Age started oral contraceptive pill	6.0	7.6	8.1	-2.9	-2.6
Ever had hysterectomy (womb removed)	5.9	6.6	11.9	3.4	1.2
Trunk predicted mass	5.8	32.9	43.5	4.7	6.6
Relative age of first facial hair	5.6	11.6	18.7	2.1	4.3
Number of full sisters	5.5	6.6	7.1	2.7	2.5
Lung FVC	5.4	27.3	32.5	-4.7	-5.7
Forced vital capacity (FVC), Best measure	5.4	19.9	20.6	-4.5	-4.4
Qualifications: nursing, teaching	5.4	8.4	12.2	-3.5	-2.1
Respiratory disease	5.3	11.7	17.6	2.4	4.2
Noisy workplace	5.3	6.5	9.0	3.0	2.0
Leg fat-free mass (right)	5.3	28.3	32.7	4.9	5.7
Leg predicted mass (right)	5.2	27.5	32.0	4.8	5.7
Frequency of unenthusiasm / disinterest in last 2 weeks	5.1	6.7	7.9	2.4	2.8
Number of children fathered	5.1	5.7	9.5	3.1	1.4
Coronary Artery Disease (CAD)	5.0	6.0	7.2	2.7	2.2
Bilateral oophorectomy (both ovaries removed)	4.9	5.7	5.9	2.4	2.4
Had other major operations	4.9	5.9	8.0	2.8	2.0
Medication: Seretide 50 evohaler	4.9	5.6	9.5	1.3	3.1
Commuting to job workplace: Car/motor vehicle	4.9	5.6	8.5	2.9	1.6
Neuroticism (Nagel 2018)	4.8	11.3	13.9	3.0	3.7
Current tobacco smoking	4.8	7.9	8.2	2.8	2.9
Pain type(s) experienced in last month: Hip pain	4.8	6.1	7.2	2.7	2.2
Irritability	4.8	8.1	14.3	1.4	3.8
Schizophrenia vs Biploar Disorder	4.7	6.2	6.5	-2.4	-2.5
Blood White Count	4.7	34.9	35.8	6.0	5.8
Pack years adult smoking proportion	4.7	7.2	10.6	2.0	3.2
Alcohol intake frequency.	4.7	11.0	19.5	4.4	1.6
Commuting to job workplace: Walk	4.7	5.0	6.8	-2.6	-1.8
Alcohol drinker status: Previous	4.7	5.4	7.6	1.8	2.8
Past tobacco smoking	4.6	8.5	12.7	-2.0	-3.6
Medication: Ibuprofen	4.6	5.5	6.1	2.5	2.2
Chronic bronchitis/emphysema (father)	4.5	5.3	6.0	2.1	2.4
Average weekly red wine intake	4.5	6.7	7.1	-2.5	-2.7
Breast Cancer	4.4	10.5	10.5	-3.2	-3.2
Alcohol usually taken with meals	4.4	7.1	7.1	-2.7	-2.7
Forced vital capacity (FVC)	4.4	17.1	19.2	-3.9	-4.4
Medication: Ibuprofen (e.g. Nurofen)	4.4	5.6	7.7	2.8	1.9
Medication: Omeprazole (e.g. Zanprol)	4.4	5.3	7.3	2.7	1.8
Tinnitus: Yes, but not now, but have in the past	4.2	4.5	7.0	2.6	1.4
Medication: Lansoprazole	4.2	4.8	8.9	3.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	4.1	5.3	7.5	1.8	2.7
Illnesses of siblings: Diabetes	4.1	5.0	7.1	2.7	1.7
Neuroticism (2016)	4.0	5.8	6.9	2.2	2.6
Back pain experienced in last month	4.0	5.9	6.6	2.6	2.3
Commuting to job workplace: Public transport	4.0	4.8	5.1	-2.1	-2.3
Pulse wave reflection index	3.9	4.8	9.3	0.6	3.0
Asthma (self-reported)	3.9	7.7	11.2	2.0	3.4
Ever taken oral contraceptive pill	3.9	4.4	4.5	2.1	2.1
Trunk fat percentage	3.8	15.3	20.5	4.5	3.2
Family relationship satisfaction	3.8	4.6	6.7	1.6	2.6
Long-standing illness, disability or infirmity	3.8	5.7	8.4	1.8	2.9
Ever smoked	3.8	6.8	10.6	1.7	3.3
Pulse rate	3.7	6.2	8.2	-2.1	-2.9
Asthma	3.7	7.3	10.9	1.9	3.3
Smoking status: Previous	3.7	5.5	8.2	1.7	2.9
Commuting to job workplace: Cycle	3.7	4.5	6.4	-2.5	-1.6
Lung FEV1/FVC ratio	3.6	18.5	36.7	-0.5	-6.1
Systolic blood pressure, automated reading	3.6	10.5	12.0	3.0	3.5
Smoking status: Current	3.6	5.7	5.7	2.4	2.4
Diastolic blood pressure, automated reading	3.6	11.2	15.4	3.9	2.6
HbA1C	3.5	3.9	4.8	-2.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.5	4.1	5.2	1.7	2.3
Frequency of depressed mood in last 2 weeks	3.4	4.8	5.5	2.4	2.0
Basal cell carcinoma (self-reported)	3.4	4.1	4.6	-2.1	-1.9
Bipolar Disorder (2018)	3.3	5.2	8.1	1.5	2.8
Medication: Ramipril	3.3	4.3	6.8	1.3	2.6
Pack years of smoking	3.3	4.9	8.1	1.3	2.9
Stomach or abdominal pain in last month	3.2	3.9	4.5	1.8	2.1
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	4.2	-1.8	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	3.9	1.9	2.0
Number of live births	3.1	4.4	6.0	2.5	1.7
Alcohol drinker status: Never	3.1	3.7	6.1	-1.1	-2.5
Heart attack	3.0	3.9	5.7	2.4	1.4
Lung cancer (father)	3.0	3.5	5.5	2.3	1.3
Tense / ‘highly strung’	3.0	5.0	5.6	2.1	2.4
Medication: Ventolin 100micrograms inhaler	3.0	3.9	4.7	1.8	2.2
Lupus	2.9	4.4	6.9	2.6	1.4
Average weekly spirits intake	2.9	3.6	5.2	2.3	1.4
Financial difficulties in last 2 years	2.9	3.9	4.4	2.1	1.8
Worry too long after embarrassment	2.9	4.8	9.4	-3.1	-0.5
Medication: Blood pressure	2.9	5.2	5.5	2.2	2.3
Type 2 Diabetes (T2D) (2018)	2.8	5.3	6.9	2.6	1.9
Breastfed as a baby	2.8	3.5	4.1	-2.0	-1.7
Peak expiratory flow (PEF)	2.8	6.5	9.5	-1.8	-3.1
Medication: Atenolol	2.7	3.4	5.4	2.3	1.2
Illnesses of siblings	2.7	3.9	5.1	-1.6	-2.3
Relative age voice broke	2.5	3.9	5.8	1.4	2.4
Mouth/teeth dental problems	2.5	3.8	4.1	-2.0	-1.9
Prospective memory result	2.5	3.1	3.2	1.8	1.8
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	4.2	1.1	2.0
Heart attack/myocardial infarction (self-reported)	2.4	3.1	4.3	2.1	1.4
Body Mass Index (BMI) (2010)	2.3	3.1	3.2	1.8	1.7
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	4.7	-1.7	-2.2
Ever had bowel cancer screening	2.3	2.7	3.3	-1.4	-1.8
Comparative body size at age 10	2.1	5.8	7.6	2.0	2.8
Depression (Nagel 2018)	2.0	3.0	3.6	1.5	1.9
Ever used hormone-replacement therapy (HRT)	1.9	2.4	2.6	1.6	1.5
Diabetes (self-reported)	1.9	3.0	4.8	1.1	2.2
Comparative height size at age 10	1.9	10.4	13.7	-3.7	-2.7
Average weekly champagne plus white wine intake	1.9	2.6	4.4	-2.1	-1.0
Glaucoma (self-reported)	1.8	2.2	2.8	-1.7	-1.2
Had menopause	1.7	2.2	3.0	-1.7	-1.2
Handedness (chirality/laterality): Left-handed	1.7	2.0	3.9	-2.0	-0.3
Average weekly fortified wine intake	1.6	1.9	2.5	1.2	1.6
Depression (self-reported)	1.6	1.9	3.5	1.9	0.5
Emphysema/chronic bronchitis	1.6	1.8	3.5	-0.4	1.9
Breast cancer (self-reported)	1.6	1.9	2.3	1.2	1.5
Hypothyroidism (self reported)	1.5	3.5	3.6	1.9	1.8
Hand grip strength (right)	1.5	4.2	5.1	2.3	1.8
Townsend deprivation index at recruitment	1.5	2.1	3.8	1.9	0.7
Hair/balding pattern: Pattern 2	1.5	1.9	3.3	0.7	1.8
Allergy	1.5	3.5	6.0	-1.0	-2.4
Osteoporosis (self-reported)	1.5	1.8	3.1	0.7	1.8
High blood pressure (siblings)	1.4	2.0	3.6	0.6	1.9
Pulse rate, automated reading	1.4	4.4	8.0	-0.9	-2.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.8	0.4	1.7
Fasting Glucose	1.3	1.6	2.9	1.7	0.6
Waist Hip Ratio (WHR)	1.3	6.0	6.2	-2.4	-2.5
Falls in the last year	1.3	1.8	3.4	-0.3	1.9
Hair/balding pattern: Pattern 3	1.3	1.9	2.1	-1.3	-1.4
Loud music exposure frequency	1.3	1.5	2.6	-1.6	-0.6
Systolic Blood Pressure	1.2	5.9	5.9	2.4	2.4
Medication: Levothyroxine sodium	1.2	2.0	2.5	1.2	1.6
Hearing difficulty/problems with background noise	1.2	1.8	2.2	-1.2	1.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	2.9	1.3	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.3	1.5	0.8
Diabetes diagnosed by doctor	1.2	1.9	2.7	1.1	1.6
Vascular/heart problems diagnosed by doctor	1.2	3.2	4.1	-1.5	-2.0
Headache pain in last month	1.1	1.9	2.1	1.4	1.4
HDL Cholesterol	1.0	1.7	3.2	-1.8	0.4
Medication for hormone replacement therapy	1.0	1.1	1.3	1.2	0.9
Supplements: Zinc	1.0	1.0	1.8	-0.5	1.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.4	1.2	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.3	-1.1	-1.1
Cardiovascular Disease	0.9	3.0	3.7	1.9	1.6
Time employed in main current job	0.9	1.0	1.7	-0.5	-1.3
Worrier / anxious feelings	0.9	1.6	2.3	1.5	1.0
Hair/balding pattern: Pattern 4	0.9	2.2	4.2	2.0	-0.4
Medication: Gliclazide	0.9	1.0	1.1	0.9	1.1
Myopia	0.9	1.3	2.5	0.3	-1.6
Bipolar Disorder (2011)	0.8	0.8	0.8	0.9	0.9
Triglycerides	0.8	1.3	2.4	-0.5	-1.5
High blood pressure	0.8	2.3	2.7	1.4	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	2.5	1.1	-1.6
Heart disease (siblings)	0.8	1.0	1.8	1.3	0.4
Bipolar Disorder or Schizophrenia	0.7	1.8	1.9	1.3	1.4
Primary Biliary Cirrhosis	0.7	1.0	2.0	-0.2	-1.4
Medication: Cholesterol lowering	0.7	1.2	1.4	1.0	1.2
Pulse wave peak to peak time	0.7	0.8	1.5	0.4	-1.2
Eye problems/disorders: None of the above	0.7	0.8	1.5	1.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	0.9	-1.0	-0.8
Hypertension (Self-reported)	0.7	2.0	2.8	1.1	1.7
Wears glasses or contact lenses	0.7	0.9	1.4	0.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.3	-0.6	1.1
Medication: Metformin	0.6	0.9	1.4	0.5	1.2
Diabetes (mother)	0.6	0.7	1.4	-0.3	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.3	1.5	-0.7
Pulse wave Arterial Stiffness index	0.6	0.8	1.2	-0.6	1.1
Supplements: Vitamin C	0.6	0.7	1.0	-1.0	0.5
High cholesterol (Self-reported)	0.6	1.1	1.6	-0.7	-1.3
Illnesses of father: High blood pressure	0.6	0.7	1.3	-1.1	-0.3
Risk taking	0.6	0.8	0.8	0.9	0.9
LDL Cholesterol	0.5	0.8	0.9	0.9	-0.9
Heel T-Score	0.5	3.8	7.2	0.6	-2.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	-1.0	-0.3
Multivitamins +/- minerals	0.5	0.6	1.0	0.5	1.0
Number of incorrect matches in round	0.5	0.8	1.3	0.5	1.1
Standing height	0.5	4.7	8.6	-2.9	-0.8
Birth weight of first child	0.5	0.9	1.7	-1.3	-0.4
Unable to work because of sickness or disability	0.5	0.7	1.3	0.1	1.1
Cholesterol lowering medication	0.5	0.7	0.7	0.8	0.9
Rheumatoid Arthritis	0.4	0.5	0.6	0.8	0.6
Height	0.4	8.7	15.7	-4.0	-1.3
Supplements: Glucosamine	0.4	0.5	0.8	0.4	-0.9
Mean time to correctly identify matches	0.4	0.8	1.0	-1.0	-0.7
Medication for cholesterol	0.4	0.6	0.6	-0.8	-0.8
Medication: Bendroflumethiazide	0.4	0.5	0.6	0.7	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	0.8	0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.8	0.3
Ovarian Cancer	0.3	0.4	0.8	0.9	0.2
Blood Red Count	0.3	3.0	4.9	-1.1	-2.2
Sensitivity / hurt feelings	0.3	0.5	0.9	-0.1	1.0
Hearing difficulty/problems: Yes	0.3	0.4	0.5	-0.6	0.7
Vitamin and mineral supplements	0.3	0.4	0.8	0.2	-0.9
Severe depression (siblings)	0.3	0.3	0.4	-0.6	0.5
Serious illness, injury or assault to yourself	0.3	0.3	0.5	0.7	0.4
Illnesses of mother	0.3	0.4	0.7	-0.1	-0.9
Length of working week for main job	0.3	0.3	0.6	-0.8	-0.2
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.8	0.4
Friendships satisfaction	0.3	0.4	0.8	-0.9	-0.1
Medication: Aspirin	0.3	0.3	0.5	-0.7	0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	0.0	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.3	-0.8
Worry (Nagel 2018)	0.2	0.4	0.5	0.6	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.2	0.6
Reaction Time	0.2	0.3	0.4	-0.6	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.7	0.0
Hand grip strength (left)	0.2	0.4	0.4	0.7	0.7
Sitting height	0.2	1.2	1.4	-1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	-0.3	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.7	-0.0
Medication: Allopurinol	0.2	0.3	0.5	-0.7	0.2
Heart disease (mother)	0.2	0.2	0.3	0.6	0.3
Medication: Aspirin	0.2	0.3	0.6	-0.8	0.1
Illnesses of father: Heart disease	0.2	0.3	0.6	0.1	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.2	-0.5	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.3	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.3	-0.6	0.5
Supplements: Calcium	0.2	0.2	0.4	-0.6	0.2
Schizophrenia (2018)	0.1	0.3	0.3	0.5	-0.5
Alzheimer’s Disease (in father)	0.1	0.2	0.2	0.5	-0.3
Mean Putamen Volume	0.1	0.1	0.2	-0.1	-0.4
Blood Eosinophil Count	0.1	0.9	1.3	0.7	1.2
Blood Platelet Count	0.1	0.8	1.0	-1.0	0.8
Tanning	0.1	1.8	3.1	1.8	0.7
Angina	0.1	0.2	0.4	-0.1	0.6
Diabetes (father)	0.1	0.1	0.2	0.1	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.6	0.0
High blood pressure (mother)	0.1	0.2	0.3	-0.5	-0.3
Nervous feelings	0.1	0.2	0.3	-0.5	0.3
Medication: Simvastatin	0.1	0.1	0.1	-0.4	0.2
Happiness	0.1	0.2	0.3	0.1	0.5
Gout (self-reported)	0.1	0.1	0.2	-0.1	0.5
Medication: Amlodipine	0.1	0.2	0.3	-0.1	0.6
Birth weight	0.1	0.2	0.4	0.1	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.6	-0.1
Angina (self-reported)	0.1	0.2	0.3	-0.2	0.6
Migraine (self-reported)	0.1	0.1	0.1	0.3	0.2
Suffer from ‘nerves’	0.1	0.2	0.4	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	-0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.7	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.2	-0.6
Medication: Blood pressure	0.1	0.1	0.3	0.2	0.5
Medication: Lisinopril	0.1	0.2	0.2	0.5	0.4
Medication: Atorvastatin	0.1	0.1	0.1	0.4	0.1
Schizophrenia (2014)	0.0	0.1	0.1	0.4	-0.0
Allergy or Eczema	0.0	0.0	0.0	-0.1	-0.1
Hair Pigment	0.0	0.4	0.8	-0.0	0.9
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.3	-0.1
Mineral and other dietary supplements	0.0	0.0	0.1	-0.2	-0.2
Hearing aid user	0.0	0.0	0.0	-0.1	-0.2

Hub : Genes

IP6K1

Models

Trait associations